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| 1 | The biological stress of early weaned piglets显示文摘Pigs experience biological stress such as physiological, environmental, and social challenges when weaned from the sow. The process of weaning is one of the most stressful events in the pig's life that can contribute to intestinal and immune system dysfunctions that result in reduced pig health, growth, and feed intake, particularly during the first week after weaning. Technological improvements in housing, nutrition, health, and management have been used to minimize some of the adverse effects of weaning stress, but a greater understanding of the biological impact of stress is needed to improve strategies to overcome weaning stress. The focus of this review paper is to briefly describe how the biological stress associated with weaning impacts intestinal morphology, structure, physiology, and intestinal immune responses that can impact subsequent production efficiencies such as growth, intake, morbidity, and mortality. | Joy M Campbell Joe D Crenshaw Javier Polo | 2013 | Journal of Animal Science and Biotechnology2013，4，2： | 83 |
| 2 | 早期断奶仔猪的生物学应激显示文摘当仔猪断奶后离开其母猪时,会遭遇到生物学应激,如生理的、环境的和社会的挑战。断奶过程是猪一生中最具应激性的事件,会造成肠道和免疫系统的机能障碍,结果导致猪健康状况、生长性能和采食量的降低,特别是断奶后首周内。饲养系统、营养、健康和管理技术的改进已被用来将断奶应激的一些不利影响降至最小程度,但是更好地了解应激的生物学作用,为改进能够克服断奶应激的策略所需要的。本综述的重点,是简要地描述与断奶有关的生物学应激是如何通过影响肠道形态、结构、生理和肠道免疫反应,进而可能会影响生产效率,如生长、采食量、发病率和死亡率。 | 陈建康 Joy M Campbell Joe D Crenshaw Javier Polo | 2014 | 国外畜牧学(猪与禽)2014，0，S1： | 8 |
| 3 | Effects of Composted and Thermally Dried Sewage Sludges on Soil and Soil Humic Acid Properties显示文摘The effect of annual additions of composted sewage sludge (CS) and thermally dried sewage sludge (TS) at 80 t ha-1 on soil chemical properties was investigated for three years in a field experiment under semiarid conditions. Humic acids (HAs) isolated by conventional procedures from CS, TS, and unamended (SO) and sludge amended soils were analysed for elemental (C, H, N, S and O) and acidic functional groups (carboxylic and phenolic) and by ultraviolet-visible, Fourier transform infrared and fluorescence spectroscopies. With respect to CS, TS had similar pH and total P and K contents, larger dry matter, total organic C, total N and C/N ratio and smaller ash content and electrical conductivity. Amendment with both CS and TS induced a number of modifications in soil properties, including an increase of pH, electrical conductivity, total organic C, total N, and available P. The CS-HA had greater O, total acidity, carboxyl, and phenolic OH group contents and smaller C and H contents than TS-HA. The CS-HA and TS-HA had larger N and S contents, smaller C, O and acidic functional group contents, and lower aromatic polycondensation and humification degrees than SO-HA. Amended soil-HAs showed C, H, N and S contents larger than SO-HA, suggesting that sludge HAs were partially incorporated into soil HAs. These effects were more evident with increasing number of sludge applications. | J. M. FERNNDEZ N. SENESI C. PLAZA G. BRUNETTI A. POLO | 2009 | Pedosphere2009，19，3： | 6 |
| 4 | AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX-MDM2 complex显示文摘发信号的酷氨酸 kinase 的解除管制经常与瘤前进和药抵抗被联系,但是它的内在的机制仅仅部分被理解。在这研究,我们在黑瘤房间在 MDMX-MDM2 heterocomplex 和 p53 的活动的稳定性上调查了受体酷氨酸 kinase AXL 的效果。我们的数据通过生长表明了那 AXL overexpression 或激活拘捕特定 6 (Gas6 ) ligand 刺激增加 MDMX 和 MDM2 蛋白质层次和减少 p53 活动。在激活之上, AXL 通过在 phosphosite Ser314 上包含 MDMX 的 phosphorylation 的 translational 以后修正稳定 MDMX,导致与 MDMX 和 MDM2 的增加的亲密关系并且赞成 MDMX 原子 translocation。Ser314 phosphorylation 能也保护 MDMX 免受调停 MDM2 的降级的伤害,导致 MDMX-MDM2 建筑群的稳定。我们作为调停的二 kinases 识别了 CDK4/6 和 p38 MAPK MDMX-MDM2 建筑群的 导致AXL 的调整,并且表明了 AXL ,通过 siRNA silencing 的任何一个或药理学抑制的那抑制, p53 的增加表示层次指向基因 P21 , MDM2 ,和美洲狮,改进 p53 小径反应到化疗,并且敏化房间到 Cisplatin 和 Vemurafenib 。我们的调查结果提供卓见进连接 AXL 到 p53 的新奇发信号轴并且提供一潜在地在黑瘤恢复 p53 功能的 druggable 小径。 | Anna de Polo Zhongling Luot Casimiro Gerarduzzi Xiang Chen John B. Little Zhi-Min Yuan | 2017 | Journal of Molecular Cell Biology2017，9，2： | 5 |
| 5 | Comparison of the patient and partner satisfaction with 700CX and Titan penile prostheses显示文摘最普遍的三部件的阴茎修复术模型是 700CX 和泰坦 ? 。在第一植入以后,我们的目的是估计病人和搭挡满足。这是 multicenter,回顾,满足了在 2009 和 2013 之间的包括标准的所有病人在被包括的 nonrandomized 学习。总共, 248 个病人同意参与。评估耐心的满足,一张验证,但是修改的 11 问题问询表被完成(编辑) ;并且二条款的问询表被给搭挡的 nonvalidated。统计分析使用了一个顺序的逻辑回归模型。248 个病人(194 与 700CX 对 54 与泰坦 ?) 和 207 对夫妇完成了问询表(165 与 700CX 对 42 与泰坦 ?) 。全面满足高。为有优先的期望的性交和高依从的两个都显示出的大可靠性。大多数病人能在 6 个月以内正确地管理阴茎修复术。手术后的阴茎弄短在 42% 盒子和 46% 中导致了一些不满(700CX /Titan ?) 。重要差别在病人问询表的三个问题被发现。有更多的病人,对 700CX 满意(P = 0.0001 ) 。有泰坦 ? 的没有病人植入比 6 个月长带了去最佳的管理。仅仅,有 700CX 的 4% 病人植入与泰坦 ? 与放气被不满足,与 24% 相对照(P = 0.0031 ) 。二个搭挡问题,一个人显示出统计上重要的差别(P = 0.0026 ) 。看起来,组 700CX 将推荐到重新植入有一个更大的趋势的修复术。全面满足为两 prostheses 很高。最后的方面树立,松驰的阴茎是令人满意的,但是两个组与它的最后的尺寸显示出重要不满。搭挡外套满足高。 | Javier Romero Otero Cesar Rojas Cruz Borja Garcia Gomez Joaquim Sarquella Geli lose Medina Polo Eduard Ruiz Castane Alfredo Rodriguez Antolin | 2017 | Asian Journal of Andrology2017，19，3： | 3 |
| 6 | Food groups, diet quality and colorectal cancer risk in the Basque Country显示文摘BACKGROUND The results obtained to date concerning food groups,diet quality and colorectal cancer(CRC)risk vary according to criteria used and the study populations.AIM To study the relationships between food groups,diet quality and CRC risk,in an adult population of the Basque Country(North of Spain).METHODS This observational study included 308 patients diagnosed with CRC and 308 ageand sex-matched subjects as controls.During recruitment,dietary,anthropometric,lifestyle,socioeconomic,demographic and health status information was collected.Adherence to the dietary recommendations was evaluated utilizing the Healthy Eating Index for the Spanish Diet and the MedDietScore.Conditional logistic regressions were used to evaluate the associations of food group intakes,diet quality scores,categorized in tertiles,with CRC risk.RESULTS The adjusted models for potential confounding factors showed a direct association between milk and dairy products consumption,in particular high-fat cheeses[odds ratio(OR)third tertile vs first tertile=1.87,95%confidence intervals(CI):1.11-3.16],and CRC risk.While the consumption of fiber-containing foods,especially whole grains(OR third tertile vs first tertile=0.62,95%CI:0.39-0.98),and fatty fish(OR third tertile vs first tertile=0.53,95%CI:0.27-0.99)was associated with a lower risk for CRC.Moreover,higher MD adherence was associated with a reduced CRC risk in adjusted models(OR third tertile vs first tertile=0.40,95%CI:0.20-0.80).CONCLUSION Direct associations were found for high-fat cheese,whereas an inverse relation was reported for fiber-containing foods and fatty fish,as well as adherence to a Mediterranean dietary pattern. | Iker Alegria-Lertxundi Carmelo Aguirre Luis Bujanda Francisco J Fernandez Francisco Polo JoseMªOrdovas MªCarmen Etxezarraga Inaki Zabalza Mikel Larzabal Isabel Portillo Marian M de Pancorbo Koldo Garcia-Etxebarria Ana MªRocandio Marta Arroyo-Izaga | 2020 | World Journal of Gastroenterology2020，26，28： | 3 |
| 7 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 8 | CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients显示文摘AIM To characterize peripheral blood natural killer(NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected patients.METHODS Peripheral mononuclear cells from 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4. NK surface cell staining was performed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(FITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(FITC); anti-CD62L(PE/Cy7), anti-CCR7(PE), anti-TRAIL(PE), anti-Fas L(PE), anti CD94(FITC). Flow cytometry data acquisition was performed on BD FACSCanto, analyzed using Flow Jo software. Frequency of fluorescence was analyzed for all single markers. Clinical records were reviewed, and epidemiological and clinical data were obtained.RESULTS Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was(6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damage. | Natalia Laufer Diego Ojeda María Laura Polo Ana Martinez Héctor Pérez Gabriela Turk Pedro Cahn Norberto Walter Zwirner Jorge Quarleri | 2017 | World Journal of Hepatology2017，9，25： | 2 |
| 9 | Effect of pharmacologically induced mydriasis on the normal variability of retinal oscillatory potentials in man 显示文摘 | Polo A di Summa A Perlini S | 1995 | Acta Ophthalmol Scand1995，73，2： | 2 |
| 10 | Enzymatic proteolysis,under high pressure of soybean whey:analysis of peptides and the aller-gen Gly m 1 in the hydrolysates显示文摘 | PENAS E PRESTAMO G POLO F | 2006 | Food Chemistry2006，99，3： | 1 |
| 11 | Hormones and Breathing显示文摘 | Tarja Saaresranta Polo Olli | 2002 | Chest2002，122，6： | 1 |
| 12 | Adsorption of benzotriazole on copper electrode surfaces in citric acid media 显示文摘 | Bastidas J M Pinilla P Polo J L | 2002 | Corrosion2002，58，11： | 1 |
| 13 | Sleep - disordered breathing and hormones 显示文摘 | Saresranta T Polo O | 2003 | Eur Respir J2003，22，： | 1 |
| 14 | The perceived value of the rural tourism stay and its effect on rural tourist behaviour 显示文摘 | Ana Isabel Polo Pen-a Dolores Mar'la Fr'las Jamilena and Miguel A' ngel Ikodr'lguez Molina | 2012 | Journal of Sustainable Tourism2012，20，8： | 1 |
| 15 | Timing of repeat elective eaesare- andelivery and neonatal respiratory outcomes显示文摘 | Farchi S Di Lallo D Polo A | 2010 | Arch Dis Child Fetal Neonatal Ed2010，95，1： | 1 |
| 16 | Learning in chemistry with virtual laboratories显示文摘 | Jimenez P M Pedrajas A P Polo J | 2003 | Journal of Chemieal Edueation2003，80，3： | 1 |
| 17 | Pulsed laser deposition of diamond from graphite targets显示文摘 | Cifre J Sanchez G | 1995 | Applied Physics Letters1995，67，4： | 1 |
| 18 | Prediction of global solar irradiance based on time series analysis: Application to solar thermal power plants energy production planning显示文摘 | Martin L Zarzalcjo J F Polo J | 2010 | Solar Energy2010，84，10： | 1 |
| 19 | Risk factors for intracranial infection secondary to penetrating craniocerebral gunshot wounds in civilian practice显示文摘 | Jimenez CM Polo J Espaa JA | 2013 | World Neurosurg2013，79，6： | 1 |
| 20 | Spinal cord direct current stimulation:finite element analysis of the elec-tric field and current density显示文摘 | Hernandez Labrado GR Polo JL López Dolado E | 2011 | Med Biol Eng Comput2011，49，： | 1 |
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