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| 1 | Transarterial chemoembolization and bland embolization for hepatocellular carcinoma显示文摘Transarterial chemoembolization(TACE)is the first line treatment for patients with intermediate stage hepatocellular carcinoma but is also increasingly being used for patients on the transplant waiting list to prevent further tumor growth.Despite its widespread use,TACE remains an unstandardized procedure,with variation in type and size of embolizing particles,type and dose of chemotherapy and interval between therapies.Existing evidence from randomized controlled trials suggest that bland transarterial embolization(TAE)has the same efficacy with TACE.In the current article,we review the use of TACE and TAE for hepatocellular carcinoma and we focus on the evidence for their use. | Emmanuel A Tsochatzis Evangelia Fatourou James O'Beirne Tim Meyer Andrew K Burroughs | 2014 | World Journal of Gastroenterology2014，20，12： | 18 |
| 2 | 运动方向的线状指示物与斑变晶中叶理交切轴(FIAs)的比较及其与板块相对运动方向的关系(英文)显示文摘过去还无人指出过板块相对运动的方向与缓倾斜叶理、逆断层和断层上的线状指示物有直接关系,这是因为缓倾斜构造上的运动方向只和变厚了的造山地层的重力塌陷有关,它们和俯冲板块传递给仰冲板块的推力没有关系。缓倾斜叶理上的运动方向的线状指示物和斑状变晶中的叶理弯曲或叶理交切轴(FIA)并无直接关系,这是因为FIA的指向受缓倾斜叶理和斑状变晶边缘上产生的、近乎垂直的叶理之间的交切面控制。在班状变晶边缘上形成的、近乎垂直的叶理在基质中的方位可能在较大范围内变动,因为它们会在稍早期间形成的叶理再活化作用影响下发生转动或遭到破坏。斑状变晶边缘上近乎垂直的叶理,与形成于早期或晚期的缓倾斜叶理的交线,在后期的生长中被圈闭在班状变晶里,此交线规定出了FIA的方位,而与叶理上的运动方向无关。从美国佛蒙特州阿巴拉契亚山脉采集的FIA资料指出,在125km×35km的一片地区内,在该地岩层所发生的多次变形中,从未曾使早期形成的FIA组的方位发生变动。这种情况要求:后来的每一代褶皱都是由于渐进的。总体不均匀缩短作用造成的。这种情况表明:FIA保存着原始的运动方向,此方向未因以后的变形而转动。 | Tim H. Bell Wang Jianqi(School of Earth Sciences, James Cook University, Townsville, Qld 4811, Australia) | 1999 | 地学前缘1999，6，3： | 5 |
| 3 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 4 | Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA显示文摘 | Luigi Warren Philip D. Manos Tim Ahfeldt Yuin-Han Loh Hu Li Frank Lau Wataru Ebina Pankaj K. Mandal Zachary D. Smith Alexander Meissner George Q. Daley Andrew S. Brack James J. Collins Chad Cowan Thorsten M. Schlaeger Derrick J. Rossi | 2010 | Cell Stem Cell2010，，5： | 4 |
| 5 | 肱骨近端骨折——关节置换术后肩关节功能的风险因素显示文摘在不同的研究中,不同类型的骨折行肩关节置换术后,导致肩关节功能不佳的风险因素各不相同。最常见的风险因素包括年龄的增加、肱骨大结节移位或截骨术。大多数研究中,肩关节置换术后肩关节功能结果总体良好,但有些研究的质量差,导致方法学评分低。因此,对这些研究的结果应谨慎看待。 | Rick Buckley James F.Kellam Tim Pohlemann 陈国奋 顾立强 | 2005 | 中华创伤骨科杂志2005，7，1： | 3 |
| 6 | Stent Thrombosis in New-Generation Drug-Eluting Stents in Patients With STEMI Undergoing Primary PCI显示文摘 | Giovanna Sarno Bo Lagerqvist Johan Nilsson Ole Frobert Kristina Hambraeus Christoph Varenhorst Ulf J. Jensen Tim T?dt Matthias G?tberg Stefan K. James | 2014 | Journal of the American College of Cardiology2014，，1： | 2 |
| 7 | Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial显示文摘 | John Primrose Stephen Falk Meg Finch-Jones Juan Valle Derek O’Reilly Ajith Siriwardena Joanne Hornbuckle Mark Peterson Myrddin Rees Tim Iveson Tamas Hickish Rachel Butler Louise Stanton Elizabeth Dixon Louisa Little Megan Bowers Sian Pugh O James Garden D | 2014 | Lancet Oncology2014，，6： | 2 |
| 8 | Economic Assessment and Review of Waterless Fracturing Technologies in Shale Resource Development: A Case Study显示文摘Our database tracking of USA water usage per well indicates that traditionally shale operators have been using, on average 3 to 6 million gallons of water; even up to 8 million for the entire life cycle of the well based on its suitability for re-fracturing to stimulate their long and lateral horizontal wells. According to our data, sourcing, storage, transportation, treatment, and disposal of this large volume of water could account for up to 10% of overall drilling and completion costs. With increasingly stringent regulations governing the use of fresh water and growing challenges associated with storage and use of produced and flowback water in hydraulic fracturing, finding alternative sources of fracturing fluid is already a hot debate among both the scientific community and industry experts. On the other hand, waterless fracturing technology providers claim their technology can solve the concerns of water availability for shale development. This study reviews high-level technical issues and opportunities in this challenging and growing market and evaluates key economic drivers behind water management practices such as waterless fracturing technologies, based on a given shale gas play in the United States and experience gained in Canada. Water costs are analyzed under a variety of scenarios with and without the use of(fresh) water. The results are complemented by surveys from several oil and gas operators. Our economic analysis shows that fresh water usage offers the greatest economic return. In regions where water sourcing is a challenge, however, the short-term economic advantage of using non-fresh water-based fracturing outweighs the capital costs required by waterless fracturing methods. Until waterless methods are cost competitive, recycled water usage with low treatment offers a similar net present value(NPV) to that of sourcing freshwater via truck, for instance. | Iman Oraki Kohshou Reza Barati Meaghan Cassey Yorro Tim Leshchyshyn Adebola T. Adejumo Usman Ahmed Imre Kugler Murray Reynolds James McAndrew | 2017 | Journal of Earth Science2017，28，5： | 2 |
| 9 | Cancer Transmission From Organ Donors—Unavoidable But Low Risk显示文摘 | Rajeev Desai Dave Collett Christopher J. Watson Philip Johnson Tim Evans James Neuberger | 2012 | Transplantation Journal2012，，12： | 2 |
| 10 | The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells显示文摘 | William J. Harris Xu Huang James T. Lynch Gary J. Spencer James R. Hitchin Yaoyong Li Filippo Ciceri Julian G. Blaser Brigit F. Greystoke Allan M. Jordan Crispin J. Miller Donald J. Ogilvie Tim C.P. Somervaille | 2012 | Cancer Cell2012，，4： | 2 |
| 11 | The structures of picornaviral proteinases显示文摘 | Joachim Seipelt Alba Guarné Ernst Bergmann Michael James Wolfgang Sommergruber Ignacio Fita Tim Skern | 1999 | Virus Research1999，，2： | 1 |
| 12 | Cytokines,macrophage lipidmetabolism and foam cells:Implications for cardiovasculardisease therapy显示文摘 | James E Daryn RM Tim GA | 2011 | Progress in Lipid Research2011，50，4： | 1 |
| 13 | Current status of sensitivity to praziquantel in a focus of potential drug resistance in Egypt显示文摘 | Sanaa Botros Hanan Sayed Neimat Amer Maged El-Ghannam James L. Bennett Tim A. Day | 2005 | International Journal for Parasitology2005，，7： | 1 |
| 14 | Numerical solution of a class of deficient polynomial systems显示文摘 | LIT Y TIM SAUER JAMES A YORKE | 1987 | SIAM J Numer Anal1987，24，2： | 1 |
| 15 | The random product homotopy and deficient polynomial systems显示文摘 | LIT Y TIM SAUER JAMES A YORKE | 1987 | Numer Math1987，51，5： | 1 |
| 16 | The Semantic Web显示文摘 | Tim Berners-Lee James Handler and Ora Lassila | 2001 | Scientific American2001，284，5： | 1 |
| 17 | The Semantic Web显示文摘 | Tim Berners-Lee James Hendler Ora Lassila | 2001 | Scientific American2001，284，： | 1 |
| 18 | The semantic Web显示文摘 | Tim Berners-Lee James Hendler Ora Lassila | 2001 | Scientific American2001，284，5： | 1 |
| 19 | The semantic web-a new form of web content that is meaningful to computers will unleash a revolution of new possibilities显示文摘 | TIM BERNERS-LEE JAMES HENDLER ORA LASSILA | 2001 | Scientific American2001，284，5： | 1 |
| 20 | The Sementic Web 显示文摘 | Tim Bemers Lee James A Hendle Ora Lassila | 2001 | Scientific American2001，284，5： | 1 |
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