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| 1 | Olive oil consumption and non-alcoholic fatty liver disease显示文摘The clinical implications of non-alcoholic fatty liver diseases(NAFLD)derive from their potential to progress to fibrosis and cirrhosis.Inappropriate dietary fat intake,excessive intake of soft drinks,insulin resistance and increased oxidative stress results in increased free fatty acid delivery to the liver and increased hepatic triglyceride(TG)accumulation.An olive oil-rich diet decreases accumulation of TGs in the liver,improves postprandial TGs,glucose and glucagonlike peptide-1 responses in insulin-resistant subjects, and upregulates glucose transporter-2 expression in the liver.The principal mechanisms include:decreased nuclear factor-kappaB activation,decreased lowdensity lipoprotein oxidation,and improved insulin resistance by reduced production of inflammatory cytokines(tumor necrosis factor,interleukin-6)and improvement of jun N-terminal kinase-mediated phosphorylation of insulin receptor substrate-1.The beneficial effect of the Mediterranean diet is derived from monounsaturated fatty acids,mainly from olive oil.In this review,we describe the dietary sources of the monounsaturated fatty acids,the composition of olive oil,dietary fats and their relationship to insulin resistance and postprandial lipid and glucose responses in non-alcoholic steatohepatitis,clinical and experimental studies that assess the relationship between olive oil and NAFLD,and the mechanism by which olive oil ameliorates fatty liver,and we discuss future perspectives. | Nimer Assy Faris Nassar Gattas Nasser Maria Grosovski | 2009 | World Journal of Gastroenterology2009，15，15： | 22 |
| 2 | Splanchnic vasodilation and hyperdynamic circulatory syndrome in cirrhosis显示文摘Portal hypertension is a clinical syndrome which leads to several clinical complications,such as the formation and rupture of esophageal and/or gastric varices,ascites,hepatic encephalopathy and hepato-renal syndrome.In cirrhosis,the primary cause of the increase in portal pressure is the enhanced resistance to portal outflow.However,also an increase in splanchnic blood flow worsens and maintains portal hypertension.The vasodilatation of arterial splanchnic vessels and the opening of collateral circulation are the determinants of the increased splanchnic blood flow.Several vasoactive systems/substances,such as nitric oxide,cyclooxygenase-derivatives,carbon monoxide and endogenous cannabinoids are activated in portal hypertension and are responsible for the marked splanchnic vasodilatation.Moreover,an impaired reactivity to vasoconstrictor systems,such as the sympathetic nervous system,vasopressin,angiotensinⅡand endothelin-1,plays a role in this process.The opening of collateral circulation occurs through the reperfusion and dilatation of preexisting vessels,but also through the generation of new vessels.Splanchnic vasodilatation leads to the onset of the hyperdynamic circulatory syndrome,a syndrome which occurs in pa-tients with portal hypertension and is characterized by increased cardiac output and heart rate,and decreased systemic vascular resistance with low arterial blood pressure.Understanding the pathophysiology of splanchnic vasodilatation and hyperdynamic circulatory syndrome is mandatory for the prevention and treatment of portal hypertension and its severe complications. | Massimo Bolognesi Marco Di Pascoli Alberto Verardo Angelo Gatta | 2014 | World Journal of Gastroenterology2014，20，10： | 21 |
| 3 | 低剂量的^(13)C-尿素可准确诊断Hp感染显示文摘 | Gatta L Ricci C Tampieri A | 2006 | 中国处方药2006，5，5： | 9 |
| 4 | Characteristics of common solid liver lesions and recommendations for diagnostic workup显示文摘Due to the widespread clinical use of imaging modalities such as ultrasonography,computed tomography and magnetic resonance imaging (MRI),previously unsuspected liver masses are increasingly being found in asymptomatic patients.This review discusses the various characteristics of the most common solid liver lesions and recommends a practical approach for diagnostic workup.Likely diagnoses include hepatocellular carcinoma (the most likely;a solid liver lesion in a cirrhotic liver) and hemangioma (generally presenting as a mass in a non-cirrhotic liver).Focal nodular hyperplasia and hepatic adenoma should be ruled out in young women.In 70% of cases,MRI with gadolinium differentiates between these lesions.Fine needle core biopsy or aspiration,or both,might be required in doubtful cases.If uncertainty persists as to the nature of the lesion,surgical resection is recommended.If the patient is known to have a primary malignancy and the lesion was found at tumor staging or follow up,histology is required only when the nature of the liver lesion is doubtful. | Nimer Assy Gattas Nasser Agness Djibre Zaza Beniashvili Saad Elias Jamal Zidan | 2009 | World Journal of Gastroenterology2009，15，26： | 9 |
| 5 | Lower baseline ALT cut-off values and HBV DNA levels better differentiate HBeAg(-) chronic hepatitis B patients from inactive chronic carriers显示文摘AIM:To determine whether new cut-off values for alanine aminotransferase(ALT)and baseline hepatitis B virus(HBV)DNA levels better differentiate HBeAg(-) chronic hepatitis B(CHB)patients from inactive chronic carriers. METHODS:Ninety-one patients[32 HBeAg(+)CHB, 19 inactive carriers and 40 HBeAg(-)CHB]were followed up for 2 years and were tested for HBV DNA levels by a PCR-based assay.ALT was tested twice during the last 6 mo using new cut-off values:ULN(upper limit of normal)30 IU/L for males,19 IU/L for females. Diagnostic accuracy,sensitivity,specificity,positive and negative predictive values were calculated by discriminant analysis. RESULTS:When using the revised ALT cut-off values, the lowest optimal HBV DNA level that differentiated HBeAg(-)CHB patients from inactive carriers was 50000 copies/mL.The diagnostic accuracy of HBV DNA to determine inactive carriers with a cut-off of 50000 copies/mL was similar to the previously recommended cut-off of 100 000 copies/mL(91%).HBV DNA levels were lower than the cut-off value in 95%of inactive carriers and in 28%of HBeAg(-)CHB patients.With ALT<30 IU/L in men and<19 IU/L in women and HBV DNA levels<100 000 copies/mL,the risk of CHB is 5%.On the other hand,if ALT values were>30 IU in men and>19 IU in women and baseline HBV DNA levels were>100000 copies/mL,the risk is 86%. CONCLUSION:New cut-off values for ALT together with HBV DNA levels proposed by AASLD(American Association for the Study of Liver Diseases)and NIH (National Institute of Health)consensus seem appropriate to characterize inactive carriers. | Nimer Assy Zaza Beniashvili Agness Djibre Gattas Nasser Maria Grosovski William Nseir | 2009 | World Journal of Gastroenterology2009，15，24： | 7 |
| 6 | Global eradication rates for Helicobacter pylori infection: systematic review and meta-analysis of sequential therapy显示文摘 | Luigi Gatta Nimish Vakil Dino Vaira Carmelo Scarpignato | 2013 | BMJ (aug )2013，，071： | 7 |
| 7 | Can endoscopic atrophy predict histological atrophy? Historical study in United Kingdom and Japan显示文摘AIM: To assess the diagnostic concordance between endoscopic and histological atrophy in the United Kingdom and Japan.METHODS: Using published data,a total of 252 patients,126 in the United Kingdom and 126 in Japan,aged 20 to 80 years,were evaluated. The extent of endoscopic atrophy was classified into five subgroups according to a modified Kimura-Takemoto classification system and was compared with histological findings of atrophy at five biopsy sites according to the updated Sydney system.RESULTS: The strength of agreement of the extent of atrophy between histology and visual endoscopic inspection showed good reproducibili ty,wi th a weighted kappa value of 0.76(P < 0.001). Multivariate analysis showed that three factors were associated with decreased concordance: Japanese ethnicity [odds ratio(OR) 0.22,95% confidence interval(CI) 0.11-0.43],older age(OR = 0.32,95%CI: 0.16-0.66) and endoscopic atrophy(OR = 0.10,95%CI: 0.03-0.36). The strength of agreement between endoscopic and histological atrophy,assessed by cancer risk-oriented grading,was reproducible,with a kappa value of 0.81(95%CI: 0.75-0.87). Only nine patients(3.6%) were endoscopically underdiagnosed with antral predominant rather than extensive atrophy and were considered false negatives.CONCLUSION: Endoscopic grading can predict histological atrophy with few false negatives,indicating that precancerous conditions can be identified during screening endoscopy,particularly in patients in western countries. | Shin Kono Takuji Gotoda Shigeaki Yoshida Ichiro Oda Hitoshi Kondo Luigi Gatta Greg Naylor Michael Dixon Fuminori Moriyasu Anthony Axon | 2015 | World Journal of Gastroenterology2015，21，46： | 6 |
| 8 | Covert hepatic encephalopathy: Agreement and predictive validity of different indices显示文摘AIM:To investigate the agreement and prognosticvalue of different measures of covert hepatic encephalopathy(CHE).METHODS:One-hundred-and-thirty-two cirrhotic outpatients underwent electroencephalography(EEG),paper-and-pencil psychometry(PHES)and critical flicker frequency,scored on the original/modified(CFFo/CFFm)thresholds.Eighty-four patients underwent Dopplerultrasound to diagnose/exclude portal-systemic shunt.Seventy-nine were followed-up for 11±7 mo in relation to the occurrence of hepatic encephalopathy(HE)-related hospitalisations.RESULTS:On the day of study,36%had gradeⅠHE,42%abnormal EEG,33%abnormal PHES and 31/21%abnormal CFFo/CFFm.Significant associations were observed between combinations of test abnormalities;however,agreement was poor(Cohen’sκ<0.4).The prevalence of EEG,PHES and CFFo/CFFm abnormalities was significantly higher in patients with gradeⅠovert HE.The prevalence of EEG and CFFm abnormalities was higher in patients with shunt.The prevalence of EEG abnormalities was significantly higher in patients with a history of HE.During follow-up,10 patients died,10were transplanted and 29 had HE-related hospitalisations.GradeⅠHE(P=0.004),abnormal EEG(P=0.008)and abnormal PHES(P=0.04)at baseline all predicted the subsequent occurrence of HE;CFF did not.CONCLUSION:CHE diagnosis probably requires a combination of clinical,neurophysiological and neuropsychological indices. | Sara Montagnese Esmeralda Balistreri Sami Schiff Michele De Rui Paolo Angeli Giacomo Zanus Umberto Cillo Giancarlo Bombonato Massimo Bolognesi David Sacerdoti Angelo Gatta Carlo Merkel Piero Amodio | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 9 | Epidural electrical stimulation for spinal cord injury显示文摘A long-standing goal of spinal cord injury research is to develop effective repair strategies,which can restore motor and sensory functions to near-normal levels.Recent advances in clinical management of spinal cord injury have significantly improved the prognosis,survival rate and quality of life in patients with spinal cord injury.In addition,a significant progress in basic science research has unraveled the underlying cellular and molecular events of spinal cord injury.Such efforts enabled the development of pharmacologic agents,biomaterials and stem-cell based therapy.Despite these efforts,there is still no standard care to regenerate axons or restore function of silent axons in the injured spinal cord.These challenges led to an increased focus on another therapeutic approach,namely neuromodulation.In multiple animal models of spinal cord injury,epidural electrical stimulation of the spinal cord has demonstrated a recovery of motor function.Emerging evidence regarding the efficacy of epidural electrical stimulation has further expanded the potential of epidural electrical stimulation for treating patients with spinal cord injury.However,most clinical studies were conducted on a very small number of patients with a wide range of spinal cord injury.Thus,subsequent studies are essential to evaluate the therapeutic potential of epidural electrical stimulation for spinal cord injury and to optimize stimulation parameters.Here,we discuss cellular and molecular events that continue to damage the injured spinal cord and impede neurological recovery following spinal cord injury.We also discuss and summarize the animal and human studies that evaluated epidural electrical stimulation in spinal cord injury. | Elliot H.Choi Sandra Gattas Nolan J.Brown John D.Hong Joshua N.Limbo Alvin Y.Chan Michael Y.Oh | 2021 | Neural Regeneration Research2021，16，12： | 5 |
| 10 | Global eradication rates for Helicobacter pylori infection: systematic review and meta-analysis of sequential therapy显示文摘 | Luigi Gatta Nimish Vakil Dino Vaira Carmelo Scarpignato | 2013 | BMJ2013，，0： | 5 |
| 11 | Novel mutation in the ligand-binding domain of the androgen receptor gene (1790p) associated with complete androgen insensitivity syndrome显示文摘在基因在敏感症候群(AIS ) 引起雄激素的 X 连接雄激素受体(AR ) 的变化,在 46 导致损害的胚胎的性区别, XY 基因人。在敏感(CAIS ) 的完全的雄激素生产女外部显型,而有在敏感(白族) 的部分雄激素的盒子有生殖器的各种各样的歧义。在敏感(MAIS ) 的温和雄激素被 undermasculinization 和男子女性型乳房描绘。这里,我们描述 2-month-old 46, XY 女病人,与所有 CAIS 的特征。在睾丸激素(T) 和二氢睾酮(DHT ) 合成背叛被排除。AR 基因定序在 790 上在鳕鱼的第二个库在 6 一 T 上在前显示出存在到 C 转变,核苷酸位置 2369,在 AR 蛋白质的 ligand 有约束力的域引起一个新奇错误感觉 Leu790Pro 变化。在有 CAIS 的一个女孩的一个新奇 AR 变化的鉴定在 AR 的 ligand 有约束力的领域由于错误感觉变化的重要性提供重要信息,它能在雄激素绑定能力,活跃符合构造的稳定,或和激活剂的相互作用导致功能的畸形。 | Florina Raicu Rossella Giuliani Valentina Gatta Chiara Palka Paolo Guanciali Franchi Pierluigi Lelli-Chiesa Stefano Tumini Liborio Stuppia | 2008 | Asian Journal of Andrology2008，10，4： | 4 |
| 12 | Culture-Based Selection Therapy for Patients Who Did Not Respond to Previous Treatment for Helicobacter pylori Infection显示文摘 | Giulia Fiorini Nimish Vakil Angelo Zullo Ilaria M. Saracino Valentina Castelli Chiara Ricci Cristina Zaccaro Luigi Gatta Dino Vaira | 2012 | Clinical Gastroenterology and Hepatology2012，，： | 3 |
| 13 | Yield Response to Deficit Irrigation and Partial Root-Zone Drying in Processing Tomato (Lycopersicon esculentum Mill,)显示文摘 | Eugenio Nardella Marcella Michela Giuliani Giuseppe Gatta Antonio De Caro | 2012 | Journal of Agricultural Science and Technology(A)2012，2，2： | 3 |
| 14 | Recent cancer survival in Europe: a 2000–02 period analysis of EUROCARE-4 data显示文摘 | Arduino Verdecchia Silvia Francisci Hermann Brenner Gemma Gatta Andrea Micheli Lucia Mangone Ian Kunkler | 2007 | Lancet Oncology2007，，9： | 3 |
| 15 | 患者独处诊室血压和非独处诊室血压与临床前靶器官损害的关系显示文摘患者独处的自动诊室血压或自动血压测量方法可能优于传统血压测量方法。目前一些国际指南建议自动化测量血压作为血压测量的首选方法。与标准血压测量方法所获数据比较,自动化测量血压与心血管事件的关系并不明确。初步数据显示:自动化测量血压可能与靶器官损害更相关。该研究的目的是评估在欧洲高血压学会卓越中心(excellence center)行超声心动图及颈动脉超声检查的564例患者独处诊室血压、非独处诊室血压与靶器官损害的关系。 | Salvetti M Paini A Aggiusti C Bertacchini F Stassaldi D Capellini S Ciuceis CD Rizzoni D Gatta R Rosei EA Muiesan ML 赵狄(摘译) 练桂丽(审校) | 2019 | 中华高血压杂志2019，0，3： | 2 |
| 16 | Occupational exposures and colorectal cancers:A quantitative overview of epidemiological evidence显示文摘A traditional belief widespread across the biomedical community was that dietary habits and genetic predisposition were the basic factors causing colorectal cancer.In more recent times,however,a growing evidence has shown that other determinants can be very important in increasing(or reducing) incidence of this malignancy.The hypothesis that environmental and occupational risk factors are associated with colorectal cancer is gaining ground,and high risks of colorectal cancer have been reported among workers in some industrial branches.The aim of this study was to investigate the epidemiologic relationship between colorectal cancer and occupational exposures to several industrial activities,by means of a scientific literature review and meta-analysis.This work pointed out increased risks of colorectal cancer for labourers occupied in industries with a wide use of chemical compounds,such as leather(RR = 1.70,95%CI:1.24-2.34),basic metals(RR = 1.32,95%CI:1.07-1.65),plastic and rubber manufacturing(RR = 1.30,95%CI:0.98-1.71 and RR = 1.27,95%CI:0.92-1.76,respectively),besides workers in the sector of repair and installation of machinery exposed to asbestos(RR = 1.40,95%CI:1.07-1.84).Based on our results,the estimated crude excess risk fraction attributable to occupational exposure ranged from about 11% to about 15%.However,homogeneous pattern of association between colorectal cancer and industrial branches did not emerge from this review. | Enrico Oddone Carlo Modonesi Gemma Gatta | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 17 | Global eradication rates for Helicobacter pylori infection: systematic review and meta-analysis of sequential therapy显示文摘 | Luigi Gatta Nimish Vakil Dino Vaira Carmelo Scarpignato | 2013 | BMJ . 2013 (aug0)2013，，： | 2 |
| 18 | Oligodendroglioma 显示文摘 | Van den Bent M J Reni M Gatta G | 2008 | Crit Rev Oncol Hemato12008，66，3： | 1 |
| 19 | Nutrition and survival in patients with liver cirrhosis显示文摘 | Alberino F Gatta A Amodio P | 2001 | Nutrition2001，17，6： | 1 |
| 20 | Determination of electroactive organic acids by anion-exchange chromatography using a copper modified electrode显示文摘 | Innocenzo G Casella Maria Gatta | 2001 | Journal of Chromatography A2001，912，： | 1 |
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