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| 1 | Clinical features and management of primary biliary cirrhosis显示文摘Primary biliary cirrhosis(PBC),which is characterised by progressive destruction of intrahepatic bile ducts,is not a rare disease since both prevalence and incidence are increasing during the last years mainly due to the improvement of case finding strategies.The prognosis of the disease has improved due to both the recognition of earlier and indolent cases,and to the wide use of ursodeoxycholic acid(UDCA).New indicators of prog-nosis are available that will be useful especially for the growing number of patients with less severe disease.Most patients are asymptomatic at presentation.Pruri-tus may represent the most distressing symptom and,when UDCA is ineffective,cholestyramine represents the mainstay of treatment.Complications of long-standing cholestasis may be clinically relevant only in very ad-vanced stages.Available data on the effects of UDCA on clinically relevant end points clearly indicate that the drug is able to slow but not to halt the progression of the disease while,in advanced stages,the only thera-peutic option remains liver transplantation. | Andrea Crosignani Pier Maria Battezzati Pietro Invernizzi Carlo Selmi Elena Prina Mauro Podda | 2008 | World Journal of Gastroenterology2008，14，21： | 23 |
| 2 | Experimental evidence on the immunopathogenesis of primary biliary cirrhosis显示文摘Primary biliary cirrhosis(PBC)is a chronic cholestatic liver disease for which an autoimmune pathogenesis is supported by clinical and experimental data,including the presence of autoantibodies and autoreactive T cells.The etiology remains to be determined,yet data suggest that both a susceptible genetic background and unknown environmental factors determine disease onset.Multiple infectious and chemical candidates have been proposed to trigger the disease in a genetically susceptible host,mostly by molecular mimicry.Most recently,several murine models have been reported,including genetically determined models as well as models induced by immunization with xenobiotics and bacteria. | Carlo Selmi Francesca Meda Anaid Kasangian Pietro Invernizzi Zhigang Tian Zhexiong Lian Mauro Podda M Eric Gershwin | 2010 | Cellular & Molecular Immunology2010，7，1： | 14 |
| 3 | Intraoperative use of indocyanine green fluorescence imaging in rectal cancer surgery: The state of the art显示文摘Indocyanine green(ICG)fluorescence imaging is widely used in abdominal surgery.The implementation of minimally invasive rectal surgery using new methods like robotics or a transanal approach required improvement of optical systems.In that setting,ICG fluorescence optimizes intraoperative vision of anatomical structures by improving blood and lymphatic flow.The purpose of this review was to summarize all potential applications of this upcoming technology in rectal cancer surgery.Each type of use has been separately addressed and the evidence was investigated.During rectal resection,ICG fluorescence angiography is mainly used to evaluate the perfusion of the colonic stump in order to reduce the risk of anastomotic leaks.In addition,ICG fluorescence imaging allows easy visualization of organs such as the ureter or urethra to protect them from injury.This intraoperative technology is a valuable tool for conducting lymph node dissection along the iliac lymphatic chain or to better identifying the rectal dissection planes when a transanal approach is performed.This is an overview of the applications of ICG fluorescence imaging in current surgical practice and a synthesis of the results obtained from the literature.Although further studies are need to investigate the real clinical benefits,these findings may enhance use of ICG fluorescence in current clinical practice and stimulate future research on new applications. | Roberto Peltrini Mauro Podda Simone Castiglioni Maria Michela Di Nuzzo Michele D'Ambra Ruggero Lionetti Maurizio Sodo Gaetano Luglio Felice Mucilli Salomone Di Saverio Umberto Bracale Francesco Corcione | 2021 | World Journal of Gastroenterology2021，27，38： | 3 |
| 4 | Deep Learning and Time Series-to-Image Encoding for Financial Forecasting显示文摘In the last decade,market financial forecasting has attracted high interests amongst the researchers in pattern recognition.Usually,the data used for analysing the market,and then gamble on its future trend,are provided as time series;this aspect,along with the high fluctuation of this kind of data,cuts out the use of very efficient classification tools,very popular in the state of the art,like the well known convolutional neural networks(CNNs)models such as Inception,Res Net,Alex Net,and so on.This forces the researchers to train new tools from scratch.Such operations could be very time consuming.This paper exploits an ensemble of CNNs,trained over Gramian angular fields(GAF)images,generated from time series related to the Standard&Poor's 500 index future;the aim is the prediction of the future trend of the U.S.market.A multi-resolution imaging approach is used to feed each CNN,enabling the analysis of different time intervals for a single observation.A simple trading system based on the ensemble forecaster is used to evaluate the quality of the proposed approach.Our method outperforms the buyand-hold(B&H)strategy in a time frame where the latter provides excellent returns.Both quantitative and qualitative results are provided. | Silvio Barra Salvatore Mario Carta Andrea Corriga Alessandro Sebastian Podda Diego Reforgiato Recupero | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，3： | 2 |
| 5 | Y chromosome loss in male patients with primary biliary cirrhosis显示文摘 | Ana Lleo Sabine Oertelt-Prigione Ilaria Bianchi Lisa Caliari Palma Finelli Monica Miozzo Roberta Lazzari Annarosa Floreani Francesca Donato Massimo Colombo M. Eric Gershwin Mauro Podda Pietro Invernizzi | 2013 | Journal of Autoimmunity2013，，： | 2 |
| 6 | Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism in medulloblastoma/PNET and Hodgkin lymphoma:a prospective cohort study显示文摘Primary hypothyroidism commonly occurs after radiotherapy(RT),and coincides with increased circulating thyroid-stimulating hormone(TSH)levels.We tested therefore the protective effect of suppressing TSH with L-thyroxine during RT for medulloblastoma/PNET and Hodgkin lymphoma(HL)in a prospective cohort study.From 1998 to 2001,a total of 37 euthyroid children with medulloblastoma/PNET plus 14 with HL,scheduled for craniospinal irradiation and mediastinum/neck radiotherapy,respectively,underwent thyroid ultrasound and free triiodothyronine(FT3),free thyroxine(FT4),and TSH evaluation at the beginning and end of craniospinal iiradiation.From 14 days before and up to the end of radiotherapy,patients were administered L-thyroxine checking every 3 days TSH to ensure a value<0.3μIU/mL.During follow-up,blood tests and ultrasound were repeated;primary hypothyroidism was considered an increased TSH level greater than normal range.Twenty-two/37 patients with medulloblastoma/PNET and all the 14 patients with HL were alive after a median 231 months from radiotherapy with 7/22 and 8/14 having correctly reached TSH levels˂0.3μIU/mL and well matched for other variables.Twenty years on,hypothyroidism-free survival rates differed significantly,being 60%±15%and 15.6%±8.2%in TSH-suppressed vs.not-TSH suppressed patients,respectively(P=0.001).These findings suggest that hypothyroidism could be durably prevented in two populations at risk of late RT sequelae,but it should be confirmed in a larger cohort. | Maura Massimino Marta Podda Lorenza Gandola Emanuele Pignoli Ettore Seregni Carlo Morosi Filippo Spreafico Andrea Ferrari Emilia Pecori Monica Terenziani | 2021 | Frontiers of Medicine2021，15，1： | 2 |
| 7 | Do procalcitonin algorithms modify mortality显示文摘 | Ferrari L Casella F Podda GM | | 0，，02： | 1 |
| 8 | MF59 is a safe and potent vaccine adjuvant for flu vaccines in humans:what did we learn during its development显示文摘 | O'HAGAN D T WACK A PODDA A | 2007 | Clin Pharmacol Ther2007，82，6： | 1 |
| 9 | An uncommon presentation of metastatic melanoma : a case report 显示文摘 | Reccia I Pisanu A Podda M | 2015 | Medicine ( Baltimore)2015，94，7： | 1 |
| 10 | Heavy metal coprecipitation with hydrozincite from mine waters caused by photosynthetic microorganisms 显示文摘 | PODDA F ZUDDAS P MINACCI A | 2000 | Appl Environ Microbiol2000，66，11： | 1 |
| 11 | Outcome of an outbreak of acute hepatitis C among healthy volunteers participating in pharmacokinetics studies显示文摘 | Alberto Larghi Massimo Zuin Andrea Crosignani Maria Lisa Ribero Cristina Pipia Pier Maria Battezzati Giorgio Binelli Francesco Donato Alessandro Remo Zanetti Mauro Podda Alessandro Tagger | 2002 | Hepatology2002，，4： | 1 |
| 12 | CD30 in normal and neoplastic cells显示文摘 | CHIARLE R PODDA A PROLLA G | 1999 | Clin Immunol1999，90，2： | 1 |
| 13 | CD30 over express ion enhances negative selection in the thymus and mediates programmmed cell death via a Bcl-2 sensitive pathway显示文摘 | Chiarle R Podda A Prolla G | | 0，，01： | 1 |
| 14 | Vereinfachtes Verfahren Zur Berechung von Tellerfedern显示文摘 | Curti G Orlando M Podda G | 1980 | Draht1980，31，11： | 1 |
| 15 | The limitations and hidden gems of the epidemiology of primary biliary cirrhosis显示文摘 | Mauro Podda Carlo Selmi Ana Lleo Luca Moroni Pietro Invernizzi | 2013 | Journal of Autoimmunity2013，，： | 1 |
| 16 | A novel keratinocyte mitogen: regulation of leptin and its funtional receptor in skin repair显示文摘 | Stallmeyer B Kampfer H Podda M | 2001 | J Invest Dermatol2001，117，1： | 1 |
| 17 | Interpreting serological tests in diagnosing autoimmune liver diseases显示文摘 | Invernizzi P Lleo A Podda M | 2007 | Semin Liver Dis2007，27，： | 1 |
| 18 | Prophylactic antibiotics in aesthetic surgery 显示文摘 | Wolfe SA Podda S | 2006 | Aesthet Surg J2006，26，1： | 1 |
| 19 | Exposure to extremely low-frequency (50 Hz) electromagnetic fields enhances adult hippocampal neurogenesis in C57BL/6 mice显示文摘 | CUCCURAZZU B LEONE L PODDA M V | 2010 | Exp Neurol2010，226，1： | 1 |
| 20 | Nodal metastasis and recurrence in papillary thyroid microcarcinoma显示文摘 | Pisanu A Saba A Podda M | 2015 | En- docrine2015，48，2： | 1 |
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