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| 1 | Effect of cis-9,trans-11-conjugated linoleic acid on cell cycle of gastric adenocarcinoma cell line(SGC-7901)显示文摘AIM: To determine the effect of cis-9, trans-1l-conjugated linoleic acid ( c9, tl 1-CLA) on the cell cycle of gastric cancer cells( SGC-7901 ) and its possible mechanism in inhibition cancer growth.METHODS: Using cell culture and immunocytochemicaltechniques, we examined the cell growth, DNA synthesis,expression of PCNA, cyclin A, B1, D1, pl6nink4a and p21clp/wafl ofSGC-7901 cells which were heated with various c9, tll-CLAconcentrations (25,50,100 and 200μnol@L-1)of c9, tll-CLA for 24and 48 h, with a negative control (0.1% ethane).RESULTS: The cell growth and DNA synthesis of SGC-7901cells were inhibited by c9, tll-CLA. SGC-7901 cells. Eightday after treatment with various concentrations of c9, tl1-CLA mentioned above, the inhibition rates were 5.92 % ,20.15 % ,75.61% and 82.44 % ,respectively and inhibitory effeotof c9, tll-CLA on DNA synthesis (except for 25 tmol/L,24h) showed significantly less 3H-TdR incorporation than thatin the negative controls (P < 0. 05 and P < 0. 01).Immunocytochemical staining demonstrated that SGC-7901cells preincubated in media supplemented with different c9,tl1-CLA concentrations at various times significantlydecreased the expressions of PCNA (the expression rateswere7.2-3.0 %,24 h and 9.1-0.9 % at 48 h, respectively),Cyclin A (l1.0-2.3 %, 24 h and 8.5-0.5 % ,48 h), B1 (4.8-1.8% at 24 h and 5.5-0.6 % at 48 h)and D1 (3.6-1.4 % at 24 hand 3.7 %-0 at 48 h) as compared with those in the negativecontrols(the expressions of PCNA, Cyclin A, B1 and D1were 6.5 % at 24h and 9.0 % at 48 h, 4.2% at 24h and5.1% at 48 h, 9.5 % at 24h and 6.0 % at 48 h,respectively)(P< 0.01), whereas the expressions of p16ink4a and p21clp/waf1,cyclin-dependent kinases inhibltors(CDKI), were increased.CONCLUSION: The cell growth and proliferation of SGC-7901cell is inhibited by c9, tll-CLA via blocking the cell cycle,with reduced expressions of cyclin A, B1 and D1 andenhanced expressions of CDKI( p16ink4a and p21cip/waf1). | Jia-Ren Liu Bai-Xiang Li Bing-Qing Chen Ying-ben Xue Yan-Mei Yang Yu-Mei Zheng,Department of Toxicological Health,Public Health College,Harbin Medical University,Harbin 150001,Heilongjiang Province,China Xiao-Hui Han ICU of Cardiological Surgery,The Second Hospital,Harbin Medical University,Harbin 150001,Heilongjiang Province,China Rui-Hai Liu,Food Science and Toxicology,Department of Food Science,Cornell University,Ithaca,NY 14853-7201,USA | 2002 | World Journal of Gastroenterology2002，8，2： | 26 |
| 2 | Microglia regulation of synaptic plasticity and learning and memory显示文摘Microglia are the resident macrophages of the central nervous system.Microglia possess varied morphologies and functions.Under normal physiological conditions,microglia mainly exist in a resting state and constantly monitor their microenvironment and survey neuronal and synaptic activity.Through the C1 q,C3 and CR3'Eat Me'and CD47 and SIRPα'Don't Eat Me'complement pathways,as well as other pathways such as CX3 CR1 signaling,resting microglia regulate synaptic pruning,a process crucial for the promotion of synapse formation and the regulation of neuronal activity and synaptic plasticity.By mediating synaptic pruning,resting microglia play an important role in the regulation of experience-dependent plasticity in the barrel cortex and visual cortex after whisker removal or monocular deprivation,and also in the regulation of learning and memory,including the modulation of memory strength,forgetfulness,and memory quality.As a response to brain injury,infection or neuroinflammation,microglia become activated and increase in number.Activated microglia change to an amoeboid shape,migrate to sites of inflammation and secrete proteins such as cytokines,chemokines and reactive oxygen species.These molecules released by microglia can lead to synaptic plasticity and learning and memory deficits associated with aging,Alzheimer's disease,traumatic brain injury,HIV-associated neurocognitive disorder,and other neurological or mental disorders such as autism,depression and post-traumatic stress disorder.With a focus mainly on recently published literature,here we reviewed the studies investigating the role of resting microglia in synaptic plasticity and learning and memory,as well as how activated microglia modulate disease-related plasticity and learning and memory deficits.By summarizing the function of microglia in these processes,we aim to provide an overview of microglia regulation of synaptic plasticity and learning and memory,and to discuss the possibility of microglia manipulation as a therapeutic to ameliorate cognitive deficits associated with aging,Alzheimer's disease,traumatic brain injury,HIV-associated neurocognitive disorder,and mental disorders. | Jessica Cornell Shelbi Salinas Hou-Yuan Huang Miou Zhou | 2022 | Neural Regeneration Research2022，17，4： | 26 |
| 3 | 四个地域小黄鱼肌肉营养成分分析与评价显示文摘小黄鱼(Larimichthys polyactis),又名小黄花鱼,鲈形目,石首鱼科,黄鱼属,在我国黄海和东海北部均有分布,是我国重要的海产经济鱼类[1],其肉味鲜美、营养价值高。目前尚无不同地域小黄鱼肌肉营养成分、营养价值、氨基酸和脂肪酸含量的差异研究。 | 王立改 Angela Cornel 楼宝 鲁琼 詹炜 陈睿毅 | 2018 | 营养学报2018，40，2： | 12 |
| 4 | 迈向2015:康奈尔大学图书馆2011—2015战略规划显示文摘1前言
康奈尔大学图书馆(CUL)的战略规划视野开阔,雄心勃勃,努力应对影响康奈尔和其他高校的主要挑战:变革速度加快,不断扩散的信息生态系统,不断缩减的经济基础,更加强调对教育的贡献,学术研究和创意表达在工作过程和成果上的区别不断模糊等等。 | Cornell University Library(著) 许德山(编译) | 2011 | 图书情报工作动态2011，，3： | 11 |
| 5 | Ceramide induces release of mitochondrial proapop-totic proteins in caspase-dependent and -independent manner in HT-29 cells显示文摘In this study, the release of mitochondrial proapoptotic intermembrane space proteins induced by ex-ogenous C2-ceramide in human colon carcinoma (HT-29) cell line was investigated. HT-29 cells were treated with 12.5, 25 and 50 μmol/L C2-ceramide in vitro. Flow cytometer was used to detect the mito-chondrial membrane potential (ΔΨm). Subcellular fractions were extracted by Mitochondrial/Cytosol Fractionation Kit after C2-ceramide treatment for 24 h. SDS-PAGE was used to determine the level of cytochrome c (Cyt c), high temperature requirement A2 (HtrA2) and second mitochondrial-derived ac-tivator of caspases (Smac) released from mitochondria, the expression of X-linked inhibitor of apop-tosis protein (XIAP) and caspase-3 for 24 h. The results showed that ΔΨm began to decrease from 6 h after 25 and 50 μmol/L C2-ceramide treatment (P<0.05) and cyclosporin A (CsA) could inhibit the col-lapse of ΔΨm through regulating mitochondrial membrane permeability transition pore. There was no effect of C2-ceramide on the expression of Cyt c, HtrA2 and Smac in the total levels. 12.5, 25 and 50 μmol/L C2-ceramide could induce Cyt c, HtrA2 and Smac to release from mitochondria to cytosol and down-regulate the expression of XIAP (P<0.05). Also there was expression of cleaved caspase-3 with C2-ceramide treatment. After the treatment with caspase inhibitor, C2-ceramide still induced the release of Cyt c and HtrA2, but Smac did not. Therefore, C2-ceramide could induce apoptosis of HT-29 cells through the mitochondria pathway. The release of Cyt c, HtrA2 and Smac from mitochondria did not occur via the same mechanism, the release of Cyt c and HtrA2 was caspase-independent and the re-lease of Smac was caspase-dependent. | ZHANG XiaoFeng1, LI BaiXiang1, ZHANG Yang1 & LIU JiaRen2 1 Public Health College, Harbin Medical University, Harbin 150081, China 2 Department of Food Science, Cornell University, New York 14853-7201, USA | 2008 | Science China(Life Sciences)2008，51，1： | 5 |
| 6 | Principles and Characteristics of Polymerization-Induced Self-Assembly with Various Polymerization Techniques显示文摘A chemical reaction that drives a physical polymer selfassembly process,namely,polymerization-induced self-assembly(PISA),combines block copolymer synthesis and nanoparticle formation efficiently at high polymer concentrations.Various nanoparticlemorphologies such as spheres,worms,and vesicles can be prepared readily in polar and nonpolarmedia.PISA has been well developed in combination with reversible addition-fragmentation chain transfer(RAFT)polymerization.Notably,developments with other polymerization methods are also achieved.In this report,first,we discuss the general principles of RAFT-PISA and the nanoparticles generated from this method.Specifically,new insights into polymer nucleation and subsequent morphological evolution are highlighted.Subsequently,PISA formulations that use other polymerization methods[atom transfer radical polymerization(ATRP),nitroxide-mediated polymerization(NMP),ring-opening metathesis polymerization(ROMP),and ring-opening polymerization(ROP)of N-carboxyanhydrides(NCAs)]are summarized in detail.Finally,more exotic PISA formulations are emphasized:these are based on organotelluriummediated living radical polymerization(TERP),living anionic polymerization(LAP),addition-fragmentation chain transfer(AFCT)polymerization,reversible complexation-mediated polymerization(RCMP),and cobalt-mediated radical polymerization(CMRP),or utilize a comonomer that undergoes radical ringopening polymerization(rROP).This reviewis concluded with a perspective on the status and potential of PISA. | Erik Jan Cornel Jinhui Jiang Shuai Chen Jianzhong Du | 2021 | CCS Chemistry2021，3，4： | 4 |
| 7 | Effects of Connection Fractures on SMRF Seismic Drift Demands显示文摘 | Nicolas Luco C. Allin Cornell | 2000 | Journal of Structural Engineering2000，，1： | 2 |
| 8 | Toxicity of Benzotriazole and Benzotriazole Derivatives to Three Aquatic Species显示文摘 | David A Pillard Jeffrey S Cornell Doree L DuFresne Mark T Hernandez | 2000 | Water Research2000，，2： | 2 |
| 9 | Flow of gases through consolidated porous media显示文摘 | Cornell D Katz D L | 1953 | Industrial and Engineering Chemistry1953，45，： | 2 |
| 10 | 微博是不是一种浪费时间的东西显示文摘'C语言'是一个新栏目,一个与编程毫无关系栏目。叫这个名字是因为Cornel的第一个字母是C,Cornel说的话自然就是C语言了。当我们说起一个IT事件,对于同一件事,不同的人可能都有不同的看法,站在不同角度的人就可能有截然相反的观点。'C语言'这个栏目试图帮你解开这个方程式,让我们一起看看X、Y、Z到底有多少种解…… | Cornel | 2010 | 电脑爱好者2010，，7： | 2 |
| 11 | Blood use in liver transplantation 显示文摘 | Lewis JH Bontempo FA Cornell F | 1987 | Transfusion1987，27，3： | 2 |
| 12 | Spectral shape, epsilon and record selection显示文摘 | Jack W.Baker C.Allin Cornell | 2006 | Earthquake Engng. Struct. Dyn2006，，9： | 2 |
| 13 | Influence of preload afterload,and contractivity on myocardial ultrosonic tissue characterization with integrated backscatter显示文摘 | NAITO J CORNEL J H SALUSTRO A | 1996 | Ultrosound Med Biol1996，22，3： | 2 |
| 14 | Spectral shape, epsilon and record selection显示文摘 | Jack W.Baker C.Allin Cornell | 2006 | Earthquake Engng Struct Dyn2006，，9： | 2 |
| 15 | Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats显示文摘Objective To evaluate the influence of an extract of Genista tinctoria L. herba(GT) or methylparaben(MP) on histopathological changes and 2 biomarkers of oxidative stress in rats subchronicly exposed to bisphenol A(BPA). Methods Adult female Wistar rats were orally exposed for 90 d to BPA(50 mg/kg), BPA+GT(35 mg isoflavones/kg) or BPA+MP(250 mg/kg). Plasma and tissue samples were taken from liver, kidney, thyroid, uterus, ovary, and mammary gland after 30, 60, and 90 d of exposure respectively. Lipid peroxidation and in vivo hydroxyl radical production were evaluated by histological analysis along with malondialdehyde and 2,3-dihydroxybenzoic acid detection. Results The severity of histopathological changes in liver and kidneys was lower after GT treatment than after BPA or BPA+MP treatment. A minimal thyroid receptor antagonist effect was only observed after BPA+MP treatment. The abnormal folliculogenesis increased in a time-dependent manner, and the number of corpus luteum decreased. No significant histological alterations were found in the uterus. The mammary gland displayed specific estrogen stimulation changes at all periods. Both MP and GT revealed antioxidant properties reducing lipid peroxidation and BPA-induced hydroxyl radical generation. Conclusion GT L. extract ameliorates the toxic effects of BPA and is proved to have antioxidant potential and antitoxic effect. MP has antioxidant properties, but has either no effect or exacerbates the BPA-induced histopathological changes. | Daniela-Saveta POPA Pompei BOLFA Bela KISS Laurian VLASE Ramona PLTINEAN Anca POP Cornel CTOI Gianina CRISAN Felicia LOGHIN | 2014 | Biomedical and Environmental Sciences2014，27，2： | 2 |
| 16 | A vector‐valued ground motion intensity measure consisting of spectral acceleration and epsilon显示文摘 | Jack W.Baker C.Allin Cornell | 2005 | Earthquake Engng Struct Dyn2005，，10： | 2 |
| 17 | Muschler, bone cells and matrices in orthopedic tissue engineering 显示文摘 | James E Flaming Charles N Cornell George F | 2000 | Orthop Clin North Am2000，31，3： | 1 |
| 18 | Sensitivity estimation within first and second order reliability methods显示文摘 | Karamchandani A Cornell C A | 1991 | Structural Safety1991，11，2： | 1 |
| 19 | Carcinoma of the duodenum 显示文摘 | Cortese AF Cornell GN | 1972 | Cancer1972，29，4： | 1 |
| 20 | Incremental dynamic analysis 显示文摘 | Dimitrios Vamvatsikos C Allin Cornell | 2002 | Earthquake Engineering And Structural Dynamics2002，31，： | 1 |
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