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| 1 | Magnetic resonance imaging:A new tool for diagnosis of acute ischemic colitis?显示文摘AIM:To define the evolution of ischemic lesions with 7T magnetic resonance imaging(7T-MRI)in an animal model of acute colonic ischemia.METHODS:Adult Sprague-Dawley rats were divided into two groups.GroupⅠ underwent inferior mesenteric artery(IMA)ligation followed by macroscopic observations and histological analysis.In groupⅡ,7T-MRI was performed before and after IMA ligation and followed by histological analysis.RESULTS:Morphological alterations started to develop 1 h after IMA ligation,when pale areas became evident in the splenic flexure mesentery and progressively worsened up to 8 h thereafter,when the mesentery was less pale,and the splenic flexure loop appeared very dark.The 7T-MRI results reflected these alterations,showing a hyperintense signal in both the intraperitoneal space and the colonic loop wall 1 h after IMA ligation;the latter progressively increased to demonstrate a reduction in the colonic loop lumen at 6 h.Eight hours after IMA ligation,MRI showed a persistent colonic mural hyperintensity associated with a reduction in peritoneal free fluid.The 7T-MRI findings were correlated with histological alterations,varying from an attenuated epithelium with glandular apex lesions at 1 h to coagulative necrosis and loss of the surface epithelium detected 8 h after IMA ligation.CONCLUSION:MRI may be used as a substitute for invasive procedures in diagnosing and grading acute ischemic colitis,allowing for the early identification of pathological findings. | Francesca Iacobellis Daniela Berritto Francesco Somma Carlo Cavaliere Marco Corona Santolo Cozzolino Franco Fulciniti Salvatore Cappabianca Antonio Rotondo Roberto Grassi | 2012 | World Journal of Gastroenterology2012，18，13： | 7 |
| 2 | Acute arterial mesenteric ischemia and reperfusion:Macroscopic and MRI findings, preliminary report显示文摘AIM:To explore the physiopathology and magnetic resonance imaging(MRI)findings in an animal model of acute arterial mesenteric ischemia(AAMI)with and without reperfusion.METHODS:In this study,8 adult Sprague-Dawley rats underwent superior mesenteric artery(SMA)ligation and were then randomly divided in two groups of 4.In groupⅠ,the ischemia was maintained for 8 h.In groupⅡ,1-h after SMA occlusion,the ligation was removed by cutting the thread fixed on the back of the animal,and reperfusion was monitored for 8 h.MRI was performed using a 7-T system.RESULTS:We found that,in the case of AAMI without reperfusion,spastic reflex ileus,hypotonic reflex ileus,free abdominal fluid and bowel wall thinning are present from the second hour,and bowel wall hyperintensity in T2-W sequences are present from the fourth hour.The reperfusion model shows the presence of early bowel wall hyperintensity in T2-W sequences after 1 h and bowel wall thickening from the second hour.CONCLUSION:Our study has shown that MRI can assess pathological changes that occur in the small bowel and distinguish between the presence and absence of reperfusion after induced acute arterial ischemia. | Luca Saba Daniela Berritto Francesca Iacobellis Mariano Scaglione Sigismondo Castaldo Santolo Cozzolino Maria Antonietta Mazzei Veronica Di Mizio Roberto Grassi | 2013 | World Journal of Gastroenterology2013，19，40： | 5 |
| 3 | Investigation of compensatory postures with videofluoromanometry in dysphagia patients显示文摘AIM: To investigate the effectiveness of head compensatory postures to ensure safe oropharyngeal transit. METHODS: A total of 321 dysphagia patients were enrolled and assessed with videofluoromanometry (VFM). The dysphagia patients were classified as follows: safe transit; penetration without aspiration; aspiration before, during or after swallowing; multiple aspirations and no transit. The patients with aspiration or no transit were tested with VFM to determine whether compensatory postures could correct their swallowing disorder. RESULTS: VFM revealed penetration without aspiration in 71 patients (22.1%); aspiration before swallowing in 17 patients (5.3%); aspiration during swallowing in 32 patients (10%); aspiration after swallowing in 21 patients (6.5%); multiple aspirations in six patients (1.9%); no transit in five patients (1.6%); and safe transit in 169 patients (52.6%). Compensatory postures guaranteed a safe transit in 66/75 (88%) patients with aspiration or no transit. A chin-down posture achieved a safe swallow in 42/75 (56%) patients, a head-turned posture in 19/75 (25.3%) and a hyperextended head posture in 5/75 (6.7%). The compensatory postures were not effective in 9/75 (12%) cases. CONCLUSION: VFM allows the speech-language therapist to choose the most effective compensatory posture without a trial-and-error process and check the effectiveness of the posture. | Antonio Solazzo Luigi Monaco Lucia Del Vecchio Stefania Tamburrini Francesca Iacobellis Daniela Berritto Nunzia Luisa Pizza Alfonso Reginelli Natale Di Martino Roberto Grassi | 2012 | World Journal of Gastroenterology2012，18，23： | 3 |
| 4 | Resveratrol corrects aberrant splicing of RYR1 pre-mRNA and Ca2+ signal in myotonic dystrophy type 1 myotubes显示文摘Myotonic dystrophy type 1(DM1) is a spliceopathy related to the mis-splicing of several genes caused by sequestration of nuclear transcriptional RNA-binding factors from non-coding CUG repeats of DMPK pre-mRNAs. Dysregulation of ryanodine receptor 1(RYR1), sarcoplasmatic/endoplasmatic Ca^2+-ATPase(SERCA) and α1 S subunit of voltage-gated Ca^2+ channels(Cav1.1) is related to Ca^2+ homeostasis and excitation-contraction coupling impairment. Though no pharmacological treatment for DM1 exists, aberrant splicing correction represents one major therapeutic target for this disease. Resveratrol(RES, 3,5,4′-trihydroxy-trans-stilbene) is a promising pharmacological tools for DM1 treatment for its ability to directly bind the DNA and RNA influencing gene expression and alternative splicing. Herein, we analyzed the therapeutic effects of RES in DM1 myotubes in a pilot study including cultured myotubes from two DM1 patients and two healthy controls. Our results indicated that RES treatment corrected the aberrant splicing of RYR1, and this event appeared associated with restoring of depolarization-induced Ca^2+ release from RYR1 dependent on the electro-mechanical coupling between RYR1 and Cav1.1. Interestingly, immunoblotting studies showed that RES treatment was associated with a reduction in the levels of CUGBP Elav-like family member 1, while RYR1, Cav1.1 and SERCA1 protein levels were unchanged. Finally, RES treatment did not induce any major changes either in the amount of ribonuclear foci or sequestration of muscleblind-like splicing regulator 1. Overall, the results of this pilot study would support RES as an attractive compound for future clinical trials in DM1. Ethical approval was obtained from the Ethical Committee of IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy(rs9879/14) on May 20, 2014. | Massimo Santoro Roberto Piacentini Alessia Perna Eugenia Pisano Anna Severino Anna Modoni Claudio Grassi Gabriella Silvestri | 2020 | Neural Regeneration Research2020，15，9： | 3 |
| 5 | Multidetector row computed tomography findings from ischemia to infarction of the large bowel显示文摘 | Stefania Romano Luigia Romano Roberto Grassi | 2006 | European Journal of Radiology2006，，3： | 1 |
| 6 | Long-Term Risk of Sustained Hypertension in White-Coat or Masked Hypertension显示文摘 | Giuseppe Mancia Michele Bombelli Rita Facchetti Fabiana Madotto Fosca Quarti-Trevano Hernan Polo Friz Guido Grassi Roberto Sega | 2009 | Hypertension2009，，2： | 1 |
| 7 | Multi-attribute classification method for spare parts inventory management显示文摘 | Marcello Braglia Andrea Grassi Roberto Montanari | 2004 | Journal of Quality in Maintenance Engineering2004，10，1： | 1 |
| 8 | Features of vulnerable plaques and clinical outcome of UA/NSTEMI: Relationship with matrix metalloproteinase functional polymorphisms显示文摘 | Nicola Fiotti Michèle Emilia Moretti Rossana Bussani Nicola Altamura Francesca Zamolo Riccardo Gerloni Laura Ukovich Elisa Ober Furio Silvestri Gabriele Grassi Roberto Adovasio Carlo Giansante | 2011 | Atherosclerosis2011，，1： | 1 |
| 9 | Multi-attribute classification method for spare parts inventory management显示文摘 | Marcello Braglia Andrea Grassi and Roberto Montanari | 2004 | Journal of Quality in Maintenance Engineering2004，101，： | 1 |
| 10 | Requirement for a standardised definition of advanced gastric cancer显示文摘 | Angelo De Sol Stefano Trastulli Veronica Grassi Alessia Corsi Ivan Barillaro Andrea Boccolini Micol Di Patrizi Giorgio Di Rocco Alberto Santoro Roberto Cirocchi Carlo Boselli Adriano Redler Giuseppe Noya Seong-Ho Kong | 2014 | Oncology Letters2014，，1： | 1 |
| 11 | Blood Pressure Variability and Organ Damage in a General Population: Results from the PAMELA Study显示文摘 | Roberto Sega Giovanni Corrao Michele Bombelli Luca Beltrame Rita Facchetti Guido Grassi Marco Ferrario Giuseppe Mancia | | 2002 (2, P)0，，： | 1 |
| 12 | Multi - attribute classification method for spare parts inventory management 显示文摘 | Marcello Braglia Andrea Grassi Roberto Montanari | 2004 | Journal of Quality in Maintenance Engineering2004，10，1： | 1 |
| 13 | Vascular and interventional radiology radiofrequency ablation of benign thyroid nodules and recurrent thyroid cancers: literature review显示文摘 | Irene Chiara Bernardi Chiara Floridi Alessandra Muollo Roberta Giacchero Gian Lorenzo Dionigi Alfonso Reginelli Gianluca Gatta Vito Cantisani Roberto Grassi Luca Brunese Gianpaolo Carrafiello | 2014 | La radiologia medica2014，，： | 1 |
| 14 | Results of treatment of distal rectal carcinoma since the introduction of total mesorectal excision: a single unit experience, 1994–2003显示文摘 | Antonio Chiappa Roberto Biffi Andrew P. Zbar Fabrizio Luca Cristiano Crotti Emilio Bertani Francesca Biella Giulia Zampino Roberto Orecchia Nicola Fazio Marco Venturino Cristiano Crosta Gian Carlo Pruneri Carmine Grassi Bruno Andreoni | 2005 | International Journal of Colorectal Disease2005，，3： | 1 |
| 15 | Expression of olfactory‐type cyclic nucleotide‐gated channels in rat cortical astrocytes显示文摘 | Maria Vittoria Podda Lucia Leone Roberto Piacentini Sara Cocco Daniele Mezzogori Marcello D’Ascenzo Claudio Grassi | 2012 | Glia2012，，9： | 1 |
| 16 | Dual-source dual-energy CT: dose reduction after endovascular abdominal aortic aneurysm repair显示文摘 | Vitaliano Buffa Antonio Solazzo Valeria D’Auria Alessandra Prete Andrea Vallone Monica Luzietti Manuela Madau Roberto Grassi Vittorio Miele | 2014 | La radiologia medica2014，，： | 1 |
| 17 | Cardiac and vascular structural changes in normotensive subjects with parental hypertension显示文摘 | Cristina Giannattasio Bianca M. Cattaneo Arduino A. Mangoni Stefano Carugo Maria L. Stella Monica Failla Silvia Trazzi Roberto Sega Guido Grassi Giuseppe Mancia | 1995 | Journal of Hypertension1995，，2： | 1 |
| 18 | Prognostic Value of Ambulatory and Home Blood Pressures Compared With Office Blood Pressure in the General Population: Follow-Up Results From the Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) Study显示文摘 | Roberto Sega Rita Facchetti Michele Bombelli Giancarlo Cesana Giovanni Corrao Guido Grassi Giuseppe Mancia | 2005 | Circulation2005，，14： | 1 |
| 19 | Mult- attribute classification method for spare parts inventory management显示文摘 | Braglia Marcello Grassi Andrea Montanari Roberto | 2004 | Journal of Quality in Maintance Engineering2004，10，1： | 1 |
| 20 | Ultrasonography (US) in the assessment of pediatric non traumatic gastrointestinal emergencies显示文摘 | Paolo Fonio Francesco Coppolino Anna Russo Alfredo D’Andrea Antonella Giannattasio Alfonso Reginelli Roberto Grassi Eugenio Annibale Genovese | 2013 | Critical Ultrasound Journal2013，，： | 1 |
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