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| 1 | Inflammation, oxidative stress and renin angiotensin system in atherosclerosis显示文摘Atherosclerosis is a chronic inflammatory disease associated with cardiovascular dysfunction including myocardial infarction, unstable angina, sudden cardiac death, stroke and peripheral thromboses. It has been predicted that atherosclerosis will be the primary cause of death in the world by 2020. Atherogenesis is initiated by endothelial injury due to oxidative stress associated with cardiovascular risk factors including diabetes mellitus, hypertension, cigarette smoking, dyslipidemia, obesity, and metabolic syndrome. The impairment of the endothelium associated with cardiovascular risk factors creates an imbalance between vasodilating and vasoconstricting factors, in particular, an increase in angiotensin Ⅱ(Ang Ⅱ) and a decrease in nitric oxide. The renin-angiotensin system(RAS), and its primary mediator Ang Ⅱ, also have a direct influence on the progression of the atherosclerotic process via effects on endothelial function, inflammation, fibrinolytic balance, and plaque stability. Anti-inflammatory agents [statins, secretory phospholipase A2 inhibitor, lipoprotein-associated phospholipase A2 inhibitor, 5-lipoxygenase activating protein, chemokine motif ligand-2, C-C chemokine motif receptor 2 pathway inhibitors, methotrexate, IL-1 pathway inhibitor and RAS inhibitors(angiotensin-converting enzyme inhibitors)], Ang Ⅱ receptor blockers and ranin inhibitors may slow inflammatory processes and disease progression. Several studies in human using anti-inflammatory agents and RAS inhibitors revealed vascular benefits and reduced progression of coronary atherosclerosis in patients with stable angina pectoris; decreased vascular inflammatory markers, improved common carotid intima-media thickness and plaque volume in patients with diagnosed atherosclerosis. Recent preclinical studies have demonstrated therapeutic efficacy of vitamin D analogs paricalcitol in Apo E-deficient atherosclerotic mice. | Kazim Husain Wilfredo Hernandez Rais A Ansari Leon Ferder | 2015 | World Journal of Biological Chemistry2015，6，3： | 84 |
| 2 | Potential beneficial effects of butyrate in intestinal and extraintestinal diseases显示文摘The multiple beneficial effects on human health of the short-chain fatty acid butyrate,synthesized from nonabsorbed carbohydrate by colonic microbiota,are well documented.At the intestinal level,butyrate plays a regulatory role on the transepithelial fluid transport,ameliorates mucosal inflammation and oxidative status,reinforces the epithelial defense barrier,and modulates visceral sensitivity and intestinal motility.In addition,a growing number of studies have stressed the role of butyrate in the prevention and inhibition of colorectal cancer.At the extraintestinal level,butyrate exerts potentially useful effects on many conditions,including hemoglobinopathies,genetic metabolic diseases,hypercholesterolemia,insulin resistance,and ischemic stroke.The mechanisms of action of butyrate are different;many of these are related to its potent regulatory effects on gene expression.These data suggest a wide spectrum of positive effects exerted by butyrate,with a high potential for a therapeutic use in human medicine. | Roberto Berni Canani Margherita Di Costanzo Ludovica Leone Monica Pedata Rosaria Meli Antonio Calignano | 2011 | World Journal of Gastroenterology2011，17，12： | 52 |
| 3 | The Basic Helix-Loop-Helix Transcription Factor MYC1 Is Involved in the Regulation of the Flavonoid Biosynthesis Pathway in Grapevine显示文摘以前的结果显示在葡萄藤(Vitis vinifera ) ,由 MYB 抄写因素的 flavonoid 小径基因的规定与基本 helix-loop-helix 蛋白质(bHLHs ) 取决于他们的相互作用。现在的学习描述从葡萄藤的因素说出 VvMYC1 的 bHLH 的第一功能的描述。这个抄写因素种系发生地与 Arabidopsis bHLH 蛋白质,它参予 flavonoid 生合成和表皮的房间命运的控制有关。二混血儿的试金表明了的短暂倡导者和酵母 VvMYC1 身体上与劝诱 flavonoid 小径基因的倡导者的 MYB5a, MYB5b, MYBA1/A2,和 MYBPA1 交往,这在 anthocyanin 或 proanthocyanidin (PA ) 包含了合成。另外,短暂倡导者试金表明 VvMYC1 涉及它的自己的表示的反馈规定。抄本在果浆的皮肤和种子与 anthocyanins 和舞步的合成在果浆发展相互关联期间 VvMYC1 铺平,建议 VvMYC1 涉及在这些机关的 anthocyanins 和 PA 合成的规定。同样, VvMYC1 和 VvMYBA1 的短暂表示在葡萄藤暂停房间导致 anthocyanin 合成。这些结果建议 VvMYC1 是在葡萄藤控制 anthocyanin 和 PA 生合成的 transcriptional 串联的部分。 | Imene Hichri Simon C. Heppel Jeremy Pillet Celine Leon Stefan Czemmel Serge Delrot Virginie Lauvergeat Jochen Bogs | 2010 | Molecular Plant2010，3，3： | 46 |
| 4 | 我国九省眼病调查中北京市顺义区50岁及以上人群盲和中、重度视力损伤患病率调查显示文摘目的调查北京市顺义区50岁及以上人群盲和中、重度视力损伤的患病率。方法以人群为基础的横断面调查。2006年4—8月对北京市顺义区50岁及以上人群进行视力和眼部检查。采用整群随机抽样方法抽取28个调查点,正式现场调查之前先进行预试验,并进行保证调查质量的重复性检验。根据村户口本逐户检录调查对象,对受检人群进行视力和眼部检查。按年龄、性别、受教育程度分别计算盲和中、重度视力损伤的患病率。各检测数据间的比较采用X^2z检验和趋势x^2检验。结果在检录的5840人中,5118人接受并完成了检查,受检率为87.64%。以世界卫生组织1973年视力损伤分类标准和最佳矫正视力计算,盲57例,患病率为1.11%;中、重度视力损伤160例,患病率为3.12%。以世界卫生组织1973年视力损伤分类标准和日常生活视力计算,盲65例,患病率为1.27%;中、重度视力损伤428例,患病率为8.36%。以最佳矫正视力计算,高龄(趋势X^2=784.23,P=0.000)、女性(x。=28.35,P=0.000)和文盲(趋势x^2=397.13,P=0.000)人群的盲和中、重度视力损伤的患病率增高。白内障是盲和中、重度视力损伤的主要原因。视网膜疾病成为导致盲和中、重度视力损伤的第二位原因。未矫正屈光不正也是导致视力损伤的重要原因。结论北京市顺义区50岁及以上人群盲的患病率较1996年有所下降,表明该区的防盲治盲工作取得成效。但是白内障仍是导致盲和中、重度视力损伤的首要原因。 | 刘虎 赵家良 陆宏 李凤荣 张扬 杨渊荃 王羽 高学成 毛进 Leon B.Ellwein 降丽娟 张文宝 | 2012 | 中华眼科杂志2012，48，3： | 44 |
| 5 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 6 | 我国九省眼病调查中北京市顺义区50岁及以上人群白内障患病率和手术状况的调查显示文摘目的了解北京市顺义区50岁及以上人群中白内障患病率、白内障手术效果、白内障手术覆盖率和白内障盲人社会负担率。方法采用整群随机抽样方法。2006年4—8月在顺义区抽取50岁及以上成人5118名进行视力和眼部检查,包括评价晶状体混浊程度和自内障手术情况。应用多元逻辑回归分析不同年龄、性别和受教育程度对白内障患病率、白内障手术覆盖率、白内障盲人社会负担率及白内障术后视力效果的影响。结果在5118名受检者中,发现白内障797例,患病率为15.57%。高龄、女性和受教育程度低的人群白内障患病率明显增高,差异均有统计学意义(P〈0.01)。在施行白内障手术的189只眼中,采用现代白内障囊外摘除联合人工晶状体(IOL)植入术(包括小切口白内障手术)123只眼(65.08%),白内障超声乳化吸除术联合IOL植入术44只眼(23.28%),IOL植入率为89.42%。术后日常生活视力和最佳矫正视力≥0.7的眼分别占总数的30.16%和61.38%,术后视力差的主要原因是晶状体后囊膜混浊和屈光不正。白内障手术覆盖率为62.22%,白内障盲人社会负担率为2.64%。随着年龄的增长和受教育程度的降低,白内障手术覆盖率逐渐降低,白内障盲人社会负担率逐渐增高,这种变化趋势有统计学意义(P〈0.01)。结论白内障是常见的致盲眼病。虽然顺义区的白内障手术覆盖率较高,但在高龄人群中白内障手术覆盖率仍然较低。白内障手术的视力预后有待于进一步提高。 | 李凤荣 赵家良 陆宏 刘虎 毛进 降丽娟 张扬 杨渊荃 Leon B.Ellwein 王羽 高学成 张文宝 | 2012 | 中华眼科杂志2012，48，3： | 38 |
| 7 | Generating optical orbital angular momentum at visible wavelengths using a plasmonic metasurface显示文摘Light beams with a helical phase-front possess orbital angular momentum along their direction of propagation in addition to the spin angular momentum that describes their polarisation.Until recently,it was thought that these two‘rotational’motions of light were largely independent and could not be coupled during light–matter interactions.However,it is now known that interactions with carefully designed complex media can result in spin-to-orbit coupling,where a change of the spin angular momentum will modify the orbital angular momentum and vice versa.In this work,we propose and demonstrate that the birefringence of plasmonic nanostructures can be wielded to transform circularly polarised light into light carrying orbital angular momentum.A device operating at visible wavelengths is designed from a space-variant array of subwavelength plasmonic nano-antennas.Experiment confirms that circularly polarised light transmitted through the device is imbued with orbital angular momentum of 62'(with conversion efficiency of at least 1%).This technology paves the way towards ultrathin orbital angular momentum generators that could be integrated into applications for spectroscopy,nanoscale sensing and classical or quantum communications using integrated photonic devices. | Ebrahim Karimi Sebastian A Schulz Israel De Leon Hammam Qassim Jeremy Upham Robert W Boyd | 2014 | Light(Science & Applications)2014，3，1： | 39 |
| 8 | Diabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations and future research显示文摘The incidence of diabetes mellitus(DM) continues to rise and has quickly become one of the most prevalent and costly chronic diseases worldwide. A close link exists between DM and cardiovascular disease(CVD), which is the most prevalent cause of morbidity and mortality in diabetic patients. Cardiovascular(CV) risk factors such as obesity, hypertension and dyslipidemia are common in patients with DM, placing them at increased risk for cardiac events. In addition, many studies have found biological mechanisms associated with DM that independently increase the risk of CVD in diabetic patients. Therefore, targeting CV risk factors in patients with DM is critical to minimize the long-term CV complications of the disease. This paper summarizes the relationship between diabetes and CVD, examines possible mechanisms of disease progression, discusses current treatment recommendations, and outlines future research directions. | Benjamin M Leon Thomas M Maddox | 2015 | World Journal of Diabetes2015，6，13： | 39 |
| 9 | 我国九省眼病调查中江苏省启东市50岁及以上人群白内障患病率和手术状况的调查显示文摘目的调查2006年江苏省启东市50岁及以上人群中白内障患病率、白内障手术覆盖率和白内障盲人社会负担率。方法采用整群随机抽样研究方法。2006年9—12月在江苏省启东市抽取16个调查点,共对5141例50岁及以上成人进行视力和眼部检查,包括裂隙灯显微镜检查评价晶状体混浊程度和白内障手术情况。应用多元逻辑回归分析受检者不同年龄、性别和受教育程度对白内障患病率、白内障手术覆盖率、白内障盲人社会负担率及白内障术后视力效果的影响。结果5141例受检者中,发现白内障1098例,患病率为21.35%。高龄、女性和受教育程度低的人群白内障患病率明显增高,差异均有统计学意义(P〈0.01)。在施行白内障手术的89只眼中,采用现代囊外摘除联合人工晶状体(IOL)植入术23只眼(25.84%),白内障超声乳化吸除术联合IOL植入术38只眼(42.70%),IOL植入率为69.66%。术后日常生活视力和最佳矫正视力90.7的眼分别占总数的24.72%和48.31%,术后视力差的主要原因是视网膜疾病、晶状体后囊膜混浊和青光眼。白内障手术覆盖率为37.96%,白内障盲人社会负担率为2.10%。随着年龄的增长和受教育程度的降低,白内障手术覆盖率逐渐降低,白内障盲人社会负担率逐渐增高,这种变化趋势有统计学意义(P〈0.01)。结论江苏省启东市高龄人群中自内障手术覆盖率仍较低,防盲工作的首要任务仍是根治白内障盲。白内障手术的视力预后有待于进一步提高。 | 管怀进 陆宏 戴追 李密 王燕 胡健艳 施健 赵家良 Leon B.Ellwein 王羽 高学成 | 2012 | 中华眼科杂志2012，48，3： | 27 |
| 10 | The role of aluminum sensing and signaling in plant aluminum resistance显示文摘As researchers have gained a better understanding in recent years into the physiological, molecular, and genetic basis of how plants deal with aluminum(Al) toxicity in acid soils prevalent in the tropics and sub‐tropics, it has become clear that an important component of these responses is the triggering and regulation of cellular pathways and processes by Al. In this review of plant Al signaling, we begin by summarizing the understanding of physiological mechanisms of Al resistance, which first led researchers to realize that Al stress induces gene expression and modifies protein function during the activation of Al resistance responses. Subsequently, an overview of Al resistance genes and their function provides verification that Al induction of gene expression plays a major role in Al resistance in many plant species. More recent research into the mechanistic basis for Al‐induced transcriptional activation of resistance genes has led to the identification of several transcription factors as well as cis‐elements in the promoters of Al resistance genes that play a role in greater Al‐induced gene expression as well as higher constitutive expression of resistance genes in some plant species. Finally,the post‐transcriptional and translational regulation of Al resistance proteins is addressed, where recent research has shown that Al can both directly bind to and alter activity of certain organic acid transporters, and also influence Al resistance proteins indirectly, via protein phosphorylation. | Jiping Liu Miguel A.Piros Leon V.Kochian | 2014 | Journal of Integrative Plant Biology2014，56，3： | 23 |
| 11 | Pathways of China's PM;air quality 2015–2060 in the context of carbon neutrality显示文摘Clean air policies in China have substantially reduced particulate matter(PM;) air pollution in recent years,primarily by curbing end-of-pipe emissions.However,reaching the level of the World Health Organization(WHO) guidelines may instead depend upon the air quality co-benefits of ambitious climate action.Here,we assess pathways of Chinese PM;air quality from 2015 to 2060 under a combination of scenarios that link global and Chinese climate mitigation pathways(i.e.global 2℃-and 1.5℃-pathways,National Determined Contributions(NDC) pledges and carbon neutrality goals) to local clean air policies.We find that China can achieve both its near-term climate goals(peak emissions) and PM;air quality annual standard(35 μg/m;) by 2030 by fulfilling its NDC pledges and continuing air pollution control policies.However,the benefits of end-of-pipe control reductions are mostly exhausted by 2030,and reducing PM;exposure of the majority of the Chinese population to below 10 μg/m;by 2060 will likely require more ambitious climate mitigation efforts such as China’ s carbon neutrality goals and global1.5℃-pathways.Our results thus highlight that China’s carbon neutrality goals will play a critical role in reducing air pollution exposure to the level of the WHO guidelines and protecting public health. | Jing Cheng Dan Tong Qiang Zhang Yang Liu Yu Lei Gang Yan Liu Yan Sha Yu Ryna Yiyun Cui Leon Clarke Guannan Geng Bo Zheng Xiaoye Zhang Steven JDavis Kebin He | 2021 | National Science Review2021，8，12： | 23 |
| 12 | Biomonitoring for traditional herbal medicinal products using DNA metabarcoding and single molecule, real-time sequencing显示文摘Global concerns have been paid to the potential hazard of traditional herbal medicinal products(THMPs). Substandard and counterfeit THMPs, including traditional Chinese patent medicine, health foods, dietary supplements, etc. are potential threats to public health. Recent marketplace studies using DNA barcoding have determined that the current quality control methods are not sufficient for ensuring the presence of authentic herbal ingredients and detection of contaminants/adulterants. An efficient biomonitoring method for THMPs is of great needed. Herein, metabarcoding and single-molecule, realtime(SMRT) sequencing were used to detect the multiple ingredients in Jiuwei Qianghuo Wan(JWQHW), a classical herbal prescription widely used in China for the last 800 years. Reference experimental mixtures and commercial JWQHW products from the marketplace were used to confirm the method. Successful SMRT sequencing results recovered 5416 and 4342 circular-consensus sequencing(CCS) reads belonging to the ITS2 and psb A-trn H regions. The results suggest that with the combination of metabarcoding and SMRT sequencing, it is repeatable, reliable, and sensitive enough to detect species in the THMPs, and the error in SMRT sequencing did not affect the ability to identify multiple prescribed species and several adulterants/contaminants. It has the potential for becoming a valuable tool for the biomonitoring of multi-ingredient THMPs. | Tianyi Xin Zhichao Xu Jing Jia Christine Leon Songnian Hu Yulin Lin Subramanyam Ragupathy Jingyuan Song Steven G.Newmaster | 2018 | Acta Pharmaceutica Sinica B2018，8，3： | 22 |
| 13 | Alcohol and hepatocellular carcinoma:A review and a point of view显示文摘It is well recognized that one cause of chronic liver disease and hepatocellular carcinoma(HCC)is alcohol consumption.Research in Italy and the United States concludes that the most common cause of HCC(responsible for 32%to 45%of HCC)is alcohol.It has recently been shown that a significant relationship between alcohol intake,metabolic changes,and hepatitis virus infection does exist.Alcohol may be a factor in the development of HCC via direct(genotoxic)and indirect mechanisms(cirrhosis).There is only one way of diagnosing HCC,which is early identification through surveillance,when curative treatments become possible.After stopping alcohol intake the risk of liver cancer decreases by 6%to 7%a year,and an estimated time period of 23 years is also needed.Therefore,surveillance is also important in former drinkers and,in our opinion,independently from the presence of compensated cirrhosis.In cases of very early stage(VES)and early stage with portal hypertension,liver transplantation is the optimal option;and in cases of associated disease,percutaneous ethanol injections,radiofrequency and microwave ablation are the ideal treatments.Despite the possibility of detecting microvascular invasion with HR,several studies and some randomized controlled trials revealed that overall survival and DSF rates in patients with VES HCC are much the same after ablation and HR.Therefore,ablation can be regarded as a firstline choice for patients with VES HCC.It is important to emphasize that the choice of treatment should be weighed carefully in the context of a multidisciplinary cancer team. | Gianni Testino Silvia Leone Paolo Borro | 2014 | World Journal of Gastroenterology2014，20，43： | 21 |
| 14 | 我国九省眼病调查中江西省吉安县50岁及以上人群白内障患病率和手术状况的调查显示文摘目的调查江西省吉安县50岁及以上人群中白内障患病率、白内障手术效果、白内障手术覆盖率和白内障盲人社会负担率。方法采用整群随机抽样方法。2006年9至11月在江西省吉安县抽取50岁及以上成人5010名进行视力和眼部检查,包括评价晶状体混浊程度和白内障手术情况。应用多元逻辑回归分析受检者的年龄、性别和受教育程度对白内障患病率、白内障手术覆盖率、白内障盲人社会负担率及白内障术后视力效果的影响。结果在5010例受检者中,发现白内障1158例,患病率为23.11%。高龄、女性人群白内障患病率明显增高,差异均有统计学意义(P〈0.01)。在施行白内障手术的99只眼中,采用现代囊外白内障摘除术联合人工晶状体(IOL)植入术50只眼(50.51%)、采用白内障超声乳化吸除联合IOL植入术5只眼(5.05%),IOL植入率为55.56%。术后日常生活视力和最佳矫正视力30.7的眼分别占总数的10.1%和45.5%,术后视力差的主要原因是晶状体后囊膜混浊和屈光不正。白内障手术覆盖率为32.29%,白内障盲人社会负担率为3.83%。随着年龄的增长,白内障盲人社会负担率逐渐增大,这种变化趋势有统计学意义(P〈0.01)。结论白内障是江西省吉安县50岁及以上人群的主要致盲性眼病。吉安县白内障手术覆盖率还不高,盲人社会负担率较重,IOL植人率偏低,白内障手术的视力预后有待于进一步提高。 | 罗荣 赵家良 易敬林 谢晖 白永泉 杨海军 Leon B.Ellwein 赖平红 李岚 黄亮 杜红岩 王羽 高学成 陆宏 | 2012 | 中华眼科杂志2012，48，6： | 20 |
| 15 | 我国九省眼病调查中广东省阳西县50岁及以上人群盲和中、重度视力损伤患病率及致病原因调查显示文摘目的 调查广东省阳西县50岁及以上人群盲和中、重度视力损伤的患病率及致病原因.方法 以人群为基础的横断面调查.2006年9月至2007年1月对广东省阳西县50岁及以上人群进行视力和眼部检查.采用整群随机抽样方法抽取28个调查点,正式现场调查之前先进行预试验,并进行保证调查质量的重复性检验.根据村户口本逐户检录调查对象.按年龄、性别和受教育程度分别计算受检者肓和中、重度视力损伤的患病率,并判断受检者盲和中、重度视力损伤的原因.采用x2检验、趋势x2检验进行各数据间的比较.结果 在检录的5 531人中,4 589人接受并完成了检查,受检率为82.97%.以世界卫生组织1973年视力损伤分类为标准,以BCVA计算,50岁及以上受检者中盲109人,患病率为2.38%,中、重度视力损伤433人,患病率为9.44%;以日常生活视力计算,盲123人,患病率为2.68%,中、重度视力损伤833人,患病率为18.15%.以BCVA计算,高龄(趋势x2=1 239.34,P<0.01)、女性(x2=37.88,P<0.01)和文盲(趋势x2=235.11,P<0.01)人群盲和中、重度视力损伤的患病率增高.白内障是盲和中、重度视力损伤的主要原因.结论 广东省阳西县50岁及以上人群盲和中、重度视力损伤的患病率在我国九省眼病调查结果中处于较高水平.白内障是导致其盲和中、重度视力损伤的主要原因. | 葛坚 何明光 赵家良 方敏 Leon B.Ellwein 何宁 杨梅 王羽 高学成 | 2014 | 中华眼科杂志2014，50，3： | 20 |
| 16 | Exploiting multi-channels deep convolutional neural networks for multivariate time series classification显示文摘 | Yi ZHENG QiLIU Enhong CHEN Yong GE J. Leon ZHAO | 2016 | Frontiers of Computer Science2016，10，1： | 20 |
| 17 | 我国九省眼病调查中江苏省启东市50岁及以上人群盲和中、重度视力损伤患病率调查显示文摘目的调查2006年江苏省启东市50岁及以上人群盲和中、重度视力损伤的患病率、致盲原因及其相关因素。方法以人群为基础的横断面调查。2006年9—12月对江苏省启东市50岁及以上人群进行视力和眼部检查。采用整群随机抽样方法抽取16个调查点,正式现场调查之前先进行预试验,并进行保证调查质量的重复性检验。根据村户口本逐户检录调查对象,对受检人群进行视力和眼部检查。按年龄、性别、受教育程度分别计算盲和中、重度视力损伤的患病率。各检测数据间的比较采用x^2检验和趋势x^2检验。结果在检录的5662人中,5141人接受并完成了检查,受检率为90.80%。以世界卫生组织1973年视力损伤分类标准和最佳矫正视力计算,盲91例,患病率为1.77%;中、重度视力损伤175例,患病率为3.40%。以世界卫生组织1973年视力损伤分类标准和日常生活视力计算,盲113例,患病率为2.20%;中、重度视力损伤354例,患病率为6.89%。以最佳矫正视力计算,高龄(趋势X^2=825.16,P=0.000)、女性(X^2=19.85,P=0.001)和文盲(趋势X^2=329.85,P=0.000)人群的盲和中、重度视力损伤的患病率增高。白内障是致盲的首要原因。结论江苏省启东市高龄和文盲中盲和中、重度视力损伤患病率较高,致盲的主要原因依次为白内障、眼底病、屈光不正、角膜瘢痕或混浊。 | 陆宏 管怀进 戴追 李密 王燕 胡健艳 施健 赵家良 Leon B.Ellwein 王羽 高学成 | 2012 | 中华眼科杂志2012，48，3： | 19 |
| 18 | Spontaneous fungal peritonitis: Epidemiology, current evidence and future prospective显示文摘Spontaneous bacterial peritonitis is a complication of ascitic patients with end-stage liver disease(ESLD); spontaneous fungal peritonitis(SFP) is a complication of ESLD less known and described. ESLD is associated to immunodepression and the resulting increased susceptibility to infections. Recent perspectives of the management of the critically ill patient with ESLD do not specify the rate of isolation of fungi in critically ill patients,not even the antifungals used for the prophylaxis,neither optimal treatment. We reviewed,in order to focus the epidemiology,characteristics,and,considering the high mortality rate of SFP,the use of optimal empirical antifungal therapy the current literature. | Marco Fiore Sebastiano Leone | 2016 | World Journal of Gastroenterology2016，22，34： | 19 |
| 19 | 主观疲劳量表与体重流失在足球训练负荷控制中的运用显示文摘对'主观疲劳量表'进行改进,使其便于获得足球运动员的'训练前自觉疲劳程度',从而能获得'训练累积自觉疲劳程度';并引入运动员的'体重流失'和'体重流失比'来对运动员训练负荷进行监控。研究假设为'运动员在训练中的‘体重流失比’和‘累积自觉疲劳程度’比‘体重流失’和‘训练后自觉疲劳程度’能更准确地反映运动员的训练负荷'。18名职业足球运动员(年龄23±3岁,身高177.2±6.2cm,体重72.9±7.2kg,BMI指数23.2±1.7)被选取为实验对象,对研究假设进行实验验证。结果显示,运动员在训练中的体重流失与训练后自觉疲劳程度不存在相关性(P>0.05),而与训练累积自觉疲劳程度呈现中度相关(P<0.05,R=0.49)。体重流失比与训练后自觉疲劳程度呈现低度相关(P<0.05,R=0.39),且与训练累积自觉疲劳程度呈现中度相关(P<0.01,R=0.52)。该结果证实了本研究的研究假设。 | 刘鸿优 Jesus-Vicente Gimenez Andres Alcolea Leon | 2015 | 体育科学2015，35，5： | 16 |
| 20 | Performance matched discretionary accrual measures显示文摘 | S.P. Kothari Andrew J. Leone Charles E. Wasley | 2004 | Journal of Accounting and Economics2004，，1： | 15 |
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