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| 1 | Bilirubin in coronary artery disease:Cytotoxic or protective?显示文摘Bilirubin has traditionally been considered a cytotoxic waste product.However,recent studies have shown bilirubin to have anti-oxidant,anti-inflammatory,vasodilatory,anti-apoptotic and anti-proliferative functions.These properties potentially confer bilirubin a new role of protection especially in coronary artery disease(CAD),which is a low grade inflammatory process exacerbated by oxidative stress.In fact,recent literature reports an inverse relationship between serum concentration of bilirubin and the presence of CAD.In this article,we review the current literature exploring the association between levels of bilirubin and risk of CAD.We conclude that current evidence is inconclusive regarding the protective effect of bilirubin on CAD.A causal relationship between low serum bilirubin level and increased risk of CAD is not currently established. | Nancy Gupta Tavankit Singh Rahul Chaudhary Sushil K Garg Gurprataap Singh Sandhu Varun Mittal Rahul Gupta Roxana Bodin Sachin Sule | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 14 |
| 2 | Blumgart's technique of pancreaticojejunostomy: Analysis of safety and outcomes显示文摘Background: Blumgart's pancreaticojejunostomy(PJ) has been described with low pancreatic leak rates. This study aimed to evaluate our experience with this technique regarding the pancreatic leak and other perioperative outcomes. Methods: We performed a single-center retrospective analysis of a cohort of 81 patients who underwent pancreaticoduodenectomy in our department from January 2011 to February 2018. The primary endpoint was the occurrence of a clinically relevant postoperative pancreatic fistula(CR-POPF) and analysis of its risk factors. Results: The CR-POPF rate was 12.3%. Fistula risk score(FRS) was the only significant risk factor for the occurrence of overall POPF in multivariate analysis. However, none of the other factors including FRS was found to be significantly associated with CR-POPF risk. A strong positive correlation was found between the CR-POPF and the incidence of delayed gastric emptying, post-pancreatectomy hemorrhage and increased length of hospital stay. Conclusion: Blumgart's technique is a safe technique of pancreatico-enteric anastomosis with low rates of CR-POPF. CR-POPF with this technique is independent of most of the preoperative and intraoperative factors. Therefore, this technique can be used for all types of the pancreas with consistently good results. | Vishal Gupta Saket Kumar Vivek Gupta Pradeep Joshi Rahul Rahul Rakesh Kumar Yadav Amit Dangi Abhijit Chandra | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 8 |
| 3 | 合成B_(4)C和天然钛铁矿陶瓷颗粒增强LM13铝硅合金基复合材料的磨损性能对比显示文摘研究以LM13铝硅合金为基体、陶瓷颗粒为增强相,采用搅拌铸造法制备的复合材料(AMCs)的干滑动磨损行为。分别采用两种不同的陶瓷颗粒增强相:合成的B_(4)C和天然的钛铁矿陶瓷颗粒。光学显微镜结果显示,增强颗粒均匀分散在基体材料中,增强颗粒使共晶硅的晶粒尺寸细化,形貌变为球形。B_(4)C增强复合材料(BRCs)的硬度提高最大,而钛铁矿增强复合材料(IRCs)由于界面化合物的形成导致基体−增强相界面结合较强,摩擦因数降低最大。与基体合金相比,复合材料的干滑动磨损性能显著提高。B_(4)C颗粒的低密度和高硬度导致BRCs中颗粒周围高的位错密度。另一方面,钛铁矿颗粒的低热导率导致IRCs表面发生早期氧化并形成摩擦层。可见,尽管两种类型的增强相的作用机制存在很大不同,他们都能改善AMCs的耐磨性能。因此,低成本钛铁矿颗粒可替代高成本B_(4)C颗粒,制备耐磨复合材料。 | Rahul GUPTA Tarun NANDA O.P.PANDEY | 2021 | Transactions of Nonferrous Metals Society of China2021，31，12： | 5 |
| 4 | Role of Joshi's external stabilization system with percutaneous screw fixation in high-energy tibial condylar fractures associated with severe soft tissue injuries显示文摘Purpose: The treatment of high-energy tibial condylar fractures which are associated with severe soft tissue injuries remains contentious and challenging. In this study, we assessed the results of Joshi's external stabilization system (JESS) by using the principle of ligamentotaxis and percutaneous screw fixation for managing high-energy tibial condylar fractures associated with severe soft tissue injuries. Methods: Between June 2008 and June 2010, 25 consecutive patients who were 17-71 years (mean, 39.7), underwent the JESS fixation for high-energy tibial condylar fractures associated with severe soft tissue injuries. Out of 25 patients, 2 were lost during follow-up and in 1 case early removal of frame was done, leaving 22 cases for final follow-up. Among them, 11 had poor skin condition with abrasions and blisters and 2 were open injuries (Gustilo-Anderson grade I & 11). The injury mechanisms were motor vehicle accidents (n - 19), fall from a height (n = 2) and assault (n - 1). The fractures were classified according to Schatzker classification system. Results: There were 7 type-V, 14 type-Vl and 1 type-IV Schatzker's tibial plateau fractures. The average interval between the injury and surgery was 6.8 days (range 2-13). The average hospital stay was 13 days (range, 7-22). The average interval between the surgery and full weight bearing was 13.6 weeks (range 11-20). The average range of knee flexion was 121° (range 105°-135°). The normal extension of the knee was observed in 20 patients, and an extensor lag of 5°-8° was noted in 2 patients. The complications included superficial pin tract infections (n 4) with no knee stiffness. Conclusion: JESS with lag screw fixation combines the benefit of traction, external fixation, and limited internal fixation, at the same time as allowing the ease of access to the soft tissue for wound checks, pin care, dressing changes, measurement of compartment pressure, and the monitoring of the neurovascular status. In a nutshell, JESS along with screw fixation offers a promising alternative treatment for high- energy tibial condylar fractures associated with severe soft tissue injuries. | Ashish Kumar Gupta Rahul Sapra Rakesh Kumar Som Prakash Gupta Devwart Kaushik Sahil Gaba Mahesh Chand Bansal Ratan Lal Dayma | 2015 | Chinese Journal of Traumatology2015，18，6： | 4 |
| 5 | Adansonia digitata L.(baobab):a review of traditional information and taxonomic description显示文摘Adansonia digitata L.(Malvaceae) is commonly known as baobab tree native to Africa.Baobab is a multi-purpose tree which offers protection and provides food,clothing and medicine as well as raw material for many useful items.The fruit pulp,seeds,leaves,flowers.roots,and bark of baobab are edible and they have been studied by scientists for their useful properties.The fruit pulp have very high vitamin C.calcium,phosphorus,carbohydrates,fibers,potassium,proteins and lipids content,which can be used in seasoning as an appetizer and also make juices.Seeds contain appreciable quantities of phosphorus,magnesium,zinc,sodium,iron,manganese,whereas they have high levels of lysine,thiamine,calcium and iron.Baobab has numerous biological properties including antimicrobial,anti-malarial,diarrhoea,anaemia,asthma,antiviral,anti-oxidant and anti-inflammatory activities amongst others.Phytochemical investigation revealed the presence of flavonoids.phytosterols.amino acids,fatty acids,vitamins and minerals.The review summarizes the information on various aspects of traditional information,taxonomic description,medicinal properties and importantly nutritional value. | Jitin Rahul Manish Kumar Jain Shishu Pal Singh Rakesh Kant Kama Anuradha Aliya Naz Anup Kumar Gupta Sujeet Kumar Mrityunjay | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，1： | 4 |
| 6 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 7 | Erythropoietin therapy after out-of-hospital cardiac arrest:A systematic review and meta-analysis显示文摘AIM To assess safety and efficacy of early erythropoietin(Epo) administration in patients with out-of-hospital cardiac arrest(OHCA).METHODS A systematic literature search was performed using PubM ed,MEDLINE,EMBASE,EBSCO,CINAHL,Web of Science and Cochrane databases,of all studies published from the inception through October 10,2016.Inclusion criteria included:(1) Adult humans with OHCA and successful sustained return of spontaneous circulation;and(2) studies including mortality/brain death,acute thrombotic events as their end points.Primary efficacyoutcome was 'brain death or Cerebral Performance Category(CPC) score of 5'.Secondary outcomes were 'CPC score 1,and 2-4','overall thrombotic events' and 'acute coronary stent thrombosis'.RESULTS We analyzed a total of 606 participants(n = 276 received Epo and n = 330 with standard of care alone) who experienced OHCA enrolled in 3 clinical trials.No significant difference was observed between the Epo and no Epo group in brain death or CPC score 5(OR = 0.77;95%CI:0.42-1.39),CPC score 1(OR = 1.16,95%CI:0.82-1.64),and CPC score 2-4(OR = 0.77,95%CI:0.44-1.36).Epo group was associated with increased thrombotic complications(OR = 2.41,95%CI:1.26-4.62) and acute coronary stent thrombosis(OR = 8.16,95%CI:1.39-47.99).No publication bias was observed.CONCLUSION Our study demonstrates no improvement in neurological outcomes and increased incidence of thrombotic events and acute coronary stent thrombosis in OHCA patients who were treated with Epo in addition to standard therapy. | Rahul Chaudhary Jalaj Garg Parasuram Krishnamoorthy Kevin Bliden Neeraj Shah Nayan Agarwal Rahul Gupta Abhishek Sharma Karl B Kern Nainesh C Patel Paul Gurbel | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 8 | Laparoscopic inguinal hernia repair in the pediatric age group-experience with 437 children显示文摘 | Sandesh V Parelkar Sanjay Oak Rahul Gupta | 2010 | Journal of Pediatric Surgery2010，45，： | 1 |
| 9 | A report of two 'traumatic encephaloceles; an unrecognized entity显示文摘 | Mohindra Sandeep Chhabra Ralesh Gupta Rahul | 2007 | Brain Injury2007，21，10： | 1 |
| 10 | True hemicranial decompression for severe pediatric cranial trauma:a short series of 4 cases and literature review显示文摘 | Monhindra Sandeep Gupta Sunil Kumar Gupta Rahul | 2006 | Surgical Neurology2006，66，3： | 1 |
| 11 | Transperitoneal versus retroperitoneal laparoscopic ureterolithotomy: a prospective randomized compar- ison study 显示文摘 | VISHWAJEET SINGH RAHUL JANAK SINHA DHEERAJ KUMAR GUPTA | 2013 | J Urol2013，189，3： | 1 |
| 12 | Abiotic Oxidation Studies of Oxo-biodegradable Polyethylene显示文摘 | M. M. Reddy Rahul K. Gupta Rakesh K. Gupta S. N. Bhattacharya R. Parthasarathy | 2008 | Journal of Polymers and the Environment2008，，1： | 1 |
| 13 | Influence of fiber orientation and thickness on the response of glass/epoxy com- posites subjected to impact loading显示文摘 | Rahul S S Velmurugan R Gupta N K | 2014 | Composites:Part B2014，60，4： | 1 |
| 14 | Unusual presentations of craniovertebral junction tuberculosis: a report of 2 cases and literature review显示文摘 | Sandeep Mohindra Sunil Kumar Gupta Satyawati Mohindra Rahul Gupta | 2006 | Surgical Neurology2006，，1： | 1 |
| 15 | Tuberculosis of the Craniovertebral Junction: Is Surgery Necessary?显示文摘 | Sunil K. Gupta Sandeep Mohindra Bhawani S. Sharma Rahul Gupta Rajesh Chhabra Kanchan K. Mukherjee Manoj K. Tewari Ashis Pathak Niranjan Khandelwal Narain M. Suresh Virender K. Khosla | 2006 | Neurosurgery2006，，6： | 1 |
| 16 | An Investigation of Melt Rheology and Thermal Stabi- lity of Poly(lactic acid)/Poly(butylene succinate) Nano- composites显示文摘 | Amita Bhatia Rahul K Gupta Sati N Bhattaeharya el al | 2009 | Journal of Applied Polymer Science2009，114，28： | 1 |
| 17 | Endoscopic Ultrasound Versus CT Scan for Detection of the Metastases to the Liver: Results of a Prospective Comparative Study显示文摘 | Pankaj Singh Phalguni Mukhopadhyay Bankim Bhatt Tushar Patel Alex Kiss Rahul Gupta Sanjay Bhat Richard A. Erickson | 2009 | Journal of Clinical Gastroenterology2009，，4： | 1 |
| 18 | Review of intelligent building construction: A passive solar archi- tecture approach 显示文摘 | Rahul V Ralegaonkar Rajiv Gupta | 2010 | Renewable and Sustainable Energy Reviews2010，14，： | 1 |
| 19 | Enhancement of Energy Absorption in Syntactic Foams by Nanoclay Incorporation for Sandwich Core Applications显示文摘 | Nikhil Gupta Rahul Maharsia | 2005 | Applied Composite Materials (-)2005，，3： | 1 |
| 20 | Review of intelligent building con-struction:A passive solar architecture approach 显示文摘 | Rahul Rajiv Gupta | 2010 | Re-newable and Sustainable Energy2010，14，8： | 1 |
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