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| 1 | Anterior resection for rectal carcinoma-risk factors for anastomotic leaks and strictures显示文摘AIM:To determine the incidence and factors responsible for anastomotic leaks and stricture following anterior resection(AR)and its subsequent management.METHODS:Retrospective analysis of data from 108 patients with rectal carcinoma who underwent AR or low anterior resection(LAR)to identify the various preoperative,operative,and post operative factors that might have influence on anastomotic leaks and strictures.RESULTS:There were 68 males and 40 females with an average of 47 years(range 21-75 years).The median distance of the tumor from the anal verge was 8 cm(range 3-15 cm).Sixty(55.6%)patients underwent handsewn anastomosis and 48(44.4%)were stapled.The median operating time was 3.5 h(range2.0-7.5 h).Sixteen(14.6%)patients had an anastomotic leak.Among these,11 patients required reexploration and five were managed expectantly.The anastomotic leak rate was similar in patients with and without diverting stoma(8/60,13.4%with stoma and 8/48;16.7%without stoma).In 15(13.9%)patients,resection margins were positive for malignancy.Ninteen(17.6%)patients developed anastomotic strictures at a median duration of 8 mo(range 3-20 mo).Among these,15 patients were successfully managed with per-anal dilatation.On multivariate analysis,advance age(>60 years)was the only risk factor for anastomotic leak(P=0.004).On the other hand,anastomotic leak(P=0.00),mucin positive tumor(P =0.021),and lower rectal growth(P=0.011)were found as risk factors for the development of an anastomotic stricture.CONCLUSION:Advance age is a risk factor for an anastomotic leak.An anastomotic leak,a mucin-secreting tumor,and lower rectal growth predispose patients to develop anastomotic strictures. | Ashok Kumar Ram Daga Paari Vijayaragavan Anand Prakash Rajneesh Kumar Singh Anu Behari Vinay K Kapoor Rajan Saxena | 2011 | World Journal of Gastroenterology2011，17，11： | 28 |
| 2 | 内蒙古大庙中新世哺乳动物群序列与环境变化显示文摘中新世是现代地理、生态、气候格局等形成的关键时期,是研究陆生哺乳动物演化与环境变化关系的理想时段。通过对内蒙古四子王旗大庙发现的中新世哺乳动物化石的研究,试图揭示同一区域哺乳动物群落演变过程、生态类型的变化及其与环境变化的关系。结果表明大庙共产出了3个时段的动物群,分别为早中新世谢家期、中中新世通古尔期以及晚中新世灞河期。从哺乳动物群落组成以及类群的演化序列上分析,大庙地区从早中新世谢家期至晚中新世灞河期生态环境相对稳定,明显不同于现代的干旱草原环境,应该是温湿的森林与开阔的草原共存的格局。 | 张兆群 王李花 Anu Kaakinen 刘丽萍 傅明楷 | 2011 | 第四纪研究2011，31，4： | 10 |
| 3 | Salt Tolerance Mechanisms and Approaches:Future Scope of Halotolerant Genes and Rice Landraces显示文摘All rice plant developmental stages are severely affected by soil salinity. Salinity-induced ionic and osmotic stresses affect stomata closure and gaseous exchange, and reduce transpiration and the rate of carbon assimilation, and hence decrease plant yield. Understanding the response of rice plants toward salinity stress at the genetic level and developing salt-tolerant varieties are the vital mandates for its effective management. This review described the present status of salt-tolerance achieved in rice by various mechanisms including the ion homeostasis(Na^+/H^+, OsNHX antiporters), compatible organic solutes(glycine betaine and proline), antioxidative genes(OsECS, OsVTE1, OsAPX and OsMSRA4.1), salt responsive regulatory elements(transcription factors, cis-acting elements and miRNAs) and genes ecoding protein kinases(MAPKs, SAPKs and STRKs). Further, the future perspective of developing salt-tolerant varieties lies in exploring halotolerant gene homologs from rice varieties, especially the landraces. Genetic diversity among rice landraces can serve as a valuable resource for future studies toward variety improvement through breeding and genome editing. Further, identification, multiplication, preservation and utilization of biodiversity among landraces are the urgent buffers to be saved as a heritage for future generations to come. | Tarun Bhatt Aditi Sharma Sanjeev Puri Anu Priya Minhas | 2020 | Rice science2020，27，5： | 6 |
| 4 | Versatile Piriformospora indica and Its Potential Applications in Horticultural Crops显示文摘Modern horticultural crop production systems target the exploitation of sustainable techniques for crop improvement while maintaining balance with the environment. Several beneficial microbes have been investigated and have yielded remarkable results. The endophytic fungus, Piriformospora indica, is one microbe group with the potential to offer numerous benefits and opportunities in modern horticultural crop production. This plant growth-promoting mycorrhizal fungus is of particular interest due to its beneficial implications in plant growth and development. The fungus has been experimentally proven to significantly improve water and nutrient/mineral absorption, early flowering, seed production/germination and plant photosynthetic capability, growth rates;especially in nutrient-deprived soils, alter the production of secondary metabolites, and promote adaptation, tolerance and/or resistance to biotic and abiotic stressors. Its unique capability to be axenically cultured makes it feasible for research and application. These attributes in combinations with its broad host range, offer immense potential for this fungus for research in horticultural plant improvement. Thus, this review highlights the potential applications of P. indica in horticultural crops research and production. | Raphael Anue Mensah Dan Li Fan Liu Na Tian Xueli Sun Xiangyang Hao Zhongxiong Lai Chunzhen Cheng | 2020 | Horticultural Plant Journal2020，6，2： | 6 |
| 5 | Leptin-induced Notch and IL-1 signaling crosstalk in endometrial adenocarcinoma is associated with invasiveness and chemoresistance显示文摘BACKGROUND Obesity is a recognized risk factor for endometrial cancer (EmCa) and other cancer types. Leptin levels are significantly increased in obese individuals. Leptin-induced signaling crosstalk [Notch, Interleukin-1 (IL-1) and leptin outcome, NILCO] has been associated with breast cancer progression. This complex signaling crosstalk affects cancer cell proliferation, migration, invasion, angiogenesis, apoptosis and chemoresistance. NILCO expression was previously detected in human EmCa. However, it is unknown whether leptin regulates NILCO and alters EmCa’s response to chemotherapeutics. It is hypothesized that leptin induces NILCO and increases aggressiveness and chemoresistance in EmCa cells. AIM To determine whether leptin induces NILCO molecules in EmCa affecting cell proliferation, aggressiveness and chemoresistance. METHODS Leptin’s effects on the expression of NILCO molecules [mRNAs and proteins for Notch receptors (Notch1-4), ligands (JAG1 and DLL4) and downstream effectors (survivin, Hey2), and leptin (OB-R) and IL-1 (IL-1R tI) receptors] was examined in EmCa cells (type I: Ishikawa, and HEC-1A, and type II: An3Ca and KLE) using Real-time PCR and Western blot analysis, respectively. In addition, the effects of leptin on cell cycle, proliferation and cell invasion were determined using cytometric analysis (Cellometer Vision CBA system), MTT cell proliferation and Matrigel-based invasion assays, respectively. Inhibitors of leptin (nanoparticlebound leptin peptide receptor antagonist-2, IONP-LPrA2), IL-1 (anti-IL-1R tI antibody) and Notch (siRNA interference RNA) were used to investigate NILCO’s effects on cell proliferation and invasion. Leptin’s effects on Paclitaxel cytotoxicity in EmCa cells was determined by the CCK8 and Cellometer-based Annexin V assays. RESULTS For the first time it was shown that leptin is an inducer of Notch in EmCa. Experimental data suggest that leptin induced the expression of NILCO molecules, promoted proliferation and S- phase progression, and reduced Paclitaxel cytotoxicity on EmCa cells. Leptin’s effects were higher in type II EmCa cells. The progression of this more aggressive form of the disease is associated with obesity. Remarkably, the use of the leptin signaling antagonist, IONPLPrA2, re-sensitized EmCa cells to Paclitaxel. CONCLUSION Present data suggest the notion that leptin-induced NILCO could be a link between obesity and EmCa progression and chemoresistance. Most aggressive type II EmCa cells were higher sensitive to leptin, which appears to increase proliferation, cell cycle progression, aggressiveness, and chemoresistance to Paclitaxel. Therefore, leptin and NILCO could be novel therapeutic targets for type II EmCa, which does not have targeted therapy. Overall, IONP-LPrA2 has a potential as a novel adjuvant drug to enhance the effectiveness of type II EmCa chemotherapy. | Danielle Daley-Brown Adriana Harbuzariu Ann Anu Kurian Gabriela Oprea-Ilies Ruben Rene Gonzalez-Perez | 2019 | World Journal of Clinical Oncology2019，10，6： | 5 |
| 6 | Cognitive functioning and depressive symptoms in adolescents with inflammatory bowel disease显示文摘AIM:To investigate cognitive functioning and depressive symptoms in adolescents with inflammatory bowel disease(IBD).METHODS:A neuropsychological test battery,including subtests of the Wechsler Adult Intelligence ScaleRevised and Ⅲ,Wechsler Memory Scale-Revised,California Verbal Learning Test(CVLT),Stroop Color-Word Test,and Trail Making Test,which assessed verbal and visual short-and long-term memory,processing speed,logical reasoning,verbal intelligence,attention,and executive functioning,was administered to 13-to 19-year-old patients with IBD(n = 34;active disease n = 20).Depressive symptoms were measured with the Beck Depression Inventory.The findings were compared with peers with non-acute juvenile idiopathic arthritis(JIA;n = 23).Patients with coexisting psychiatric disorders were excluded.RESULTS:The IBD group,especially patients in the acute phase,made more perseverative errors in the CVLT test that assessed verbal memory than the JIA group(6.0 ± 4.3 vs 3.3 ± 2.9,P < 0.01),but no other differences between the IBD and JIA groups were observed in the neuropsychological tests.The difference was close to statistical significance,even when glucocorticoid medication was controlled for(P < 0.052).The IBD group had more depressive symptoms than the JIA group(7.9 ± 7.6 vs 4.0 ± 4.0,P < 0.05).Approximately one third of the IBD group had at least mild depressive symptoms,and those with acute illness had the highest scores.However,depressive symptoms were not related to the difference in the verbal memory test(perseverative errors in the CVLT) between the IBD and JIA groups.CONCLUSION:Adolescents with acute IBD may have mild verbal memory problems but no major cognitive deficits compared to peers with JIA. | Anu E Castaneda Annamari Tuulio-Henriksson Eeva T Aronen Mauri Marttunen Kaija-Leena Kolho | 2013 | World Journal of Gastroenterology2013，19，10： | 5 |
| 7 | Anal cancer in Chinese:human papillomavirus infection and altered expression of p53显示文摘AnalcancerinChinese:humanpapilomavirusinfectionandalteredexpressionofp53LAIMaoDe,LUOMinJie,YAOJianErandCHENPeiHuiSubject... | LAI MaoDe, LUO MinJie, YAO JianEr and CHEN PeiHuiKeywords anus neoplasms papillomavirus infection DNA, viral p53 gene gene expression polymerase chain reaction | 1998 | World Journal of Gastroenterology1998，4，4： | 4 |
| 8 | 印度梨形孢提高香蕉抗热性的生理生化机制显示文摘为研究印度梨形孢(Piriformospora Indica)对香蕉抗热性的影响及其生理生化机制,测定和比较了45℃高温处理0 h、3 h、6 h、12 h和24 h的有/无定殖的“天宝蕉”叶片中抗氧化活性物质活性或含量及激素含量变化情况.结果显示:高温处理后有/无P.indica定殖的香蕉叶片中H2O2含量呈先升后降的变化趋势,脯氨酸(Pro)和丙二醛(MDA)含量呈下降趋势,同时,P.indica定殖的香蕉叶片中H2O2、Pro和MDA含量均高于无定殖对照.高温处理下香蕉叶片超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、过氧化物酶(POD)和苯丙氨酸酶(PAL)活性均逐步升高,且P.indica定殖的香蕉叶片中这些指标均低于无定殖组.P.indica定殖的香蕉多酚氧化酶(PPO)活性在高温处理各时间点变化不显著,而无定殖组PPO活性在高温处理3 h时显著升高.高温处理前后P.indica定殖香蕉叶片中吲哚乙酸(IAA)和赤霉素(GA)含量均低于无定殖组,脱落酸(ABA)含量显著高于无定殖组,茉莉酸(JA)和水杨酸(SA)含量差异不大.上述结果表明P.indica可以通过提高香蕉叶片中H2O2、Pro、MDA和ABA含量以及抑制IAA和GA含量提高香蕉抗热能力. | BODJRENOU Mahoudjro David 孙雪丽 MENSAH Raphael Anue 李丹 刘范 田娜 赖钟雄 程春振 | 2020 | 应用与环境生物学报2020，26，6： | 4 |
| 9 | 8Spheres微球联合碘油TACE治疗原发性肝癌的疗效及安全性显示文摘目的:探讨8Spheres适形栓塞微球联合碘油肝动脉化疗栓塞(TACE)治疗原发性肝癌的近期疗效及安全性。方法:收集我院原发性肝癌患者共64例。其中试验组(8Spheres栓塞微球+碘油栓塞)32例,对照组(单纯碘油栓塞)32例。比较两组患者介入治疗前及治疗后1周、1个月肝功能指标及甲胎蛋白(AFP)的变化。术后3个月、6个月评价两组患者肿瘤局部反应。同时比较两组患者术后并发症发生情况。结果:患者基线临床特征无统计学差异(均P〉0.05)。术后1个月两组患者肝功能均改善,但试验组肝功能指标ALT、AST和TBiL明显优于对照组(均P〈0.05)。术后1周及1个月AFP水平显著下降(均P〈0.01),且术后1个月试验组AFP水平显著低于对照组(P〈0.01)。术后6个月试验组肿瘤客观反应率(P〈0.05)及疾病控制率(P〈0.01)均显著高于对照组,且试验组疾病进展率显著低于对照组(P〈0.01)。两组患者术后总并发症发生率无显著性差异(P〉0.05)。结论:与单纯碘油TACE相比,8Spheres栓塞微球联合碘油TACE对治疗原发性肝癌近期疗效显著,安全性较高,值得临床推广。其远期临床疗效及生存获益有待进一步随访研究。 | 吴宝林 周军 凌公豪 Anu John 龙清云 | 2018 | 武汉大学学报(医学版)2018，39，2： | 4 |
| 10 | Optimization of Distributed Solar Photovoltaic Power Generation in Day-ahead Electricity Market Incorporating Irradiance Uncertainty显示文摘This paper proposes a simple and practical approach to model the uncertainty of solar irradiance and determines the optimized day-ahead(DA)schedule of electricity mar-ket.The problem formulation incorporates the power output of distributed solar photovoltaic generator(DSPVG)and forecasted load demands with a specified level of certainty.The proposed approach determines the certainty levels of the random variables(solar irradiance and forecasted load demand)from their probability density function curves.In this process of optimization,the energy storage system(ESS)has also been mod-eled based on the fact that the energy stored during low locational marginal price(LMP)periods and dispatched during high LMP periods would strengthen the economy of DA schedule.The objective of the formulated non-linear optimization problem is to maximize the social welfare of market participants,which incorporates the assured generation outputs of DSPVG,subject to real and reactive power balance and transmission capability constraints of the system and charging/dis-charging and energy storage constraints of ESS.The simulation has been performed on the Indian utility 62-bus system.The results are presented with a large number of cases to demonstrate the effectiveness of the proposed approach for the efficient,economic and reliable operation of DA electricity markets. | Anu Singla Kanwardeep Singh Vinod Kumar Yadav | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，3： | 4 |
| 11 | Colitis cystica profunda of the rectum: An unexpected operative finding显示文摘Colitis cystic profunda is a rare entity benign condition of the colon and rectum that can mimic suspicious polyps or malignancy. The commonest sites of affectation are the rectum and the sigmoid colon but it can be unusually widely distributed in the colon. The aetiology of this condition is not fully elucidated and confident diagnosis can only be made on histological features. We hereby describe a patient who presented with significant rectal symptoms and an unexpected finding of a submucosal mucous cyst mimicking a suspicious rectal polyp and highlighted its significance and the review of the literature. | Abraham A Ayantunde Claire Strauss Malathi Sivakkolunthu Anu Malhotra | 2016 | World Journal of Clinical Cases2016，4，7： | 3 |
| 12 | Analysis of Codon Usage Pattern of Banana Basic Secretory Protease Gene显示文摘[Objective] The objective of this study was to understand the codon usage bias pattern of banana pathogenesis-related 17 gene, Basic Secretory Protease gene(MaBSP). [Method] Relative codon usage patterns of MaBSP were calculated using the software CodonW version 1.4.2. and the web-based tool(http://gffzzabfedfa7ad0f4614hu6qfqc0k0nwc69bn.ffgz.tsg.suse.edu.cn/codon/).[Result] Our findings showed that C-ended and G-ended codons were the most preferential except the TER codon UGA which was coded for by just one codon. The ENc value, relationship between AT bias and GC bias, Random synonymous codon usage(RSCU) and CAI all showed that codon bias usage existed in MaBSP gene.[Conclusion] The codon usage patterns of MaBSP gene is principally influenced by natural selection in the third position. However, other multiple factors also influence this pattern. | Mensah Raphael Anue Sun Xueli Cheng Chunzhen Lai Zhongxiong | 2019 | Plant Diseases and Pests2019，10，1： | 3 |
| 13 | A new insight into electrochemical detection of eugenol by hierarchical sheaf-like mesoporous NiCo2O4显示文摘NiCo 2 有像捆的 nanostructure 形态学的 O 4 nanosheets 被热水的反应由退火跟随了的一出灵巧的一步舞综合了处理。给人深刻印象地, NiCo 2 O 4 nanosheets 展览 eugenol 的快速的察觉。察觉的线性范围从 1500 M,并且察觉的限制是 5.4 下午。NiCo 2 O 4 修改了电极表明的高敏感,好重覆性和重制度,和长期的稳定性(在在 30 天的反应的 7% 减少) 。把工作基于这,为 eugenol 氧化的电气化学的反应机制被建议,并且另外, NiCo 2 O 4 修改了电极成功地在药的香油样品为 eugenol 的分析被采用。为在药的香油样品的 eugenol 的恢复价值在范围 98.7%105.5% 。 | Mylamparambil Udayan Anu Prathap Chao Wei Shengnan Sun Zhichuan J. Xu | 2015 | Nano Research2015，8，8： | 3 |
| 14 | Census of Kuiper Comets-the TAOS Project显示文摘Cometary nuclei, the remnant icy bodies of planet formation, located at the outer edge of the solar system, are relatively poorly studied because of their small sizes and thus faintness. Thus far more than a hundred large members (size about 100 km) of this cometary population in the Kuiper belt have been identified. Smaller bodies (10 km) are much too faint to image directly and their number so far can only be extrapolated on theoretical grounds. The Taiwan-America Occultation Survey (TAOS) will conduct a census of the number of Kuiper belt objects down to a few km size by monitoring chance stellar occultations by these cometary nuclei. We will set up an array of small (50cm), wide-field (f/1 9) telescopes, each equipped with a 2K squared CCD camera, along a 7 km baseline in central Taiwan at an elevation above ~ 3000 m. The robot telescopes will operate in a coincidence mode, so the sequence and timing of any candidate occultation event can be recorded and distinguished against a false detection. The Lawrence Livermore National Laboratory, the National Central University, and the Academia Sinica, will each contribute one telescope system. Researchers from an international variety of institutes are also participating in the project. Our experiment provides the only means to study the cometary population in the small-sized end of the distrbution. A great number of scientific byproducts, notably variable stars, will also derive from the huge TAOS database, some 10, 000 giga-bytes worth of photometrical measuremements per year. | Wen Ping ChenOther TAOS team members: C. Alcock, K. Cook, S. Marshall, M. Hammergren(LLNL) T. Lee, C. Yuan, C. Y. Wen, S. K. King(ASIAA) W. S. Tsay, W. Ip, C. Lemme, J. H. Wang(NCU) T. Axelrod(ANU) I. de Pater(UCB) J.Lissauer(Ames) Y. I. Byun(Yonsei | 1999 | 天文研究与技术1999，，S1： | 3 |
| 15 | Experimental investigation into transient pressure pulses during pneumatic conveying of fine powders using Shannon entropy显示文摘 | Amit Goel Anu Mittal S.S. Mallick Atul Sharma | 2016 | Particuology2016，14，6： | 3 |
| 16 | Inflammation in Alzheimer’s disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors显示文摘 | Antero Salminen Johanna Ojala Anu Kauppinen Kai Kaarniranta Tiina Suuronen | 2009 | Progress in Neurobiology2009，，3： | 2 |
| 17 | Alterations in the polysialylated neural cell adhesion molecule and retinal ganglion cell density in mice with diabetic retinopathy显示文摘AIM:To investigate the impact of polysialylated neural cell adhesion molecule(PSA-NCAM)on the survival of retinal ganglion cells(RGCs)in the experimentally induced diabetes in mice.METHODS:Diabetes was induced in 2.5 months old Swiss Webster mice by intraperitoneal injection of streptozotocin(STZ,90 mg/kg)once daily for two consecutive days.Examination of the proteins of interest in the retinas from diabetic mice at 2mo after diabetes induction was performed using immunohistochemistry and Western blot analysis.RGCs were counted in the wholemounted retinas,and Brn3a marker was used.RESULTS:Examination of retinas from diabetic mice at 2mo after diabetes induction revealed a considerable reduction in RGC density.Our experiments also demonstrated a redistribution of PSA-NCAM in the retina of diabetic animals.PSA-NCAM immunoreactivity was diminished in the inner part of the retina where RGCs were located.In contrast,an enhanced PSA-NCAM immunoreactivity was detected in the outer layers of the retina.PSA-NCAM signal was co-localized with glial fibrillary acidic protein immunoreactivity in the Müller cell branches.Previous studies have shown that matrix metalloproteinase-9(MMP-9)is responsible for the reduction in PSA-NCAM levels in neuronal cells.The reduced levels of PSA-NCAM in inner layers(nerve fiber layer,ganglion cell layer)were accompanied by the increased expression of MMP-9.In contrast,in the outer retinal layers,the expression of MMP-9 was much less pronounced.CONCLUSION:MMP-9 induces PSA-NCAM shedding in the inner part of the retina and the decreased level of PSA-NCAM in the inner part of the retina might be,at least in part,responsible for the loss of RGCs in diabetic mice. | Natalia Lobanovskaya Monika Jürgenson Anu Aonurm-Helm Alexander Zharkovsky | 2018 | International Journal of Ophthalmology(English edition)2018，11，10： | 2 |
| 18 | Fluxes of methane, carbon dioxide and nitrous oxide in boreal lakes and potential anthropogenic effects on the aquatic greenhouse gas emissions显示文摘 | Jari T. Huttunen Jukka Alm Anu Liikanen Sari Juutinen Tuula Larmola Taina Hammar Jouko Silvola Pertti J. Martikainen | 2003 | Chemosphere2003，，3： | 2 |
| 19 | In Vivo Function of Tic22, a Protein Import Component of the Intermembrane Space of Chloroplasts显示文摘进叶绿体的 Preprotein 进口在外部、内部的叶绿体信封膜(TOC 和 TIC ) 取决于 macromolecular 机械。两机械被 intermembrane 空间(IMS ) 的部件互连,这被建议。也就是说在其它之中, Tic22,二仔细联系了 isoforms 在 Arabidopsis thaliana 存在,也就是 atTic22-III 和 atTic22-IV。我们由分析相应基因的 T-DNA 插入线在 vivo 调查了 Tic22 的功能。当在单个基因的 T-DNA 插入引起了仅仅细微的缺点时,两 isoforms 的双异种在植物的光合的表演显示出延迟的生长,在热点条件下面的苍白的显型,减少的进口率,和减小。后者被变化在变异的植物的代谢物内容支持什么时候与相比野类型。因此,我们的结果支持 Tic22 直接涉及叶绿体 preprotein 进口并且可能在叶绿体生物的续生说指向到 Tic22 的特别重要性高进口率的时间的观点。 | Mareike Rudolf Anu B. Machettira Lucia E. Groβ Katrin L. Weber Kathrin Bolte Tihana Bionda Maik S. Sommer Uwe G. Maier Andreas RM. Weber Enrico Schleiff Joanna Tripp | 2013 | Molecular Plant2013，6，3： | 2 |
| 20 | Inflammation in Alzheimer’s disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors显示文摘 | Antero Salminen Johanna Ojala Anu Kauppinen Kai Kaarniranta Tiina Suuronen | 2009 | Progress in Neurobiology2009，，3： | 2 |
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