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| 1 | Pharmacomicrobiomics: a novel route towards personalized medicine?显示文摘在药反应的内部个人的异质是影响病人幸福并且在社会水平上提出庞大的临床、金融的负担的一个严重问题。Pharmacogenomics 在关于药反应可变性或药毒性的对单个基因背景的影响的研究的最前线,并且最近,内脏 microbiome,也被称为第二个染色体,在这个方面作为一个重要播放器被认出了。而且, microbiome 是为由于机会改进药功效和安全操作它的作文的一个很吸引人的目标。Pharmacomicrobiomics 是调查 microbiome 变化和药反应和布置(吸收,分发,新陈代谢和排泄) 的相互影响的一个新兴的领域。在这评论,我们提供历史的概述并且在在内脏 microbiome,主人和药之间的复杂相互作用上检验当前的最先进的知识。我们主张那联合 pharmacogenomics 和 pharmacomicrobiomics 将为在个性化的药做主要进展提供一个重要基础。 | Marwah Doestzada Arnau Vich Vila Alexandra Zhernakova Debby P.Y. Koonen Rinse K. Weersma Daan J. TOUW Folkert Kuipers Cisca Wijmenga Jingyuan Fu | 2018 | Protein & Cell2018，9，5： | 7 |
| 2 | A Subpopulation of CD26 + Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer显示文摘 | Roberta Pang Wai Lun Law Andrew C.Y. Chu Jensen T. Poon Colin S.C. Lam Ariel K.M. Chow Lui Ng Leonard W.H. Cheung Xiao R. Lan Hui Y. Lan Victoria P.Y. Tan Thomas C. Yau Ronnie T. Poon Benjamin C.Y. Wong | 2010 | Cell Stem Cell2010，，6： | 4 |
| 3 | Gastric Cancer Chemoprevention显示文摘 | Victoria P.Y. Tan Benjamin C.Y. Wong | 2013 | Gastroenterology Clinics of North America2013，，2： | 2 |
| 4 | Analysis of sources of innovation, technological innovation capabilities, and performance: An empirical study of Hong Kong manufacturing industries显示文摘 | Richard C.M. Yam William Lo Esther P.Y. Tang Antonio K.W. Lau | 2010 | Research Policy2010，，3： | 2 |
| 5 | 大鳞大马哈鱼垂体促甲状腺素和促性腺激素分离纯化的研究显示文摘本文报道应用ConA-Sepharose 4B.亲和层析、凝胶过滤层析、离子交换层析及免疫亲和层析等技术,首次从大鳞大马哈鱼垂体中分离纯化了促甲状腺素(sTSH)和促性腺激素(sGTH)。在TSH生物测定中,纯化的。sTSH制品具有明显促进虹鳟幼鱼甲状腺体内分泌甲状腺素(T4)的生物活性,而sGTH无此活性。在GTH生物测定中,制备的sGTH具有显著诱导虹鳟卵母细胞体外培养成熟(GVBD)及分泌17α、20β-二氢孕酮的能力,而sTSH无此活性。HPLC表明sTSH和sGTH的分子量分别为27500和38000道尔顿。作者用SDS聚丙烯酰胺凝胶电泳(SDS-PAGE)和等电聚焦检测了激素的纯度及等电点,用RIA或ELISA方法测定了几种垂体激素在sTSH终产物中的污染程度。 | 陈松林 B.布里顿 P.Y.勒巴依 | 1991 | 动物学报1991，37，3： | 2 |
| 6 | Matrix metalloproteinase 9 mRNA: An early prognostic marker for patients with acute stroke显示文摘 | Colin A. Graham Rebecca W.Y. Chan Dexter Y.S. Chan Cangel P.Y. Chan Lawrence K.S. Wong Timothy H. Rainer | 2011 | Clinical Biochemistry . 2011 (4-5)2011，，： | 2 |
| 7 | The angiosuppressive effects of 20(R)- ginsenoside Rg 3显示文摘 | Patrick Y.K. Yue Daisy Y.L. Wong P.K. Wu P.Y. Leung N.K. Mak H.W. Yeung L. Liu Zongwei Cai Zhi-Hong Jiang T.P.D. Fan Ricky N.S. Wong | 2006 | Biochemical Pharmacology2006，，4： | 1 |
| 8 | Lay-up optimization of multilayered anisotropic cylinders based on a 3-D elasticity solution显示文摘 | P.Y. Tabakov E.B. Summers | 2005 | Computers and Structures2005，，5： | 1 |
| 9 | Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle显示文摘 | Debby P.Y. Koonen Jan F.C. Glatz Arend Bonen Joost J.F.P. Luiken | 2005 | BBA - Molecular and Cell Biology of Lipids2005，，3： | 1 |
| 10 | A botryoid rhabdomyosarcoma diagnosed as a choledochal cyst显示文摘 | L. Margain‐Deslandes T. Gelas C. Bergeron J.P. Pracros S. Collardeau‐Frachon A. Lachaux P.Y. Mure | 2013 | Pediatr Blood Cancer2013，，12： | 1 |
| 11 | Paleohydrologic bounds and extreme flood frequency of the Upper Arkansas River, Colorado, USA显示文摘 | J.F. England J.E. Godaire R.E. Klinger T.R. Bauer P.Y. Julien | 2010 | Geomorphology2010，，1： | 1 |
| 12 | Luminescence properties of sol–gel derived spherical SiO 2 @Gd 2 (WO 4 ) 3 :Eu 3+ particles with core–shell structure显示文摘 | P.Y. Jia X.M. Liu M. Yu Y. Luo J. Fang J. Lin | 2006 | Chemical Physics Letters2006，，4： | 1 |
| 13 | Numerical analysis of the stress–strain distributions in the particle reinforced metal matrix composite SiC/6064Al显示文摘 | M.N. Yuan Y.Q. Yang C. Li P.Y. Heng L.Z. Li | 2012 | Materials and Design2012，，： | 1 |
| 14 | Rethinking the use of radiation and chemotherapy after radical hysterectomy: a clinical–pathologic analysis of a Gynecologic Oncology Group/Southwest Oncology Group/Radiation Therapy Oncology Group trial显示文摘 | Bradley J. Monk Jianmin Wang Samuel Im Richard J. Stock William A. Peters P.Y. Liu Rolland J. Barrett Jonathan S. Berek Luis Souhami Perry W. Grigsby William Gordon David S. Alberts | 2004 | Gynecologic Oncology2004，，3： | 1 |
| 15 | Influence of the temperature on residual stresses and springback effect in an aluminium alloy显示文摘 | R. Grèze P.Y. Manach H. Laurent S. Thuillier L.F. Menezes | 2010 | International Journal of Mechanical Sciences2010，，9： | 1 |
| 16 | Extrauterine Intrapartum Treatment (EXIT) in bilateral primary fetal hydrothorax显示文摘 | P.Y. Henry C.S. Aravindan K. Sivakumar H.R. Krishna | 2009 | The Indian Journal of Pediatrics2009，，1： | 1 |
| 17 | The effect of reactive element additions on the selective oxidation, growth and adhesion of chromia scales显示文摘 | P.Y. Hou J. Stringer | 1995 | Materials Science & Engineering A1995，，1： | 1 |
| 18 | Numerical study of springback using the split-ring test for an AA5754 aluminum alloy显示文摘 | H. Laurent R. Grèze M.C. Oliveira L.F. Menezes P.Y. Manach J.L. Alves | 2010 | Finite Elements in Analysis & Design2010，，9： | 1 |
| 19 | Extension of the target cascading formulation to the design of product families显示文摘 | M. Kokkolaras R. Fellini H.M. Kim N.F. Michelena P.Y. Papalambros | 2002 | Structural and Multidisciplinary Optimization2002，，4： | 1 |
| 20 | The evolving influence of laparoscopy and laparoscopic ultrasonography on patients with hepatocellular carcinoma显示文摘 | Eric C.H. Lai Chung Ngai Tang Joe P.Y. Ha David K.K. Tsui Michael K.W. Li | 2008 | The American Journal of Surgery2008，，5： | 1 |
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