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| 1 | Endoscopic retrograde cholangiopancreatography in cirrhosis-a systematic review and meta-analysis focused on adverse events显示文摘AIM To investigate indications and outcomes of endoscopic retrograde cholangiopancreatography(ERCP) in cirrhotics, especially adverse events. Patients with cirrhosis undergoing ERCP are believed to have increased risk. However, there is a paucity of literature describing the indications and outcomes of ERCP procedures in patients with cirrhosis, especially focusing on adverse events.METHODS We performed a systematic appraisal of major literature databases, including PubMed and EMBASE, with a manual search of literature from their inception until April 2017.RESULTS A total of 6,505 patients from 15 studies were analyzed(male ratio 59%, mean age 59 years), 11% with alcoholic and 89% with non-alcoholic cirrhosis, with 56.2% Child-Pugh class A, and 43.8% class B or C. Indications for ERCP included choledocholithiasis 60.9%, biliary strictures 26.2%, gallstone pancreatitis 21.1% and cholangitis 15.5%. Types of interventions included endoscopic sphincterotomy 52.7%, biliary stenting 16.7% and biliary dilation 4.6%. Individual adverse events included hemorrhage in 4.58%(95%CI: 2.77-6.75%, I^2 = 85.9%), post-ERCP pancreatitis(PEP) in 3.68%(95%CI: 1.83-6.00%, I^2 = 89.5%), cholangitis in 1.93%(95%CI: 0.63-3.71%, I^2 = 87.1%) and perforation in 0.00%(95%CI: 0.00-0.23%, I^2 = 37.8%). Six studies were used for comparison of ERCPrelated complications in cirrhosis vs non-cirrhosis, which showed higher overall rates of complications in cirrhosis patients with pooled OR of 1.63(95%CI: 1.27-2.09, I2 = 65%): higher rates of hemorrhage with OR of 2.05(95%CI: 1.62-2.58, I^2 = 2.1%) and PEP with OR of 1.33(95%CI: 1.04-1.70, I2=65%), but similar cholangitis rates with OR of 1.23(95%CI: 0.67-2.26, I^2 = 44.3%).CONCLUSION There is an overall higher rate of adverse events related to ERCP in patients with cirrhosis, especially hemorrhage and PEP. A thorough risk/benefit assessment should be performed prior to undertaking ERCP in patients with cirrhosis. | Shailender Singh Mashiana Amaninder Singh Dhaliwal Harlan Sayles Banreet Dhindsa Ji Won Yoo Qing Wu shailender singh Ali A Siddiqui Gordon Ohning Mohit Girotra Douglas G Adler | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，11： | 6 |
| 2 | First performance evaluation of a dual-source CT (DSCT) system显示文摘 | Thomas G. Flohr Cynthia H. McCollough Herbert Bruder Martin Petersilka Klaus Gruber Christoph Sü? Michael Grasruck Karl Stierstorfer Bernhard Krauss Rainer Raupach Andrew N. Primak Axel Küttner Stefan Achenbach Christoph Becker Andreas Kopp Bernd M. Ohnes | 2006 | European Radiology2006，，6： | 3 |
| 3 | Epistaxis in end stage liver disease masquerading as severe upper gastrointestinal hemorrhage显示文摘AIM:To describe the prevalence,diagnosis,treatment,and outcomes of end stage liver disease(ESLD) patients with severe epistaxis thought to be severe upper gastrointestinal hemorrhage(UGIH).METHODS:This observational single center study included all consecutive patients with ESLD and epistaxis identified from consecutive subjects hospitalized with suspected UGIH and prospectively enrolled in our databases of severe UGIH between 1998 and 2011.RESULTS:A total of 1249 patients were registered for severe UGIH in the data basis,461(36.9%) were cirrhotics. Epistaxis rather than UGIH was the bleeding source in 20 patients. All patients had severe coagulopathy. Epistaxis was initially controlled in all cases. Fifteen(75%) subjects required posterior nasal packing and 2(10%) embolization in addition to correction of coagulopathy. Five(25%) patients died in the hospital,12(60%) received orthotopic liver transplantation(OLT),and 3(15%) were discharged without OLT. The mortality rate was 63% in patients without OLT.CONCLUSION:Severe epistaxis in patients with ESLD is(1) a diagnosis of exclusion that requires upper endoscopy to exclude severe UGIH;and(2) associated with a high mortality rate in patients not receiving OLT. | Marine Camus Dennis M Jensen Jason D Matthews Gordon V Ohning Thomas O Kovacs Rome Jutabha Kevin A Ghassemi Gustavo A Machicado Gareth S Dulai | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 4 | Evidence for alterations in central noradrenergic signaling in irritable bowel syndrome显示文摘 | Steven Berman Brandall Suyenobu Bruce D. Naliboff Joshua Bueller Jean Stains Heng Wong Mark Mandelkern Leah Fitzgerald Gordon Ohning Arpana Gupta Jennifer S. Labus Kirsten Tillisch Emeran A. Mayer | 2012 | Neuroimage2012，，4： | 3 |
| 5 | The effects of anti-vascular endothelial growth factor agents on human retinal pigment epithelial cells under high glucose conditions显示文摘AIM: To investigate the effects of high glucose levels and anti-vascular endothelial growth factor(VEGF) agents(bevacizumab,ranibizumab and aflibercept) on retinal pigment epithelium(RPE) cells.METHODS: ARPE-19 cells were cultured at different glucose levels(5.5 mmol/L,25 mmol/L,and 75 mmol/L).Cell viability was evaluated by MTT assay at 3d after treatment with D-glucose.Cell migration ability was measured by wound healing assay at 3d.A cell death detection kit was used to assess apoptosis at 3 and 14 d.Cell proliferation was assessed by EdU assay at 3d.The culture medium was treated with anti-VEGF agents at clinically relevant concentrations.The experiment was then repeated at a different glucose level.RESULTS: The viability and migration of ARPE-19 cells were significantly decreased in the presence of 75 mmol/L as compared to 5.5 mmol/L glucose.The percentage of TUNEL-positive cells was significantly increased and the proliferative potential was decreased with 75 mmol/L compared to 5.5 mmol/L glucose.There were no significant differences in the results between 25 mmol/L and 5.5 mmol/L glucose.In the presence of 75 mmol/L glucose,the groups treated with anti-VEGF showed decreased cell viability and proliferation and increased apoptosis.However,there were no significant differences between the anti-VEGF groups.CONCLUSION: High glucose level decreases the viability,wound healing ability,and proliferation of RPE cells,while increasing apoptosis.Furthermore,anti-VEGF agents interfered with the physiological functions of RPE cells under high-glucose conditions,accompanied by decreases in cell viability and proliferation. | Jong Rok Oh Jung Woo Han Yoon Kyung Kim Young-Hoon Ohn Tae Kwann Park | 2017 | International Journal of Ophthalmology(English edition)2017，10，2： | 2 |
| 6 | Percutaneous vertebroplasty treat ment of steroid-induced osteoporotic compression fractures 显示文摘 | Ohn MM Michelle P Neal N | 1998 | Arthritis and Rheumatism1998，41，1： | 1 |
| 7 | Data envelopment analysis and its applicationto the measurement of efficiency in higher education 显示文摘 | OHNS J | 2006 | Economics of Edu- cation Review2006，25，3： | 1 |
| 8 | Measurement of hydrogen permeation through nickel in the elevated显示文摘 | Lee S K Ohn Y G Noh S J | 2013 | Journal of the Korean Physical Society2013，63，10： | 1 |
| 9 | Measurement of synergy and spasticity during functional movement of the post-stoke hemiplegic upper limb显示文摘 | OHN SUK HOOH WOO-KYOUNG YO0 DEOG YOUNG KIM | 2013 | Journal of Electromyography and Kinesiology2013，23，2： | 1 |
| 10 | Longitudinal changes of resting-state functional connectivity during motor recovery after stroke显示文摘 | Park CH Chang WH Ohn SH | 2011 | Stroke2011，42，5： | 1 |
| 11 | Developing injury surveillance in accident and emergency department 显示文摘 | Stone DH Momison A Ohn Tr | 1998 | Arch Dis Child1998，78，： | 1 |
| 12 | Collagenase ex- pres-sion and activity in the stromal cells from giant cell tumor of bone显示文摘 | Cowan R Mak IW Colte~ohn N | 2009 | Bone2009，45，9： | 1 |
| 13 | Enhancing motor perfor- mance by anodal transcranial direct current stimulation in subacute stroke patients显示文摘 | Kim DY Ohn SH Yang E J | 2009 | Am J Phys Med Rehabil2009，88，10： | 1 |
| 14 | 亚洲稻作文化传播中的台语民族角色:基于地理信息系统的解释显示文摘文章以历史比较语言学理论为指导,探寻栽培稻的起源。关于栽培稻起源的论断需要细致的田野工作考察和分析,文章运用地理信息系统的科技手段,对稻作起源进行科学分析与研究。文章得出以下结论:稻田灌溉技术在大约2000年前原始台语时期已经发展相对完善;原始台语起源可以追溯到黔桂地区,壮傣民族稻田灌溉技术,包括修理运河和水坝的技术也是起源于那里,而非云南。 | Ohn Hartmann Wei Luo Vinya Sysamouth 莫海文(译) 李锦芳(译) | 2016 | 百色学院学报2016，29，2： | 1 |
| 15 | Synthetic approaches to phorbols via the intramolecular nitrile oxide cycloaddition: stereocontrol of the b-c ring junction显示文摘 | SHIGENO K OHNE K YAMAGUCHI T | 1992 | Heterocycles1992，33，： | 1 |
| 16 | First performance evaluation of a dual-source CT (DSCT) system显示文摘 | Thomas G. Flohr Cynthia H. McCollough Herbert Bruder Martin Petersilka Klaus Gruber Christoph Süβ Michael Grasruck Karl Stierstorfer Bernhard Krauss Rainer Raupach Andrew N. Primak Axel Küttner Stefan Achenbach Christoph Becker Andreas Kopp Bernd M. Ohnes | 2006 | European Radiology2006，，2： | 1 |
| 17 | A Study of Genetic Variation and Relationships within the Bamboo Subtribe Bambusinae using Amplified Fragment Length Polymorphism 显示文摘 | Jin PL Ruth K Ohn S | 2000 | Annals of Botany2000，85，： | 1 |
| 18 | Developing injury surveillance in accident and emergency department显示文摘 | Momison A Ohn TT | 1998 | Arch Dis Child1998，78，： | 1 |
| 19 | Con sensu s recomm endati on sfor the m anagem en t of chron ic heart failu re 显示文摘 | Pack er M C ohn JN Ab raham W T | 2009 | Am J Card iol2009，83，2： | 1 |
| 20 | Who's afraid of peer review? 显示文摘 | OHN BOHANNON | 2013 | Science2013，342，6154： | 1 |
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