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| 1 | Posterior Capsule Opacification in Silicone and Hydrophobic Acrylic Intraocular Lenses with Sharp-edge Optics Six Years After Surgery显示文摘 | Lorenz Vock Alja Crnej Oliver Findl Thomas Neumayer Wolf Buehl Stefan Sacu Georg Rainer Rupert Menapace | 2009 | American Journal of Ophthalmology2009，，4： | 1 |
| 2 | Investigating the needle dynamic response during insertion into soft tissue 显示文摘 | T Alja'afreh | 2010 | Proceedings of the Institution of Mechanical Engineers Part H: Journal of Engineering in Medicine (S0954-4119)2010，224，4： | 1 |
| 3 | Folksonomy link prediction based on a tripartite graph for tag recommendation显示文摘 | Rawashdeh M Kim H N Alja'am J M | 2013 | Journal of Intelligent Information System2013，40，2： | 1 |
| 4 | Effect of Fluorescein Dye Staining of the Tear Film on Scheimpflug Measurements of Central Corneal Thickness显示文摘 | Nino Hirnschall Alja Crnej Vinod Gangwani Oliver Findl | 2012 | Cornea2012，，1： | 1 |
| 5 | Epigenetics in psychiatry:Beyond DNA methylation显示文摘The global burden of psychopathologies appears to be underestimated,since the global psychiatric disorder burden is exceeding other medical burdens.To be able to address this problem more effectively,we need to better understand the etiology of psychiatric disorders.One of the hallmarks of psychiatric disorders appears to be epigenetic dysregulation.While some epigenetic modifications(such as DNA methylation)are well known and studied,the roles of others have been investigated much less.DNA hydroxymethylation is a rarely studied epigenetic modification,which as well as being an intermediate stage in the DNA demethylation cycle is also an independent steady cell state involved in neurodevelopment and plasticity.In contrast to DNA methylation,DNA hydroxymethylation appears to be related to an increase in gene expression and subsequent protein expression.Although no particular gene or genetic locus can be at this point linked to changes in DNA hydroxymethylation in psychiatric disorders,the epigenetic marks present good potential for biomarker identification because the epigenetic landscape is a result of the interplay between genes and environment,which both influence the development of psychiatric disorders,and because hydoxymethylation changes are particularly enriched in the brain and in synapse-related genes. | Katarina Kouter IrisŠalamon Arčan Alja VidetičPaska | 2023 | World Journal of Psychiatry2023，13，6： | 1 |
| 6 | First steps towards cross-national transfer in integrating mobility management and land use planning in the EU and Switzerland显示文摘 | Tom Rye Janina Welsch Alja? Plevnik Roberto de Tommasi | 2010 | Transport Policy2010，，3： | 1 |
| 7 | BDNF methylation and mRNA expression in brain and blood of completed suicides in Slovenia显示文摘BACKGROUND Suicide is a major public health problem.Worldwide,around 800000 people die by suicide every year.Suicide is a multifactorial disorder,with numerous environmental and genetic risk factors involved.Among the candidate genes,changes in the BDNF locus at the gene,epigenetic,mRNA,and protein expression levels have been implicated in psychiatric disorders,including suicidal behavior and completed suicides.AIM To investigate changes in BDNF methylation and expression of four alternative BDNF transcripts for association with completed suicide.METHODS This case-control study included 42 unrelated male Caucasian subjects,where 20 were control subjects who died following acute cardiac arrest,and 22 were suicide victims who died by hanging.DNA and RNA were extracted from brain tissue(Brodmann area 9 and hippocampus)and from blood.DNA methylation and mRNA expression levels were determined by targeted bisulfite next-generation sequencing and reverse-transcription quantitative PCR.Statistical analysis was done by use of two-tailed Student’s t tests for two independent samples,and the Benjamini-Hochberg procedure was implemented for correction for multiple comparisons.RESULTS In DNA from brain tissue,there were no significant differences in BDNF methylation between the study groups.However,data showed significantly reduced DNA methylation of the BDNF region upstream of exon I in blood samples of suicide victims compared to the controls(5.67±0.57 vs 6.83±0.64,P_(corr)=0.01).In Brodmann area 9 of the brain of the suicide victims but not in their hippocampus,there was higher expression of BDNF transcript I-IX(NM_170731.4)compared to the controls(0.077±0.024 vs 0.05±0.013,P=0.042).In blood,expression analysis for the BDNF transcripts was not feasible due to extensive RNA degradation.CONCLUSION Despite the limitations of the study,the obtained data further support a role for BDNF in suicidality.However,it should be noted that suicidal behavior is a multifactorial disorder with numerous environmental and genetic risk factors involved. | Sandra Ropret Katarina Kouter TomažZupanc Alja Videtic Paska | 2021 | World Journal of Psychiatry2021，11，12： | 1 |
| 8 | Institutional quality dataset显示文摘 | ALJA? KUN?I? | 2013 | Journal of Institutional Economics2013，，1： | 1 |
| 9 | Can Online Tutors Improve the Quality of E-Learning?显示文摘 | Viktorija Suli and Alja Suli | 2007 | lssues in Informing Science and Information Technology2007，，4： | 1 |
| 10 | Investigating the needle dynamic response during insertion into soft tissue 显示文摘 | Alja' afreh T | 2010 | Journal of Engineering in Medicine2010，224，4： | 1 |
| 11 | Depressive disorder and antidepressants from an epigenetic point of view显示文摘Depressive disorder is a complex,heterogeneous disease that affects approximately 280 million people worldwide.Environmental,genetic,and neurobiological factors contribute to the depressive state.Since the nervous system is susceptible to shifts in activity of epigenetic modifiers,these allow for significant plasticity and response to rapid changes in the environment.Among the most studied epigenetic modifications in depressive disorder is DNA methylation,with findings centered on the brain-derived neurotrophic factor gene,the glucocorticoid receptor gene,and the serotonin transporter gene.In order to identify biomarkers that would be useful in clinical settings,for diagnosis and for treatment response,further research on antidepressants and alterations they cause in the epigenetic landscape throughout the genome is needed.Studies on cornerstone antidepressants,such as selective serotonin reuptake inhibitors,selective serotonin and norepinephrine reuptake inhibitors,norepinephrine,and dopamine reuptake inhibitors and their effects on depressive disorder are available,but systematic conclusions on their effects are still hard to draw due to the highly heterogeneous nature of the studies.In addition,two novel drugs,ketamine and esketamine,are being investigated particularly in association with treatment of resistant depression,which is one of the hot topics of contemporary research and the field of precision psychiatry. | Iris Šalamon Arčan Katarina Kouter Alja Videtič Paska | 2022 | World Journal of Psychiatry2022，12，9： | 0 |
| 12 | ‘Omics’of suicidal behaviour:A path to personalised psychiatry显示文摘Psychiatric disorders,including suicide,are complex disorders that are affected by many different risk factors.It has been estimated that genetic factors contribute up to 50%to suicide risk.As the candidate gene approach has not identified a gene or set of genes that can be defined as biomarkers for suicidal behaviour,much is expected from cutting edge technological approaches that can interrogate several hundred,or even millions,of biomarkers at a time.These include the‘-omic’approaches,such as genomics,transcriptomics,epigenomics,proteomics and metabolomics.Indeed,these have revealed new candidate biomarkers associated with suicidal behaviour.The most interesting of these have been implicated in inflammation and immune responses,which have been revealed through different study approaches,from genome-wide single nucleotide studies and the micro-RNA transcriptome,to the proteome and metabolome.However,the massive amounts of data that are generated by the‘-omic’technologies demand the use of powerful computational analysis,and also specifically trained personnel.In this regard,machine learning approaches are beginning to pave the way towards personalized psychiatry. | Katarina Kouter Alja Videtic Paska | 2021 | World Journal of Psychiatry2021，11，10： | 0 |
| 13 | The Qatari Environment Friendly Web Portal显示文摘 | Jihad M. AlJa'am Abusin Rahama Abdlah A. Sabri Mohamad H. Abbasi | 2011 | 通讯和计算机(中英文版)2011，8，7： | 0 |
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