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| 1 | Genotype phenotype classification of hepatocellular adenoma显示文摘Studies that compare tumor genotype with phenotype have provided the basis of a new histological/molecular classification of hepatocellular adenomas. Based on two molecular criteria (presence of a TCF1/HNF1α or β-catenin mutation), and an additional histological criterion (presence or absence of an inflammatory infiltrate), subgroups of hepatocellular adenoma can be defined and distinguished from focal nodular hyperplasia. Analysis of 96 hepatocellular adenomas performed by a French collaborative network showed that they can be divided into four broad subgroups: the fi rst one is defi ned by the presence of mutations in TCF1 gene inactivating the hepatocyte nuclear factor 1 (HNF1α); the second by the presence of β-catenin activating mutations; the category without mutations of HNF1α or β-catenin is further divided into 2 subgroups depending on the presence or absence of in? ammation. Therefore, the approach to the diagnosis of problematic benign hepatocytic nodules may be entering a new era directed by new molecular information. It is hoped that immunohistological tools will improve significantly diagnosis of liver biopsy in our ability to distinguish hepatocellular adenoma from focal nodular hyperplasia (FNH), and to delineate clinically meaningful entities within each group to define the best clinical management. The optimal care of patients with a liver nodule will benefit from the recent knowledge coming from molecular biology and the combined expertise of hepatologists, pathologists, radiologists, and surgeons. | Paulette Bioulac-Sage Jean Frédéric Blanc Sandra Rebouissou Charles Balabaud Jessica Zucman-Rossi | 2007 | World Journal of Gastroenterology2007，13，19： | 7 |
| 2 | Relationship between the severity of hepatitis C virus-related liver disease and the presence of Helicobacter species in the liver: A prospective study显示文摘AIM: To determine the presence of Helicobacter species DNA in the liver of chronic hepatitis C (CHC) patients with and without cirrhosis as compared to controls, and to identify the bacterial species involved. METHODS: Seventy-nine consecutive patients (HBV and HIV negative) with a liver sample obtained after liver biopsy or hepatic resection were studied: 41 with CHC without cirrhosis, 12 with CHC and cirrhosis, and 26 controls (HCV negative). Polymerase chain reactions (PCRs) targeting Helicobacter 16S rDNA and species- specific were performed on DNA extracted from the liver. A gastric infection with H pylori was determined by serology and confirmed by 13C-urea breath test. RESULTS: Overall, Helicobacter 16S rDNA was found in 16 patients (20.2%). Although positive cases tended to be higher in CHC patients with cirrhosis (41.6%) than in those without cirrhosis (17.0%) or in controls (15.4%), the difference was not statistically significant (P =0.08). H pylori-like DNA was identified in 12 cases and H. pullorum DNA in 2, while 2 cases remained unidenti- fied. Gastric infection with H pylori was found in only 2 of these patients. CONCLUSION: Our results do not confirm the associ- ation of Helicobacter species DNA in the liver of CHC patients with advanced liver disease. The lack of correlation between positive H pylori serology and the presence of H pylori-like DNA in the liver may indicate the presence of a variant of this species. | Laurent Castéra Anne Pedeboscq Marcia Rocha Brigitte Le Bail Corinne Asencio Victor de Lédinghen Pierre-Henri Bernard Christophe Laurent Marie-Edith Lafon Maylis Capdepont Patrice Couzigou Paulette Bioulac-Sage Charles Balabaud FrancisMégraud Armelle Ménard | 2006 | World Journal of Gastroenterology2006，12，45： | 3 |
| 3 | A Hepatocellular Carcinoma 5-Gene Score Associated With Survival of Patients After Liver Resection显示文摘 | Jean–Charles Nault Aurélien De Reyniès Augusto Villanueva Julien Calderaro Sandra Rebouissou Gabrielle Couchy Thomas Decaens Dominique Franco Sandrine Imbeaud Francis Rousseau Daniel Azoulay Jean Saric Jean–Frédéric Blanc Charles Balabaud Paulette Bioulac | 2013 | Gastroenterology2013，，1： | 3 |
| 4 | Smoothelin,a new marker to determine the origin of liver fibrogenic cells显示文摘AIM:To explore this hypothesis that smooth muscle cells may be capable of acquiring a myofibroblastic phenotype,we have studied the expression of smoothelin in fibrotic conditions.METHODS:Normal liver tissue(n=3)was obtained from macroscopically normal parts of hepatectomy,taken at a distance from hemangiomas.Pathological specimens included post-burn cutaneous hypertrophic scars(n=3),fibrotic liver tissue(n=5),cirrhotic tissue(viral and alcoholic hepatitis)(n=5),and hepatocellular carcinomas(n=5).Tissue samples were fixed in 10%formalin and embedded in paraffin for immunohistochemistry or were immediately frozen in liquid nitrogen-cooled isopentane for confocal microscopy analysis.Sections were stained with antibodies against smoothelin,which is expressed exclusively by smooth muscle cells,andα-smooth muscle actin,which is expressed by both smooth muscle cells and myofibroblasts.RESULTS:In hypertrophic scars,α-smooth muscle actin was detected in vascular smooth muscle cells and in numerous myofibroblasts present in and around nodules,whereas smoothelin was exclusively expressed in vascular smooth muscle cells.In the normal liver,vascular smooth muscle cells were the only cells that expressα-smooth muscle actin and smoothelin.In fibrotic areas of the liver,myofibroblasts expressingα-smooth muscle actin were detected.Myofibroblasts co-expressingα-smooth muscle actin and smoothelin were observed,and their number was slightly increased in parallel with the degree of fibrosis(absent in liver with mild or moderate fibrosis;5%to 10%positive in liver showing severe fibrosis).In cirrhotic septa,numerous myofibroblasts co-expressedα-smooth muscle actin and smoothelin(more than 50%).In hepatocellular carcinomas,the same pattern of expression forα-smooth muscle actin and smoothelin was observed in the stroma reaction surrounding the tumor and around tumoral cell plates.In all pathological liver samples,α-smooth muscle actin and smoothelin were co-expressed in vascular smooth muscle cells.CONCLUSION:During development of advanced liver fibrosis,a subpopulation of myofibroblasts expressing smoothelin may be derived from vascular smooth muscle cells,illustrating the different cellular origins of myofibroblasts. | Sébastien Lepreux Christelle Guyot Fabrice Billet Chantal Combe Charles Balabaud Paulette Bioulac-Sage Alexis Desmoulière | 2013 | World Journal of Gastroenterology2013，19，48： | 2 |
| 5 | Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis显示文摘 | Jean Charles Nault Julien Calderaro Luca Di Tommaso Charles Balabaud Elie Serge Zafrani Paulette Bioulac‐Sage Massimo Roncalli Jessica Zucman‐Rossi | 2014 | Hepatology2014，，6： | 2 |
| 6 | Results of treatment of sep- tic knee arthritis:A retrospective series of 40 cases显示文摘 | Balabaud L Gaudias J Boeri C | 2007 | Knee Surg Sports Traumatol Arthrose2007，15，4： | 1 |
| 7 | Morphologic investigation of sinusoidal cells显示文摘 | Le Bail B Balabaud C | 1993 | Semin Liver Dis1993，13，1： | 1 |
| 8 | microRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations显示文摘 | Ladeiro Y Couchy G Balabaud C | 2008 | Hepato- logy2008，47，6： | 1 |
| 9 | MicroRNA profiling in hepatocellular tumors is associated to clin- ical festures an oncogene tumor suppressor gene mutations 显示文摘 | LADEIRO Y COUCHY G BALABAUD C | 2008 | Hepatology2008，47，： | 1 |
| 10 | Focal nodular hyperplasia, hepatocellular adenomas : past, present, future 显示文摘 | Bioulac-Sage P Balabaud C Zucman-Rossi J | 2010 | Gastroenterol Clin Bio12010，34，67： | 1 |
| 11 | Innervation of the sinusoidal wall:regulation of the sinusoidal diameter显示文摘 | Ueno T Bioulac-Sage p Balabaud C | 2004 | Anat Rec A Discov Mol Cell Evol Biol2004，280，1： | 1 |
| 12 | Perinodular CK19 loss in hepatocarcinogenesis显示文摘 | Paulette Bioulac-Sage Charles Balabaud | 2011 | Clinics and Research in Hepatology and Gastroenterology2011，，12： | 1 |
| 13 | MicroRNA profiling in hepatocellular tumors is associated with clinical features and onco- gene/tumor suppressor gene mutations 显示文摘 | Ladeiro of Couchy G Balabaud C | 1955 | Hepatology1955，47，6： | 1 |
| 14 | Results of treatment of septic knee arthritis: a retrospective series of 40 eases 显示文摘 | Balabaud L Gaudias J Boeri C | 2007 | Knee Surg Sports Trau -- matol Arthrose2007，15，4： | 1 |
| 15 | Results of treat- ment of septic knee arthrltis: a retrospective series of 40 cases 显示文摘 | Balabaud L Gaudias J Boeri C | 2007 | Knee Surg Sports Traumatol Arthrosc2007，15，4： | 1 |
| 16 | Results of treatment of septic knee arthritis : a retrospective series of 40 cases显示文摘 | Balabaud L Gaudias J Boeri C | 2007 | Knee Surg Sports Traumatol Arthrosc2007，15，： | 1 |
| 17 | MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations 显示文摘 | Ladeiro Y Couehy G Balabaud C | 2008 | Hepatology2008，47，6： | 1 |
| 18 | Interest of the Mini Mental State Examination to detect cognitive defects after cardiac surgery显示文摘 | Weissrock S Levv F Balabaud V | 2005 | Ann Fr Anesth Reanim2005，24，10： | 1 |
| 19 | Subtype classifica-tion of hepatocellular adenoma显示文摘 | Cross-Ref M Bioulac-Sage P Balabaud C | 2010 | Dig Surg2010，27，1： | 1 |
| 20 | Subtype classifica tion of hepatocellular adenoma显示文摘 | Bioulac-Sage P Balabaud C Zucman-Rossi J | 2010 | Dig Surg2010，27，： | 1 |
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