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| 1 | Irritable bowel syndrome: A microbiome-gut-brain axis disorder?显示文摘Irritable bowel syndrome(IBS) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help diagnose the disorder and treatment options are limited to management of the symptoms. The concept of a dysregulated gut-brain axis has been adopted as a suitable model for the disorder. The gut microbiome may play an important role in the onset and exacerbation of symptoms in the disorder and has been extensively studied in this context. Although a causal role cannot yet be inferred from the clinical studies which have attempted to characterise the gut microbiota in IBS, they do confirm alterations in both community stability and diversity. Moreover, it has been reliably demonstrated that manipulation of the microbiota can influence the key symptoms, including abdominal pain and bowel habit, and other prominent features of IBS. A variety of strategies have been taken to study these interactions, including probiotics, antibiotics, faecal transplantations and the use of germ-free animals. There are clear mechanisms through which the microbiota can produce these effects, both humoral and neural. Taken together, these findings firmly establish the microbiota as a critical node in the gut-brain axis and one which is amenable to therapeutic interventions. | Paul J Kennedy John F Cryan Timothy G Dinan Gerard Clarke | 2014 | World Journal of Gastroenterology2014，20，39： | 20 |
| 2 | Gut memories: Towards a cognitive neurobiology of irritable bowel syndrome显示文摘 | Paul J. Kennedy Gerard Clarke Eamonn M.M. Quigley John A. Groeger Timothy G. Dinan John F. Cryan | 2011 | Neuroscience and Biobehavioral Reviews2011，，1： | 2 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | Origin of the northern Atlantic’s Heinrich events显示文摘 | Wallace Broecker Gerard Bond Mieczyslawa Klas Elizabeth Clark Jerry McManus | 1992 | Climate Dynamics (-)1992，，3： | 1 |
| 5 | Water Management in France:Delegation and Market Based Auto-Regulation International显示文摘 | Ephriam Clark Gerard Mondello | 2003 | Journal of Public Administration London2003，，3： | 1 |
| 6 | Synchronous tumours of the unilateral parotid gland: rare or undetected?显示文摘 | Clark J Zeebregts Walter J.B Mastboom Gerard van Noort Rob J.van Det | 2002 | Journal of Cranio-Maxillofacial Surgery2002，，1： | 1 |
| 7 | How good is capsule endoscopy for detection of periampullary lesions? Results of a tertiary-referral center显示文摘 | John O. Clarke Samuel A. Giday Priscilla Magno Eun Ji Shin Jonathan M. Buscaglia Sanjay B. Jagannath Gerard E. Mullin | 2008 | Gastrointestinal Endoscopy2008，，2： | 1 |
| 8 | Identification of a putative intestinal stem cell and early lineage marker; musashi-1显示文摘 | Christopher S. Potten Catherine Booth Gregory L. Tudor Dawn Booth Gerard Brady Patricia Hurley Gary Ashton Robert Clarke Shin-ichi Sakakibara Hideyuki Okano | 2003 | Differentiation2003，，1： | 1 |
| 9 | Shear-Induced demixing in polystyrene/poly (vinyl methyl ether)blends显示文摘 | Gerard H Higgins J S Clarke N | 1999 | Macromolecules1999，32，： | 1 |
| 10 | Downregulation of Umbilical Cord Blood Levels of miR-374a in Neonatal Hypoxic Ischemic Encephalopathy显示文摘 | Ann-Marie Looney Brian H. Walsh Gerard Moloney Sue Grenham Ailis Fagan Gerard W. O’Keeffe Gerard Clarke John F. Cryan Ted G. Dinan Geraldine B. Boylan Deirdre M. Murray | 2015 | The Journal of Pediatrics2015，，2： | 1 |
| 11 | Identification of a putative intestinal stem cell and early lineage marker; musashi-1显示文摘 | Christopher S. Potten Catherine Booth Gregory L. Tudor Dawn Booth Gerard Brady Patricia Hurley Gary Ashton Robert Clarke Shin-ichi Sakakibara Hideyuki Okano | 2003 | Differentiation2003，，1： | 1 |
| 12 | A Paradigm for Functional Tissue Engineering of Articular Cartilage via Applied Physiologic Deformational Loading显示文摘 | Clark T. Hung Robert L. Mauck Christopher C.-B. Wang Eric G. Lima Gerard A. Ateshian | 2004 | Annals of Biomedical Engineering2004，，1： | 1 |
| 13 | Ballast Evaluation Using Ground-penetrating Radar显示文摘 | Gerard Gallagher Quentin Leiper Maxwell Clark and Michael Forde | 2000 | Railway Gazette International2000，，2： | 1 |
| 14 | Bioactive Stratified Polymer Ceramic-Hydrogel Scaffold for Integrative Osteochondral Repair显示文摘 | Jie Jiang Amy Tang Gerard A. Ateshian X. Edward Guo Clark T. Hung Helen H. Lu | 2010 | Annals of Biomedical Engineering2010，，6： | 1 |
| 15 | The probiotic Bifidobacteria infantis : An assessment of potential antidepressant properties in the rat显示文摘 | Lieve Desbonnet Lillian Garrett Gerard Clarke John Bienenstock Timothy G. Dinan | 2008 | Journal of Psychiatric Research2008，，2： | 1 |
| 16 | Ballast evaluation using gTound-penetrating radar显示文摘 | Gerard Gallagher Quentin Leiper Maxwell Clark | 2000 | Railway Gazette International2000，，2： | 1 |
| 17 | The microbiome: stress, health and disease显示文摘 | Rachel D. Moloney Lieve Desbonnet Gerard Clarke Timothy G. Dinan John F. Cryan | 2014 | Mammalian Genome (-)2014，，1： | 1 |
| 18 | From Response to Resilience:Emergency Management Reform in New Zealand显示文摘 | BRITTON NEIL R GERARD J CLARKE | 2000 | Natural Hazards Review2000，1，3： | 1 |
| 19 | “Digging in the Dirt”faecal microRNAs as dietary biomarkers of host-microbe interactions显示文摘The role of diet and nutrition in maintaining a healthy lifestyle has become a central part of chronic disease prevention(1).Chronic conditions such as cancer,Inflammatory bowel disease(IBD)and obesity are more prevalent in people with poor diets(2).Food consumption is controlled by physiological systems such as the gut-microbiome and distinct neuroendocrine pathways that overlap to promote host nutritional gain resulting in people living longer healthier lives(3).A recent analysis of the global burden of disease by the World Health Organization(WHO),noted that factors associated with poor diet,including obesity and malnutrition,critically undermine health and wellbeing.They note that undernutrition,deficiencies in key nutrients and obesity have high social and economic impacts.Cardiovascular disease,cancer,diabetes,and respiratory diseases account for 77%of all diseases and are responsible for 86%of all premature deaths(4).There is an appreciation that diets that reduce or eliminate red meats and animal fats results in the reduction of many of the indicators of poor diet,such as body mass index(BMI)and levels of cholesterol in the blood. | Gerard M.Moloney John F.Cryan Gerard Clarke | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 0 |
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