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| 1 | The enhanced element enrichment in the supercritical states of granite–pegmatite systems显示文摘In this paper, we show that supercritical fluids have a greater significance in the generation of pegmatites,and for ore-forming processes related to granites than is usually assumed. We show that the supercritical melt or fluid is a silicate phase in which volatiles; principally H_2O are completely miscible in all proportions at magmatic temperatures and pressures. This phase evolves from felsic melts and changes into hydrothermal fluids, and its unique properties are particularly important in sequestering and concentrating low abundance elements, such as metals. In our past research, we have focused on processes observed at upper crustal levels, however extensive work by us and other researchers have demonstrated that supercritical melt/fluids should be abundant in melting zones at deep-crustal levels too. We propose that these fluids may provide a connecting link between lower and upper crustal magmas,and a highly efficient transport mechanism for usually melt incompatible elements. In this paper, we explore the unique features of this fluid which allow the partitioning of variouselements and compounds, potentially up to extreme levels,and may explain various features both of mineralization and the magmas that produced them. | Rainer Thomas Paul Davidson Karen Appel | 2019 | Acta Geochimica2019，38，3： | 8 |
| 2 | The human TTAGGG repeat factors I and 2 bind to a subsetof interstitial telomeric sequences and satellite repeats显示文摘 | Thomas Simonet Laure-Emmanuelle Zaragosi Claude Philippe Kevin Lebrigand Cldmentine Schouteden Adeline Augereau Serge Bauwens Jing Ye Marco Santagostino Elena Giulotto Frederique Magdinier Beatrice Horard Pascal Barbry Rainer Waldmann Eric Gilson | 2011 | Cell Research2011，21，7： | 7 |
| 3 | Effect of Bacillus subtilis and Bacillus licheniformis supplementation in diets with low-and high-protein content on ileal crude protein and amino acid digestibility and intestinal microbiota composition of growing pigs显示文摘Background: Bacillus spp. seem to be an alternative to antimicrobial growth promoters for improving animals' health and performance. However, there is little information on the effect of Bacillus spp. in combination with different dietary crude protein(CP) levels on the ileal digestibility and microbiota composition. Therefore, the objective of this study was to determine the effect of Bacillus spp. supplementation to low-(LP) and high-protein diets(HP) on ileal CP and amino acid(AA) digestibility and intestinal microbiota composition.Methods: Eight ileally cannulated pigs with an initial body weight of 28.5 kg were randomly allocated to a rowcolumn design with 8 pigs and 3 periods of 16 d each. The assay diets were based on wheat-barley-soybean meal with two protein levels: LP(14% CP, as-fed) and HP diet(18% CP, as-fed). The LP and HP diets were supplemented with or without Bacil us spp. at a level of 0.04%(as-fed). The apparent ileal digestibility(AID) and standardized ileal digestibility(SID) of CP and AA was determined. Bacterial community composition from ileal digesta was analyzed by Illumina amplicon sequencing and quantitative real-time PCR. Data were analyzed as a 2 × 2 factorial design using the GLIMMIX procedures of SAS.Results: The supplementation with Bacillus spp. did not affect both AID and SID of CP and AA in growing pigs.Moreover, there was no difference in AID of CP and AA between HP and LP diets, but SID of cystine, glutamic acid,glycine, and proline was lower(P < 0.05) in pigs fed the HP diets. The HP diets increased abundance of Bifidobacterium spp. and Lactobacillus spp.,(P < 0.05) and by amplicon sequencing the latter was identified as predominant genus in microbiota from HP with Bacillus spp., whereas dietary supplementation of Bacillus spp. increased(P < 0.05) abundance of Roseburia spp.Conclusions: The HP diet increased abundance of Lactobacillus spp. and Bifidobacterium spp.. The supplementation of Bacil us spp. resulted in a higher abundance of healthy gut associated bacteria without affecting ileal CP and AA digestibility, whereas LP diet may reduce the flow of undigested protein to the large intestine of pigs. | Chanwit Kaewtapee Katharina Burbach Georgina Tomforde Thomas Hartinger Amelia Camarinha-Silva Sonja Heinritz Jana Seifert Markus Wiltafsky Rainer Mosenthin Pia Rosenfelder-Kuon | 2017 | Journal of Animal Science and Biotechnology2017，8，3： | 5 |
| 4 | Targeting of Vacuolar Membrane Localized Members of the TPK Channel Family显示文摘Arabidopsis thaliana 的双人脚踏车毛孔钾隧道家庭的四个成员(TPK1, 2, 3,和 5 ) 居住在 vacuolar 膜,而 TPK4 是一条血浆膜 K+ 隧道。由构造在 TPK1 和 TPK4 之间的怪物,我们试图识别涉及 trafficking 进程并且发现 TPK1 细胞质的 C 终端域(CT ) 为 ER-是批评的隧道域 -- 象排序 Golgi 步一样。后面的指导地点的 mutagenesis,我们识别了为 TPK1 的嗯出口要求的一个 diacidic 主题(DLE ) 。然而,在 C 终点的这个 diacidic 主题没在 TPK 家庭的另外的成员之中被保存,并且排序的 TPK3 独立于它的 CT。而且, TPK1 的 14-3-3 绑定地点,为隧道激活必要,不涉及隧道排序。 | Marcel Dunkel Andreas Latz Karin Schumacher Thomas Muller Dirk Becker Rainer Hedrich | 2008 | Molecular Plant2008，1，6： | 5 |
| 5 | Salt Stress Triggers Phosphorylation of the Arabidopsis Vacuolar K+ Channel TPK1 by Calcium-Dependent Protein Kinases (CDPKs)显示文摘 | Andreas Latz Norbert Mehlmer Simone Zapf Thomas D. Mueller Bernhard Wurzinger Barbara Pfister Edina Csaszar Rainer Hedrich Markus Teige Dirk Becker | 2013 | Molecular Plant2013，6，4： | 5 |
| 6 | First performance evaluation of a dual-source CT (DSCT) system显示文摘 | Thomas G. Flohr Cynthia H. McCollough Herbert Bruder Martin Petersilka Klaus Gruber Christoph Sü? Michael Grasruck Karl Stierstorfer Bernhard Krauss Rainer Raupach Andrew N. Primak Axel Küttner Stefan Achenbach Christoph Becker Andreas Kopp Bernd M. Ohnes | 2006 | European Radiology2006，，6： | 3 |
| 7 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 8 | Meta-Analysis of Retrograde Signaling in Arabidopsis thaliana Reveals a Core Module of Genes Embedded in Complex Cellular Signaling Networks显示文摘Plastid-to-nucleus 发信号为响应 environmentaland 的细胞的新陈代谢的协作和调整是必要的植物房间的发展暗示。许多运作后退表明小径被描述了被反应的氧种类,光合作用氧化还原作用不平衡, tetrapyrrole 中介,和 othermetabolic 特点要触发的那 arethought。这里,我们基于 transcriptome 和蛋白质相互作用数据报导元分析。比较 outputof 这些小径揭示在 operationalretrograde 发信号上侵犯的六不同来源刺激的公共和怪癖。我们的学习提供新奇卓见进这些小径的相互影响,支持当还未知的存在 ofan 基因的核心反应模块在测试的所有条件下面正在被调整。我们的分析进一步的 highlightsaffiliated 规章的 cis 元素并且分类 abscisic 酸并且作为涉及反应 cascadesfollowing 的第二等的部件的基于植物生长素的发信号一个 plastidial 信号。我们的学习提供结构的全球分析和不同小径 involvedin plastid-to-nucleus 在这建筑群上发信号和一个新看法的接口细胞的通讯 network.Key 词: | Christine GlaiBer Georg Haberer Iris Finkemeier Thomas Pfannschmidt Tatjana Kleine Dario Leister KarI-Josef Dietz Rainer Erich Haiusler Bernhard Grimm Klaus Franz Xaver Mayer | 2014 | Molecular Plant2014，7，7： | 2 |
| 9 | Reversal of Central Nervous System and Cardiac Toxicity After Local Anesthetic Intoxication by Lipid Emulsion Injection显示文摘 | Rainer J. Litz Thomas Roessel Axel R. Heller Sebastian N. Stehr | 2008 | Anesthesia & Analgesia2008，，： | 2 |
| 10 | Staging of Klatskin tumours (hilar cholangiocarcinomas): comparison of MR cholangiography, MR imaging, and endoscopic retrograde cholangiography显示文摘 | Thomas J. Vogl Wolfram O. Schwarz Matthias Heller Christopher Herzog Stephan Zangos Rainer E. Hintze Peter Neuhaus Renate M. Hammerstingl | 2006 | European Radiology2006，，10： | 2 |
| 11 | H elicobacter pylori outer membrane protein HopQ identified as a novel T4SS ‐associated virulence factor显示文摘 | Elena Belogolova Bianca Bauer Malvika Pompaiah Hiroshi Asakura Volker Brinkman Claudia Ertl Sina Bartfeld Taras Y. Nechitaylo Rainer Haas Nikolaus Machuy Nina Salama Yuri Churin Thomas F. Meyer | 2013 | Cell Microbiol2013，，11： | 2 |
| 12 | Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods显示文摘Neutralizing antibodies targeting the receptor-binding domain(RBD)of the SARS-CoV-2 spike(S)block severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)entry into cells via surface-expressed angiotensin-converting enzyme 2(ACE2).We used a surrogate virus neutralization test(sVNT)and SARS-CoV-2 S protein-pseudotyped vesicular stomatitis virus(VSV)vector-based neutralization assay(pVNT)to assess the degree to which serum antibodies from coronavirus disease 2019(COVID-19)convalescent patients interfere with the binding of SARS-CoV-2 S to ACE2.Both tests revealed neutralizing anti-SARS-CoV-2 S antibodies in the sera of ~90% of mildly and 100% of severely affected COVID-19 convalescent patients.Importantly,sVNT and pVNT results correlated strongly with each other and to the levels of anti-SARS-CoV-2 S1 IgG and IgA antibodies.Moreover,levels of neutralizing antibodies correlated with the duration and severity of clinical symptoms but not with patient age.Compared to pVNT,sVNT is less sophisticated and does not require any biosafety labs.Since this assay is also much faster and cheaper,sVNT will not only be important for evaluating the prevalence of neutralizing antibodies in a population but also for identifying promising plasma donors for successful passive antibody therapy. | Berislav Bosnjak Saskia Catherina Stein Stefanie Willenzon Anne Katrin Cordes Wolfram Puppe Gunter Bernhardt Inga Ravens Christiane Ritter Christian R.Schultze-Florey Nina Godecke Jorg Martens Hannah Kleine-Weber Markus Hoffmann Anne Cossmann Mustafa Yilmaz Isabelle Pink Marius M.Hoeper Georg M.N.Behrens Stefan Pohlm ann Rainer Blasczyk Thomas F.Schulz Reinhold Forster | 2021 | Cellular & Molecular Immunology2021，18，4： | 2 |
| 13 | Evolution of a tourmaline-bearing lawsonite eclogite from the Elekda? area (Central Pontides, N Turkey): evidence for infiltration of slab-derived B-rich fluids during exhumation显示文摘 | Rainer Altherr Gültekin Topuz Horst Marschall Thomas Zack Thomas Ludwig | | 0，，： | 1 |
| 14 | First performance evaluation of a dual-source CT (DSCT) system显示文摘 | Thomas G. Flohr Cynthia H. McCollough Herbert Bruder Martin Petersilka Klaus Gruber Christoph Süβ Michael Grasruck Karl Stierstorfer Bernhard Krauss Rainer Raupach Andrew N. Primak Axel Küttner Stefan Achenbach Christoph Becker Andreas Kopp Bernd M. Ohnes | 2006 | European Radiology2006，，2： | 1 |
| 15 | A three-dimentsional, physically based compact model for IC VDMOS transistors显示文摘 | Victory James McAndrew Colin C Thoma Rainer | 1998 | Microelectronics Journal1998，29，： | 1 |
| 16 | Posterior Capsule Opacification in Silicone and Hydrophobic Acrylic Intraocular Lenses with Sharp-edge Optics Six Years After Surgery显示文摘 | Lorenz Vock Alja Crnej Oliver Findl Thomas Neumayer Wolf Buehl Stefan Sacu Georg Rainer Rupert Menapace | 2009 | American Journal of Ophthalmology2009，，4： | 1 |
| 17 | Locating features in source code 显示文摘 | Thomas Eisenbarth Rainer Koschke Daniel Simon | 2003 | IEEE Trans Software Eng2003，29，3： | 1 |
| 18 | Late Results of Heterotopic Autotransplantation of Splenic Tissue into the Greater Omentum显示文摘 | Thomas Weber Ernst Hanisch Richard Paul Baum Rainer Maria Seufert | 1998 | World Journal of Surgery1998，，8： | 1 |
| 19 | 64-slice multidetector coronary CT angiography: in vitro evaluation of 68 different stents显示文摘 | David Maintz Harald Seifarth Rainer Raupach Thomas Flohr Michael Rink Torsten Sommer Murat ?zgün Walter Heindel Roman Fischbach | 2006 | European Radiology2006，，4： | 1 |
| 20 | Biochronostratigraphy of the Reingraben Turnover (Hallstatt Facies Belt): Local black shale events controlled by regional tectonics, climatic change and plate tectonics显示文摘 | Thomas Hornung Rainer Brandner | 2005 | Facies (-)2005，，1： | 1 |
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