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| 1 | JUPITER-02 trial: advancing survival for recurrent metastatic nasopharyngeal carcinoma and next steps显示文摘Nasopharyngeal carcinoma(NPC)is a disease with unique epidemiology.It is endemic in Southern China,Southeast Asia,and North Africa,and typically affects males more than females in the 30-60 years age group[1].Globally,133,354 NPC cases were diagnosed in 2020 with 80,008;deaths in the same year[2].While the survival rates of early-stage NPC after radiotherapy(RT)are high,dis-ease recurrences are common in locoregionally-advanced NPC,with the predominant pattern of failure being dis-tant metastasis[3].In this clinical scenario,palliative chemotherapy is the primary treatment modality。 | Laura Ling Ying Tan Quynh-Thu Le Nancy Ying Ying Lee Melvin Lee Kiang Chua | 2022 | Cancer Communications2022，42，1： | 2 |
| 2 | It Takes Two to Tango: Entrepreneurship and Creativity in Troubled Times--Vietnam 2012显示文摘 | Nancy K. Napier Dang Le Nguyen Vu Quan Hoang Vuong | 2012 | Journal of Sociology Study2012，2，9： | 2 |
| 3 | High Prognostic Impact of Flow Cytometric Minimal Residual Disease Detection in Acute Myeloid Leukemia: Data From the HOVON/SAKK AML 42A Study显示文摘 | Monique Terwijn Wim L.J. van Putten Angèle Kelder Vincent H.J. van der Velden Rik A. Brooimans Thomas Pabst Johan Maertens Nancy Boeckx Georgine E. de Greef Peter J.M. Valk Frank W.M.B. Preijers Peter C. Huijgens Angelika M. Dr?ger Urs Schanz Mojca Jongen | 2013 | Journal of Clinical Oncology2013，，31： | 1 |
| 4 | The use of an alginic acid matrix to support in vitor development of isolated murine blastomeres显示文摘 | Nancy LE Glen PN Michael CD | 1990 | Journal of in vitro fertilization and embryo transfer1990，7，1： | 1 |
| 5 | Mindfulness based stress reduction in post-treatment breast cancer patients: an examination of symptoms and symptom clusters显示文摘 | Cecile A. Lengacher Richard R. Reich Janice Post-White Manolete Moscoso Melissa M. Shelton Michelle Barta Nancy Le Pinky Budhrani | 2012 | Journal of Behavioral Medicine2012，，1： | 1 |
| 6 | Addition of bevacizumab to standard chemoradiation for locoregionally advanced nasopharyngeal carcinoma (RTOG 0615): a phase 2 multi-institutional trial显示文摘 | Nancy Y Lee Qiang Zhang David G Pfister John Kim Adam S Garden James Mechalakos Kenneth Hu Quynh T Le A Dimitrios Colevas Bonnie S Glisson Anthony TC Chan K Kian Ang | 2012 | Lancet Oncology2012，，2： | 1 |
| 7 | Swidden Transformations and Rural Livelihoods in Southeast Asia显示文摘 | R. A. Cramb Carol J. Pierce Colfer Wolfram Dressler Pinkaew Laungaramsri Quang Trang Le Elok Mulyoutami Nancy L. Peluso Reed L. Wadley | 2009 | Human Ecology2009，，3： | 1 |
| 8 | Addition of bevacizumab to standard chemoradiation for locoregionally advanced nasopharyngeal carcinoma (RTOG 0615): a phase 2 multi-institutional trial显示文摘 | Nancy Y Lee Qiang Zhang David G Pfister John Kim Adam S Garden James Mechalakos Kenneth Hu Quynh T Le A Dimitrios Colevas Bonnie S Glisson Anthony TC Chan K Kian Ang | 2012 | Lancet Oncology2012，，2： | 1 |
| 9 | Next- generation sequencing improves the diagnosis of Lhyroid fna specimens with indeterminate cytology 显示文摘 | Marie Le mercier Nicky D'haene Nancy De Neve | 2015 | Histopathology2015，66，2： | 1 |
| 10 | Intensity-Modulated Radiotherapy for Tumors of the Nasal Cavity and Paranasal Sinuses: Clinical Outcomes and Patterns of Failure显示文摘 | Ellen A. Wiegner Megan E. Daly James D. Murphy Jonathan Abelson Chris H. Chapman Melody Chung Yao Yu A. Dimitrios Colevas Michael J. Kaplan Nancy Fischbein Quynh-Thu Le Daniel T. Chang | 2012 | International Journal of Radiation Oncology Biology Physics2012，，1： | 1 |
| 11 | The tetraspanin CD9 associates with the integrin α6β4 in cultured human epidermal keratinocytes and is involved in cell motility显示文摘 | Barbara Baudoux Diego Castanares-Zapatero Michèle Leclercq-Smekens Nancy Berna Yves Poumay | 2000 | European Journal of Cell Biology2000，，1： | 1 |
| 12 | FAK Is required for c‐Met/β‐catenin‐driven hepatocarcinogenesis显示文摘 | Na Shang Maribel Arteaga Ali Zaidi Jimmy Stauffer Scott J. Cotler Nancy J. Zeleznik‐Le Jiwang Zhang Wei Qiu | 2015 | Hepatology2015，，1： | 1 |
| 13 | MFSD7c functions as a transporter of choline at the blood–brain barrier显示文摘Mutations in the orphan transporter MFSD7c(also known as Flvcr2),are linked to Fowler syndrome.Here,we used Mfsd7c knockout(Mfsd7c–/–)mice and cell-based assays to reveal that MFSD7c is a choline transporter at the blood–brain barrier(BBB).We performed comprehensive metabolomics analysis and detected differential changes of metabolites in the brains and livers of Mfsd7c–/–embryos.Particularly,we found that choline-related metabolites were altered in the brains but not in the livers of Mfsd7c–/–embryos.Thus,we hypothesized that MFSD7c regulates the level of choline in the brain.Indeed,expression of human MFSD7c in cells significantly increased choline uptake.Interestingly,we showed that choline uptake by MFSD7c is greatly increased by choline-metabolizing enzymes,leading us to demonstrate that MFSD7c is a facilitative transporter of choline.Furthermore,single-cell patch clamp analysis showed that the import of choline by MFSD7c is electrogenic.Choline transport function of MFSD7c was shown to be conserved in vertebrates,but not in yeasts.We demonstrated that human MFSD7c is a functional ortholog of HNM1,the yeast choline importer.We also showed that several missense mutations identified in patients exhibiting Fowler syndrome had abolished or reduced choline transport activity.Mice lacking Mfsd7c in endothelial cells of the central nervous system suppressed the import of exogenous choline from blood but unexpectedly had increased choline levels in the brain.Stable-isotope tracing study revealed that MFSD7c was required for exporting choline derived from lysophosphatidylcholine in the brain.Collectively,our work identifies MFSD7c as a choline exporter at the BBB and provides a foundation for future work to reveal the disease mechanisms of Fowler syndrome. | Xuan Thi Anh Nguyen Thanh Nha Uyen Le Toan Q.Nguyen Hoa Thi Thuy Ha Anna Artati Nancy C.P.Leong Dat T.Nguyen Pei Yen Lim Adelia Vicanatalita Susanto Qianhui Huang Ling Fam Lo Ngah Leong Isabelle Bonne Angela Lee Jorge L.Granadillo Catherine Gooch Dejie Yu Hua Huang Tuck Wah Soong Matthew Wook Chang Markus R.Wenk Jerzy Adamski Amaury Cazenave-Gassiot Long N.Nguyen | 2024 | Cell Research2024，34，3： | 0 |
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