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| 1 | 加拿大基层医疗改革的创新型及多元化策略显示文摘基层医疗卫生服务体系在世界各国的医疗卫生服务系统中均发挥着重要作用。在过去十年中,加拿大省及地方卫生系统运用了多种方法改善基层医疗卫生服务,改革方案涵盖了目标医疗组织架构、医疗服务者薪酬、医疗服务者数量、医疗服务质量及安全性等方面,改革成果大大提升了家庭医学这个专业实践领域的吸引力,家庭医学吸引了越来越多的医学应届毕业生。这对我国健全基层医疗卫生服务体系具有重要借鉴意义。为此,本刊特别翻译和报道了加拿大基层医疗改革的创新型及多元化策略,敬请关注! | Erin Strumpf Jean-Frédéric Levesque Natalie Coyle Brian Hutchison Marsha Barnes Robert J.Wedel 魏亚萌 | 2015 | 中国全科医学2015，18，31： | 4 |
| 2 | Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's disease显示文摘AIM: To determine if hyperpolarisation-activated nucleotide-gated(HCN) channels exist in human colon, and to investigate the expression of HCN channels in Hirschsprung's disease.METHODS:We investigated HCN1,HCN2,HCN3 and HCN4 protein expression in pull-through specimens from patients with Hirschsprung’s disease(HSCR,n=10)using the proximal-most ganglionic segment and distalmost aganglionic segment,as well as in healthy control specimens obtained at the time of sigmoid colostomy closure in children who had undergone anorectoplasty for imperforate anus(n=10).Fluorescent immunohistochemistry was performed to assess protein distribution,which was then visualized using confocal microscopy.RESULTS:No HCN1 channel expression was observed in any of the tissues studied.Both HCN2 and HCN4proteins were found to be equally expressed in the aganglionic and ganglionic bowel in HSCR and controls.HCN3 channel expression was found to be markedly decreased in the aganglionic colon vs ganglionic colon and controls.HCN2-4 channels were seen to be expressed within neurons of the myenteric and submucosal plexus of the ganglionic bowel and normal controls,and also co-localised to interstitial cells of Cajal in all tissues studied.CONCLUSION:We demonstrate HCN channel expression in human colon for the first time.Reduced HCN3expression in aganglionic bowel suggests its potential role in HSCR pathophysiology. | Anne Marie O’Donnell David Coyle Prem Puri | 2015 | World Journal of Gastroenterology2015，21，18： | 4 |
| 3 | Load transfer for axially,Loaded piles in clay 显示文摘 | Coyle H M Reese L C | 1996 | ASCE1996，97，2： | 2 |
| 4 | Outcomes of middle cerebral artery occlusion in hypertensive and normotensive rats显示文摘 | Coyle P | 1984 | Hypertension1984，6，2： | 2 |
| 5 | 'I’m here to help': How companies’ microblog responses to consumer problems influence brand perceptions显示文摘 | James R. Coyle Ted Smith Glenn Platt | 2012 | Journal of Research in Interactive Marketing2012，，1： | 2 |
| 6 | Oxidative Stress in Neurodegenerative Diseases显示文摘 | N A Simonian J T Coyle | 1996 | Annual Review of Pharmacology and Toxicology1996，，： | 2 |
| 7 | An Assessment of Case- based Reasoning for Spare Fiherlng显示文摘 | Sarah Jane Delany Padraig Cunningham Lorcan Coyle | | The Artificial Intelligence Review0，23，4： | 1 |
| 8 | Improving the strength of fully composite steel-concrete-steel beam elements by increased surface roughness-an experimental study显示文摘 | SUBEDI N K COYLE N R | 2002 | Engineering Structures2002，24，8： | 1 |
| 9 | Oxidative stress in neurodegenerative diseases显示文摘 | SIMONIAN N A COYLE J T | 1996 | Annu Rev Pharmacol Toxicol1996，36，： | 1 |
| 10 | Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration 显示文摘 | Romijn JA Coyle EF Sidossis LS | 1993 | American J Physiol1993，265，： | 1 |
| 11 | Effects of detraining on cardiovascular responese to exercise: Role of blood volume 显示文摘 | Coyle EF Hemmert MK Coggan AR | 1986 | J Appl Physiol1986，60，1： | 1 |
| 12 | Alzheimer's disease: a disorder of cortical eholinergic innervation 显示文摘 | Coyle JT Priee DL DeLong MR | 1983 | Science1983，219，： | 1 |
| 13 | Physician- Industry Relations: Part 2 : Organizational issues显示文摘 | Coyle S L for the Ethics and Human Rights Committee American College of Physicians- American Society of Internal Medicine | 2002 | Ann Intern Meal2002，，136： | 1 |
| 14 | Thermally sprayed CaZrO3 coatings 显示文摘 | GARCIA E CANO C COYLE T W | 2008 | Journal of Thermal Spray Technology2008，17，： | 1 |
| 15 | Alzheimer's disease: a dis-order of cortical cholinergie innervation显示文摘 | Coyle JT Price D J Delong MR | 1983 | Science1983，219，： | 1 |
| 16 | Oxidative stress in neurodegenerative disease显示文摘 | Simonian NA Coyle JT | 1996 | Annu Rev Pharmacol Toxicol1996，36，： | 1 |
| 17 | The Possible of Deontic Logic 显示文摘 | Coyle S | 2002 | Ratio Juris2002，，15： | 1 |
| 18 | Family caregiver burden :results of a longitudinal study of breast cancer patient s and their principal caregivers 显示文摘 | Grunfeld E Coyle D Whelan T | 2004 | CMAJ2004，170，12： | 1 |
| 19 | MRI characteristics of nodular fasciitis of the musculoskeletal system显示文摘 | COYLE J WHITE L M DICKSON B | 2013 | Skeletal Ra- diol2013，42，7： | 1 |
| 20 | Eliminating extravasation events:a multidisciplinary approach显示文摘 | Coyle C E Griffie J Czaplewski L M | 2014 | J Infus Nurs2014，37，3： | 1 |
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