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| 1 | 北京城乡两社区轻度认知功能障碍发病率调查显示文摘目的:调查轻度认知功能障碍的发病率及其人群特别是城乡人群之间的分布特点,探讨轻度认知功能障碍发病的社会人口学及生物学危险因素。方法:根据2004年基线研究资料,对北京西城区和大兴区两个社区1859名≥65岁认知正常老人进行5年后再次调查;通过10/66国际痴呆研究项目组(简称10/66项目组)的全套神经心理学问卷(包括老年精神状况量表及计算机诊断系统,认知测验系统、知情人问卷及社会人口学背景问卷和危险因素问卷等)调查获得资料,运用10/66项目组广义轻度认知功能障碍标准诊断程序对随访对象进行诊断,描述轻度认知功能障碍5年累积发病率,探讨轻度认知功能障碍的社会人口学特点及生物学危险因素。采用5年累积发病率及年平均发病率的计算方法计算轻度认知功能障碍的发病率,采用单因素和多因素Cox回归方法分析轻度认知功能障碍发病的危险因素。结果:193名老人确诊为轻度认知功能障碍新发病例,5年累积发病率为10.38%[95%可信区间(95%CI):9.00%~11.82%],平均年发病率2.17%(95%CI:1.76%~2.30%)。高龄(大于90岁)、居住在农村、脑卒中史、糖尿病史以及肥胖是轻度认知功能障碍的危险因素[危险比值(HR)分别为4.66(95%CI:1.41~15.48);2.54(95%CI:1.72~3.75);3.04(95%CI:1.63~5.68);2.00(95%CI:1.14~3.50)和4.97(95%CI:3.53~7.01)],而有配偶以及较多的体育锻炼是轻度认知功能障碍的保护因素[HR分别为0.55(95%CI:0.40~0.76)和0.34(95%CI:0.14~0.84)]。结论:北京市城乡两社区≥65岁老年人轻度认知功能障碍5年累积发病率为10.38%,年平均发病率为2.17%,与国内外多数研究接近。高龄、居住在农村、脑卒中、糖尿病及肥胖是发病的危险因素;针对轻度认知功能障碍的危险因素进行干预有重要的社会意义和临床价值。 | 禚传君 黄悦勤 刘肇瑞 王瑛 刘棉 李淑然 李硕 李玉敏 肖存利 郑志华 邵钧 肖秋霞 PRINCE Martin | 2012 | 中国心理卫生杂志2012，26，10： | 32 |
| 2 | Clinical and experimental research in antituberculosis drug-induced hepatotoxicity:a review显示文摘Drug-induced liver injury is the common adverse effect seen in patients receiving antituberculosis drugs(ATDs). There are several risk factors associated with the development of hepatotoxicity in such patients. Though there have been appreciable efforts taken by carrying out studies investigating the efficacy of several natural and synthetic compounds in minimising this effect, the only choice available for clinicians is withdrawal of drugs. This review would give a precise idea of ATD-induced hepatotoxicity,its underlying mechanisms and alternative therapies for the same. | Udhaya Lavinya Baskaran Evan Prince Sabina | 2017 | Journal of Integrative Medicine2017，15，1： | 20 |
| 3 | Scutellarin protects oxygen/glucose-deprived astrocytes and reduces focal cerebral ischemic injury显示文摘Scutellarin, a bioactive flavone isolated from Scutellaria baicalensis, has anti-inflammatory, anti-neurotoxic, anti-apoptotic and anti-oxidative effects and has been used to treat cardiovascular and cerebrovascular diseases in China. However, the mechanisms by which scutellarin mediates neuroprotection in cerebral ischemia remain unclear. The interaction between scutellarin and nicotinamide adenine dinucleotide phosphate oxidase 2(NOX2) was assessed by molecular docking study, which showed that scutellarin selectively binds to NOX2 with high affinity. Cultures of primary astrocytes isolated from the cerebral cortex of neonatal Sprague-Dawley rats were pretreated with 2, 10 or 50 μM scutellarin for 30 minutes. The astrocytes were then subjected to oxygen/glucose deprivation by incubation for 2 hours in glucose-free Dulbecco's modified Eagle's medium in a 95% N2/5% CO_2 incubator, followed by simulated reperfusion for 22 hours. Cell viability was assessed by cell counting kit-8 assay. Expression levels of NOX2, connexin 43 and caspase-3 were assessed by western blot assay. Reactive oxygen species were measured spectrophotometrically. Pretreatment with 10 or 50 μM scutellarin substantially increased viability, reduced the expression of NOX2 and caspase-3, increased the expression of connexin 43, and diminished the levels of reactive oxygen species in astrocytes subjected to ischemia-reperfusion. We also assessed the effects of scutellarin in vivo in the rat transient middle cerebral artery occlusion model of cerebral ischemia-reperfusion injury. Rats were given intraperitoneal injection of 100 mg/kg scutellarin 2 hours before surgery. The Bederson scale was used to assess neurological deficit, and 2,3,5-triphenyltetrazolium chloride staining was used to measure infarct size. Western blot assay was used to assess expression of NOX2 and connexin 43 in brain tissue. Enzyme-linked immunosorbent assay was used to detect 8-hydroxydeoxyguanosine(8-OHd G), 4-hydroxy-2-nonenal(4-HNE) and 3-nitrotyrosin(3-NT) in brain tissue. Immunofluorescence double staining was used to determine the co-expression of caspase-3 and Neu N. Pretreatment with scutellarin improved the neurological function of rats with focal cerebral ischemia, reduced infarct size, diminished the expression of NOX2, reduced levels of 8-OHd G, 4-HNE and 3-NT, and reduced the number of cells co-expressing caspase-3 and Neu N in the injured brain tissue. Furthermore, we examined the effect of the NOX2 inhibitor apocynin. Apocynin substantially increased connexin 43 expression in vivo and in vitro. Collectively, our findings suggest that scutellarin protects against ischemic injury in vitro and in vivo by downregulating NOX2, upregulating connexin 43, decreasing oxidative damage, and reducing apoptotic cell death. | Jing-Bo Sun Yan Li Ye-Feng Cai Yan Huang Shu Liu Patrick KK Yeung Min-Zhen Deng Guang-Shun Sun Prince LM Zilundu Qian-Sheng Hu Rui-Xin An Li-Hua Zhou Li-Xin Wang Xiao Cheng | 2018 | Neural Regeneration Research2018，13，8： | 16 |
| 4 | Delineation of groundwater potential zones in Theni district,Tamil Nadu,using remote sensing,GIS and MIF techniques显示文摘为地下水资源的探索的遥感数据和地理信息系统(GIS ) 的集成在地下水研究的领域里成为了突破,它在估计帮助,监视,并且保存地下水资源。在现在的论文,为对在 Theni 区域的地下水可获得性的评价的各种各样的地下水潜力地区用遥感和 GIS 技术被描出。印度 toposheets 和 IRS-1C 卫星形象的调查被用来准备各种各样的题目的层 viz。岩性学,斜坡,陆地使用,貌,排水,土壤,和降雨在 ArcGIS 用特征被转变到光栅数据到光栅变换器工具。这些因素的光栅地图被分配从多影响因素(MIF ) 计算的一个固定分数和重量技术。而且,每加权的题目的层统计上被计算得到地下水潜力地区。因此获得的地下水潜力地区被划分成四个范畴, viz,很差、差、好、很好的地区。结果在学习区域描绘地下水潜力地区并且发现在更好计划和地下水资源的管理有用。 | N.S.Magesh N.Chandrasekar John Prince Soundranayagam | 2012 | Geoscience Frontiers2012，3，2： | 15 |
| 5 | 北京市城乡两社区老年痴呆发病率及危险因素的研究显示文摘目的 描述北京市城乡两社区≥65岁老人老年期痴呆发病率及人群和城乡分布特征,并探讨发病的危险因素.方法 该研究为国际10/66痴呆协作研究5年随访研究的中国区域调查部分内容.研究采用一阶段痴呆研究方法,于2009年至2010年间对北京市西城区和大兴区2025名≥65岁的非痴呆老人进行随访,根据国际10/66标准进行痴呆诊断,并采用Cox比例风险回归模型进行危险因素的分析.结果 新发老年期痴呆病例173例,5年累积发病率为8.54%,平均年发病率为1.77%(95%可信区间:1.47 ~1.97).多因素Cox回归模型分析结果显示,高龄、吸烟、腰臀比大和脑卒中病史是老年期痴呆的危险因素(均P<0.001或<0.05),体育锻炼是保护因素(P =0.003).结论 北京市城乡两社区老年期痴呆发病率高于以往调查结果,控制吸烟、防治脑卒中和提倡体育锻炼可以降低老年期痴呆的发病危险. | 刘肇瑞 黄悦勤 王瑛 禚传君 刘棉 李淑然 郑志华 李硕 李玉敏 Martin Prince | 2013 | 中华精神科杂志2013，46，6： | 13 |
| 6 | 2017年哮喘研究进展:发病机制、生物制剂和遗传学显示文摘总结了近年来部分关于哮喘最重要的研究进展。首先,关注哮喘发展和加重机制的新发现,随后讨论了新的潜在的哮喘生物标志物,包括射线性标记物的使用。第二,过去一年里临床医师已经开始使用几种治疗哮喘的新型生物制剂,总结这些药物的应用进展及其对哮喘临床治疗的影响。第三,探讨了哮喘遗传学的重要发现和哮喘表型的异质性,如同环境因素一样,这些因素在哮喘的发展和急性发作过程中也发挥着重要的作用。最后,讨论了医学知识的进步以及它们将如何影响哮喘的防治。 | Mitchell H. Grayson Scott Feldman Benjamin T. Prince Priya J. Patel Elizabeth C. Matsui Andrea J. Apter 杨玲(翻译) 刘婷(翻译) 刘春涛(审校/点评) | 2018 | 中华临床免疫和变态反应杂志2018，12，6： | 13 |
| 7 | 包膜型缓/控释肥料研究现状及其在功能农业中的应用展望显示文摘当前,我国农业发展进入了继高产农业、绿色农业之后的第三个发展阶段——功能农业阶段,即通过科学技术手段生产出具有健康改善功能的农产品。施用缓/控释功能肥料,实现对作物的“精准给肥”是功能农业的关键科学问题之一。缓/控释肥料凭借其可显著提高肥料利用率、减轻因养分流失造成的环境污染、提高作物产量及品质等优点受到国内外研究人员的广泛关注。其中包膜型缓/控释肥料通过包膜材料的设计,可更好地实现对养分的控释。综述了国内外包膜型缓/控释肥料的研究现状,分析了包膜型缓/控释肥料在实际应用中存在的问题,并对包膜型缓/控释肥料在功能农业中的应用进行了展望。 | 陈冠霖 赵其国 Danso Prince Ofori 鲁亚普 王张民 尹雪斌 | 2021 | 肥料与健康2021，48，3： | 13 |
| 8 | Immune checkpoint inhibitor-related hepatotoxicity:A review显示文摘The application of immune checkpoint inhibitors(ICI)in advanced cancer has been a major development in the last decade.The indications for ICIs are constantly expanding into new territory across different cancers,disease stages and lines of therapy.With this increased use,adverse events including immune checkpoint inhibitor-related hepatotoxicity(ICH)have emerged as an important clinical problem.This along with the introduction of ICI as first-and second-line treatments for advanced hepatocellular carcinoma makes ICH very relevant to gastroenterologists and hepatologists.The incidence of ICH varies between 1%-20%depending on the number,type and dose of ICI received.Investigation and management generally involve excluding differential diagnoses and following a stepwise escalation of withholding or ceasing ICI,corticosteroid treatment and adding other immunosuppressive agents depending on the severity of toxicity.The majority of patients with ICH recover and some may even safely recommence ICI therapy.Guideline recommendations are largely based on evidence derived from retrospective case series which highlights a priority for future research. | Devika Remash David S Prince Catriona McKenzie Simone I Strasser Steven Kao Ken Liu | 2021 | World Journal of Gastroenterology2021，27，32： | 9 |
| 9 | Etiopathogenesis of primary biliary cirrhosis显示文摘Primary biliary cirrhosis(PBC) is an autoimmune disease of the liver characterized by progressive bile duct destruction eventually leading to cirrhosis and liver failure.The serological hallmark of the disease is the presence of circulating antimitochondrial antibodies(AMA).These reflect the presence of autoreactive T and B cells to the culprit antigens,the E2 subunits of mitochondrial 2-oxo-acid dehydrogenase enzymes,chiefly pyruvate dehydrogenase(PDC-E2).The disease results from a combination of genetic and environmental risk factors.Genetic predisposition is indicated by the higher familial incidence of the disease particularly among siblings and the high concordance rate among monozygotic twins.Environmental triggering events appear crucial to disrupt a pre-existing unstable immune tolerance of genetic origin allowing,after a long latency,the emergence of clinical disease.Initiating mimetopes of the vulnerable epitope of the PDC-E2 autoantigen can be derived from microbes that utilize the PDC enzyme or,alternatively,environmental xenobiotics/chemical compounds that modify the structure of native proteins to make them immunogenic.A further alternative as a source of antigen is PDC-E2 derived from apoptotic cells.In the effector phase the biliary ductular cell,by reason of itsproclivity to express the antigen PDC-E2 in the course of apoptosis,undergoes a multilineage immune attack comprised of CD4+ and CD8+ T cells and antibody.In this article,we critically review the available evidence on etiopathogenesis of PBC and present interpretations of complex data,new developments and theories,and nominate directions for future research. | Ana Lleo Pietro Invernizzi Ian R Mackay Harry Prince Ren-Qian Zhong M Eric Gershwin | 2008 | World Journal of Gastroenterology2008，14，21： | 9 |
| 10 | Comparison between endoscopic sphincterotomy vs endoscopic sphincterotomy associated with balloon dilation for removal of bile duct stones:A systematic review and meta-analysis based on randomized controlled trials显示文摘AIM To compare gallstones removal rate and incidence of bleeding, pancreatitis, use of mechanical lithotripsy, cholangitis and perforation between isolated sphincterotomy vs sphincterotomy associated with balloon dilation of papilla in choledocholithiasis through the meta-analysis of randomized clinical trials. METHODS We conducted a systematic review according to the PRISMA guidelines. Literature search was restricted to randomized controlled trials(RCTs) on Med Line, Cochrane Library, LILACS, and EMBASE database platforms in July 2017. The manual search included references of retrieved articles. We extracted data focusing on outcomes: The primary endpoint was the stones removal rate; Secondary endpoints were rates of pancreatitis, bleeding, use of mechanical lithotripsy(ML), perforation and cholangitis. RESULTS Eleven RCTs with 1824 patients were included. EST was associated with more post-endoscopic retrograde cholangiopancreatography(ERCP) bleeding [FE RD-0.02, CI(-0.03,-0.00), I2 = 33%, P = 0.05] and more need of mechanical lithotripsy in general [RE RD-0.16, CI(-0.25,-0.06), I2 = 90%, P = 0.002] and in subgroup analysis of stones greater than 15 mm [RE RD-0.20, CI(-0.38,-0.02), I2 = 82%, P = 0.003]. Incidence of pancreatitis [FE RD-0.01, CI(-0.03, 0.01), I2 = 0, P = 0.36], cholangitis [FE RD-0.00, CI(-0.01, 0.01), I2 =0, P = 0.97] and perforation [FE RD-0.01, CI(-0.01, 0.00), I2 = 0, P = 0.23] was similar between the groups as well as similar stone removal rates in general [FE RD-0.01, CI(-0.01, 0.04), I2 = 0, P = 0.23] and pooled analysis of stones greater than 15 mm [FE RD-0.02, CI(-0.02, 0.07), I2 = 11%, P = 0.31]. CONCLUSION Through meta-analysis of randomized clinical trials we found that isolated sphincterotomy was associated with more post-ERCP bleeding and more need for mechanical lithotripsy. However, there was no statistical difference in the stone removal rate between isolated sphincterotomy and sphincterotomy associated with balloon dilation in the approach to remove gallstones. | Cesar Capel de Clemente Junior Wanderley Marques Bernardo Tomazo Prince Franzini Gustavo Oliveira Luz Marcos Eduardo Lera dos Santos Jonah Maxwell Cohen Diogo Turiani Hourneaux de Moura Fábio Ramalho Tavares Marinho Martin Coronel Paulo Sakai Eduardo Guimaraes Hourneaux de Moura | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，8： | 8 |
| 11 | Piperine,an active ingredient of black pepper attenuates acetaminophen-induced hepatotoxicity in mice显示文摘Objective:To explore the hepatoprotective and antioxidant effects of piperine against acetaminophen-induced hepatotoxicity in mice.Methods:In mice,hepatotoxicity was induced by a single dose of acetaminophen(900 mg/kg b.w.i.p.).Piperine(25 mg/kg b.w.i.p.) and standard drug silymarin(25 mg/kg b.w.i.p.) were given to mice,30 min after the single injection of acetaminophen.After 4 h,the mice were decapitated.Activities of liver marker enzymes [(aspartate transaminase(AST),alanine transaminase(ALT),and alkaline phosphatase(ALP)]and inflammatory mediator tumour necrosis factor-alpha(TNF-α) were estimated in serum,while lipid peroxidation and antioxidant status(superoxide dismutase,catalase,glutathione peroxidase, glutathione reductase,glutathione-s-transferase and glutathione) were determined in liver homogenate of control and experimental mice.Results:Acetaminophen induction(900 mg/kg b.w.i.p.) significantly increased the levels of liver marker enzymes,TNF-α,and lipid peroxidation,and caused the depletion of antioxidant status.Piperine and silymarin treatment to acetaminophen challenged mice resulted in decreased liver marker enzymes activity,TNF-αand lipid peroxidation levels with increase in antioxidant status.Conclusions:The results clearly demonstrate that piperine shows promising hepatoprotective effect as comparable to standard drug silymarin. | Evan Prince Sabina Annie Deborah Harris Souriyan Deborah Jackline Mahaboob Khan Rasool | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 7 |
| 12 | 我国硒资源变硒产业的重点、难点和发展实践显示文摘从整体来看我国硒资源较为匮乏,约有72%的地区属于缺硒地区,同时我国存在256个富硒地区。部分富硒地区立足自身硒资源优势,大力发展硒产业,实现了硒资源向硒产业的转化,但仍面临一些问题和挑战。本研究从硒产业发展的标准化、智慧化、绿色化、品牌化4个方面系统地梳理了我国硒产业发展存在的难点问题,指出我国硒产业发展的重点方向,介绍了我国富硒地区硒产业发展实践,最后从加强标准化、智慧化、绿色化及品牌化等“四化”的建设角度,为我国硒资源更好地变为硒产业,提供了有关综合解决方案的系统性思考。 | 尹雪斌 刘晓航 赵其国 王晓虎 罗琴 陈清清 王张民 Prince Ofori Danso 刘乐渝 | 2021 | 科技促进发展2021，17，10： | 5 |
| 13 | 对香豆酸对佐剂性关节炎大鼠的抗过氧化作用(英文)显示文摘目的:研究对香豆酸,一种食物中含有的酚酸对佐剂性关节炎大鼠的抗过氧化治疗作用。方法:大鼠右后肢脚垫皮内注射0.1mL弗氏完全佐剂诱发关节炎。于佐剂注射后第11~18天连续给药8d,治疗组用药为对香豆酸(100mg/kg大鼠体质量,腹腔内给药),阳性对照组药物为吲哚美辛(3mg/kg大鼠体质量,腹腔内给药)。对佐剂性关节炎大鼠的肝脏、脾脏、血浆内脂质过氧化作用水平和抗氧化水平的变化进行测量,同时分析大鼠后肢的影像学改变以衡量对香豆酸的抗氧化作用。结果:佐剂性关节炎大鼠经对香豆酸治疗后,脂质过氧化作用和抗氧化水平恢复近正常值。影像学观察发现,治疗组大鼠的软组织肿胀、骨侵蚀及关节间隙狭窄情况得到缓解。结论:对香豆酸对佐剂性关节炎大鼠有明显的治疗作用,这种治疗作用可能与其抗氧化作用相关。 | Samuel Joshua Pragasam Vachana Murunikara Evan Prince Sabina Mahaboobkhan Rasool | 2012 | 中西医结合学报2012，10，8： | 4 |
| 14 | Efficacy of boswellic acid on lysosomal acid hydrolases,lipid peroxidation and anti-oxidant status in gouty arthritic mice显示文摘Objective:To evaluate the efficacy of boswellic acid against monosodium urate crystal-induced inflammation in mice.Methods:The mice were divided into four experimental groups.GroupⅠserved as control;mice in groupⅡwere injected with monosodium urate crystal;groupⅢconsisted of monosodium urate crystal-induced mice who were treated with boswellic acid(30mg/kg/b.w.);groupⅣcomprised monosodium urate crystal-induced mice who were treated with indomethacin(3mg/kg/b.w.).Paw volume and levels/activities of lysosomal enzymes,lipid peroxidation,anti-oxidant status and inflammatory mediator TNF-αwere determined in control and monosodium urate crystal-induced mice.In addition,the levels ofβ-glucuronidase and lactate dehydrogenase were also measured in monosodium urate crystal-incubated polymorphonuclear leucocytes(PMNL)in vitro.Results:The activities of lysosomal enzymes,lipid peroxidation,and tumour necrosis factor-αlevels and paw volume were increased significantly in monosodium urate crystal-induced mice,whereas the activities of antioxidant status were in turn decreased.However,these changes were modulated to near normal levels upon boswellic acid administration.In vitro,boswellic acid reduced the level ofβ-glucuronidase and lactate dehydrogenase in monosodium urate crystal-incubated PMNL in concentration dependent manner when compared with control cells.Conclusions:The results obtained in this study further strengthen the anti-inflammatory/antiarthritic effect of boswellic acid,which was already well established by several investigators. | Evan Prince Sabina Haridas Indu Mahaboobkhan Rasool | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，2： | 4 |
| 15 | A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis显示文摘 | Stephen Stewart Martin Prince Margaret Bassendine Mark Hudson Oliver James David Jones Chris Record Christopher P. Day | 2007 | Journal of Hepatology2007，，2： | 3 |
| 16 | 阿尔茨海默症新药T-588的合成显示文摘 | 熊飞 Prince 陈春 杨琍苹 | 2001 | 华东师范大学学报(自然科学版)2001，，3： | 3 |
| 17 | Modeling,Parameter Measurement,and Control of PMSG-based Grid-connected Wind Energy Conversion System显示文摘The design of reliable controllers for wind energy conversion systems(WECSs)requires a dynamic model and accurate parameters of the wind generator.In this paper,a dynamic model and the parameter measurement and control of a direct-drive variable-speed WECS with a permanent magnet synchronous generator(PMSG)are presented.An experimental method is developed for measuring the key parameters of the PMSG.The measured parameters are used in the design of the controllers.The generator-side converter is controlled using a vector control scheme that maximizes the power extraction under varying wind speeds.A model predictive controller(MPC)is designed for the grid-side voltage source converter(VSC)to regulate the active and reactive power flows to the power grid by controlling the d-and q-axis currents in the synchronous reference frame.The MPC predicts the future values of the control variables and takes control actions based on the minimum value of the cost functions.To comply with the grid code requirement,a modified design approach for an LCL filter is presented and incorporated into the system.The design process is simple and incorporates significant filter parameters while avoiding iterative calculations.The comparative analysis of the designed filter with conventional L,LC,and iterative LCL filters demonstrates the effectiveness of the modified design approach.The proposed wind energy system with MPC and LCL filter is simulated in MATLAB/Simulink and experimentally implemented in the laboratory using the dSpace digital signal processor(DSP)system.The simulation and experimental results validate the efficacy of the designed controllers using the measured parameters and show dynamic and steady-state performance under varying wind speeds. | Mohammad Kamruzzaman Khan Prince Graduate Mohammad TArif Ameen Gargoom Aman MTOo Md Enamul Haque | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，5： | 3 |
| 18 | Hip joint center localisation: A biomechanical application to hip arthroplasty population显示文摘AIM: To determine hip joint center(HJC) location on hip arthroplasty population comparing predictive and functional approaches with radiographic measurements.METHODS: The distance between the HJC and the mid-pelvis was calculated and compared between the three approaches. The localisation error between the predictive and functional approach was compared using the radiographic measurements as the reference. The operated leg was compared to the non-operated leg.RESULTS: A significant difference was found for the distance between the HJC and the mid-pelvis when comparing the predictive and functional method. The functional method leads to fewer errors. A statistical difference was found for the localization error between the predictive and functional method. The functional method is twice more precise.CONCLUSION: Although being more individualized, the functional method improves HJC localization and should be used in three-dimensional gait analysis. | Vicky Bouffard Mickael Begon Annick Champagne Payam Farhadnia Pascal-André Vendittoli Martin Lavigne Franois Prince | 2012 | World Journal of Orthopedics2012，3，8： | 3 |
| 19 | 生姜提取物6-姜酚对对乙酰氨基酚致小鼠肝脏毒性的保护作用(英文)显示文摘目的:研究生姜提取物6-姜酚对对乙酰氨基酚致小鼠肝脏毒性的保护作用。方法:实验组小鼠在腹腔注射对乙酰氨基酚(900 mg/kg)30 min后,分别给予6-姜酚(30 mg/kg)或标准对照药水飞蓟素(25 mg/kg)。注射对乙酰氨基酚4 h后处死小鼠,检测血清中天冬氨酸氨基转移酶、丙氨酸氨基转移酶、碱性磷酸酶活性,总胆红素的含量及肝匀浆中脂质过氧化及抗氧化情况,如超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶、谷胱甘肽转移酶活性及还原型谷胱甘肽含量。结果:与对照组相比,6-姜酚及水飞蓟素均能显著降低对乙酰氨基酚引起的小鼠血清天冬氨酸氨基转移酶、丙氨酸氨基转移酶、碱性磷酸酶活性及总胆红素含量的升高(P<0.05)。此外,6-姜酚及水飞蓟素有效控制了肝脏内丙二醛的形成及各种抗氧化酶的降低(P<0.05)。结论:本研究的结果证实了6-姜酚具有与水飞蓟素相当的保肝作用。 | Evan Prince Sabina Samuel Joshua Pragasam Suresh Kumar Mahaboobkhan Rasool | 2011 | 中西医结合学报2011，9，11： | 3 |
| 20 | 经肝动脉^90Y放射性栓塞治疗的新进展显示文摘放射性栓塞治疗(RE)是经过10余年探索而建立起来的一种治疗模式,发展迅速。该文对RE领域新进展进行综述,就RE患者选择、疗效判断以及将来的临床应用进行探讨。 | 李莉(译) 冯对平(译) 李思进(审校) Arthur J.A.T. Braat Maarten L.J. Smits Manon N.G.J.A. Braat Andor F. van den Hoven Jip F. Prince Hugo W.A.M. de Jong Maurice A.A.J. van den Bosch Marnix G.E.H. Lam | 2018 | 中华核医学与分子影像杂志2018，38，8： | 2 |
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