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| 1 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 2 | Changes in meat quality of ovine longissimus dorsi muscle in response to repeated freeze and thaw显示文摘 | Jun Qi Chunbao Li Yinji Chen Feifei Gao Xinglian Xu Guanghong Zhou | 2012 | Meat Science2012，，4： | 2 |
| 3 | <ce:link locator='fx1'/> Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients显示文摘 | Junliang Fu Dongping Xu Zhenwen Liu Ming Shi Ping Zhao Baoyun Fu Zheng Zhang Huiyin Yang Hui Zhang Chunbao Zhou Jinxia Yao Lei Jin Huifen Wang Yongping Yang Yang-Xing Fu Fu-Sheng Wang | 2007 | Gastroenterology2007，，7： | 1 |
| 4 | Meat quality and cooking attributes of thawed pork with different low field NMR T21显示文摘 | LI Chunbao LIU Dengyong ZHOU Guanghong | 2011 | Meat Science2011，92，2： | 1 |
| 5 | Changes of meat quality characteristics and intramuscular connective tissue of beef semitendinosus muscle during postmortem aging for Chinese Yellow bulls显示文摘 | LI Chunbao ZHOU Guanghong XU Xinglian | 2008 | International Journal of Food Science and Technology2008，43，： | 1 |
| 6 | Changes of meat qualitycharacteristics and intramuscular connective tissue of beef semitendino-sus muscle during postmortem aging for Chinese Yellow bulls显示文摘 | LI Chunbao ZHOU Guanghong XU Xinglian | 2008 | International Journal of Food Science and Technology2008，43，5： | 1 |
| 7 | Meat quality and cooking attributes of thawed pork with different low field NMR T2j 显示文摘 | Li Chunbao Liu Dengyong Zhou Guanghong | 2012 | Meat Science2012，92，2： | 1 |
| 8 | Comparisons of meat quality characteristics and intramuscular connective tissue between beef longissimus dorsi and semitendinosus muscles from Chinese yellow bulls显示文摘 | LI Chunbao ZHOU Guanghong XU Xinglian | 2007 | Journal of Muscle Foods2007，18，2： | 1 |
| 9 | <ce:link locator='fx1'/> Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients显示文摘 | Junliang Fu Dongping Xu Zhenwen Liu Ming Shi Ping Zhao Baoyun Fu Zheng Zhang Huiyin Yang Hui Zhang Chunbao Zhou Jinxia Yao Lei Jin Huifen Wang Yongping Yang Yang-Xing Fu Fu-Sheng Wang | 2007 | Gastroenterology2007，，7： | 1 |
| 10 | Meat quality and cooking attributes of thawed pork with different low field NMR T 21显示文摘 | Chunbao Li Dengyong Liu Guanghong Zhou Xinglian Xu Jun Qi Peilei Shi Tianlan Xia | 2011 | Meat Science2011，，2： | 1 |
| 11 | <ce:link locator='fx1'/> Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients显示文摘 | Junliang Fu Dongping Xu Zhenwen Liu Ming Shi Ping Zhao Baoyun Fu Zheng Zhang Huiyin Yang Hui Zhang Chunbao Zhou Jinxia Yao Lei Jin Huifen Wang Yongping Yang Yang-Xing Fu Fu-Sheng Wang | 2007 | Gastroenterology2007，，7： | 1 |
| 12 | Changes of intramuscular phospholipids and free fatty acids during the processing of Nanjing dry-cured duck显示文摘 | Weimin Xu Xinglian Xu Guanghong Zhou Daoying Wang Chunbao Li | 2007 | Food Chemistry2007，，2： | 1 |
| 13 | Meat quality and cooking attributes of thawed pork with different low field NMR T21 显示文摘 | Li Chunbao Liu Dengyong Zhou Guanghong | 2012 | Meat Science2012，92，2： | 1 |
| 14 | Meat quality and cooking attributes of thawed pork with different low field NMR T21显示文摘 | Chunbao Li Dengyong Liu Guanghong Zhou | 2012 | Meat Science2012，92，： | 1 |
| 15 | Changes of meat quality characteristics and intramuscular connective tissue of beef Semitendino- sus muscle during postmortem aging for Chinese Yellow bulls显示文摘 | LI Chunbao ZHOU Guanghong XU Xinghan | 2008 | International Journal of Food Science and Technology2008，43，： | 1 |
| 16 | Dynamical changes of beef intramuscular connective tissue and muscle fiber during heating and their effects on beef shear torce显示文摘 | LI Chunbao ZHOU Guanghong XU Xinglian | 2010 | Food and Bioprocess Technology2010，3，： | 1 |
| 17 | Meat quality and cooking attributes of thawed pork with different low field NMR T21显示文摘 | LI Chunbao LIU Dengyong ZHOU Guanghong | 2012 | Meat Science2012，92，2： | 1 |
| 18 | <ce:link locator='fx1'/> Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients显示文摘 | Junliang Fu Dongping Xu Zhenwen Liu Ming Shi Ping Zhao Baoyun Fu Zheng Zhang Huiyin Yang Hui Zhang Chunbao Zhou Jinxia Yao Lei Jin Huifen Wang Yongping Yang Yang-Xing Fu Fu-Sheng Wang | 2007 | Gastroenterology2007，，7： | 1 |
| 19 | <ce:link locator='fx1'/> Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients显示文摘 | Junliang Fu Dongping Xu Zhenwen Liu Ming Shi Ping Zhao Baoyun Fu Zheng Zhang Huiyin Yang Hui Zhang Chunbao Zhou Jinxia Yao Lei Jin Huifen Wang Yongping Yang Yang-Xing Fu Fu-Sheng Wang | 2007 | Gastroenterology2007，，7： | 1 |
| 20 | Electricalstimulation affects metabolic enzyme phosphorylation, protease activation, and meat tenderization in beef显示文摘 | LI Chunbao ZHOU Guanghong LAMETSCH R | 2012 | Journal of Animal Science2012，90，： | 1 |
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