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| 1 | Ionized jet deposition of antimicrobial and stem cell friendly silver-substituted tricalcium phosphate nanocoatings on titanium alloy显示文摘Orthopedic infections pose severe societal and economic burden and interfere with the capability of the implanted devices to integrate in the host bone,thus significantly increasing implants failure rate.To address infection and promote integration,here nanostructured antibacterial and bioactive thin films are proposed,obtained,for the first time,by Ionized Jet Deposition(IJD)of silver-substituted tricalcium phosphate(Ag-TCP)targets on titanium.Coatings morphology,composition and mechanical properties are characterized and proof-of-concept of biocompatibility is shown.Antimicrobial efficacy is investigated against four Gram positive and Gram negative bacterial strains and against C.albicans fungus,by investigating the modifications in planktonic bacterial growth in the absence and presence of silver.Then,for all bacterial strains,the capability of the film to inhibit bacterial adhesion is also tested.Results indicate that IJD permits a fine control over films composition and morphology and deposition of films with suitable mechanical properties.Biological studies show a good efficacy against Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Enterococcus faecalis and against fungus Candida albicans,with evidences of efficacy against planktonic growth and significant reduction of bacterial cell adhesion.No cytotoxic effects are evidenced for equine adipose tissue derived mesenchymal stem cells(ADMSCs),as no reductions are caused to cells viability and no interference is assessed in cells differentiation towards osteogenic lineage,in the presence of silver.Instead,thanks to nanostructuration and biomimetic composition,tricalcium phosphate(TCP)coatings favor cells viability,also when silver-substituted.These findings show that silver-substituted nanostructured coatings are promising for orthopedic implant applications. | Gabriela Graziani Katia Barbaro Inna V.Fadeeva Daniele Ghezzi Marco Fosca Enrico Sassoni Gianluca Vadalà Martina Cappelletti Francesco Valle Nicola Baldini Julietta V.Rau | 2021 | Bioactive Materials2021，6，8： | 2 |
| 2 | A classification for community discovery methods in complex networks显示文摘 | Coscia Michele Giannotti Fosca Pedreschi Dino | | 0，，5： | 1 |
| 3 | Long-Term Risk of Sustained Hypertension in White-Coat or Masked Hypertension显示文摘 | Giuseppe Mancia Michele Bombelli Rita Facchetti Fabiana Madotto Fosca Quarti-Trevano Hernan Polo Friz Guido Grassi Roberto Sega | 2009 | Hypertension2009，，2： | 1 |
| 4 | The neuroadrenergic hypothesis inhypertension: Current evidence显示文摘 | Guido G Gino S Fosca QT | 2010 | Exp Physiol2010，95，2： | 1 |
| 5 | Anonymity preserving pattern discovery显示文摘 | Maurizio Atzori Francesco Bonchi Fosca Giannotti Dino Pedreschi | 2008 | The VLDB Journal2008，，4： | 1 |
| 6 | Multidimensional networks: foundations of structural analysis显示文摘 | Michele Berlingerio Michele Coscia Fosca Giannotti Anna Monreale Dino Pedreschi | 2013 | World Wide Web (-)2013，，5： | 1 |
| 7 | Web Log Data Warehousing and Mining for Intelligent Web Caching 显示文摘 | Francesco Bonchi Fosca Giannotti Cristian Gozzi | 2001 | Data and Knowledge Engineering2001，39，2： | 1 |
| 8 | In vitro characterization of novel nanostructured collagen-hydroxyapatite composite scaffolds doped with magnesium with improved biodegradation rate for hard tissue regeneration显示文摘New materials are required for bone healing in regenerative medicine able to temporarily substitute damaged bone and to be subsequently resorbed and replaced by endogenous tissues.Taking inspiration from basic composition of the mammalian bones,composed of collagen,apatite and a number of substitution ions,among them magnesium(Mg2+),in this work,novel composite scaffolds composed of collagen(10%)-hydroxyapatite(HAp)(90%)and collagen(10%)-HAp(80%)-Mg(10%)were developed.The lyophilization was used for composites preparation.An insight into the nanostructural nature of the developed scaffolds was performed by Scanning Electron Microscopy coupled with Energy Dispersive X-Ray and Transmission Electron Microscopy coupled with Energy Dispersive X-Ray.The HAp nanocrystallite clusters and Mg nanoparticles were homogeneously distributed within the scaffolds and adherent to the collagen fibrils.The samples were tested for degradation in Simulated Body Fluid(SBF)solution by soaking for up to 28 days.The release of Mg from collagen(10%)-HAp(80%)-Mg(10%)composite during the period of up to 21 days was attested,this composite being characterized by a decreased degradation rate with respect to the composite without Mg.The developed composite materials are promising for applications as bone substitute materials favouring bone healing and regeneration. | Iulian V.Antoniac Aurora Antoniac Eugeniu Vasile Camelia Tecu Marco Fosca Viktoriya G.Yankova Julietta V.Rau | 2021 | Bioactive Materials2021，6，10： | 1 |
| 9 | Big Data Research in Italy: A Perspective显示文摘这篇文章的目的在于综述在大数据背景下一些意大利大学正在从事的研究项目。本文不求面面俱到,目的是提供从意大利不同领域收集到的有关大数据管理方面的问题的实际解决方案。 | Sonia Bergamaschi Emanuele Carlini Michelangelo Ceci Barbara Furletti Fosca Giannotti Donato Malerba Mario Mezzanzanica Anna Monreale Gabriella Pasi Dino Pedreschi Raffele Perego Salvatore Ruggieri | 2016 | Engineering2016，2，2： | 1 |
| 10 | Essential hypertension and the sympathetic nervous system显示文摘 | Guido Grassi Fosca Quarti-Trevano Raffaella Dell’Oro Giuseppe Mancia | 2008 | Neurological Sciences2008，，1： | 1 |
| 11 | Superhard tungsten tetraboride films prepared by pulsed laser deposition method 显示文摘 | RAU J V LATINI A TEGHIL R DE BONIS A FOSCA M CAMINITI R ALBERTINI V R | 2011 | ACS Appl Mater & Interf2011，3，9： | 1 |
| 12 | Properties of pulsed laser deposited fluorinated hydroxyapatite films on titanium显示文摘 | J.V. Rau V.V. Smirnov S. Laureti A. Generosi G. Varvaro M. Fosca D. Ferro S. Nunziante Cesaro V. Rossi Albertini S.M. Barinov | 2010 | Materials Research Bulletin2010，，9： | 1 |
| 13 | Aclassificationfor community discovery methods in complex networks 显示文摘 | Michele Coscia Fosca Giannotti Dino Pedreschi | 2011 | StatisticalAnalysis and Data Mining2011，4，5： | 1 |
| 14 | Factors influencing the drug release from calcium phosphate cements显示文摘Thanks to their biocompatibility,biodegradability,injectability and self-setting properties,calcium phosphate cements(CPCs)have been the most economical and effective biomaterials of choice for use as bone void fillers.They have also been extensively used as drug delivery carriers owing to their ability to provide for a steady release of various organic molecules aiding the regeneration of defective bone,including primarily antibiotics and growth factors.This review provides a systematic compilation of studies that reported on the controlled release of drugs from CPCs in the last 25 years.The chemical,compositional and microstructural characteristics of these systems through which the control of the release rates and mechanisms could be achieved have been discussed.In doing so,the effects of(i)the chemistry of the matrix,(ii)porosity,(iii)additives,(iv)drug types,(v)drug concentrations,(vi)drug loading methods and(vii)release media have been distinguished and discussed individually.Kinetic specificities of in vivo release of drugs from CPCs have been reviewed,too.Understanding the kinetic and mechanistic correlations between the CPC properties and the drug release is a prerequisite for the design of bone void fillers with drug release profiles precisely tailored to the application area and the clinical picture.The goal of this review has been to shed light on these fundamental correlations. | Marco Fosca Julietta V.Rau Vuk Uskokovi | 2022 | Bioactive Materials2022，7，1： | 0 |
| 15 | Quality control methods in musculoskeletal tissue engineering:from imaging to biosensors显示文摘Tissue engineering is rapidly progressing toward clinical application.In the musculoskeletal field,there has been an increasing necessity for bone and cartilage replacement.Despite the promising translational potential of tissue engineering approaches,careful attention should be given to the quality of developed constructs to increase the real applicability to patients.After a general introduction to musculoskeletal tissue engineering,this narrative review aims to offer an overview of methods,starting from classical techniques,such as gene expression analysis and histology,to less common methods,such as Raman spectroscopy,microcomputed tomography,and biosensors,that can be employed to assess the quality of constructs in terms of viability,morphology,or matrix deposition.A particular emphasis is given to standards and good practices(GXP),which can be applicable in different sectors.Moreover,a classification of the methods into destructive,noninvasive,or conservative based on the possible further development of a preimplant quality monitoring system is proposed.Biosensors in musculoskeletal tissue engineering have not yet been used but have been proposed as a novel technology that can be exploited with numerous advantages,including minimal invasiveness,making them suitable for the development of preimplant quality control systems. | Daniele Zuncheddu Elena Della Bella Andrea Schwab Dalila Petta Gaia Rocchitta Silvia Generelli Felix Kurth Annapaola Parrilli Sophie Verrier Julietta V.Rau Marco Fosca Margherita Maioli Pier Andrea Serra Mauro Alini Heinz Redl Sibylle Grad Valentina Basoli | 2021 | Bone Research2021，9，4： | 0 |
| 16 | 大数据研究在意大利的远景显示文摘这篇文章的目的在于综述在大数据背景下一些意大利大学正在从事的研究项目。本文不求面面俱到,目的是提供从意大利不同领域收集到的有关大数据管理方面的问题的实际解决方案。 | Sonia Bergamaschi Emanuele Carlini Michelangelo Ceci Barbara Furletti Fosca Giannotti Donato Malerba Mario Mezzanzanica Anna Monreale Gabriella Pasi Dino Pedreschi Raffele Perego Salvatore Ruggieri | 2016 | Engineering2016，2，2： | 0 |
| 17 | Don’t stop me now, I’m having such a good time! Czechoslovakian wolfdogs renovate the motivation to play with a bow显示文摘Dogs engage in play behavior at every age and the play bow is their most iconic playful posture.However,the function of this posture is still under debate.Here,we selected the Czechoslovakian Wolfdog(CWD)as a model breed to clarify the function of the play bow.We analyzed frame-by-frame 118 sessions of 24 subjects and recorded 76 play bow events.We found that all the play bows were performed in the visual field of the playmate suggesting that the sender takes into account the attentional state of the receiver when releasing the signal.By drawing survival curves and using log-rank test we found that play bow was mainly performed during a short pause in an ongoing session and that its performance triggered the playmate’s reaction again.These findings show that play bow functions in restoring the partner motivation to play.Finally,by using a sequential analysis and a generalized mixed model,we found no evidence supporting the metacommunicative function of the play bow.The signal did not necessarily precede a contact offensive behavior(e.g.,play biting and play pushing)and it was not affected by the level of asymmetry of the play session.In conclusion,in CWDs play bow can be considered a visual signal useful to maintain the motivation to play in the receiver.Therefore,we suggest that the mismatched number of play bows emitted by the 2 players in a given session can be predictive of their different motivations to play. | Veronica Maglieri Anna Zanoli Fosca Mastrandrea Elisabetta Palagi | 2023 | Current Zoology2023，69，1： | 0 |
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