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| 1 | Emerging targets in cancer drug resistance显示文摘Drug resistance is a complex phenomenon that frequently develops as a failure to chemotherapy during cancer treatment.Malignant cells increasingly generate resistance to various chemotherapeutic drugs through distinct mechanisms and pathways.Understanding the molecular mechanisms involved in drug resistance remains an important area of research for identification of precise targets and drug discovery to improve therapeutic outcomes.This review highlights the role of some recent emerging targets and pathways which play critical role in driving drug resistance. | Shashank Kumar Prem Prakash Kushwaha Sanjay Gupta | 2019 | Cancer Drug Resistance2019，2，2： | 3 |
| 2 | Varna-based optimization:a novel method for capacitated controller placement problem in SDN显示文摘Recently,software defined networking(SDN)is a promising paradigm shift that decouples the control plane from the data plane.It can centrally monitor and control the network through softwarization,i.e.,controller.Multiple controllers are a necessity of current SDN based WAN.Placing multiple controllers in an optimum way is known as controller placement problem(CPP).Earlier,solutions of CPP only concentrated on propagation latency but overlooked the capacity of controllers and the dynamic load on switches,which is a significant factor in real networks.In this paper,we develop a novel optimization algorithm named varna-based optimization(VBO)and use it to solve CPP.To the best of our knowledge,this is the first attempt to minimize the total average latency of SDN along with the implementation of TLBO and Jaya algorithms to solve CPP for all twelve possible scenarios.Our experimental results show that TLBO outperforms PSO,and VBO outperforms TLBO and Jaya algorithms in all scenarios for all topologies. | Ashutosh Kumar SINGH Saurabh MAURYA Shashank SRIVASTAVA | 2020 | Frontiers of Computer Science2020，14，3： | 1 |
| 3 | Chemistry and Biological Activities of Flavonoids: An Overview显示文摘 | Shashank Kumar Abhay K Pandey K P Lu | 2013 | The Scientific World Journal2013，，2： | 1 |
| 4 | Bulbine frutescens phytochemicals as novel ABC-transporter inhibitor:a molecular docking and molecular dynamics simulation study显示文摘Aim:The present in silico study aimed to evaluate the ATP-binding cassette(ABC)transporter inhibition potential of Bulbine frutescens(B.frutescens)phytochemicals.Methods:Several previous studies and databases were used to retrieve the ligands and target protein structure.The molecular docking study was performed using the Auto Dock Tools,and the GROMACS package was applied to accomplish molecular dynamics simulation.Results:Utilizing the molecular docking and simulation approach,~25 phytochemicals were screened against the ABC transporter protein.Docking score analysis revealed that B.frutescens phytochemical 4’-Demethylknipholone 2’-β-D-glucopyranoside exhibited strong binding on the ABC transporter protein with a minimum binding score-9.8 kcal/mol in comparison to the standard ABC transporter inhibitor diltiazem(-6.86 kcal/mol).Furthermore,molecular dynamics simulation for 4’-Demethylknipholone 2’-β-D-glucopyranoside showed an acceptable root mean square deviation,radius of gyration,root mean square fluctuation,and hydrogen bond,in addition to other lead compounds.Conclusion:The in-silico study demonstrated that B.frutescens phytochemical 4’-Demethylknipholone 2’-β-D-glucopyranoside possesses anti-drug resistance properties and requires further testing in preclinical settings. | Prem Prakash Kushwaha Santosh Kumar Maurya Amit Singh Kumari Sunita Prajapati Atul Kumar Singh Mohd Shuaib Shashank Kumar | 2021 | Journal of Cancer Metastasis and Treatment2021，7，1： | 1 |
| 5 | Current therapeutic modalities and chemopreventive role of natural products in liver cancer:Progress and promise显示文摘Liver cancer is a severe concern for public health officials since the clinical cases are increasing each year,with an estimated 5-year survival rate of 30%–35%after diagnosis.Hepatocellular carcinoma(HCC)constitutes a significant subtype of liver cancer(approximate75%)and is considered primary liver cancer.Treatment for liver cancer mainly depends on the stage of its progression,where surgery including,hepatectomy and liver transplantation,and ablation and radiotherapy are the prime choice.For advanced liver cancer,various drugs and immunotherapy are used as first-line treatment,whereas second-line treatment includes chemotherapeutic drugs from natural and synthetic origins.Sorafenib and lenvatinib are first-line therapies,while regorafenib and ramucirumab are secondline therapy.Various metabolic and signaling pathways such as Notch,JAK/STAT,Hippo,TGF-β,and Wnt have played a critical role during HCC progression.Dysbiosis has also been implicated in liver cancer.Drug-induced toxicity is a key obstacle in the treatment of liver cancer,necessitating the development of effective and safe medications,with natural compounds such as resveratrol,curcumin,diallyl sulfide,and others emerging as promising anticancer agents.This review highlights the current status of liver cancer research,signaling pathways,therapeutic targets,current treatment strategies and the chemopreventive role of various natural products in managing liver cancer. | Amit Kumar Singh Shiv Vardan Singh Ramesh Kumar Shashank Kumar Sabyasachi Senapati Abhay K Pandey | 2023 | World Journal of Hepatology2023，15，1： | 1 |
| 6 | Plant disease resistance genes: Current status and future directions显示文摘 | Mayank Anand Gururani Jelli Venkatesh Chandrama Prakash Upadhyaya Akula Nookaraju Shashank Kumar Pandey Se Won Park | 2012 | Physiological and Molecular Plant Pathology2012，，： | 1 |
| 7 | Mechanism and recent updates on insulin-related disorders显示文摘Insulin,a small protein with 51 amino acids synthesized by pancreatic β-cells,is crucial to sustain glucose homeostasis at biochemical and molecular levels.Numerous metabolic dysfunctions are related to insulin-mediated altered glucose homeostasis.One of the significant pathophysiological conditions linked to the insulin associated disorder is diabetes mellitus(DM)(type 1,type 2,and gestational).Insulin resistance(IR)is one of the major underlying causes of metabolic disorders despite its association with several physiological conditions.Metabolic syndrome(MS)is another pathophysiological condition that is associated with IR,hypertension,and obesity.Further,several other pathophysiological disorders/diseases are associated with the insulin malfunctioning,which include polycystic ovary syndrome,neuronal disorders,and cancer.Insulinomas are an uncommon type of pancreatic β-cell-derived neuroendocrine tumor that makes up 2% of all pancreatic neoplasms.Literature revealed that different biochemical events,molecular signaling pathways,microRNAs,and microbiota act as connecting links between insulin disorder and associated pathophysiology such as DM,insuloma,neurological disorder,MS,and cancer.In this review,we focus on the insulin-related disorders and the underlying mechanisms associated with the pathophysiology. | Shashank Kumar Sabyasachi Senapati Neetu Bhattacharya Amit Bhattacharya Shashank Kumar Maurya Hadiya Husain Jasvinder Singh Bhatti Abhay Kumar Pandey | 2023 | World Journal of Clinical Cases2023，11，25： | 1 |
| 8 | An assessment of oil spill detection using Sentinel 1 SAR-C images显示文摘Identification of an oil spill is additionally essential to evaluate the potential spread and float from the source to the adjacent coastal terrains.In such manner,usage of Synthetic Aperture RADAR(SAR)information for the recognition and checking of oil spills has gotten extensive consideration as of late,because of their wide zone inclusion,day-night and all-weather capabilities.The present examination studies an oil spill occurred in the Al Khafji region by applying Sentinel 1 SAR-C images.Al Khafji is on the borderline between Saudi Arabia and Kuwait in the Persian Gulf and it is detected as an unbiased zone.Al Khafji region can possibly deliver in excess of 7472.403 m³barrels of oil for every day(m³/d).Approaches dependent on multi-sensor satellite images examination have been produced for distinguishing oil spills from referred to common leaks just as oil slick procedures.In this paper,one of these techniques is associated with Sentinel 1 images of a known region of natural oil leakage and of an ongoing oil slick incident in Al Khafji zone.The Synthetic Aperture Radar(SAR)is perceived as the most significant remote sensing apparatus for the ocean and ocean waters oil slick examination,recording,documentation and propagation.Specifically,this paper examines oil spills recognition in the Persian Gulf surveyed by utilizing Sentinel-1(SAR-C)imageries.Results demonstrated the significance of the VV polarization of the Sentinel-1 for recognizing oil-spills just as the diminished utility of the VH polarization in this sole circumstance. | Sudhir Kumar Chaturvedi Saikat Banerjee Shashank Lele | 2020 | Journal of Ocean Engineering and Science2020，5，2： | 0 |
| 9 | Dietary phytochemicals and their role in cancer chemoprevention显示文摘Epidemiological studies suggest a close association between diet and cancer initiation,which provides evidence that the dietary components may be effectively developed as chemopreventive agents[1].These pieces of evidence are further supported by several case-control and cohort studies,which overwhelmingly support a converse association between the intake of phytochemicals and cancer risk[2,3].A number of clinical studies have been conducted demonstrating that dietary phytochemicals have the ability to inhibit tumorigenesis[4].Components presenting in fruit and vegetables termed“bioactive”phytochemicals belong to several classes of micronutrients,including flavonoids,polyphenols,and dietary fiber.These components have the ability to reduce the cancer risk alone or by interactions between them. | Shashank Kumar Sanjay Gupta | 2021 | Journal of Cancer Metastasis and Treatment2021，7，1： | 0 |
| 10 | Resistance to second generation antiandrogens in prostate cancer: pathways and mechanisms显示文摘Androgen deprivation therapy targeting the androgens/androgen receptor(AR)signaling continues to be the mainstay treatment of advanced-stage prostate cancer.The use of second-generation antiandrogens,such as abiraterone acetate and enzalutamide,has improved the survival of prostate cancer patients;however,a majority of these patients progress to castration-resistant prostate cancer(CRPC).The mechanisms of resistance to antiandrogen treatments are complex,including specific mutations,alternative splicing,and amplification of oncogenic proteins resulting in dysregulation of various signaling pathways.In this review,we focus on the major mechanisms of acquired resistance to second generation antiandrogens,including AR-dependent and AR-independent resistance mechanisms as well as other resistance mechanisms leading to CRPC emergence.Evolving knowledge of resistance mechanisms to AR targeted treatments will lead to additional research on designing more effective therapies for advanced-stage prostate cancer. | Shiv Verma Kumari Sunita Prajapati Prem Prakash Kushwaha Mohd Shuaib Atul Kumar Singh Shashank Kumar Sanjay Gupta | 2020 | Cancer Drug Resistance2020，3，4： | 0 |
| 11 | Security Attacks in Named Data Networking: A Review and Research Directions显示文摘Contents such as audios,videos,and images,contribute most of the Internet traffic in the current paradigm.Secure content sharing is a tedious issue.The existing security solutions do not secure data but secure the communicating endpoints.Named data networking(NDN)secures the data by enforcing the data publisher to sign the data.Any user can verify the data by using the public key of the publisher.NDN is resilient to most of the probable security attacks in the TCP/IP model due to its new architecture.However,new types of attacks are possible in NDN.This article surveys the most significant security attacks in NDN such as interest flooding attacks,cache privacy attacks,cache pollution attacks,and content poisoning attacks.Each attack is classified according to their behavior and discussed for their detection techniques,countermeasures,and the affected parameters.The article is an attempt to help new researchers in this area to gather the domain knowledge of NDN.The article also provides open research issues that could be addressed by researchers. | Naveen Kumar Ashutosh Kumar Singh Abdul Aleem Shashank Srivastava | 2019 | Journal of Computer Science & Technology2019，34，6： | 0 |
| 12 | Role of prostate cancer stem-like cells in the development of antiandrogen resistance显示文摘Androgen deprivation therapy(ADT)is the standard of care treatment for advance stage prostate cancer.Treatment with ADT develops resistance in multiple ways leading to the development of castration-resistant prostate cancer(CRPC).Present research establishes that prostate cancer stem-like cells(CSCs)play a central role in the development of treatment resistance followed by disease progression.Prostate CSCs are capable of self-renewal,differentiation,and regenerating tumor heterogeneity.The stemness properties in prostate CSCs arise due to various factors such as androgen receptor mutation and variants,epigenetic and genetic modifications leading to alteration in the tumor microenvironment,changes in ATP-binding cassette(ABC)transporters,and adaptations in molecular signaling pathways.ADT reprograms prostate tumor cellular machinery leading to the expression of various stem cell markers such as Aldehyde Dehydrogenase 1 Family Member A1(ALDH1A1),Prominin 1(PROM1/CD133),Indian blood group(CD44),SRY-Box Transcription Factor 2(Sox2),POU Class 5 Homeobox 1(POU5F1/Oct4),Nanog and ABC transporters.These markers indicate enhanced self-renewal and stemness stimulating CRPC evolution,metastatic colonization,and resistance to antiandrogens.In this review,we discuss the role of ADT in prostate CSCs differentiation and acquisition of CRPC,their isolation,identification and characterization,as well as the factors and pathways contributing to CSCs expansion and therapeutic opportunities. | Prem Prakash Kushwaha Shiv Verma Shashank Kumar Sanjay Gupta | 2022 | Cancer Drug Resistance2022，5，2： | 0 |
| 13 | 为什么针对轻度急性胆源性胰腺炎所实施胆囊切除术越来越少?基于美国再入院数据库(2010-2014)对胆囊切除术的趋势评估及预测因素分析显示文摘背景:当前指南推荐对因轻度急性胆源性胰腺炎(MABP)入院患者行胆囊切除术,其治疗效果更佳。本研究旨在评估在美国因MABP入院的患者施行胆囊切除术的全国趋势,并分析施行胆囊切除术及30天再入院的影响因素。方法:通过美国国家再入院数据库的诊断代码,收集2010-2014年间的MABP入院病例。比较不同临床特征病例的胆囊切除率。采用多因素模型分析施行胆囊切除术及30天再入院的影响因素。结果:从数据库中筛选出255,695例MABP住院病例,其30天再入院率为12.6%。有43.8%的病例接受了胆囊切除术,25.0%行经内镜逆行性胆胰管造影(ERCP)加括约肌切开术。研究期间,两种术式都呈现了一个下降趋势(P<0.001)。多因素分析显示,行ERCP加括约肌切开术或胆囊切除术的病例,其30天再入院率均显著下降,OR值(95%CI)分别为0.78(0.74-0.84)和0.37(0.35-0.39)。结论:对于MABP患者,在首次入院时行胆囊切除术或ERCP加乳头切开术均可降低30天再入院风险。尽管获益显著,而且指南也推荐在MABP首次入院期间行胆囊切除术,但胆囊切除率在全国范围内却呈现了一个下降的趋势。有必要进一步探究临床实践与指南所存在的这种差异的深层原因。 | Sushil Kumar Garg Fateh Bazerbachi Shashank Sarvepalli Shounak Majumder Shanthi Swaroop Vege | 2019 | Gastroenterology Report2019，7，5： | 0 |
| 14 | Acute suppurative oesophagitis with fever and cough: A case report显示文摘BACKGROUND Suppurative oesophagitis is a diffuse inflammation of the oesophagus characterized by suppurative exudate or pus formation.Suppurative infections can affect any part of the gastrointestinal tract,most commonly the stomach,with inflammation involving the entire gastric cavity.However,cases extending beyond the cardia or pylorus and involving the oesophagus,small intestine,and colon are rare.Usually such cases are discovered during surgery or autopsy.CASE SUMMARY We report a rare case of acute suppurative oesophagitis.A 57-year-old man presented at the Emergency Department of our hospital with fever and productive cough.The patient had a significant history of lower oesophageal mucosal frostbite.He was successfully diagnosed and treated with repeated gastroscopy,appropriate antibiotics,and innovative symptomatic treatment.CONCLUSION Early diagnosis and appropriate treatment of acute suppurative oesophagitis are critical.Nutritional support,postural drainage,and other symptomatic treatments must be considered. | Chang-Jun Men Shashank Kumar Singh Guo-Liang Zhang Ye Wang Cong-Wei Liu | 2020 | World Journal of Clinical Cases2020，8，15： | 0 |
| 15 | Distally based peroneus brevis muscle flap: A single centre experience显示文摘Purpose: Defects aro und the distal one third of the leg and ankle are difficult to man age by con servative measures or simple split thickness skin graft. Distally based peroneus brevis muscle flap is a well described flap for such defects. Methods: This is a retrospective analysis conducted on 25 patients with soft tissue and bony defects of distal third of lower leg and an kle, which were treated using distally based per on eus brevis muscle flap from January 2013 to January 2018. Information regarding patient demographics, etiology, size and location of defects and complications were collected. All patients were followed up for at least 3 months after surgery. Results: There were 21 males and 4 females with the mean age of 39 (5-76) years. The most comm on cause of injuries was road traffic accident, followed by complicated open injury. The average size of defects was 20 (4—50) cm^2. The mean operating time was 75 (60-90) min for flap harvest and inset. We had no patient with complete loss of the flap. Five patients (20%) had marginal necrosis of the flap and two patie nts have graft loss due to un derlyi ng hematoma and required sec on dary split thickness skin grafting. Conclusion: The distally based peroneus brevis muscle flap is a safe optio n w 让h reliable an atomy for small to moderate sized defects following low velocity injury around the ankle. The commonest complication encountered is skin graft loss which can be reduced by primary delayed grafting. | Subhash Sahu Amish Jayantilal Gohil Shweta Patil Shashank Lamba Kingsly Paul Ashish Kumar Gupta | 2019 | Chinese Journal of Traumatology2019，22，2： | 0 |
| 16 | An Improved Methodology to Overcome Key Issues in Human Fecal Metagenomic DNA Extraction显示文摘Microbes are ubiquitously distributed in nature, and recent culture-independent studies have highlighted the significance of gut microbiota in human health and disease. Fecal DNA is the primary source for the majority of human gut microbiome studies. However, further improvement is needed to obtain fecal metagenomic DNA with sufficient amount and good quality but low host genomic DNA contamination. In the current study, we demonstrate a quick, robust, unbiased,and cost-effective method for the isolation of high molecular weight(>23 kb) metagenomic DNA(260/280 ratio >1.8) with a good yield(55.8 ± 3.8 ng/mg of feces). We also confirm that there is very low human genomic DNA contamination(eubacterial: human genomic DNA marker genes = 2^(27.9):1) in the human feces. The newly-developed method robustly performs for fresh as well as stored fecal samples as demonstrated by 16 S r RNA gene sequencing using 454 FLX+.Moreover, 16 S r RNA gene analysis indicated that compared to other DNA extraction methods tested, the fecal metagenomic DNA isolated with current methodology retains species richnessand does not show microbial diversity biases, which is further confirmed by q PCR with a known quantity of spike-in genomes. Overall, our data highlight a protocol with a balance between quality,amount, user-friendliness, and cost effectiveness for its suitability toward usage for cultureindependent analysis of the human gut microbiome, which provides a robust solution to overcome key issues associated with fecal metagenomic DNA isolation in human gut microbiome studies. | Jitendra Kumar Manoj Kumar Shashank Gupta Vasim Ahmed Manu Bhambi Rajesh Pandey Nat Singh Chauhan | 2016 | Genomics, Proteomics & Bioinformatics2016，14，6： | 0 |
| 17 | Implantable photoelectronic charging(I-PEC)for medical implants显示文摘Medical implants with functionalities such as sensing,health monitoring,stimulation,diagnosis,and physiological treatment are rapidly growing.With the increasing functional sophistication and addition of modules such as data transmission,on-chip processing,and data storage,energy demand of the implantable system is also growing.Using implantable energy harvester either to recharge or ultimately replace hazardous battery is essential to provide a long-term sustainable solution.Energy harvesting techniques using piezoelectric,thermoelectric,radio frequency power transmission,biofuel,and photoelectronic(or sometimes termed as“photovoltaic”in terms of solar light harvesting,i.e.,PV)conversion,have been attempted for the implantable,but these methods are currently limited by insufficient power output,large footprint,and low efficiency.Nevertheless,the planar PV with potential of lighter weight,higher energy density,and higher efficiency,provides promising power solution for in-body medical implants.In this short review,we will discuss the potential opportunities and challenges associated with PV's for medical implants,covering materials,to devices,and to system level requirements. | Kai Wang Sumanta Kumar Karan Mohan Sanghadasa Congcong Wu Shashank Priya | 2022 | Energy Reviews2022，1，2： | 0 |
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