|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells显示文摘Previously, we demonstrated that a plant steroid, diosgenin, altered cell cycle distribution and induced apoptosis in the human osteosarcoma 1547 cell line. The objective of this study was to investigate if the antiproliferative effect of diosgenin was similar for different human cancer cell lines such as laryngocarcinoma HEp-2 and melanoma M4Beu cells. Moreover, this work essentially focused on the mitochondrial pathway. We found that diosgenin had an important and similar antiproliferative effect on different types of cancer cells. In addition, our new results show that diosgenininduced apoptosis is caspase-3 dependent with a fall of mitochondrial membrane potential, nuclear localization of AIF and poly (ADP-ribose) polymerase cleavage. Diosgenin treatment also induces p53 activation and cell cycle arrest in the different cell lines studied. | Cecile CORBIERE Bertrand LIAGRE Faraj TERRO Jean-Louis BENEYTOUT | 2004 | Cell Research2004，14，3： | 29 |
| 2 | CD36: linking lipids to the NLRP3 inflammasome, atherogenesis and atherothrombosis显示文摘 | Cecile Oury | 2014 | Cellular & Molecular Immunology2014，11，1： | 9 |
| 3 | Nitric Oxide in Plants: Production and Cross-talk with Ca^2+ Signaling显示文摘氮的氧化物(没有) 是在动物在生理的过程的一个宽数组执行关键功能的两价的气体。过去的几年在植物关于它的角色揭示了大部分。被硝酸盐 reductase (NR ) 并且经由化学小径不从亚硝酸根综合,这很好被建立。为没有生产是从由到目前为止非识别的酶的 L 精氨酸的 catalysed 的一条其他的在小径的出现正在增加证据。矛盾的结果处于特定的生理的条件关于这些酶的各自的参与被报导了。尽管大部分尚待被证明,我们假设这些矛盾能被说明因为由过去常不压制合成的药理学代理人的有限特性而且由象在硝酸盐的硝酸盐可渗透的阴离子隧道的迟钝一样的 L 精氨酸的减少的内容 reductase- 或 nitrate/nitrite-deficient 种。另一个未解决的问题使不在植物位于效果下面的分子的机制担心。这里,我们提供证据包括 MAPK 和 SnRK2 的第二送信人 Ca2+ ,以及蛋白质 kinases,是很嘴巧的调停人没有信号。这些调查结果关于在植物的不基于的发信号的开的新观点。 | Angelique Besson-Bard Cecile Courtois Adrien Gauthier Jennifer Dahan Grazyna Dobrowolska Sylvain Jeandroz Alain Pugin David Wendehenne | 2008 | Molecular Plant2008，1，2： | 9 |
| 4 | Cytoreductive surgery and intraperitoneal chemotherapy for colorectal peritoneal metastases显示文摘AIM:To systematically review the available evidence regarding cytoreductive surgery(CRS) and intraperitoneal chemotherapy(IPC) for colorectal peritoneal metastases(CPM).METHODS:An electronic literature search was carried out to identify publications reporting oncological outcome data(overall survival and/or disease free survival and/or recurrence rates)following CRS and IPC for treatment of CPM.Studies reporting outcomes following CRS and IPC for cancer subtypes other than colorectal were only included if data were reported independently for colorectal cancer-associated cases;in addition studies reporting outcomes for peritoneal carcinomatosis of appendiceal origin were excluded.RESULTS:Twenty seven studies,published between1999 and 2013 with a combined population of 2838patients met the predefined inclusion criteria.Included studies comprised 21 case series,5 case-control studies and 1 randomised controlled trial.Four studies provided comparative oncological outcome data for patients undergoing CRS in combination with IPC vs systemic chemotherapy alone.The primary indication for treatment was CPM in 96%of cases(2714/2838)and recurrent CPM(rCPM)in the remaining 4%(124/2838).In the majority of included studies(20/27)CRS was combined with hyperthermic intraperitoneal chemotherapy(HIPEC).In 3 studies HIPEC was used in combination with early post-operative intraperitoneal chemotherapy(EPIC),and 2 studies used EPIC only,following CRS.Two studies evaluated comparative outcomes with CRS+HIPEC vs CRS+EPIC for treatment of CPM.The delivery of IPC was performed using an'open'or'closed'abdomen approach in the included studies.CONCLUSION:The available evidence presented in this review indicates that enhanced survival times can be achieved for CPM after combined treatment with CRS and IPC. | Reza Mirnezami Brendan J Moran Kate Harvey Tom Cecil Kandiah Chandrakumaran Norman Carr Faheez Mohamed Alexander H Mirnezami | 2014 | World Journal of Gastroenterology2014，20，38： | 6 |
| 5 | 不同针头设计的预灌封注射器用于预防接种的对比研究显示文摘目的探讨5切面27G与3切面25G两种针头设计的预灌封注射器在受试者的疼痛感、接种护士的穿刺阻力以及注射部位不良事件等预防接种实践中的差异。方法采用随机双盲平行对照临床试验。将604例受试者随机分为2组,试验组299例使用5切面27G预灌封注射器,对照组305例使用3切面25G预灌封注射器接种甲肝疫苗,同时2组均使用3切面25G预灌封注射器接种乙肝疫苗作为自身对照。比较受试者疼痛与穿刺阻力,并比较受试者注射部位皮肤不良反应情况。结果采用视觉模拟量表(VAS)和疼痛程度语言等级量表中文版(C-PIVRS)评分法对甲肝疫苗穿刺时的疼痛感进行分级评价,试验组中等及以上疼痛比例分别为7.02%、16.55%;对照组分别为15.73%、20.32%,组间差异有统计学意义(均P≤0.001)。对照组注射甲肝时穿刺皮肤阻力VAS评分显著高于试验组(P<0.001)。试验组注射部位皮肤不良反应发生率低于对照组,分别为47.49%和65.25%(P<0.001)。结论5切面27G预灌封注射器用于疫苗接种时,受试者的疼痛度、针头的穿刺阻力以及注射部位不良事件发生率显著低于3切面25G针头设计的预灌封注射器。 | 吕敏 白霜 高培 王怀 富继业 史如晶 董琳 Florence Schwarzenbach Cecile Berteau 吴疆 | 2019 | 中华全科医学2019，17，11： | 6 |
| 6 | L-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes显示文摘 | Cecile Apert Paola Romagnoli Joost P, M. van Meerwijk | 2018 | Protein & Cell2018，9，4： | 5 |
| 7 | Outcomes in randomized controlled trials of exercise interventions in solid organ transplant显示文摘AIM To identify the outcome measures that have been used in randomized controlled trials(RCTs) of exercise training in solid organ transplant(SOT) recipients and to link these outcomes to the International Classification of Functioning, Disability and Health(ICF) framework.METHODS Electronic literature searches of MEDLINE, EMBASE, CINAHL, Cochrane, Scopus, and Web of Science were performed. We sought RCTs that investigated the effect of exercise training in SOT recipients. Reference lists of all eligible publications were searched for other appropriate studies not identified by the electronic search. A complete list of outcome measures used in the RCTs was generated and each of these was linked to an ICF category.RESULTS Four hundred and thirteen articles were retrieved, of which 35 met our inclusion criteria. The studies included were designed to compare the effects of exercise training programs to usual care or to another exercise training program and reported on recipients of heart(n = 21), kidney(n = 9), lung(n = 3) or liver(n = 2) transplant. Of the 126 outcome measures identified, 62 were used as primary outcome measures. The most commonly occurring primary outcomes were aerobic capacity using the peak VO2(n = 13), quality of life using the shortform-36(n = 8), and muscle strength(n = 7). Theseoutcome measures were linked to 113 ICF categories and the majority of outcomes fall into the body function domain(n = 93). CONCLUSION There is little standardization in outcome measures used in RCTs of exercise interventions in SOT recipients. The ICF framework can be used to select a core set of outcomes that cross all domains of ICF and that would be appropriate to all SOT recipients. | Tania Janaudis-Ferreira Sunita Mathur Stacey Konidis Catherine M Tansey Cecile Beaurepaire | 2016 | World Journal of Transplantation2016，6，4： | 4 |
| 8 | Is it growing exponentially fast? -Impact of assuming exponential growth for characterizing and forecasting epidemics with initial near-exponential growth dynamics显示文摘The increasing use of mathematical models for epidemic forecasting has highlighted the importance of designing models that capture the baseline transmission characteristics in order to generate reliable epidemic forecasts.Improved models for epidemic forecasting could be achieved by identifying signature features of epidemic growth,which could inform the design of models of disease spread and reveal important characteristics of the transmission process.In particular,it is often taken for granted that the early growth phase of different growth processes in nature follow early exponential growth dynamics.In the context of infectious disease spread,this assumption is often convenient to describe a transmission process with mass action kinetics using differential equations and generate analytic expressions and estimates of the reproduction number.In this article,we carry out a simulation study to illustrate the impact of incorrectly assuming an exponential-growth model to characterize the early phase(e.g.,3e5 disease generation intervals)of an infectious disease outbreak that follows near-exponential growth dynamics.Specifically,we assess the impact on:1)goodness of fit,2)bias on the growth parameter,and 3)the impact on short-term epidemic forecasts.Our findings indicate that devising transmission models and statistical approaches that more flexibly capture the profile of epidemic growth could lead to enhanced model fit,improved estimates of key transmission parameters,and more realistic epidemic forecasts. | Gerardo Chowell Cecile Viboud | 2016 | Infectious Disease Modelling2016，1，1： | 4 |
| 9 | Diabetic nephropathy:Treatment with phosphodiesterase type 5 inhibitors显示文摘The importance of nitric oxide(NO) in vascular physiology is irrefutable;it stimulates the intracellular production of cyclic guanosine monophosphate(cGMP),initiating vascular smooth muscle relaxation.This biochemical process increases the diameter of small arteries,regulating blood flow distribution between arterioles and the microvasculature.The kidney is no exception,since NO predominantly dilates the glomerular afferent arterioles.It is now evident that the vascular production of cGMP can be augmented by inhibitors of phosphodiesterase type 5(PDE 5),the enzyme which breakdowns this cyclic nucleotide.This has clinical relevance,since diabetic nephropathy(DN) a major microvascular complication of diabetes mellitus and the most common cause of end-stage renal disease,increases intraglomerular capillary pressure,leading to glomerular hypertension.PDE 5 inhibitors may have,therefore,the potential to reduce glomerular hypertension.This review describes the use of PDE 5 inhibitors to improve the metabolic,haemodynamic and inflammatory pathways/responses,all of which are dysfunctional in DN. | Cecil Stanley Thompson | 2013 | World Journal of Diabetes2013，4，4： | 4 |
| 10 | 亚欧城市林业合作与欧洲城市林业实践显示文摘文章回顾了亚欧城市林业合作的背景与进程,总结了欧洲城市林业发展在城市森林规划、森林资源概况、森林的产品和服务、林业科学研究、公共政策和林业教育方面的实践。最后提出欧洲城市林业发展的主要趋势和对中国城市林业的借鉴与启示。 | 李智勇 Cecil C.Konijnendijk | 2006 | 中国城市林业2006，4，1： | 4 |
| 11 | Compound screening platform using human induced pluripotent stem cells to identify small molecules that promote chondrogenesis显示文摘Articular cartilage,which is mainly composed of collagen Ⅱ,enables smooth skeletal movement.Degeneration of collagen Ⅱ can be caused by various events,such as injury,but degeneration especially increases over the course of normal aging.Unfortunately,the body does not fully repair itself from this type of degeneration,resulting in impaired movement.Microfracture,an articular cartilage repair surgical technique,has been commonly used in the clinic to induce the repair of tissue at damage sites.Mesenchymal stem cells(MSC)have also been used as cell therapy to repair degenerated cartilage.However,the therapeutic outcomes of all these techniques vary in different patients depending on their age,health,lesion size and the extent of damage to the cartilage.The repairing tissues either form fibrocartilage or go into a hypertrophic stage,both of which do not reproduce the equivalent functionality of endogenous hyaline cartilage.One of the reasons for this is inefficient chondrogenesis by endogenous and exogenous MSC.Drugs that promote chondrogenesis could be used to induce self-repair of damaged cartilage as a non-invasive approach alone,or combined with other techniques to greatly assist the therapeutic outcomes.The recent development of human induced pluripotent stem cell(iPSCs),which are able to self-renew and differentiate into multiple cell types,provides a potentially valuable cell resource for drug screening in a“more relevant”cell type.Here we report a screening platform using human iPSCs in a multi-well plate format to identify compounds that could promote chondrogenesis. | Sheng-Lian Yang Erica Harnish Thomas Leeuw Uwe Dietz Erika Batchelder Paul SWright Jane Peppard Paul August Cecile Volle-Challier Francoise Bono Jean-Marc Herbert Juan Carlos Izpisua Belmonte | 2012 | Protein & Cell2012，3，12： | 3 |
| 12 | Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study显示文摘 | Mark S Pearce Jane A Salotti Mark P Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola L Howe Cecile M Ronckers Preetha Rajaraman Alan W Craft Louise Parker Amy Berrington de González | 2012 | The Lancet . 2012 (9840)2012，，： | 3 |
| 13 | Terahertz endoscopic imaging for colorectal cancer detection:Current status and future perspectives显示文摘Terahertz(THz) imaging is progressing as a robust platform for myriad applications in the field of security,health,and material science.The THz regime,which comprises wavelengths spanning from microns to millimeters,is non-ionizing and has very low photon energy:Making it inherently safe for biological imaging.Colorectal cancer is one of the most common causes of death in the world,while the conventional screening and standard of care yet relies exclusively on the physician's experience.Researchers have been working on the development of a flexible THz endoscope,as a potential tool to aid in colorectal cancer screening.This involves building a single-channel THz endoscope,and profiling the THz response from colorectal tissue,and demonstrating endogenous contrast levels between normal and diseased tissue when imaging in reflection modality.The current level of contrast provided by the prototype THz endoscopic system represents a significant step towards clinical endoscopic application of THz technology for invivo colorectal cancer screening.The aim of this paper is to provide a short review of the recent advances in THz endoscopic technology and cancer imaging.In particular,the potential of single-channel THz endoscopic imaging for colonic cancer screening will be highlighted. | Pallavi Doradla Cecil Joseph Robert H Giles | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，8： | 3 |
| 14 | Plant Cell Wall Proteomics: Mass Spectrometry Data, a Trove for Research on Protein Structure/Function Relationships显示文摘Proteomics 在整个有机体或在净化的细胞器允许蛋白质表示的大规模学习。特别地,分开胶化的蛋白质的集体 spectrometry (MS ) 分析不仅为蛋白质鉴定,而且为蛋白质结构生产数据,地点,并且也处理。深入的分析从 Arabidopsis thaliana 的变白的胚轴房间墙 proteomics 在 MS 数据上被执行。这些分析证明 multigene 家庭的高度相应的成员能被区分。介绍 93% 氨基酸身份的二 lectins 用采指纹的肽质量被识别。尽管象 extensins 那样的结构的蛋白质或 hydroxyproline/proline-rich 蛋白质(H/PRPs ) 的鉴定是艰巨的, MS 系列的不同类型被利用识别并且描绘 H/PRP。在几房间墙蛋白质(CWP ) 的成熟事件用地点印射被分析。氨基酸的 CWP 以及 hydroxylation 或氧化的 N-glycosylation 也被探索,增加信息改进我们 CWP 结构 / 功能关系的理解。一个生物信息的工具被开发借助于 MS 定位成熟分泌蛋白质和 N-glycosylation 的 N 终点。 | Cecile Albenne Herve Canut Georges Boudart Yu Zhang Helene San Clemente Rafael Pont-Lezica Elisabeth Jamet | 2009 | Molecular Plant2009，2，5： | 2 |
| 15 | Genetic transformation of strawberry by Agrobacterium tumefaciens using a leaf disk regeneration system显示文摘 | Narender S. Nehra Ravindra N. Chibbar Kutty K. Kartha Raju S. S. Datla William L. Crosby Cecil Stushnoff | 1990 | Plant Cell Reports1990，，6： | 2 |
| 16 | Gene therapy and erectile dysfunction: the current status显示文摘为可勃起的机能障碍(编辑) 的当前的可得到的处理选择是有效的然而并非没有失败或副作用。尽管 phosphodiesterasetype 的发展 5 (PDE5 ) 禁止者(即 sildenafil, tadalafil 和 vardenafil ) 革命化了编辑的治疗,这些口头的药要求按需的存取并且不作为与糖尿病、前列腺切除术以后、严重的 veno 闭塞的疾病状态有关的有效 intreating 编辑。在编辑的治疗的改进依赖于理解人的肉体的光滑的肌肉音调并且在相关分子的目标的鉴定上的规定。未来编辑治疗可能考虑象基因治疗那样的分子的技术的申请。作为一个潜在的治疗学的工具,没有影响休息阴茎功能,基因治疗可能“在需求上”为 alteringintracavernous 压力提供一个有效、特定的工具。然而,基因治疗的安全仍然是一个主要障碍在作为一个主流的处理被接受让编辑基因治疗目的在编辑治好内在的条件前克服,包括纤维变性。而且,基因治疗可能帮助由改进阴茎氮的 oxidebioactivity 延长 PDE5 禁止者的功效。因为它的地点和可接近性,处于松驰的状态的低阴茎循环流动和 endotheliallined (花格平顶) 的存在空格,把基因治疗用于阴茎是可行的。这评论在编辑的管理提供基因治疗的当前的角色的简短卓见。 | David H. W. Lau Sashi S. Kommu Emad J. Siddiqui Cecil S. Thompson Robert J. Morgan Dimitri P. Mikhailidis Faiz H. Mumtaz | 2007 | Asian Journal of Andrology2007，9，1： | 2 |
| 17 | Pulmonary Angiogenesis in a Rat Model of Hepatopulmonary Syndrome显示文摘 | Junlan Zhang Bao Luo Liping Tang Yongming Wang Cecil R. Stockard Inga Kadish Thomas Van Groen William E. Grizzle Selvarangan Ponnazhagan Michael B. Fallon | 2009 | Gastroenterology2009，，3： | 2 |
| 18 | Lessons from French national guidelines on the treatment of venous thrombosis and central venous catheter thrombosis in cancer patients显示文摘 | Dominique Farge Cecile Durant Stéphane Villiers Anne Long Alfred Mahr Michel Marty Philippe Debourdeau | 2010 | Thrombosis Research2010，，： | 2 |
| 19 | Distributed Data Acquisition and Control by Software Bus显示文摘Increasing global competition forces manufacturers of products from alltechnical fields to guarantee a high product quality for a long period of time. At thesame time it is necessary to minimize production costs. In order to meet all theserequirements, on-line data acquisition and processing are of increasing importancein distributed automation systems. A software bus operating on industrial Ethernethas an ability to minimize operating costs by offering easy installation, scalability,high degree of reliability and remote monitoring and control. | Cecil Bruce-Boye Dmitry A.Kazakov | 2004 | 自动化博览2004，21，5： | 2 |
| 20 | A conceptual framework for ex ante valuation of ecosystem services of brownfield greening from a systematic perspective显示文摘Introduction:Although Brownfield greening(BG)can be a crucial solution to green space deficiency in dense urban areas,the potential benefits of different BG initiatives have rarely been quantitatively pre-evaluated.Here,the concept and main features of BG and its costs and benefits are firstly depicted.Next,a conceptual framework is presented which combines ecosystem service(ESS)valuation,economic cost-benefit analysis,and spatial pattern analysis.The framework is used to perform ex ante valuation of the ESS value of BG in Xuhui District,Shanghai.Outcomes:The scenario comparison results show that it can spatially reflect a closer-to-reality value of ESS at the urban scale instead of a theoretical value at the site scale.The ultimate values of ESS(After economic and landscape adjustments)in the composite scenario is more than 21%higher than those in the full-eco scenario,whereas the initial values of ESS(before the adjustments)in the former was 14%lower than those in the latter.These results suggest that a considerable part of brownfield greening projects need to be implemented in the more populated and economically vibrant areas instead of solely in the ecological construction zone,thereby correspondingly providing more cultural and regulation services and forming a better urban green space network.Conclusion:The framework provides a simple,science-based,and feasible tool for making BG decisions from a systematic perspective in dense urban areas.It can help meet the need for applying ESS knowledge to BG-based green space planning and policy making in the context of urban sustainable development. | Qicheng Zhong Lang Zhang Yi Zhu Cecil Konijnendijk van den Bosch Jigang Han Guilian Zhang Yuezhong Li | 2020 | Ecosystem Health and Sustainability2020，6，1： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员