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| 1 | Co-expression of CDX2 and MUC2 in gastric carcinomas: Correlations with clinico-pathological parameters and prognosis显示文摘AIM: To evaluate the role of CDX2 homeobox protein as a predictor for cancer progression and prognosis as well as its correlation with MUC2 expression. CDX2 represents a transcription factor for various intestinal genes (including MUC2) and thus an important regulator of intestinal differentiation, which could previously be identified in gastric carcinomas and intestinal metaplasia.METHODS: Formalin-fixed and paraffin-embedded tissues from 190 gastric carcinoma patients were stained with monodonal antibodies recognizing CDX2 and MUC2, respectively. Immunoreactivity was evaluated semiquantitatively and statistical analyses including χ2 tests, uni- and multi-variate survival analyses were performed.RESULTS: CDX2 was mostly expressed in a nuclear or supranuclear pattern, whereas MUC2 showed an almost exclusive supranuclear reactivity. Both antigens were present in >80% of areas exhibiting intestinal metaplasia. An immunoreactivity in >5% of the tumor area was observed in 57% (CDX2) or in 21% (MUC2) of the carcinomas. The presence of both molecules did not correlate with WHO,significantly stronger vlUC2 expression in mucinous tumors). CDX2 correlated with a lower pT and pN stage in the subgroups of intestinal and stage I cancers and was associated with MUC2 positivity. A prognostic impact of CDX2 or MUC2 was not observed. CONCLUSION: CDX2 and MUC2 play an important role in the differentiation of normal, inflamed, and neoplastic gastric tissues. According to our results, loss of CDX2 may represent a marker of tumor progression in early gastric cancer and carcinomas with an intestinal phenotype. | Kristina Roessler Stefan P.M(o|¨)nig Paul M.Schneider Franz-Georg Hanisch Stephanie Landsberg Juergen Thiele Arnulf H.H(o|¨)lscher Hans P.Dienes Stephan E.Baldus | 2005 | World Journal of Gastroenterology2005，11，21： | 15 |
| 2 | Laparoscopic surgery:A qualified systematic review显示文摘AIM: To review current applications of the laparoscopic surgery while highlighting the standard procedures across different fields.METHODS: A comprehensive search was undertaken using the Pub Med Advanced Search Builder. A total of 321 articles were found in this search. The following criteria had to be met for the publication to be selected: Review article, randomized controlled trials, or metaanalyses discussing the subject of laparoscopic surgery. In addition, publications were hand-searched in the Cochrane database and the high-impact journals. A total of 82 of the findings were included according to matching the inclusion criteria. Overall, 403 full-text articles were reviewed. Of these, 218 were excluded due to not matching the inclusion criteria. RESULTS: A total of 185 relevant articles were identified matching the search criteria for an overview of the current literature on the laparoscopic surgery. Articles covered the period from the first laparoscopic application through its tremendous advancement over the last several years. Overall, the biggest advantage of the procedure has been minimizing trauma to the abdominal wall compared with open surgery. In the case of cholecystectomy, fundoplication, and adrenalectomy, the procedure has become the gold standard without being proven as a superior technique over the open surgery in randomized controlled trials. Faster recovery, reduced hospital stay, and a quicker return to normal activities are the most evident advantages of the laparoscopic surgery. Positive outcomes, efficiency, a lower rate of wound infections, and reduction in the perioperative morbidity of minimally invasive procedures have been shown in most indications. CONCLUSION: Improvements in surgical training and developments in instruments, imaging, and surgical techniques have greatly increased safety and feasibility of the laparoscopic surgical procedures. | Alexander Buia Florian Stockhausen Ernst Hanisch | 2015 | World Journal of Methodology2015，5，4： | 15 |
| 3 | Comparative evaluation of the prognostic value of MUC1,MUC2,sialyl-Lewis(a) and sialyl-Lewis(x) antigens in colorectal adenocarcinoma显示文摘 | Baldus SE Monig SP Hanisch FG | 2002 | Histopathology2002，40，5： | 2 |
| 4 | Neuroanatomical localization pharmacological chasactefization and functions of CGRP, related peptides and their receptors 显示文摘 | Van Rossum D Hanisch UK Quifion R | 1997 | Neurosci Biobehav Rev1997，21，5： | 1 |
| 5 | Glycoprotein identification and localization of O-glycosylation sites by mass spectrometric analysis of deglycosylated/alkylaminylated peptide fragments显示文摘 | Hanisch FG Jovanovic M Peter-Katalinic J | 2001 | Anal Biochem2001，290，1： | 1 |
| 6 | Immunology of O-glycosylated proteins:approaches to the design of a MUC1 glycopeptide-based tumor vaccine显示文摘 | Hanisch FG Ninkovic T | 2006 | Curr Protein Pept Sci2006，7，4： | 1 |
| 7 | Lactate inmase and oxygen desaturation in mitochoudrial disorders - evaluation of two diagnostic screening protocols 显示文摘 | Hanisch F Mtiller T Muser A | 2006 | J Neurol2006，253，4： | 1 |
| 8 | MuSK antibody positive myasthenia gravis plasma modifies MURF-1 expression in C2C12 cultures and mouse muscle in vivo 显示文摘 | Bau V Hanisch F Hain B | 2006 | Klin Monatsbl Augenheilkd2006，223，1： | 1 |
| 9 | Microglia as a source and target of cytokines 显示文摘 | Hanisch UK | 2002 | Glia2002，40，2： | 1 |
| 10 | Physiology of microglia 显示文摘 | Kettenmann H Hanisch U K Noda M | 2011 | Physiol Rev2011，91，2： | 1 |
| 11 | Physiology of microglia 显示文摘 | Kettenmann H Hanisch UK Noda M | 2011 | Physiol Rev2011，91，2： | 1 |
| 12 | Notch signaling,the segmentation clock,and the patterning of vertebrate somites显示文摘 | Lewis J Hanisch A Holder M | 2009 | J Biol2009，8，4： | 1 |
| 13 | Altered glycosylation of the MUC 1 protein core contributes to colon carcinoma-associated increase of mucin bound sialyl-Lewis (x) expression 显示文摘 | Hanski C Drechsler K Hanisch FG | 1993 | Cancer Res1993，53，17： | 1 |
| 14 | Cardiac pacing in children: a 15 - year experience显示文摘 | BEDER SD HANISCH DG COHEN MH | 1985 | AM Hcart J1985，109，： | 1 |
| 15 | A novel variant of IGF2BP2 is associated with type 2 diabetes and affects expression of a functional splicing isoform 显示文摘 | Prokunina - Olsson L Hanisch JJ Jackson AU | 2008 | Diabetes2008，57，1： | 1 |
| 16 | Microglia显示文摘 | van Rossum D Hanisch UK | 2004 | Metab Brain Dis2004，19，3： | 1 |
| 17 | Dysfunctional attention networks in children with attention deficit/hyperactivity disorder:evidence from an event related functional magnetic resonance imaging study显示文摘 | Konrad K Neufang S Hanisch C | 2006 | Biol Psychiat2006，59，7： | 1 |
| 18 | Powering tomorrow's cars显示文摘 | Hanisch C | 1999 | Environmental Science & Technology1999，33，6： | 1 |
| 19 | Physiology of micro- glia显示文摘 | Kettenmann H Hanisch UK Noda MA | | Physiol Rev0，91，2： | 1 |
| 20 | Oxypnictide SmFeAs (O, F) superconductor: a candi- date for high-field magnet applications 显示文摘 | Kazumasa lida Jens Hanisch Chiara Tarantini | 2013 | Scientific Reports2013，3，： | 1 |
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