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| 1 | 缺血性脑卒中和出血性脑卒中患者发病前后血压的变化显示文摘《中国高血压防治指南2010》指出,急性脑卒中的血压处理缺乏足够的临床试验证据,参考建议如下:急性脑卒中溶栓前血压应控制在<185/110mm Hg(1mm Hg=0.133kPa)。对急性缺血性脑卒中发病24h内血压升高的患者应谨慎处理,收缩压≥180mm Hg或舒张压≥100mm Hg或伴有严重心功能不全、主动脉夹层、高血压脑病者,一般不予降压。降压的合理目标是24h内血压降低约15%。有高血压病史且正在服用降压药物者,如神经功能平稳,可于脑卒中发病后24h开始使用降压药物。因此,了解脑卒中患者发病前后的血压情况对临床治疗有重要的意义。Fischer等研究者探讨缺血性脑卒中和出血性脑卒中患者发病前后血压的变化情况。结果表明,缺血性脑卒中患者发病后首次测量的收缩压低于出血性脑卒中。与发病前比较,缺血性脑卒中发病后收缩压略升高(约10.6mm Hg),24h内轻度降低(约13.6mm Hg);而出血性脑卒中发病后,收缩压明显升高(约40.7mm Hg),24h内明显下降(约41.1mm Hg)。出血性脑卒中发病前几天及几周的平均收缩压逐渐增加,而缺血性脑卒中无明显变化。出血性脑卒中患者发病3h内的最高收缩压比发病前高50.0 mm Hg,而缺血性脑卒中则低5.2mm Hg。综上所述,与发病前比较,出血性脑卒中发病后收缩压升高,而缺血性脑卒中无明显变化。 | Fischer U Cooney MT Bull LM Silver LE Chalmers J Anderson CS Mehta Z Rothwell PM 林东杰 叶鹏 | 2014 | 中华高血压杂志2014，22，4： | 13 |
| 2 | 俄罗斯出口关税调整对中国木材市场的影响显示文摘俄罗斯是中国最大的原木进口来源国,俄罗斯政府宣布从2010年1月起将原木出口关税从当前的6.5%增加到80%。本文通过建立中国区域木材市场模型,模拟了俄罗斯原木出口关税提高将对我国各地区的木材市场产生的数量影响。由模型得到的结论是:东北地区将受到的影响最大,森林资源的采伐压力会因为进口关税的大幅度提高而增加;中部地区的采伐量将增加约2%左右;而西部和南部地区的采伐数量几乎不变。从全国范围来看,我国采伐总量将增加3.23%。从地区间的贸易影响来看,中部地区的木材进口会流向东北地区,来弥补东北进口木材数量减少带来的影响。据此,文章最后提出了相应的政策建议:进口渠道的多元化,保证国内的木材安全;相关政府部门应进一步为中国林业加工企业到俄罗斯投资提供便利和引导,从而进一步明晰产业分工格局;从俄罗斯进来的原木减少,应将大部分板材落地加工,促使地区木材产品结构调整和产业升级,逐渐改变单以加工锯材为主的产品结构。 | 王兰会 刘俊昌 Steven Northway Gary Bull | 2011 | 中国人口·资源与环境2011，21，1： | 5 |
| 3 | Diagnosis in bile acid-CoA:Amino acid N-acyltransferase deficiency显示文摘Cholate-CoA ligase(CCL) and bile acid-CoA:amino acid N-acyltransferase(BAAT) sequentially mediate bile-acid amidation.Defects can cause intrahepatic cholestasis.Distinction has required gene sequencing.We assessed potential clinical utility of immunostaining of liver for CCL and BAAT.Using commercially available antibodies against BAAT and CCL,we immunostained liver from an infant with jaundice,deficiency of amidated bile acids,and transcription-terminating mutation in BAAT.CCL was normally expressed.BAAT expression was not detected.Immunostaining may facilitate diagnosis in bileacid amidation defects. | Nedim Hadzi Laura N Bull Peter T Clayton AS Knisely | 2012 | World Journal of Gastroenterology2012，18，25： | 3 |
| 4 | 地中海膳食干预研究中来自胆碱通路的血浆代谢物与心血管病风险的关系显示文摘血浆甜菜碱水平以及胆碱代谢水平与主要心血管病终点之间的联系仍不清楚。研究者评估了胆碱通路的代谢物与偶发心血管病风险以及地中海膳食干预的潜在调节效应之间的相关性。 | 黄洁 叶鹏 Guasch-Ferré M Hu FB Ruiz-Canela M Bulló M Toledo E Wang DD Corella D Gómez-Gracia E Fiol M Estruch R Lapetra J Fitó M Arós F Serra-Majem L Ros E Dennis C Liang L Clish CB Martínez-González MA Salas-Salvadó J | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 5 | Molecular and morphological evidence for a new grass genus, Dupontiopsis (Poaceae tribe Poeae subtribe Poinae s.l.), endemic to alpine Japan, and implications for the reticulate origin of Dupontia and Arctophila within Poinae s.l.显示文摘在 Poaceae 部落 Poeae subtribes Puccinellinae (=Coleanthinae ) 以内的种系发生的分析, Phleinae, Poinae s.l (包括的 Alopecurinae ) ,和 Miliinae (PPAM clade ) ,表明先前在 Poa 放的一种代表属于 subtribe Poinae s.l 的一个新 monotypic 类, Dupontiopsis 情报。nov, D。hayachinensis 梳子。nov。(基于 Poa hayachinensis ) ,对在北日本的湿、多碎石的、蛇的、高山的产地地方性。这个类与二个 circumarctic Poinae 类, Arctophila 和 Dupontia 形成强烈支持的 clade (爸爸) ,在质体和原子 ribosomal DNA 顺序数据的种系发生的分析。形态学和 DNA 顺序分析为 D 提供支持。是的 hayachinensis 从 Arctophila 或 Dupontia 不同的一个系,与对一个位置的中等 DNA 支持作为到这二个类的姐妹。 Dupontiopsis 类似于这些在它的几花的小穗状花小穗的另外的 monotypic 类,词根通常3神经,与经常 awned 稀释干膜质的顶(作为在 Dupontia )并且有在词根的底附近的头发的一个王冠的胼胝,但是在它的翻身词根不同,粗糙的 palea 龙骨,比第一个词根短的颖。我们的调查建议 DAD clade 的最近的分享的祖先从一个单个杂交事件演变,作为 hexaploid,可能在西方的 Beringia。祖先的可能的出身被认为在排除 Poa 的 Poinae-Alopecurinae clade 以内。我们为 duodecaploid Dupontia fisheri 的可能的第二等的杂交和基因渗入向证据提供 Puccinellia。有毛乎乎的胼胝的 PPAM 的长期的类的关键,和在在 PPAM 接受的类的词法人物的一张补加的表格被提供。 | Robert J. Soreng Lynn J. Gillespie Hidehisa Koba Ekaterina Boudko Roger D. Bull | 2015 | Journal of Systematics and Evolution2015，53，2： | 2 |
| 6 | Beyond just a tight fortress:contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer显示文摘Novel effective treatment is direly needed for patients with pancreatic ductal adenocarcinoma(PDAC).Therapeutics that target the driver mutations,especially the KRAS oncoprotein and its effector cascades,have been ineffective.It is increasing clear that the extensive fibro-inflammatory stroma(or desmoplasia)of PDAC plays an active role in the progression and therapeutic resistance of PDAC.The desmoplastic stroma is composed of dense extracellular matrix(ECM)deposited mainly by the cancer-associatedfibroblasts(CAFs)and infiltrated with various types of immune cells.The dense ECM functions as a physical barrier that limits tumor vasculatures and distribution of therapeutics to PDAC cells.In addition,mounting evidence have demonstrated that both CAFs and ECM promote PDAC cells aggressiveness through multiple mechanisms,particularly engagement of the epithelial-mesenchymal transition(EMT)program.Acquisition of a mesenchymal-like phenotype renders PDAC cells more invasive and resistant to therapyinduced apoptosis.Here,we critically review seminal and recent articles on the signaling mechanisms by which each stromal element promotes EMT in PDAC.We discussed the experimental models that are currently employed and best suited to study EMT in PDAC,which are instrumental in increasing the chance of successful clinical translation. | Ashenafi Bulle Kian-Huat Lim | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 7 | Combined morphological-spectral unsupervised image segmentation显示文摘 | O'Callaghan R J Bull D R | 2005 | IEEE Transactions on Image Processing2005，14，1： | 1 |
| 8 | The wilson disease gene is a putative copper transporting P- type ATPase similar to the Menkes gene 显示文摘 | Thomas GR Rommens JM | 1993 | Nature Genet1993，5，12： | 1 |
| 9 | Fetal and placental size and risk of hypertension in edult life显示文摘 | Barker DJ Bull AR Osmond C | 1990 | BMJ1990，301，6746： | 1 |
| 10 | Pulmonary hypertensive crises following surgery for congenital heart defects in young children 显示文摘 | Hopkins R A Bull C Haworth S G | 1991 | Eur J Cardiothorac Surg1991，5，12： | 1 |
| 11 | Biome- chanical differences in soccer kicking with the preferred andnon-preferred leg显示文摘 | DORGE H C BULL ANDERSEN T SIMONSEN E B | 2002 | J Sport Sci2002，20，4： | 1 |
| 12 | Reconstitution of the vascular wall in vitro: A novel model to study interactions between endothelial and smooth muscle cells显示文摘 | van Bull - Wortelboer MF Brinkman HJM Dingemans KP | 1986 | Exp Cell Res1986，162，： | 1 |
| 13 | Towards a theory of entrepreneurship显示文摘 | Bull Ivan Willard GE | 1993 | Journal of Business Venturing1993，8，3： | 1 |
| 14 | The immunogenicity of platelet membrane glycoproteins显示文摘 | Kunicki TJ Furihata K Bull B | 1987 | Transfusion Med Rev1987，1，： | 1 |
| 15 | Improved enzymelinked immunosorbent assay to detect didecyldimethylammonium chloride,a quaternary ammonium compound显示文摘 | Bull J P Serreqi A N Gamboa H R | 1998 | J Agric Food Chem1998，467，： | 1 |
| 16 | Combined Morphological-Spectral Unsupervised Image Segmentation显示文摘 | O'CALLAGHAN R J BULL DR | 2005 | IEEE Transactions on Image Process2005，4，1： | 1 |
| 17 | Relationship of air tempernature to various chemical,haematological and haemostatic variables显示文摘 | Bull G M Brozovic M Chakrabarti R | 1979 | J Clin pathol1979，32，12： | 1 |
| 18 | Gold and trace element zonation in pyrite using a laser imaging technique: Implications for the timing of gold in orogenic and Carlin- style sediment- hosted deposits 显示文摘 | R R Large L Danyushevsky C Hollit V Maslennikov S Meffer S Gilbert S Bull R Scott P Emsbo H Thomas B Singh J Foster | 2009 | Economic Geology2009，104，5： | 1 |
| 19 | A silldy of various estimators for the derivation of quality control procedures from patient erythrocyte indices 显示文摘 | Bull BS | 1974 | Am J Clin Pathol1974，61，： | 1 |
| 20 | Multiple molecular mechanisms underlying subdiagnostic variants of Marfan syndrome 显示文摘 | Montgomery RA Geraghty MT Bull E | 1998 | Am J Hum Genet1998，63，6： | 1 |
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