| 1 | Global histone post-translational modifications and cancer:Biomarkers for diagnosis,prognosis and treatment?显示文摘Global alterations in epigenetic landscape are now recognized as a hallmark of cancer. Epigenetic mechanismssuch as DNA methylation,histone modifications,nucleosome positioning and non-coding RNAs are proven to have strong association with cancer. In particular,covalent post-translational modifications of histone proteins are known to play an important role in chromatin remodeling and thereby in regulation of gene expression. Further,histone modifications have also been associated with different aspects of carcinogenesis and have been studied for their role in the better management of cancer patients. In this review,we will explore and discuss how histone modifications are involved in cancer diagnosis,prognosis and treatment. | Shafqat Ali Khan Divya Reddy Sanjay Gupta | 2015 | World Journal of Biological Chemistry2015，6，4： | 4 |
| 6 | Selective separation, detection of zotepine and mass spectral characterization of degradants by LC–MS/MS/QTOF显示文摘A simple, precise, accurate stability-indicating gradient reversed-phase high-performance liquid chromatographic(RP–HPLC) method was developed for the quantitative determination of zotepine(ZTP) in bulk and pharmaceutical dosage forms in the presence of its degradation products(DPs). The method was developed using Phenomenex C18column(250 mm 4.6 mm i.d., 5 mm) with a mobile phase containing a gradient mixture of solvents, A(0.05% trifluoroacetic acid(TFA), pH?3.0) and B(acetonitrile). The eluted compounds were monitored at 254 nm; the run time was within 20.0 min, in which ZTP and its DPs were well separated, with a resolution of 41.5. The stress testing of ZTP was carried out under acidic, alkaline, neutral hydrolysis, oxidative, photolytic and thermal stress conditions. ZTP was found to degrade significantly in acidic, photolytic, thermal and oxidative stress conditions and remain stable in basic and neutral conditions.The developed method was validated with respect to specificity, linearity, limit of detection, limit of quantification, accuracy, precision and robustness as per ICH guidelines. This method was also suitable for the assay determination of ZTP in pharmaceutical dosage forms. The DPs were characterized by LC–MS/MS and their fragmentation pathways were proposed. | M.V.N. Kumar Talluri Naveen Reddy Kandimalla Raju Bandu Divya Chundi Ramesh Marupaka Ragampeta Srinivas | 2014 | Journal of Pharmaceutical Analysis2014，4，2： | 0 |
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