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| 1 | Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer显示文摘The prognosis of patients with metastatic colorectal cancer(m CRC) remain poor despite the impressive improvement of treatments observed over the last 20 years that led to an increase in median overall survival from 6 mo, with the only best supportive care, to approximately 30 mo with the introduction of active chemotherapy drugs and targeted agents. The monoclonal antibodies(mo Abs) cetuximab and panitumumab, directed against the epidermal growth factor receptor(EGFR), undoubtedly represent a major step forward in the treatment of m CRC, given the relevant efficacy in terms of progression-free survival, overall survival, response rate, and quality of life observed in several phase Ⅲ clinical trials among different lines of treatment. However, the anti-EGFR mo Abs were shown only to be effective in a subset of patients. For instance, KRAS and NRAS mutations have been identified as biomarkers of resistance to these drugs, improving the selection of patients who might derive a benefit from these treatments. Nevertheless, several other alterations might affect the response to these drugs, and unfortunately, even the responders eventually become resistant by developing secondary(or acquired) resistance in approximately 13-18 mo. Several studies highlighted that the landscape of responsible alterations of both primary and acquired resistance to anti-EGFR drugs biochemically converge into MEK-ERK and PIK3CA-AKT pathways. In this review, we describe the currently known mechanisms of primary and acquired resistance to anti-EGFR mo Abs together with the various strategies evaluated to prevent, overcame or revert them. | Vincenzo Sforza Erika Martinelli Fortunato Ciardiello Valentina Gambardella Stefania Napolitano Giulia Martini Carminia della Corte Claudia Cardone Marianna L Ferrara Alfonso Reginelli Giuseppina Liguori Giulio Belli Teresa Troiani | 2016 | World Journal of Gastroenterology2016，22，28： | 6 |
| 2 | Investigation of compensatory postures with videofluoromanometry in dysphagia patients显示文摘AIM: To investigate the effectiveness of head compensatory postures to ensure safe oropharyngeal transit. METHODS: A total of 321 dysphagia patients were enrolled and assessed with videofluoromanometry (VFM). The dysphagia patients were classified as follows: safe transit; penetration without aspiration; aspiration before, during or after swallowing; multiple aspirations and no transit. The patients with aspiration or no transit were tested with VFM to determine whether compensatory postures could correct their swallowing disorder. RESULTS: VFM revealed penetration without aspiration in 71 patients (22.1%); aspiration before swallowing in 17 patients (5.3%); aspiration during swallowing in 32 patients (10%); aspiration after swallowing in 21 patients (6.5%); multiple aspirations in six patients (1.9%); no transit in five patients (1.6%); and safe transit in 169 patients (52.6%). Compensatory postures guaranteed a safe transit in 66/75 (88%) patients with aspiration or no transit. A chin-down posture achieved a safe swallow in 42/75 (56%) patients, a head-turned posture in 19/75 (25.3%) and a hyperextended head posture in 5/75 (6.7%). The compensatory postures were not effective in 9/75 (12%) cases. CONCLUSION: VFM allows the speech-language therapist to choose the most effective compensatory posture without a trial-and-error process and check the effectiveness of the posture. | Antonio Solazzo Luigi Monaco Lucia Del Vecchio Stefania Tamburrini Francesca Iacobellis Daniela Berritto Nunzia Luisa Pizza Alfonso Reginelli Natale Di Martino Roberto Grassi | 2012 | World Journal of Gastroenterology2012，18，23： | 3 |
| 3 | Intracranial Hemorrhage and Hyperperfusion Syndrome following Carotid Artery Stenting:Risk Factors,Prevention,and Treatment显示文摘 | ABOU-CHEBL A YADAV JS REGINELLI JP | 2004 | J Am Coll Cardiol(S0735-1097)2004，43，9： | 1 |
| 4 | Ankle fracture: radiographic approach according to the Lauge-Hansen classification显示文摘 | Russo A Reginelli A Zappia M | 2013 | Musculoskelet Surg2013，97，2： | 1 |
| 5 | Intestinal Ischemia: US-CT findings correlations显示文摘 | A Reginelli EA Genovese S Cappabianca F Iacobellis D Berritto P Fonio F Coppolino R Grassi | 2013 | Critical Ultrasound Journal2013，，1： | 1 |
| 6 | Intracranial Hemor rhage and hyperperfusion syndrome following carotid artery stent ing risk factors,prevention, and treatment显示文摘 | Abou - Chebl A Yadav JS Reginelli JP | 2004 | J Am Coll Cardiol2004，43，9： | 1 |
| 7 | Intracranial hem orrhage and hyperperfusion syndrome following carotid artery stenting: risk factors, prevention,and treatment显示文摘 | Abou-Chebl A Yadav JS Reginelli JP | 2004 | J Am Coll Cardiol2004，43，9： | 1 |
| 8 | Intracranial hemorrhage and hyperperfusion syndrome following carotid artery stenting: risk factors, prevention, and treatment 显示文摘 | Abou-Chebl A Yadav JS Reginelli JP | 2004 | J Am Coll Cardiol2004，43，9： | 1 |
| 9 | lntracranial hemorrhage and hyperperfusion syndrome following carotid artery stenting: risk factors, prevention, and treatment 显示文摘 | Abou-Chebl A Yadav JS Reginelli JP | 2004 | J Am Collcardiol2004，43，： | 1 |
| 10 | Intracranial Hemorrhage and Hyperperfusion Syndrome following Carotid Artery Stenting:Risk Factors,Prevention, and Treatment显示文摘 | Abou-chebl A Yadav JS Reginelli JP | 2004 | J Am Coll Cardiol(S0735-- 1097)2004，43，9： | 1 |
| 11 | Intracranial hemorrhage and hyperfusion syndrome following carotid artery stenting:risk factors,prevention,and treatment显示文摘 | Abou-Chebl A Yadav JS Reginelli JP | 2004 | J Am Coll Cardiol2004，43，9： | 1 |
| 12 | Intracra- nial hemorrhage and hyperperfusion syndrome following ca- rotid artery stenting: risk factors, prevention, and treat- ment 显示文摘 | Abou-Chebl A Yadav J S Reginelli J P | 2004 | J Am Coll Cardiol2004，43，9： | 1 |
| 13 | Intracranial hemorrhage and hyperperfusion syndrome following carotid artery stenting: risk factors, prevention, and treatment显示文摘 | Abou-Chebl A Yadav JS Reginelli JP | 2004 | J Am Coil Cardiol2004，43，9： | 1 |
| 14 | Intracranial hemorrhage and hyperperfusion syndrome following carotid artery stenting: risk factors, prevention, and treatment 显示文摘 | Abou-Chebl A Reginelli J Bajzer CT | 2004 | J Am Coll Cardiol2004，43，9： | 1 |
| 15 | Intracranial hemorrhage and hyperperfusion syndrome following carotid artery stenting: risk factors, prevention, and treatment显示文摘 | Abou-Chebl A Yadav JS Reginelli JP | 2004 | J Am Coil Cardiol2004，43，： | 1 |
| 16 | Intracranial hemor- rhage and hyperperfusion syndrome following carotid artery stenting: risk factors, prevention, and treatment 显示文摘 | Abou-Chebl A Yadav J S Reginelli J P | 2004 | J Am Coil Cardiol2004，43，9： | 1 |
| 17 | Intracranial hemorrhage and hyperperfusion syndrome following carotid artery stenting:risk factors,prevention,and treatment显示文摘 | Yadav JS Reginelli JP | 2004 | J Am Coll Cardiol2004，43，： | 1 |
| 18 | Intensive treatment of hypertension decreases the risk of hyperperfusion and intracerebral hemorrhage following carotid artery stenting 显示文摘 | Abou-Chebl A Reginelli J Bajzer CT | 2007 | Catheter Cardiovasc Interv2007，69，5： | 1 |
| 19 | Dynamic MRI defecography vs entero-colpo-cysto-defecography in the evaluation of midline pelvic floor hernias in female pelvic floor disorders显示文摘 | Salvatore Cappabianca Alfonso Reginelli Francesca Iacobellis | 2011 | International Journal of Colorectal Disease2011，26，9： | 1 |
| 20 | Ankle fracture:Radiographic approach according to the Lauge-Hansen classification显示文摘 | Russo A Reginelli A Zappia M | 2013 | Mus-culoskelet Surg2013，97，2： | 1 |
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