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| 1 | Perfusion computed tomography in renal cell carcinoma显示文摘Various imaging modalities are available for the diagnosis, staging and response evaluation of patients with renal cell carcinoma(RCC). While contrast enhanced computed tomography(CT) is used as the standard of imaging for size, morphological evaluation and response assessment in RCC, a new functional imaging technique like perfusion CT(p CT), goes down to the molecular level and provides new perspectives in imaging of RCC. p CT depicts regional tumor perfusion and vascular permeability which are indirect parameters of tumor angiogenesis and thereby provides vital information regarding tumor microenvironment. Also response evaluation using p CT may predate the size criteria used in Response Evaluation Criteria in Solid Tumors, as changes in the perfusion occurs earlier following tissue kinase inhibitors before any actual change in size. This may potentially help in predicting prognosis, better selection of therapy and more accurate and better response evaluation in patients with RCC. This article describes the techniques and role of p CT in staging and response assessment in patients with RCCs. | Chandan J Das Usha Thingujam Ananya Panda Sanjay Sharma Arun Kumar Gupta | 2015 | World Journal of Radiology2015，7，7： | 8 |
| 2 | Global histone post-translational modifications and cancer:Biomarkers for diagnosis,prognosis and treatment?显示文摘Global alterations in epigenetic landscape are now recognized as a hallmark of cancer. Epigenetic mechanismssuch as DNA methylation,histone modifications,nucleosome positioning and non-coding RNAs are proven to have strong association with cancer. In particular,covalent post-translational modifications of histone proteins are known to play an important role in chromatin remodeling and thereby in regulation of gene expression. Further,histone modifications have also been associated with different aspects of carcinogenesis and have been studied for their role in the better management of cancer patients. In this review,we will explore and discuss how histone modifications are involved in cancer diagnosis,prognosis and treatment. | Shafqat Ali Khan Divya Reddy Sanjay Gupta | 2015 | World Journal of Biological Chemistry2015，6，4： | 4 |
| 3 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 4 | Emerging targets in cancer drug resistance显示文摘Drug resistance is a complex phenomenon that frequently develops as a failure to chemotherapy during cancer treatment.Malignant cells increasingly generate resistance to various chemotherapeutic drugs through distinct mechanisms and pathways.Understanding the molecular mechanisms involved in drug resistance remains an important area of research for identification of precise targets and drug discovery to improve therapeutic outcomes.This review highlights the role of some recent emerging targets and pathways which play critical role in driving drug resistance. | Shashank Kumar Prem Prakash Kushwaha Sanjay Gupta | 2019 | Cancer Drug Resistance2019，2，2： | 3 |
| 5 | Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma显示文摘AIM:To investigate cell type specific distribution ofβ-actin expression in gastric adenocarcinoma and its correlation with clinicopathological parameters.METHODS:β-actin is a housekeeping gene,frequently used as loading control,but,differentially expresses in cancer.In gastric cancer,an overall increased expression ofβ-actin has been reported using tissue disruptive techniques.At present,no histological data is available to indicate its cell type-specific expression and distribution pattern.In the present study,we analyzedβ-actin expression and distribution in paired normal and tumor tissue samples of gastric adenocarcinoma patients using immunohistochemistry(IHC),a tissue non-disruptive technique as well as tissue disruptive techniques like reverse transcriptase-polymerase chain reaction(RT-PCR)and western blotting.Correlation ofβ-actin level with clinicopathological parameters was done using univariate analysis.RESULTS:The results of this study showed significant overexpression,at both mRNA and protein level in tumor tissues as confirmed by RT-PCR(1.47±0.13 vs2.36±0.16;P<0.001)and western blotting(1.92±0.26 vs 2.88±0.32;P<0.01).IHC revealed thatβ-actin expression is majorly distributed between epithelial and inflammatory cells of the tissues.Inflammatory cells showed a significantly higher expression compared to epithelial cells in normal(2.46±0.13 vs 5.92±0.23,P<0.001),as well as,in tumor tissues(2.79±0.24 vs6.71±0.14,P<0.001).Further,comparison of immunostaining between normal and tumor tissues revealed that both epithelial and inflammatory cells overexpressβ-actin in tumor tissues,however,significant difference was observed only in inflammatory cells(5.92±0.23vs 6.71±0.14,P<0.01).Moreover,combined expression in epithelial and inflammatory cells also showed significant increase(4.19±0.15 vs 4.75±0.14,P<0.05)in tumor tissues.In addition,univariate analysis showed a positive correlation ofβ-actin level of inflammatory cells with tumor grade(P<0.05)while epithelial cells exhibited negative correlation(P>0.05).CONCLUSION:In gastric cancer,β-actin showed an overall higher expression predominantly contributed by inflammatory or tumor infiltrating immune cells of the tissue microenvironment and correlates with tumor grade. | Shafqat A Khan Monica Tyagi Ajit K Sharma Savio G Barreto Bhawna Sirohi Mukta Ramadwar Shailesh V Shrikhande Sanjay Gupta | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 6 | Draft genome sequence of a less-known wild Vigna: Beach pea(V. marina cv. ANBp-14-03)显示文摘Beach pea or beach cowpea(Vigna marina(Burm.)Merr.)belongs to the family Fabaceae.It is a close relative of cultivated Vigna species such as adzuki bean(V.angularis),cowpea(V.unguiculata),mung bean(V.radiata),and blackgram(V.mungo),and is distributed throughout the tropics.With its ability to tolerate salt stress,beach pea has great potential to contribute salt-tolerance genes for developing salt-tolerant cultivars in cultivated Vigna species.However,it is still underutilized in Vigna breeding programs.A draft genome sequence of beach pea was generated using a high-throughput next-generation sequencing platform,yielding 23.7 Gb of sequence from 79,929,868 filtered reads.A de novo genome assembly containing 68,731 scaffolds gave an N50 length of 10,272 bp and the assembled sequences totaled 365.6 Mb.A total of 35,448 SSRs,including 3574 compound SSRs,were identified and primer pairs for most of these SSRs were designed.Genome analysis identified 50,670 genes with mean coding sequence length 1042 bp.Phylogenetic analysis revealed highest sequence similarity with V.angularis,followed by V.radiata.Comparison with the V.angularis genome revealed 16,699 SNPs and 2253 InDels and comparison with the V.radiata genome revealed 17,538 SNPs and 2300 InDels.To our knowledge this is the first draft genome sequence of beach pea derived from an accession(ANBp-14-03)adapted locally in the Andaman and Nicobar Islands of India.The draft genome sequence may facilitate the genetic enhancement in cultivated Vigna species. | Awnindra Kumar Singh A.Velmurugan Debjyoti Sen Gupta Jitendra Kumar Ravi Kesari Aravind Konda Narendra Pratap Singh Sibnarayan Dam Roy Utpal Biswas R.Rahul Kumar Sanjay Singh | 2019 | The Crop Journal2019，7，5： | 2 |
| 7 | Determinants of the variability in corporate effective tax rates: Evidence from longitudinal data显示文摘 | Sanjay Gupta Kaye Newberry | 1997 | Journal of Accounting and Public Policy1997，，1： | 2 |
| 8 | Geo-metric modelling of end mills显示文摘 | Puneet Tandon Phalguni Gupta Sanjay G Dhande | 2005 | Computer - Aided Design & Applications2005，2，14： | 1 |
| 9 | Stable structure of platinum carbides: A first principles investigation on the structure, elastic, electronic and phonon properties显示文摘 | Venu Mankad Nikita Rathod Sanjay D. Gupta Sanjeev K. Gupta Prafulla K. Jha | 2011 | Materials Chemistry and Physics2011，，3： | 1 |
| 10 | Impact of C-arm CT on Hepatic Arterial Interventions for Hepatic Malignancies显示文摘 | Michael J. Wallace Ravi Murthy Paresh P. Kamat Teri Moore Sujaya H. Rao Joe Ensor Sanjay Gupta Kamran Ahrar David C. Madoff Stephen E. McRae Marshall E. Hicks | 2007 | Journal of Vascular and Interventional Radiology2007，，12： | 1 |
| 11 | Laparoscopic inguinal hernia repair in the pediatric age group-experience with 437 children显示文摘 | Sandesh V Parelkar Sanjay Oak Rahul Gupta | 2010 | Journal of Pediatric Surgery2010，45，： | 1 |
| 12 | Triple tube drainage for “difficult” gastroduodenal perforations:A prospective study显示文摘AIM To prospectively study the outcome of difficult gastroduodenal perforations(GDPs) treated by triple tube drainage(TTD) in order to standardize the procedure.METHODS Patients presenting to a single surgical unit of a tertiary hospital with difficult GDPs(large, unfavourable local and systemic factors) were treated with TTD(gastrostomy, duodenostomy and feeding jejunostomy). Postoperative parameters were observed like time to return of bowel sounds, time to start enteral feeds, time to start oral feeds, daily output of all drains, time to clamping/removal of all drains, time for skin to heal, complications, hospital stay, and, mortality. Descriptive statistics were used. RESULTS Between December 2013 and April 2015, 20 patients undergoing TTD for GDP were included, with mean age of 44.6 ± 19.8 years and male:female ratio of 17:3. Mean pre-operative APACHE Ⅱ scores were 10.85 ± 3.55; most GDPs were prepyloric(9/20; 45%) or proximal duodenal(8/20; 40%) and mean size was 1.83 ± 0.59 cm(largest 2.5 cm). Median times of resumption of enteral feeding, removal of gastrostomy, removal of duodenostomy,removal of feeding jejunostomy and oral feeding were 4 d(4-5 IQR), 13(12-16.5 IQR), 16(16.25-22.25 IQR), 18(16.5-24 IQR) and 12 d(10.75-18.5 IQR) respectively. Median hospital stay was 22 d(19-26 IQR) while mortality was 4/20(20%). CONCLUSION TTD for difficult GDP is feasible, easy in the emergency, and patients recover in two-three weeks. It obviates the need for technically demanding and riskier procedures. | Nitin Agarwal Nishant Kumar Malviya Nikhil Gupta Iqbal Singh Sanjay Gupta | 2017 | World Journal of Gastrointestinal Surgery2017，9，1： | 1 |
| 13 | Taxes and corporate charity: empirical evidence from microlevel panel data 显示文摘 | BOATSMAN JAMES R SANJAY GUPTA | 1996 | National Tax Journal1996，，6： | 1 |
| 14 | Bronchial Artery Embolization for the Management of Hemoptysis in Oncology Patients: Utility and Prognostic Factors显示文摘 | Gin R. Wang Joe E. Ensor Sanjay Gupta Marshall E. Hicks Alda L. Tam | 2009 | Journal of Vascular and Interventional Radiology2009，，： | 1 |
| 15 | Kinetic Growth Rate after Portal Vein Embolization Predicts Posthepatectomy Outcomes: Toward Zero Liver-Related Mortality in Patients with Colorectal Liver Metastases and Small Future Liver Remnant显示文摘 | Junichi Shindoh Mark J. Truty Thomas A. Aloia Steven A. Curley Giuseppe Zimmitti Steven Y. Huang Armeen Mahvash Sanjay Gupta Michael J. Wallace Jean-Nicolas Vauthey | 2013 | Journal of the American College of Surgeons2013，，： | 1 |
| 16 | Selective Growth-Inhibitory,Cell-Cycle Deregulatory and Apoptotic Response of Apigenin in Normal versus Human Prostate Carcinoma Cells显示文摘 | Sanjay Gupta Farrukh Afaq Hasan Mukhtar | 2001 | Biochemical and Biophysical Research Communications2001，287，： | 1 |
| 17 | Synthesis of 2,4,6-trisubstituted pyrimidine and triazine heterocycles as antileishmanial agents显示文摘 | Naresh Sunduru Anu Agarwal Sanjay Babu Katiyar Nishi Neena Goyal Suman Gupta Prem M.S. Chauhan | 2006 | Bioorganic & Medicinal Chemistry2006，，23： | 1 |
| 18 | Taxes and Corporate Charity:Empirical Evidence from Micro-level Panel Data显示文摘 | Boatsman R.James Sanjay Gupta | | 0，，49： | 1 |
| 19 | Biliary changes in extrahepatic portal venous obstruction: compression by collaterals or ischemic?显示文摘 | Radha K. Dhiman Pankaj Puri Yogesh Chawla Mukut Minz Jayapalli R. Bapuraj Sanjay Gupta Birendra Nagi Sudha Suri | 1999 | Gastrointestinal Endoscopy1999，，： | 1 |
| 20 | Performance modeling of asynchronous data transfer methods of IEEE 802.11 MAC protocol显示文摘 | Harshal S. Chhaya Sanjay Gupta | 1997 | Wireless Networks1997，，3： | 1 |
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