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| 1 | Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice显示文摘最近的研究开始在心脏的肥大和机能障碍的致病揭示了 microRNAs (miRNAs ) 的关键角色。在这研究,我们测试了是否转变生长 factor-β(TGF-β) 调整 miRNA 在心脏的肥大和心失败(HF ) 的发展起了一个枢轴的作用。我们观察到 miR-27b 是在 cardiomyocyte 特定的 Smad4 猛烈老鼠的心的 upregulated,它开发了心脏的肥大。在 vitro,实验证明 miR-27b 表示能被 TGF-β 禁止; 1 并且它的 overexpression 支持了 hypertrophic 房间生长,当 miR-27b 抑制导致了 hypertrophic 房间的抑制时,生长由 phenylephrine (PE ) 引起了处理。而且,有 miR-27b 的 cardiomyocyte 特定的 overexpression 的转基因的老鼠的分析表明 miR-27b overexpression 是足够的导致心脏的肥大和机能障碍。我们验证了 peroxisome 激活 proliferator 的 receptor-γ(PPAR-γ) 作为在 cardiomyocyte 的 miR-27b 的一个直接目标。一致地, miR-27b 转基因的老鼠显著地显示了 PPAR-γ 的底层;比控制鼠标。而且,在用在一只 pressure-overload-induced 老鼠的特定的 antagomir 的 miR-27b 的 vivo silencing, HF 的模型增加了心脏的 PPAR-γ表示,稀释心脏的肥大和机能障碍。我们的学习的结果表明那 TGF-β 1-regulated miR-27b 涉及心脏的肥大的规定,并且为心脏病作为一个有效治疗学的目标验证 miR-27b。 | Jian Wang Yao Song Yan Zhang Han Xiao Qiang Sun Ning Hou Shuilong Guo Youliang Wang Kaiji Fan Dawei Zhan Lagabaiyila Zha Yang Cao Zhenhua Li Xuan Cheng Youyi Zhang Xiao Yang | 2012 | Cell Research2012，22，3： | 36 |
| 2 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 3 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 4 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 5 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 6 | Fingered Intrusion of Shallow Saucer-shaped Igneous Sills: Insights from the Jiaojiang Sag, East China Sea显示文摘An extensive suite of igneous sills was intruded into the Tertiary sedimentary section of the Jiaojiang sag,East China Sea.This suite has been well imaged offshore through 2D and 3D seismic surveys,showing a close relationship with CO2 content in nearby gas discoveries.A new observational model,which incorporates simple upward propagation,simple horizontal propagation,and transgressive propagation,was proposed to interpret these sill intrusions.In this model,the source magma of the saucer-shaped sills was injected from their lowest points near the center.The transgressive propagation can be interpreted as a combination of the vertical and horizontal propagation.Most shallow sub-volcanic intrusions in the Jiaojiang sag exhibit fingered characteristics,both vertically and horizontally.The vertical fingered propagation produced saucer-shaped sills arranged in the flower style.Along the brims of lower sills could usually be found the upper sills,which are interpreted to have formed simultaneously with or later than the lower feeder sills.In the second type,the chilled paths of the older sills were reutilized by subsequent intrusions.The horizontal fingered propagation formed sheet intrusions that exhibit groove,lobate,tubular,and crevasse splaylike geometry in plan view.In 3D view,the sheet intrusions have still preserved the lower center and higher rim that similar with the sub-rounded saucer-shaped sills.Although fracture propagation may be important,flow inflation was the key mechanism of magma intrusion.Further consideration of the mechanisms underlying sill formation may help explain the fingered characteristics of sill propagation. | GUO Rui ZHANG Gongcheng ZHANG Jinwei ZHAO Xingbin LIU Junbang YUAN Dawei SONG Shuang | 2013 | Acta Geologica Sinica(English Edition)2013，87，5： | 8 |
| 7 | Influence of aircraft surface distribution on electromagnetic scattering characteristics显示文摘In this paper,two typical stealth aircraft concepts(wing fuselage blended and flyingwing) were designed.Then three gradually changed surface distribution models with the same planform for each concept were created.Based on the multilevel fast multipole algorithm(MLFMA),the vertical polarization transmitting/vertical polarization receiving(VV) and horizontal polarization transmitting/horizontal polarization receiving(HH) radar cross section(RCS) characteristics were simulated with five frequencies between 0.1 and 1.0 GHz.The influences and mechanisms of aircraft surface distribution on electromagnetic scattering characteristics were investigated.The results show that for the wing fuselage blended concept,the W RCS of this frequency range is higher than the HH RCS in most cases,while it is just the opposite for the flying-wing concept.As for the two aircraft concepts,the RCS levels of HH and W both decrease with the frequency increasing,but the HH RCS has a faster downward trend.The surface distribution has little influence on HH RCS characteristics.On the contrary,it has a significant impact on W RCS characteristics,and the amplitude of the VV RCS increases with the surface thickness. | Liu Dawei Huang Jun Song Lei Ji Jinzu | 2017 | Chinese Journal of Aeronautics2017，30，2： | 8 |
| 8 | LiNbO3-coated LiNi0.8Co0.1Mn0.1O2 cathode with high discharge capacity and rate performance for all-solid-state lithium battery显示文摘In order to obtain high power density,energy density and safe energy storage lithium ion batteries(LIB)to meet growing demand for electronic products,oxide cathodes have been widely explored in all-solidstate lithium batteries(ASSLB)using sulfide solid electrolyte.However,the electrochemical performances are still not satisfactory,due to the high interfacial resistance caused by severe interfacial instability between sulfide solid electrolyte and oxide cathode,especially Ni-rich oxide cathodes,in charge-discharge process.Ni-rich LiNi0.8Co0.1Mn0.1O2(NCM811)material at present is one of the most key cathode candidates to achieve the high energy density up to 300 Wh kg^-1 in liquid LIB,but rarely investigated in ASSLB using sulfide electrolyte.To design the stable interface between NCM811 and sulfide electrolyte should be extremely necessary.In this work,in view of our previous work,LiNbO3 coating with about 1 wt% content is adopted to improve the interfacial stability and the electrochemical performances of NCM811 cathode in ASSLB using Li10GeP2S12 solid electrolyte.Consequently,LiNbO3-coated NCM811 cathode displays the higher discharge capacity and rate performance than the reported oxide electrodes in ASSLB using sulfide solid electrolyte to our knowledge. | Xuelei Li Liubing Jin Dawei Song Hongzhou Zhang Xixi Shi Zhenyu Wang Lianqi Zhang Lingyun Zhu | 2020 | Journal of Energy Chemistry2020，29，1： | 7 |
| 9 | Planning and analysis of the demonstration project of the MVDC distribution network in Zhuhai显示文摘The DC distribution system is an important development direction of the distribution system,which can improve the reliability and the quality of the power supply,and support the new energy,the energy storage,the electric vehicles,and the flexible access of AC and DC loads to grid.To realize the demonstration application of the DC distribution technology,China's first demonstration project of the medium voltage DC distribution network will be built in Zhuhai,Guangdong Province to support the construction of the city energy internet.First,this paper analyzes the demand of the DC distribution network project,and puts forward the construction content and construction target.Then,it designs and analyzes the electrical connection mode,system operation mode,and startup and shutdown mode of the DC distribution network,and proposes the overall project construction plan.Finally,it conducts the specific project design and analysis,which mainly in elude the selection of equipment such as inverters,DC transformers and DC circuit breakers,the design and analysis of the DC control and protection system,the design and analysis of the overvoltage protection and the configuration scheme of the lightning arrester,and analysis of the system transient characteristics.The design and analysis of the engineering program is a combination of China's distribution network engineering practice and technical characteristics,which lays a solid foundation for the advancement of the DC power distribution technology in China,and has reference value and demonstration effect for the design and construction of other projects. | Lu QU Zhanqing YU Qiang SONG Zhichang YUAN Biao ZHAO Dawei YAO Jianfu CHEN Yao LIU Rong ZENG | 2019 | Frontiers in Energy2019，13，1： | 7 |
| 10 | Multiobjective optimal dispatch of microgrid based on analytic hierarchy process and quantum particle swarm optimization显示文摘Owing to the rapid development of microgrids(MGs)and growing applications of renewable energy resources,multiobjective optimal dispatch of MGs need to be studied in detail.In this study,a multiobjective optimal dispatch model is developed for a standalone MG composed of wind turbines,photovoltaics,diesel engine unit,load,and battery energy storage system.The economic cost,environmental concerns,and power supply consistency are expressed via subobjectives with varying priorities.Then,the analytic hierarchy process algorithm is employed to reasonably specify the weight coefficients of the subobjectives.The quantum particle swarm optimization algorithm is thereafter employed as a solution to achieve optimal dispatch of the MG.Finally,the validity of the proposed model and solution methodology are con firmed by case studies.This study provides refere nee for mathematical model of multiojective optimizati on of MG and can be widely used in current research field. | Yuxin Zhao Xiaotong Song Fei Wang Dawei Cui | 2020 | Global Energy Interconnection2020，3，6： | 6 |
| 11 | b-DAZL:A novel gene in bovine spermatogenesis显示文摘DAZL 基因在 gametogenesis 起一个重要作用。这基因的 Microdeletion 和变化经常在脊椎动物和无脊椎动物与绝育被联系了。这里,包含 DAZL 基因的完全的开的读物框架的 cDNA,它编码通常认为的 RRM RNA 有约束力的蛋白质,被 RT-PCR 从牛的纸巾孤立。孤立的基因被叫作 b-DAZL。基于计算机的地点分析证明 b-DAZL 在染色体 1 的结束附近被定位。b-DAZL 基因和它的脊椎动物相当或相同事物分享了高核苷酸类似(90 94%) 在编码区域并且在 genomic 组织,每由 10 前 ons 和 9 introns 组成。他们的蛋白质产品包含了一个高度保存的 RNA 有约束力的主题,一次唯一的 DAZ 重复,和 PUM2 和 PABP 交往领域。RT-PCR 试金表明 b-DAZL 在睾丸和卵巢被表示。然而,没有信号在无菌的雄的牛牦牛的睾丸被检测。不育的男性的睾丸的微观结构显示出很少的 spermatocytes 但是主要体的房间。这些观察与有有缺点的 DAZL 表示的睾丸的典型显型一致。随后的基因察觉研究显示那抄写拘捕可能在牛牦牛的睾丸导致一个 b-DAZL 抄本缺点。我们的结果建议 b-DAZL 可以涉及精子发生,并且基因的那抄写拘捕在牛牦牛与男绝育被联系。 | Qingbo Zhang Qifa Li Jiahuang Li Xinfu Li Zhenshan Liu Dawei Song Zhuang Xie | 2008 | Progress in Natural Science:Materials International2008，18，10： | 6 |
| 12 | Weakly magnetic field-assisted synthesis of magnetite nano-particles in oxidative co-precipitation显示文摘This paper presents experimental results on weakly magnetic field-assisted synthesis of magnetite (Fe3O4) nano-particles in an oxidative co-precipitation method,in comparison to the case without magnetic induction. The XRD results show that a weakly magnetic induction below 220 Gs could accelerate the phase transformation from goethite (-FeOOH) to magnetite (Fe3O4),and affect the crystal structure,the particle size/morphology and magnetic response of the magnetite nano-particles synthesized. In addition,a higher concentration of the FeCl2 solution in the synthesis reaction led to finer particles,both with and without magnetic induction. | Dawei Hu Yanmin Wang Qi Song | 2009 | Particuology2009，7，5： | 6 |
| 13 | Discovery,Identification and Comparative Analysis of Non-Specific Lipid Transfer Protein (nsLtp) Family in Solanaceae显示文摘Plant non-specific lipid transfer proteins (nsLtps) have been reported to be involved in plant defense activity against bacterial and fungal pathogens. In this study, we identified 135 (122 putative and 13 previously identified) Solanaceae nsLtps, which are clustered into 8 different groups. By comparing with Boutrot's nsLtp classification, we classified these eight groups into five types (I, II, IV, IX and X). We compared Solanaceae nsLtps with Arabidopsis and Gramineae nsLtps and found that (1) Types I, II and IV are shared by Solanaceae, Gramineae and Arabidopsis; (2) Types III, V, VI and VIII are shared by Gramineae and Arabidopsis but not detected in Solanaceae so far; (3) Type VII is only found in Gramineae whereas type IX is present only in Arabidopsis and Solanaceae; (4) Type X is a new type that accounts for 52.59% Solanaceae nsLtps in our data, and has not been reported in any other plant so far. We further built and compared the three-dimensional structures of the eight groups, and found that the major functional diversification within the nsLtp family could be predated to the monocot/dicot divergence, and many gene duplications and sequence variations had happened in the nsLtp family after the monocot/dicot divergence, especially in Solanaceae. | Wanfei Liu Dawei Huang Kan Liu Songnian Hu Jun Yu Gang Gao Shuhui Song | 2010 | Genomics, Proteomics & Bioinformatics2010，8，4： | 4 |
| 14 | Forced Convection Heat Transfer in Porous Structure: Effect of Morphology on Pressure Drop and Heat Transfer Coefficient显示文摘A light-weight structure with sufficient mechanical strength and heat transfer performance is increasingly required for some thermal management issues.The porous structure with the skeleton supporting the ambient stress and the pores holding the flowing fluid is considered very promising,attracting significant scientific and industrial interest over the past few decades.However,due to complicated morphology of the porous matrices and thereby various performance of the pressure drop and heat transfer coefficients (HTC),the comprehensive comparison and evaluation between different structures are largely unclear.In this work,recent researches on the efforts of forced convection heat transfer in light-weight porous structure are reviewed;special interest is placed in the open-cell foam,lattice-frame,structured packed bed,and wire-woven structures.Their experimental apparatus,morphological of the porous structures,effect of morphology on pressure drop and HTC,and further applications are discussed.The new method which measure morphology accurately should be paid more attention to develop more accuracy correlation.Also,the most research focused on low Reynolds number and existing structure,while very few researchers investigated the property of forced convection heat transfer in high velocity region and developed new porous structure. | ZHAO Jiafei SUN Mingrui ZHANG Lunxiang HU Chengzhi TANG Dawei YANG Lei SONG Yongchen | 2021 | Journal of Thermal Science2021，30，2： | 4 |
| 15 | A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo显示文摘排序 nexins (SNX )phosphoinositide 有约束力的蛋白质在在 vitro 排序各种各样的膜蛋白质被含有,但是在里面他们的 vivo 功能仍然保持大部分未知。我们以前报导 SNX10 是 SNX 家庭基因的一个独特成员因为它在房间举办 vacuolation 活动。我们在这研究由 loss-of-function 试金调查 SNX10 的生物功能并且证明 SNX10 在有教养的房间为主要的睫的形成被要求。在 zebrafish, SNX10 为内脏的机关的左右的 patterning 在 Kupffer 的泡和必需品涉及 ciliogenesis。机械学地, SNX10 与复杂的 V-ATPase 交往并且指向它到 ciliogenesis 被开始的中心体。象 SNX10 一样, V-ATPase 在 vitro 并且在 vivo 调整 ciliogenesis 并且对 SNX10 那么 synergistically 做。我们进一步发现 SNX10 和 V-ATPase 调整 Rab8a 的睫的 trafficking,它是睫的膜扩展的一个批评管理者。这些结果识别为 ciliogenesis 是关键的一条 SNX10/V-ATPase-regulated 小囊的 trafficking 小径,并且表明通过在各种各样的机关的睫形成的规定, SNX10/V-ATPase 在早胚胎的开发期间起一个必要作用。 | Yanqun Chen Bin Wu Liangliang Xu Huapeng Li Jianhong Xia Wenguang Yin Zhuo Li Dawei Shi Song Li Shuo Lin Xiaodong Shu Duanqing Pei | 2012 | Cell Research2012，22，2： | 4 |
| 16 | ASAF: altered spontaneous activity fingerprinting in Alzheimer’s disease based on multisite fMRI显示文摘Several monocentric studies have noted alterations in spontaneous brain activity in Alzheimer's disease (AD), although there is no consensus on the altered amplitude of low-frequency fluctuations in AD patients. The main aim of the present study was to identify a reliable and reproducible abnormal brain activity pattern in AD. The amplitude of local brain activity (AM), which can provide fast mapping of spontaneous brain activity across the whole brain, was evaluated based on multisite rs-fMRI data for 688 subjects (215 normal controls (NCs), 221 amnestic mild cognitive impairment (aMCI) 252 AD). Two-sample t-tests were used to detect group differences between AD patients and NCs from the same site. Differences in the AM maps were statistically analyzed via the Stouffer's meta-analysis. Consistent regions of lower spontaneous brain activity in the default mode network and increased activity in the bilateral hippocampus/parahippocampus, thalamus, caudate nucleus, orbital part of the middle frontal gyrus and left fusiform were observed in the AD patients compared with those in NCs. Significant correlations (P? | Jiachen Li Dan Jin Ang Li Bing Liu Chengyuan Song Pan Wang Dawei Wang Kaibin Xu Hongwei Yang Hongxiang Yao Bo Zhou Alexandre Bejanin Gael Chetelat Tong Han Jie Lu Qing Wang Chunshui Yu Xinqing Zhang Yuying Zhou Xi Zhang Tianzi Jiang Yong Liu Ying Han | 2019 | Science Bulletin2019，64，14： | 3 |
| 17 | Immune responses of a designed HIV-1 DNA vaccine on rhesus monkeys显示文摘An effective HIV-1 vaccine will be the ultimate solution for the prevention of HIV/AIDS, though HAART plays important roles in treating the disease. In this study, a large-scale recombinant DNA plasmid containing a designed HIV-1 multi-epitope- p24 chimeric gene was prepared and purified. Rhesus monkeys were then inoculated muscularly with the plasmid for four times in week 0, 4, 8 and 18. Whole blood was collected two weeks after the third and fourth inoculation, followed by serum and pe- ripheral blood mononuclear cell (PBMC) separation. The CTL activity and proliferation of PBMCs stimu- lated by macaque MHC-I-restricted HIV-1 CTL epi- tope peptide were analyzed by MTT and LDH release assay, respectively. Th1 cytokines in supernatant of cultured PBMC stimulated by HIV-1 CTL epitope peptide and anti-HIV-1 antibody in serum were as- sayed by ELISA. The results showed that increased CTL target-killing activity, higher secretion of Th1 cytokines (IFN-γ and IL-2) and promoted proliferative reaction of monkey PBMCs stimulated by HIV-1 CTL epitope peptide were detected in the immunization group inoculated by the recombinant DNA vaccine for three times, which were further enhanced by the fourth inoculation. At the same time, HIV-1 specific antibody in serum of immunized monkeys was higher than that in controls. We concluded that the designedHIV-1 DNA vaccine may induce HIV-1 specific cellular and humoral immunity on monkeys. | ZHANG Lishu JIN Ningyi SONG Yingjin SUN Yansong WANG Hong ZHAN Dawei MA Hewen SHANG Yupu JIN Hongtao HONG Baoqing LI Chang | 2006 | Chinese Science Bulletin2006，51，13： | 3 |
| 18 | Ameliorating the interfacial issues of all-solid-state lithium metal batteries by constructing polymer/inorganic composite electrolyte显示文摘Lithium metal is one of the most promising anodes for next-generation batteries due to its high capacity and low reduction potential.However,the notorious Li dendrites can cause the short life span and safety issues,hindering the extensive application of lithium batteries.Herein,Li_(7)La_(3)Zr_(2)O_(12)(LLZO)ceramics are integrated into polyethylene oxide(PEO)to construct a facile polymer/inorganic composite solid-state electrolyte(CSSE)to inhibit the growth of Li dendrites and widen the electrochemical stability window.Given the feasibility of our strategy,the designed PEO-LLZO-LiTFSI composite solid-state electrolyte(PLLCSSE)exhibits an outstanding cycling property of 134.2 mAh g^(-1) after 500 cycles and the Coulombic efficiency of 99.1%after 1000 cycles at 1 C in LiFePO_(4)-Li cell.When cooperated with LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)(NCM622)cathode,the PLL-CSSE renders a capacity retention of 82.4%after 200 cycles at 0.2 C.More importantly,the uniform dispersion of LLZO in PEO matrix is tentative tested via Raman and FT-IR spectra and should be responsible for the improved electrochemical performance.The same conclusion can be drawn from the interface investigation after cycling.This work presents an intriguing solid-state electrolyte with high electrochemical performance,which will boost the development of all-solid-state lithium batteries with high energy density. | Su Wang Qifang Sun Wenxiu Peng Yue Ma Ying Zhou Dawei Song Hongzhou Zhang Xixi Shi Chunliang Li Lianqi Zhang | 2021 | Journal of Energy Chemistry2021，30，7： | 2 |
| 19 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 20 | Molecular Cloning and Bioinformatics Analysis of TypeⅢSecretion System Effector Protein Va1686 Gene of Vibrio alginolyticus显示文摘In this study,Va1686 gene was cloned from Vibrio alginolyticus. The total length of the gene is 1 164 bp,and it could encode 387 amino acids. The physicochemical properties,protein structure,genetic evolutionary relationship and antigenic characteristics of the effect protein Va1686 of V. alginolyticus HY9901 type Ⅲ secretion system were studied and analyzed by bioinformatics methods and tools. The results showed that Va1686 is a stable hydrophilic and acidic protein without a transmembrane region and a signal peptide,and secondary structure to α-helix. The evolutionary analysis showed that V. alginolyticus HY9901 and V.harveyi were clustered together,which indicated that the genetic relationship between the two species was the closest. Va1686 contains a Fic superfamily conserved domain associated with cell division. Bioinformatics analysis showed that the B-cell preponderant epitopes of Va1686 might be localized in the regions of 48-49,82-85,125-126,150-153,185-186,236-237 and so on. The 3D structure model of Va1686 subunit was simulated by SWISS-MODEL software and it was found that the vop S of V. parahaemolyticus was similar and the similarity was 89. 46%. In this study,the feasibility of Va1686 as a common antigen of Vibrio was verified from the perspective of bioinformatics,which laid the foundation for the next step in vaccine development. | Zhihao WU Mingjie FAN Jiaming LIAO Huanying PANG Chuanhao PAN Dawei SONG Mingsheng QIU Shuanghu CAI Jichang JIAN | 2018 | Agricultural Biotechnology2018，7，5： | 2 |
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