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| 1 | Chronic Liver Failure-Sequential Organ Failure Assessment is better than the Asia-Pacific Association for the Study of Liver criteria for defining acute-on-chronic liver failure and predicting outcome显示文摘AIM:To compare the utility of the Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA)and Asia-Pacific Association for the Study of Liver(APASL)definitions of acute-on-chronic liver failure(ACLF)in predicting short-term prognosis of patients with ACLF.METHODS:Consecutive patients of cirrhosis with acute decompensation were prospectively included.They were grouped into ACLF and no ACLF groups as per CLIF-SOFA and APASL criteria.Patients were followed up for 3 mo from inclusion or mortality whichever was earlier.Mortality at 28-d and 90-d was compared between no ACLF and ACLF groups as per both criteria.Mortality was also compared between different grades of ACLF as per CLIF-SOFA criteria.Prognostic scores like CLIF-SOFA,Acute Physiology and ChronicHealth Evaluation(APACHE)-Ⅱ,Child-Pugh and Model for End-Stage Liver Disease(MELD)scores were evaluated for their ability to predict 28-d mortality using area under receiver operating curves(AUROC).RESULTS:Of 50 patients,38 had ACLF as per CLIFSOFA and 19 as per APASL criteria.Males(86%)were predominant,alcoholic liver disease(68%)was the most common etiology of cirrhosis,sepsis(66%)was the most common cause of acute decompensation while infection(66%)was the most common precipitant of acute decompensation.The 28-d mortality in no ACLF and ACLF groups was 8.3%and 47.4%(P=0.018)as per CLIF-SOFA and 39%and 37%(P=0.895)as per APASL criteria.The 28-d mortality in patients with no ACLF(n=12),ACLF grade 1(n=11),ACLF grade 2(n=14)and ACLF grade 3(n=13)as per CLIF-SOFA criteria was 8.3%,18.2%,42.9%and76.9%(χ2 for trend,P=0.002)and 90-d mortality was 16.7%,27.3%,78.6%and 100%(χ2 for trend,P<0.0001)respectively.Patients with prior decompensation had similar 28-d and 90-d mortality(39.3%and 53.6%)as patients without prior decompensation(36.4%and 63.6%)(P=NS).AUROCs for 28-d mortality were 0.795,0.787,0.739 and 0.710 for CLIF-SOFA,APACHE-Ⅱ,Child-Pugh and MELD scores respectively.On multivariate analysis of these scores,CLIF-SOFA was the only significant independent predictor of mortality with an odds ratio 1.538(95%CI:1.078-2.194).CONCLUSION:CLIF-SOFA criteria is better than APASL criteria to classify patients into ACLF based on their prognosis.CLIF-SOFA score is the best predictor of short-term mortality. | Radha K Dhiman Swastik Agrawal Tarana Gupta Ajay Duseja Yogesh Chawla | 2014 | World Journal of Gastroenterology2014，20，40： | 26 |
| 2 | Insight of magnesium alloys and composites for orthopedic implant applications-a review显示文摘Magnesium(Mg)and its alloys have been widely researched for orthopedic applications recently.Mg alloys have stupendous advantages over the commercially available stainless steel,Co-Cr-Ni alloy and titanium implants.Till date,extensive mechanical,in-vitro and in-vivo studies have been done to improve the biomedical performance of Mg alloys through alloying,processing conditions,surface modification etc.This review comprehensively describes the strategies for improving the mechanical and degradation performance of Mg alloys through properly tailoring the composition of alloying elements,reinforcements and processing techniques.It also highlights the status and progress of research in to(i)the selection of nutrient elements for alloying,reinforcement and its effects(ii)type of Mg alloy system(binary,ternary and quaternary)and composites(iii)grain refinement for strengthening through severe plastic deformation techniques.Furthermore it also emphasizes on the importance of Mg composites with regard to hard tissue applications. | R Radha D Sreekanth | 2017 | Journal of Magnesium and Alloys2017，5，3： | 21 |
| 3 | 赤霉素对甘蔗发芽和早期蔗茎生长的潜在调节作用(英文)显示文摘以甘蔗品种CoSe92423单芽为材料,在盘栽条件下研究赤霉素(GA3)对甘蔗生长特点和生化特性的影响。将甘蔗单芽分别浸入10,20,50和100mg·L-1赤霉素溶液中24h,以清水为对照,将处理的芽段种植于网室泥盘中。结果表明,低水平GA3处理(10,20,和50mg·L-1)均可刺激蔗芽生长和甘蔗植株的生长,根数、根和叶片鲜重、蔗茎鲜重、叶面积以及茎长均有所增加。与对照相比(70%),赤霉素可使蔗芽萌发早,发芽率高,其中以50mg·L-1GA3处理的发芽率最高,为90%。经赤霉素处理的甘蔗株高和茎重分别增加90%~110%、252%~282%,其中以20mg·L-1GA3处理最高。此外,赤霉素处理的蔗芽中还原糖和IAA含量也有所增加,且均以20mg·L-1GA3处理最高。因此,低水平赤霉素均对蔗芽萌发和生长具有刺激作用,但高水平赤霉素则对甘蔗生长有抑制作用。 | Radha Jain S. N. Singh S. Solomon A. Chandra | 2010 | 广西农业科学2010，41，9： | 10 |
| 4 | Ischemic colitis masquerading as colonic tumor:Case report with review of literature显示文摘Ischemic colitis can mimic a carcinoma on computed tomographic (CT) imaging or endoscopic examination. A coexisting colonic carcinoma or another potentially obstructing lesion has also been described in 20% of the cases of ischemic colitis. CT scan can differentiate it from colon cancer in 75% of cases. However, colonoscopy is the preferred method for diagnosing ischemic colitis as it allows for direct visualization with tissue sampling. Varied presentations of ischemic colitis have been described as an ulcerated or submucosal mass or as a narrowed segment of colon with ulcerated mucosa on colonoscopy. Awareness and early recognition of such varied presentations of a common condition is necessary to differentiate from a colonic carcinoma, and to avoid unnecessary surgery and related complications. | Parakkal Deepak Radha Devi | 2011 | World Journal of Gastroenterology2011，17，48： | 8 |
| 5 | Genetic polymorphism in CD14 gene, a co-receptor of TLR4 associated with non-alcoholic fatty liver disease显示文摘AIM To evaluate the pathogenic role of toll-like receptor(TLR) gene polymorphisms in patients with nonalcoholic fatty liver disease(NAFLD).METHODS Two hundred and fifty subjects(NAFLD = 200, healthy volunteers = 50) underwent polymerase chain reaction and restriction fragment length polymorphism to assess one polymorphism in the toll-like receptor 2(TLR2) gene(A753G), two polymorphisms in the TLR4 gene(TLR4 Asp299 Gly and Thr399 Ile allele), and two polymorphisms in the cluster of differentiation 14(CD14)(C-159 T and C-550T) gene, a co-receptor of TLR4. Association of TLR gene polymorphisms with NAFLD and its severity was evaluated by genetic models of association.RESULTS On both multiplicative and recessive models of gene polymorphism association, there was significant association of CD14 C(-159) T polymorphism with NAFLD; patients with TT genotype had a 2.6 fold increased risk of developing NAFLD in comparison to CC genotype. There was no association of TLR2 Arg753 Gln, TLR4 Asp299 Gly, Thr399 Ile, and CD14 C(-550) T polymorphisms with NAFLD. None of the TLR gene polymorphisms had an association with histological severity of NAFLD.CONCLUSION Patients with CD14 C(-159) T gene polymorphism, a co-receptor of TLR4, have an increased risk of NAFLD development. | Shweta Kapil Ajay Duseja Bal Krishan Sharma Bhupesh Singla Anuradha Chakraborti Ashim Das Pallab Ray Radha K Dhiman Yogesh Chawla | 2016 | World Journal of Gastroenterology2016，22，42： | 7 |
| 6 | Mechanical and corrosion behaviour of hydroxyapatite reinforced Mg-Sn alloy composite by squeeze casting for biomedical applications显示文摘Magnesium alloys have gained increasing attention for biomedical applications due to their biocompatibility and the biodegradability.Hydroxyapatite(HA)is known to be a highly bioactive because of its similar chemical and crystallographic structures to bone.Therefore,HA is believed to be a potential ceramic material for the fabrication of Mg based composites,to combine the advantages of both Mg and HA.But,in general,the composites known to be more susceptible to corrosion attack than the matrix alloy.Hence,in the present work,Sn is used as an alloying element to evaluate its effect on mechanical as well as corrosion properties of Mg/HA composites.Mg with 5 wt%HA and Mg-1 wt%Sn-5 wt%HA composites were prepared separately by stir assisted squeeze casting route.The phase analysis and microstructure were characterized by X-ray diffraction(XRD)and scanning electron microscope(SEM)coupled with energy dispersive spectroscopy(EDS)respectively.Mechanical properties were evaluated by conducting the compression and micro hardness tests.Corrosion properties of as-cast composites were studied by linear polarization,Tafel and electrochemical impedance spectroscopy(EIS)techniques.The results of both XRD and SEM-EDS revealed that the main constitutional phases of as-cast Mg/HA composites were a-Mg and HA whereas,in Mg-Sn/HA composites,the phase Mg^Sn was observed along with fine distribution of HA particles.In both the cases,no interfacial reactions observed.The yield strength,ultimate compression strength and hardness were found to be increased with the addition of Sn in Mg/HA composites.Furthermore,the addition of Sn also played an important role in increasing the corrosion resistance of the Mg/HA composites which was attributed the refinement of grain size and the formation of Mg2Sn phase along the grain boundaries.Hence,it was concluded that the addition of Sn improves both mechanical and corrosion properties of Mg/HA composites. | R Radha D.Sreekanth | 2020 | Journal of Magnesium and Alloys2020，8，2： | 6 |
| 7 | Novel coumarin–benzimidazole derivatives as antioxidants and safer anti-inflammatory agents显示文摘Inspired from occurrence of anti-inflammatory activity of 3-substituted coumarins and antiulcer activity of various 2-substituted benzimidazoles,novel compounds have been designed by coupling coumarin derivatives at 3-position directly or through amide linkage with benzimidazole nucleus at 2-position.The resultant compounds are expected to exhibit both anti-inflammatory and antioxidant activities along with less gastric toxicity profile.Two series of coumarin–benzimidazole derivatives(4a–e and 5a–e)were synthesized and evaluated for anti-inflammatory activity and antioxidant activity.Compounds 4c,4d and 5a displayed good anti-inflammatory(45.45%,46.75%and 42.85%inhibition,respectively,versus 54.54% inhibition by indomethacin)and antioxidant(IC_(50) of 19.7,13.9 and 1.2 mmol/L,respectively,versus 23.4 mmol/L for butylatedhydroxytoluene)activities.Evaluation of ulcer index and in vivo biochemical estimations for oxidative stress revealed that compounds 4d and 5a remain safe on gastric mucosa and did not induce oxidative stress in tissues.Calculation of various molecular properties suggests the compounds to be sufficiently bioavailable. | Radha Krishan Arora Navneet Kaur Yogita Bansal Gulshan Bansal | 2014 | Acta Pharmaceutica Sinica B2014，4，5： | 6 |
| 8 | Metathesis synthesis, characterization, spectral and photoactivity studies of Ln_(2/3)MoO_4(Ln=La, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Er and Y)显示文摘Rare earth ortho-oxomolybdates of composition Ln2/3MoO 4(Ln=La, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Er and Y) were prepared by metathesis reaction. All these materials were characterized by powder X-ray diffraction, Fourier transform-infrared spectroscopy(FT-IR) and UV-Vis diffuse reflectance spectra. The Rietveld analysis of all the samples was carried out to obtain the unit cell parameters and reliability factors. All the materials were crystallized in tetragonal lattice with I41/a space group. The infrared spectra of all the samples were characterized by bands due to MoO 2–4 units. The bandgap energies of all the samples were obtained from UV-Vis DRS spectra. The luminescence spectra of Ln2/3MoO 4(Ln=Pr, Eu and Dy) showed characteristic transitions of the rare earth ions. The visible light photocatalytic activity of all the samples was studied against degradation of methylene blue. | Radha Velchuri Suresh Palla G.Ravi Naveen Kumar Veldurthi J.R.Reddy M.Vithal | 2015 | Journal of Rare Earths2015，33，8： | 5 |
| 9 | 微博信息采集及群体行为分析显示文摘随着在线社会关系网络的迅猛发展,每天数以千万计的人通过发表、评论、分享等方式,产生和传播各类话题.对在线社会关系数据的感知与收集、存储管理、群体行为等进行研究,能更好地挖掘和分析社会关系网络.由于微博平台的登录、数据显示与处理等方面与传统网络平台有很大差异,传统网络爬虫不适于对微博信息的全面抓取.本文采用模拟用户浏览行为方法来爬取海量微博数据,通过数据包截取与分析等手段获取相关信息.实验结果表明该方法的有效性.在此基础上,以收集的微博数据为研究对象,对群体行为进行了分析. | 高凯 王九硕 马红霞 周二亮 Radha Ganesan | 2013 | 小型微型计算机系统2013，34，10： | 5 |
| 10 | A new technique of combined endoscopic sclerotherapy and ligation for variceal bleeding显示文摘AIM: To develop a technique of combined endoscopic sclerotherapy and ligation (ESL) in which both techniques of endoscopic sclerotherapy (ES) and endoscopic variceal ligation (EVL) can be optimally used.METHODS: ESL was performed in 10 patients (age 46.4±7.9;9 males, 1 female) with cirrhosis of liver using sclerotherapy needle and Speedband, Superview multiple band ligater (Boston Scientific, Microvasive, Watertown, MA). A single band was placed 5-10 cm proximal to the gastro-esophageal junction over each varix from proximal to distal margin,followed by intravariceal injection of 1.5 % ethoxysclerol (4 ml each) 2 to 3 cm proximal to the gastroesophageal junction on the ligated varices distal to deployed band. EVL was then performed at the injection site. Similarly other varices were also injected and ligated from distal to proximally. In the subsequent sessions, ES alone was performed to sclerose small varices at the gastroesophageal junction.RESULTS: ESL was successfully performed in all patients.A median of 3 (ESL 1, ES 2) sessions (ranged 1-4) were required to eradicate the varices in 9 (90 %) of 10 patients.Recurrence of varices without bleed was seen in 1 patient during a mean follow-up of 10.3 months (ranged 6-15).Two patients died of liver failure. None died of variceal bleeding. None of the patients had procedure related complications.CONCLUSION: ESL may be useful in the fast eradication of esophageal varices. However, randomised controlled trials are required to find out its relative efficacy and impact on variceal recurrence in comparison to ES or EVL. | Radha K.Dhiman Yogesh K.Chawla | 2003 | World Journal of Gastroenterology2003，9，5： | 4 |
| 11 | 中国奢侈品消费群体的新动向显示文摘10年来,中国奢侈品消费市场迅速发展,形成了5类奢侈品消费群体:“财富新贵”、“时尚新宠”,“尚酷新族”,并对这3类群体的形成、特征和动向等作了具体分析,提出了奢侈品经营商和购物中心如何适应、引导的意见。 | Radha Chadha | 2006 | 国际商业技术2006，，1： | 3 |
| 12 | Gut microbiota and hepatic encephalopathy显示文摘 | Radha K. Dhiman | 2013 | Metabolic Brain Disease2013，，2： | 3 |
| 13 | Regeneration of tree species in the sub-tropical forest of Alaknanda Valley, Garhwal Himalaya, India显示文摘We studied the regeneration of tree species in the sub-tropical forest of Alaknanda Valley in Garhwal Himalaya, India. The overall regeneration status was fairly good in the study area. Seedling density ranged between 520 and 1,240 seedlings per ha while the density of saplings varied between 400 and 800 saplings per ha. Out of eight sites studied, five sites, viz., A1 , A2 , B1 , B2and C2contained the highest number of seedlings (280-480 per ha) and saplings (200-440 per ha) for Pinus roxburghii and remaining three sites viz., C1, D1and D2represented the highest number of seedlings (240-400 per ha) and saplings (200-240 per ha) for Anogeissus latifolius. The DBH class distribution of the tree species revealed that the highest number of individuals was concentrated in the lower diameter classes while smallest numbers were found in the higher diameter classes. Species such as Acacia catechu, Anogeissus latifolius, Dalbergia sissoo, Engelhardtia spicata, Lannea coromandelica, Mallotus philippensis and Pinus roxburghii have the largest number of saplings and seedlings in the lower DBH classes, suggesting that they have good regeneration potential. Other species such as Aegle marmelos, Bauhinia variegata, Bombax ceiba, Cassia fistula, Erythrina variegata, Haldinia cordifolia, Mangifera indica, Ougeinia oojeinensis, Phyllanthus emblica, Syzygium cumini, Terminalia alata and Toona hexandra have either no or very small number of saplings in the lower DBH classes, which indicates that the status of these species implies poor regeneration. | Radha BALLABHA J. K. TIWARI P. TIWARI | 2013 | Forestry Studies in China2013，15，2： | 2 |
| 14 | Hemoglobin A1c in early postpartum screening of women with gestational diabetes显示文摘AIM:To assess the utility of hemoglobin A1c(HbA1c) in the early postpartum screening of women with gestational diabetes mellitus(GDM).METHODS:Over a 3 years period,HbA1c estimations were undertaken in addition to and simultaneously with the traditional oral glucose tolerance test(OGTT),in 203 women with GDM as a part of early postpartum screening for dysglycaemia,at 6 wk post-partum.World Health Organization criteria was used for diagnosing diabetes:fasting blood glucose(FBG) ≥ 7.0 mmol/Land/or 2-h postprandial blood glucose(PPBG) ≥ 11.1 mmol/L and/or HbA1c ≥ 48 mmol/mol;and impaired glycaemiastate:impaired fasting glucose 6.1-6.9 mmol/L and/or impaired glucose tolerance 7.8-11.0 mmol/L and/or HbA1c:42-47 mmol/mol.RESULTS:Mean FBG,2-h PPBG and HbA1c were 4.9 ± 0.7 mmol/L,5.6 ± 2.0 mmol/L and 38 ± 5 mmol/mol respectively.FBG,2-h PPBG and HbA1c detected 6(3%),7(3.5%) and 11(5.4%) cases of diabetes respectively,and 11(5.4%),25(12.3%) and 23(11.3%) cases of pre-diabetes state respectively.HbA1c values ≥ 48 mmol/mol(≥ 6.5%) showed a diagnostic sensitivity of 71.4% and specificity of 98.5% for diabetes in comparison to OGTT in receiver operating characteristics curve analysis.At HbA1c cut-off 44 mmol/mol,sensitivity and specificity were 100% and 92.3% respectively [area under the curve:0.98(95%CI:0.96-1.00)].Sensitivity and specificity for detecting high risk 'impaired glycaemia' state [HbA1c 42 mmol/mol(6.0%)] were 28% and 80%,respectively.CONCLUSION:HbA1c level ≥ 48 mmol/mol(≥ 6.5%) has reasonable sensitivity and high specificity in comparison to OGTT for early postpartum screening of diabetes in GDM.At 6 th week postpartum screening,if FBG is normal and HbA1c < 44 mmol/mol OGTT is not recommended. | Mahesh V Katreddy Joseph M Pappachan Sarah E Taylor Radha Indusekhar Ananth U Nayak Alan M Nevill | 2013 | World Journal of Diabetes2013，4，3： | 2 |
| 15 | The Role of Thrombolysis in the Clinical Management of Deep Vein Thrombosis显示文摘 | Radha Krishna Popuri Suresh Vedantham | 2011 | Arteriosclerosis, Thrombosis, and Vascular Biology2011，，3： | 2 |
| 16 | APACHE II score is superior to SOFA , CTP and MELD in predicting the short‐term mortality in patients with acute‐on‐chronic liver failure ( ACLF )显示文摘 | Ajay Duseja Narendra S Choudhary Sachin Gupta Radha Krishan Dhiman Yogesh Chawla | 2013 | Journal of Digestive Diseases2013，，9： | 2 |
| 17 | Indian patients with nonalcoholic fatty liver disease presenting with raised transaminases are different at presentation显示文摘 | Ajay Duseja Ashim Das Radha Krishan Dhiman Yogesh Kumar Chawla Reena Das Sanjay Bhadada Ravinder Sialy Kiran Kumar Thumburu Anil Bhansali Naveen Kalra | 2007 | World Journal of Gastroenterology2007，13，4： | 2 |
| 18 | Multiple biological activities of curcumin: A short review显示文摘 | Radha K. Maheshwari Anoop K. Singh Jaya Gaddipati Rikhab C. Srimal | 2005 | Life Sciences2005，，18： | 2 |
| 19 | Structural roles of calcium ions and side chains in welan:an X-ray study显示文摘 | Chandrasekaran R Radha A Lee E J | 1994 | Carbohydr Res1994，252，15： | 1 |
| 20 | Structural roles of calcium ions and side chains in welan:an X-ray study显示文摘 | Chandraseksran R Radha A Lee E J | | 0，，： | 1 |
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