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| 1 | 中国影子银行:是否对金融系统的稳定构成威胁显示文摘一、何为中国影子银行近期关于'民间借贷市场'风波的报道,诸如浙江省温州市的民间借贷危机事件,使得中国影子银行系统的脆弱性令人忧虑。随着影子银行的借贷规模在过去两年的迅速扩张,这种担忧是无可厚非的。我们估计目前影子银行系统借贷约占中国信贷总额的22%左右(相当于金融机构贷款余额总量的29%左右)。因此,考虑到其规模。 | Alicia Garcia Herrero Stephen Schwarts Le Xia George Xu | 2012 | 金融发展评论2012，，1： | 11 |
| 2 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 3 | An overview of semiconductor photocatalysis 显示文摘 | Andrew Mills Stephen Le Hunte | 1997 | J Photochem and Photobiol A: Chemistry1997，108，： | 1 |
| 4 | Disturbance and landscape dynamics in the Chequamegon National Forest Wisconsin, USA, from 1972 to 2001显示文摘 | Mary K. Bresee Jim Le Moine Stephen Mather Kimberley D. Brosofske Jiquan Chen Thomas R. Crow John Rademacher | 2004 | Landscape Ecology2004，，3： | 1 |
| 5 | An overview of semiconductor photocatalysis 显示文摘 | ANDREW MILLS STEPHEN LE HUNTE | 1997 | Journal of Photochem- istry and Photobiology A: Chemistry1997，108，1： | 1 |
| 6 | Sensitivity and specificity of the semiquantitative latex agglutination D-dimer assay for the diagnosis of acute pulmonary embolism as defined by computed tomographic angiography显示文摘 | David AF Peter LE Stephen JS | 2004 | Mayo Clin Proceed2004，79，2： | 1 |
| 7 | 显示文摘 | Andrew Mills Stephen Le Hunte | 1997 | Journal of Photochemistry and Photobiology A: Chemistry1997，108，1： | 1 |
| 8 | Greenness in semi-arid areas across the globe 1981–2007 — an Earth Observing Satellite based analysis of trends and drivers显示文摘 | Rasmus Fensholt Tobias Langanke Kjeld Rasmussen Anette Reenberg Stephen D. Prince Compton Tucker Robert J. Scholes Quang Bao Le Alberte Bondeau Ron Eastman Howard Epstein Andrea E. Gaughan Ulf Hellden Cheikh Mbow Lennart Olsson Jose Paruelo Christian Schw | 2012 | Remote Sensing of Environment2012，，： | 1 |
| 9 | 超级高铁显示文摘BIG的创始合伙人比亚克评价说:'通过超级高铁,我们定义了一个由客舱和站门组成的交通出行生态系统。人们不必等车,也不再需要候车厅,超级高铁用接近超音速的速度将集体社会和个人自由联系在一起。在未来,这种崭新的出行方式将改变我们对时空的习惯认知,我们脑海中对城市版图的理解也将随之改变。' | Erik Berg Kreider Adi Krainer Ashton Stare Cheyenne Vandevoorde Cristian Lera Daniele Pronesti Derek Wong Domenic Schmid Evan Wiskup Francesca Portesine Hugo Soo Kristian Hindsberg Lam Le Nguyen Lasse Kristensen Linda Halim Maureen Rahman Ovidiu Munteanu Pei Pei Yang Ryan Duval Stephen Steckel Terrence Chew Thomas Christoffersen Tore Banke Veronica Moretti Yehezkiel Wiliardy 曲鸿(译) | 2019 | 城市环境设计2019，0，2： | 1 |
| 10 | Deleton ofβintegrins in mice results in inner cell mass failure and periimplantion lethality显示文摘 | Stephens LE Sutherland AE Kilmanskaya IV | 1996 | Dev Dyn1996，206，： | 1 |
| 11 | Gut Hormone Profiles Following Bariatric Surgery Favor an Anorectic State, Facilitate Weight Loss, and Improve Metabolic Parameters显示文摘 | Carel W. le Roux Simon J. B. Aylwin Rachel L. Batterham Cynthia M. Borg Frances Coyle Vyas Prasad Sandra Shurey Mohammad A. Ghatei Ameet G. Patel Stephen R. Bloom | 2006 | Annals of Surgery2006，，1： | 1 |
| 12 | Matemal selective serotonin reuptake inhibitor use during pregnancy and newborn neurobehaviour显示文摘 | Zeskind PS Stephens LE | 2004 | Pediatrics2004，113，2： | 1 |
| 13 | Effects of Monotherapy With an HMG-CoA Reductase Inhibitor on the Progression of Coronary Atherosclerosis as Assessed by Serial Quantitative Arteriography: The Canadian Coronary Atherosclerosis Intervention Trial显示文摘 | David Waters Lyall Higginson Peter Gladstone Brian Kimball Michel Le May Stephen J. Boccuzzi Jacques Lespérance | 1994 | Circulation1994，，3： | 1 |
| 14 | An overview of semiconductor photoeatalvsis 显示文摘 | Andrew Mills Stephen Le Hunte | 1997 | J Photochem and Photobiol A:Chemistry1997，108，： | 1 |
| 15 | Tailoring mind-body therapies to individual needs:patients' program preference and psychological traits as moderators of the effects of mindfulness- basedcancer recovery and supportive-expressive therapy in distressed breast cancersurvivors显示文摘 | Carlson LE Tamagawa R Stephen J | 2014 | J Nail Cancer Inst Monogr2014，2014，50： | 1 |
| 16 | Randomized controlled trial of mindfulness-based cancer recovery versus supportive expressive group therapy for distressed survivors of breast cancer 显示文摘 | Carlson LE Doll R Stephen J | 2013 | J Clin Oncol2013，31，25： | 1 |
| 17 | Cancer Risks for MLH 1 and MSH 2 Mutation Carriers显示文摘 | James G. Dowty Aung K. Win Daniel D. Buchanan Noralane M. Lindor Finlay A. Macrae Mark Clendenning Yoland C. Antill Stephen N. Thibodeau Graham Casey Steve Gallinger Loic Le Marchand Polly A. Newcomb Robert W. Haile Graeme P. Young Paul A. James Graham G. | 2013 | Human Mutation2013，，3： | 1 |
| 18 | New Gene Variants Associated with the Risk of Chronic HBV Infection显示文摘Some patients with chronic hepatitis B virus(HBV)infection failed to clear HBV,even persistently continue to produce antibodies to HBV.Here we performed a two stage genome wide association study in a cohort of Chinese patients designed to discover single nucleotide variants that associate with HBV infection and clearance of HBV.The first stage involved genome wide exome sequencing of 101 cases(HBsAg plus anti-HBs positive)compared with 102 control patients(antiHBs positive,HBsAg negative).Over 80%of individual sequences displayed 209 sequence coverage.Adapters,uncertain bases[10%or low-quality base calls([50%)were filtered and compared to the human reference genome hg19.In the second stage,579 chronic HBV infected cases and 439 HBV clearance controls were sequenced with selected genes from the first stage.Although there were no significant associated gene variants in the first stage,two significant gene associations were discovered when the two stages were assessed in a combined analysis.One association showed rs506121-“T”allele[within the dedicator of cytokinesis 8(DOCK8)gene]was higher in chronic HBV infection group than that in clearance group(P=0.002,OR=0.77,95%CI[0.65,0.91]).The second association involved rs2071676—A allele within the Carbonic anhydrase(CA9)gene that was significantly elevated in chronic HBV infection group compared to the clearance group(P=0.0003,OR=1.35,95%CI[1.15,1.58]).Upon replication these gene associations would suggest the influence of DOCK8 and CA9 as potential risk genetic factors in the persistence of HBV infection. | Mengjie Fan Jing Wang Sa Wang Tengyan Li Hong Pan Hankui Liu Huifang Xu Daria V.Zhernakova Stephen J.O’Brien Zhenru Feng Le Chang Erhei Dai Jianhua Lu Hongli Xi Yanyan Yu Jianguo Zhang Binbin Wang Zheng Zeng | 2020 | Virologica Sinica2020，35，4： | 1 |
| 19 | Oxyntomodulin Suppresses Appetite and Reduces Food Intake in Humans显示文摘 | Mark A. Cohen Sandra M. Ellis Carel W. Le Roux Rachel L. Batterham Adrian Park Michael Patterson Gary S. Frost Mohammad A. Ghatei Stephen R. Bloom | 2003 | The Journal of Clinical Endocrinology & Metabolism2003，，10： | 1 |
| 20 | cGMP increa- ses antioxidant function and attenuates oxidant cell death in mouse lung mierevaseular endothelial cells by a protein kinase G- dependent mechanism 显示文摘 | Stephens RS Rentsendorj O Servinsky LE | 2010 | Am J Physiol Lung Cell Mol Physiol2010，299，3： | 1 |
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