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| 1 | Digital subtraction angiography for the analysis of supraaortic vessels: What is its role nowadays?显示文摘For about 50 years, angiography represented the only imaging method for studying carotid arteries in order to detect the presence of pathological stenosis due to atherosclerotic plaque. Recently, thanks to the use of non-invasive methods, physicians are able to study and quantify the presence of carotid atherosclerosis in vivo These procedures have enabled the introduction of new concepts: (1) the degree of carotid stenosis is approxi- mate to the volume and extension of carotid plaque; and (2) a set of parameters, easily identifiable by com- puted tomography angiography, magnetic resonance angiogram and ultra-sound echo-color Doppler, are closely linked to the development of ischemic symptoms and can significantly increase the risk of stroke regard- less of the degree of stenosis. In light of these findings vulnerable plaques should be identified early, and the role of Digital Subtraction Angiography which is a purely technical luminal technique should be determined. | Luca Saba | 2011 | World Journal of Radiology2011，3，6： | 6 |
| 2 | Acute arterial mesenteric ischemia and reperfusion:Macroscopic and MRI findings, preliminary report显示文摘AIM:To explore the physiopathology and magnetic resonance imaging(MRI)findings in an animal model of acute arterial mesenteric ischemia(AAMI)with and without reperfusion.METHODS:In this study,8 adult Sprague-Dawley rats underwent superior mesenteric artery(SMA)ligation and were then randomly divided in two groups of 4.In groupⅠ,the ischemia was maintained for 8 h.In groupⅡ,1-h after SMA occlusion,the ligation was removed by cutting the thread fixed on the back of the animal,and reperfusion was monitored for 8 h.MRI was performed using a 7-T system.RESULTS:We found that,in the case of AAMI without reperfusion,spastic reflex ileus,hypotonic reflex ileus,free abdominal fluid and bowel wall thinning are present from the second hour,and bowel wall hyperintensity in T2-W sequences are present from the fourth hour.The reperfusion model shows the presence of early bowel wall hyperintensity in T2-W sequences after 1 h and bowel wall thickening from the second hour.CONCLUSION:Our study has shown that MRI can assess pathological changes that occur in the small bowel and distinguish between the presence and absence of reperfusion after induced acute arterial ischemia. | Luca Saba Daniela Berritto Francesca Iacobellis Mariano Scaglione Sigismondo Castaldo Santolo Cozzolino Maria Antonietta Mazzei Veronica Di Mizio Roberto Grassi | 2013 | World Journal of Gastroenterology2013，19，40： | 5 |
| 3 | Carotid artery endarterectomy in patients with symptomatic non-stenotic carotid artery disease显示文摘Object We sought to determine the safety and efficacy in secondary stroke prevention of carotid endarterectomy(CEA)in patients with symptomatic non-stenotic carotid artery disease(SyNC).Methods This was a single-centre retrospective case series.All patients who underwent CEA for unilateral anterior circulation cerebrovascular events with ipsilateral<50%carotid stenosis from 2002 to 2020 were included.Imaging hallmarks including the degree of luminal stenosis and the presence of various vulnerable plaque characteristics(eg,intraplaque haemorrhage(IPH)on MR angiography,ulceration or low-density plaque on CT angiography)were assessed.The presence of vulnerable plaque characteristics was compared between arteries ipsilateral to the ischaemic event and contralateral arteries.The prevalence of perioperative/intraoperative complications,as well as recurrent ischaemic events at follow-up was determined.Results Thirty-two patients were included in the analysis,of which 25.0%were female.Carotid arteries ipsilateral to an ischaemic event had a significantly higher prevalence of IPH when compared with contralateral arteries(80.0%vs 0.0%;p<0.001).There were no intraoperative complications.One patient(3.1%)developed symptoms of transient ipsilateral ischaemia 1 day following CEA which resolved without treatment.In a median follow-up of 18.0 months(IQR 5.0-36.0),only one patient(3.1%)experienced a transient neurologic deficit with complete resolution(annualised rate of recurrent stroke after CEA of 1.5%for a total follow-up of 788 patient-months following CEA).All other patients(31/32,96.9%)were free of recurrent ischaemic events.Conclusion CEA appears to be safe and well-tolerated in patients with SyNC.Additional studies with larger cohorts and longer follow-up intervals are needed in order to determine the role of CEA in this patient population. | Valentina Nardi John C Benson Anthony S Larson Waleed Brinjikji Luca Saba Fredric B Meyer Giuseppe Lanzino Amir Lerman Luis E Savastano | 2022 | Stroke & Vascular Neurology2022，7，3： | 1 |
| 4 | Anatomic variations of arterial liver vascularization: an analysis by using MDCTA 显示文摘 | Luca Saba Giorgio Mallarinietc | 2011 | Surg Radiol Anat2011，33，： | 1 |
| 5 | Multidetector-row CT angiography in the study of atherosclerotic carotid arteries显示文摘 | Luca Saba Roberto Sanfilippo Raimondo Pirisi Luigi Pascalis Roberto Montisci Giorgio Mallarini | 2007 | Neuroradiology2007，，8： | 1 |
| 6 | Obesity and pericallosal lipoma in X-linked emery-dreifuss muscular dystrophy:A case report-Does Emerin play a role in adipocyte differentiation?显示文摘Emery dreifuss muscular dystrophy(EDMD) is a rare genetic syndrome consisting of tendon retractions,progressive muscle atrophy and cardiac involvement.We report a case of an obese patient affected by the familial X-linked form in which a pericallosal lipoma was found during investigation for a suspected acute vasculopathy.To date,EDMD has never been associated with cerebral lipomas and the X-linked form was never considered to be involved in lipodystrophic syndromes or non-muscular conditions.Our case confirms the variable expressivity of the disease and suggests a possible role of Emerin in the intranuclear regulation of signals for adipocyte cell differentiation. | Fabio Spanu Luca Saba | 2018 | World Journal of Radiology2018，10，7： | 1 |
| 7 | Anatomic variations of arte rial liver vascularization: an analysis by using MDCTA显示文摘 | Luca Saba Giorgio Mallarinietc | 2011 | Surg Radiol Anat2011，33，7： | 1 |
| 8 | Clinical study ofperoneal artery perforators with computed tomographic an-giography:implications for fibular flap harvest显示文摘 | Diego Ribuffo Matteo Atzeni Luca Saba | 2010 | Surg Ra-diol Anat2010，32，： | 1 |
| 9 | Learning curve in the detection of ovarian and deep endometriosis by using Magnetic Resonance显示文摘 | Luca Saba Stefano Guerriero Rosa Sulis Monica Pilloni Silvia Ajossa Gianbenedetto Melis Giorgio Mallarini | 2010 | European Journal of Radiology2010，，2： | 1 |
| 10 | Intima Media Thickness Variability (IMTV) and its association with cerebrovascular events: A novel marker of carotid atherosclerosis?显示文摘 | Luca Saba Giorgio Mallarini Roberto SanfiliMAPo | 2012 | Cardiovascular Diagnosis and Therapy2012，2，： | 1 |
| 11 | Carotid artery wall thickness and ischemic symptoms: evaluation using multi-detector-row CT angiography显示文摘 | Luca Saba Roberto Sanfilippo Luigi Pascalis Roberto Montisci Giancarlo Caddeo Giorgio Mallarini | 2008 | European Radiology2008，，9： | 1 |
| 12 | Imaging of the Carotid Artery Vulnerable Plaque显示文摘 | Luca Saba Michele Anzidei Beatrice Cavallo Marincola Mario Piga Eytan Raz Pier Paolo Bassareo Alessandro Napoli Lorenzo Mannelli Carlo Catalano Max Wintermark | 2014 | CardioVascular and Interventional Radiology2014，，3： | 1 |
| 13 | Carotid artery wall thickness: comparison between sonography and multi-detector row CT angiography显示文摘 | Luca Saba Roberto Sanfilippo Roberto Montisci Giorgio Mallarini | 2010 | Neuroradiology2010，，2： | 1 |
| 14 | Bidirectional link between diabetes mellitus and coronavirus disease 2019 leading to cardiovascular disease:A narrative review显示文摘Coronavirus disease 2019(COVID-19)is a global pandemic where several comorbidities have been shown to have a significant effect on mortality.Patients with diabetes mellitus(DM)have a higher mortality rate than non-DM patients if they get COVID-19.Recent studies have indicated that patients with a history of diabetes can increase the risk of severe acute respiratory syndrome coronavirus 2 infection.Additionally,patients without any history of diabetes can acquire newonset DM when infected with COVID-19.Thus,there is a need to explore the bidirectional link between these two conditions,confirming the vicious loop between“DM/COVID-19”.This narrative review presents(1)the bidirectional association between the DM and COVID-19,(2)the manifestations of the DM/COVID-19 loop leading to cardiovascular disease,(3)an understanding of primary and secondary factors that influence mortality due to the DM/COVID-19 loop,(4)the role of vitamin-D in DM patients during COVID-19,and finally,(5)the monitoring tools for tracking atherosclerosis burden in DM patients during COVID-19 and“COVID-triggered DM”patients.We conclude that the bidirectional nature of DM/COVID-19 causes acceleration towards cardiovascular events.Due to this alarming condition,early monitoring of atherosclerotic burden is required in“Diabetes patients during COVID-19”or“new-onset Diabetes triggered by COVID-19 in Non-Diabetes patients”. | Vijay Viswanathan Anudeep Puvvula Ankush D Jamthikar Luca Saba Amer M Johri Vasilios Kotsis Narendra N Khanna Surinder K Dhanjil Misha Majhail Durga Prasanna Misra Vikas Agarwal George D Kitas Aditya M Sharma Raghu Kolluri Subbaram Naidu Jasjit S Suri | 2021 | World Journal of Diabetes2021，12，3： | 0 |
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