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| 1 | Early changes of graft function,cytokines and superoxide dismutase serum levels after donor liver denervation and Kupffer cell depletion in a rat-to-rat liver transplantation model显示文摘BACKGROUND:Hepatic reperfusion injury may cause acute inflammatory damage,producing significant organ dysfunction,and is an important problem in liver transplantation.This experiment aimed to study early changes of hepatic function after donor liver denervation and Kupffer cell depletion in rat-to-rat liver transplantation and to evaluate the effect of pre-treatment on liver reperfusion injury.METHODS:Donor rats were divided into four groups:control group;group G was pre-treated with gadolinium chloride(G),an inhibitor of Kupffer cells;group H with hexamethonium(H),a sympathetic ganglionic blocking agent;and group HG,with combined H and G pre-treatment.Under the same conditions,serum alanine aminotransferase(ALT),arterial ketone body ratio(AKBR),tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6),and superoxide dismutase(SOD)of recipient rats were assessed at 4,8,16 and 24 hours after liver transplantation.Histological studies of the grafts were compared.RESULTS:HG pre-treatment significantly decreased ALT,TNF-α,and IL-6 levels,increased AKBR and SOD levels,and demonstrated less pathological damage at 8,16 and 24 hours compared with the control group.Similar trends were also found in the other groups(G and H).However,the differences among them were not significant at 4 post-operative hours.CONCLUSIONS:Donor denervation and Kupffer cell depletion had preventive effect on liver reperfusion injury.HG pre-treatment is a feasible and reproducible method to protect grafts from reperfusion injury. | Catena Marco Ferla Gianfranco | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，2： | 7 |
| 2 | Donor denervation and elimination of Kupffer cells affect expression of P-selectin and ICAM-1 in liver graft显示文摘BACKGROUND:The non-function and dysfunction of primary liver graft likely involves dependence on Kupffer cells and hepatic innervation. The present experiment was designed to study the expression of P-selectin and intercellular adhesion molecule-1(ICAM-1) mRNA in liver graft and to elucidate the role of Kupffer cells and the sympathetic nerve of the liver in down-regulating this expression. METHODS:Donor rats were given hexamethonium,a sympathetic ganglionic blocking agent,and/or gadolinium chloride,an inhibitor of Kupffer cells. Then the changes of graft P-selectin and ICAM-1 mRNA expression were measured after liver transplantation. RESULTS:The expressions of P-selectin and ICAM-1 mRNA were increased after liver transplantation,and down-regulated by liver denervation and elimination of Kupffer cells. CONCLUSIONS:Live donor denervation and elimination of Kupffer cells down-regulated the expressions of P-selectin and ICAM-1 mRNA in grafts. This may decrease graft ischemia/reperfusion injury. | Zhu, Hong Guo, Yong-Zhang Zhang, Jie Hu, Ming-Dao Tang, Ji-Hong Tian, Da-Guang Yong-Jun, A. Sun, Feng Wei, Xiao-Ping | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，4： | 6 |
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