|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pancreatic enzyme replacement therapy for pancreatic exocrine insufficiency in the 21^(st) century显示文摘Restitution of normal fat absorption in exocrine pancreatic insufficiency remains an elusive goal. Although many patients achieve satisfactory clinical results with enzyme therapy, few experience normalization of fat absorption, and many, if not most, will require individualized therapy. Increasing the quantity of lipase administered rarely eliminates steatorrhea but increases the cost of therapy. Enteric coated enzyme microbead formulations tend to separate from nutrients in the stomach precluding coordinated emptying of enzymes and nutrients. Unprotected enzymes mix well and empty with nutrients but are inactivated at pH 4 or below. We describe approaches for improving the results of enzyme therapy including changing to, or adding, a different product, adding non-enteric coated enzymes,(e.g., giving unprotected enzymes at the start of the mealand acid-protected formulations later), use of antisecretory drugs and/or antacids, and changing the timing of enzyme administration. Because considerable lipid is emptied in the first postprandial hour, it is prudent to start therapy with enteric coated microbead prior to the meal so that some enzymes are available during that first hour. Patients with hyperacidity may benefit from adjuvant antisecretory therapy to reduce the duodenal acid load and possibly also sodium bicarbonate to prevent duodenal acidity. Comparative studies of clinical effectiveness of different formulations as well as the characteristics of dispersion, emptying, and dissolution of enteric-coated microspheres of different diameter and density are needed; many such studies have been completed but not yet made public. We discuss the history of pancreatic enzyme therapy and describe current use of modern preparations, approaches to overcoming unsatisfactory clinical responses, as well as studies needed to be able to provide reliably effective therapy. | Tony Trang Johanna Chan David Y Graham | 2014 | World Journal of Gastroenterology2014，20，33： | 17 |
| 2 | Prevalence of Helicobacter pylori infection and atrophic gastritis in patients with dyspeptic symptoms in Myanmar显示文摘AIM: To survey the detailed analyses for Helicobacter pylori(H. pylori) infection and gastric mucosal status in Myanmar.METHODS: A total of 252 volunteers with dyspeptic symptoms(155 female and 97 male; mean age of 43.6 ± 14.2 years) was participated in Yangon and Mandalay. The status of H. pylori infection was determined based on 5 different tests including rapid urease test, culture, histology, immunohistochemistry and serology. Histological scores were evaluated according to the update Sydney system and the Operative Link for Gastritis Assessment system. Pepsinogen(PG)Ⅰand PG Ⅱ were measured using enzyme-linked immunosorbent assays.RESULTS: The overall prevalence of H. pylori infectionwas 48.0%. There was no relationship between age and infection rate. Even in young group(less than 29 years old), the H. pylori infection rate was relatively high(41.9%). The prevalence of H. pylori infection was significantly higher in Yangon than that of Mandalay. H. pylori infection was significantly associated with the presence of gastric mucosal atrophy. All 7 subjects with peptic ulcer were infected with H. pylori. Although H. pylori-positive subjects showed stronger gastritis than H. pylori-negative subjects, most cases had mild gastritis.CONCLUSION: We revealed the prevalence of H. pylori infection in patients with dyspeptic symptoms in Myanmar. The H. pylori infection was a risk factor for peptic ulcer and stronger gastritis. | Thein Myint Seiji Shiota Ratha-korn Vilaichone New Ni Than Than Aye Miyuki Matsuda Trang Thi Huyen Tran Tomohisa Uchida Varocha Mahachai Yoshio Yamaoka | 2015 | World Journal of Gastroenterology2015，21，2： | 10 |
| 3 | Stem cell-based therapy for human diseases显示文摘Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated.Stem cell-based therapy,including human pluripotent stem cells(hPsCs)and multipotent mesenchymal stem cells(MSCs),has recently emerged as a key player in regenerative medicine.hPSCs are defined as self-renewable cell types conferring the ability to differentiate into various cellular phenotypes of the human body,including three germ layers.MsCs are multipotent progenitor cells possessing self-renewal ability(limited in vitro)and differentiation potential into mesenchymal lineages,according to the International Society for Cell and Gene Therapy(ISCT).This review provides an update on recent clinical applications using either hPSCs or MSCs derived from bone marrow(BM),adipose tissue(AT),or the umbilical cord(UC)for the treatment of human diseases,including neurological disorders,pulmonary dysfunctions,metabolic/endocrine-related diseases,reproductive disorders,skin burns,and cardiovascular conditions.Moreover,we discuss our own clinical trial experiences on targeted therapies using MsCs in a clinical setting,and we propose and discuss the MSC tissue origin concept and how MSC origin may contribute to the role of MSCs in downstream applications,with the ultimate objective of facilitating translational research in regenerative medicine into clinical applications.The mechanisms discussed here support the proposed hypothesis that BM-MSCs are potentially good candidates for brain and spinal cord injury treatment,AT-MSCs are potentially good candidates for reproductive disorder treatment and skin regeneration,and UC-MsCs are potentially good candidates for pulmonary disease and acute respiratory distress svndrometreatment. | Duc M.Hoang Phuong T.Pham Trung Q.Bach Anh T.L.Ngo Quyen T.Nguyen Trang T.K.Phan Giang H.Nguyen Phuong T.T.Le Van T.Hoang Nicholas R.Forsyth Michael Heke Liem Thanh Nguyen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 7 |
| 4 | Ternary Ni-Co-Fe oxyhydroxide oxygen evolution catalysts:Intrinsic activity trends,electrical conductivity,and electronic band structure显示文摘Nickel-,cobalt-,and iron-based(oxy)hydroxides comprise the most-commonly studied electrocatalysts for the oxygen-evolution reaction(OER)in alkaline solution.A fundamental understanding of composition-structure-activity relationships for mixed-metal Ni-Co and Ni-Co-Fe(oxy)hydroxides is important to guide the design of advanced OER catalysts.Here we use cyclic voltammetry,chronopotentiometry,inductively-coupled plasma-optical emission spectroscopy,and in situ electrical conductivity measurements to characterize the properties and activity of various compositions of Ni-Co-Fe(oxy)hydroxides prepared by cathodic co-electrodeposition.Consistent with previous studies,we find Fe is essential for the mixed-metal(oxy)hydroxides to achieve high OER activity.In the rigorous absence of Fe(achieved by using specially cleaned electrolytes),the most-active Ni-Co(oxy)hydroxide composition has an OER turn-over frequency only twice that ofpure Co(oxy)hydroxide,suggesting minimal synergism between the two metals.The addition of Co to Ni-Fe(oxy)hydroxides shifts the onset of electrical conductivity to lower potentials,but has little effect on the intrinsic OER activity,with the most-active Ni-Co-Fe(oxy)hydroxide having an OER turn-over frequency only -1.5 times that of the Ni-Fe(oxy)hydroxides.The magnitudes of the electrical conductivities are similar for all the compositions measured.Density-functional-theory-calculated projected density of states show a significant contribution of all chemical elements at the valence band edge of the mixed-metal oxyhydroxide electronic structure,demonstrating significant electronic hybridization between the elements.The calculations suggest the involvement of all the elements in modulating the electronic structure at putative Fe-based active sites that are probably located at edges or defects in the two-dimensional oxyhydroxide sheets. | Michaela Burke Stevens Lisa J. Enman Ester Hamal Korkus Jeremie Zaffran Christina D. M. Trang James Asbury Matthew G. Kast Maytal Caspary Toroker Shannon W. Boettcher | 2019 | Nano Research2019，12，9： | 5 |
| 5 | Mechanism of Japanese encephalitis virus genotypes replacement based on human,porcine and mosquito-originated cell lines model显示文摘Objective:To examine the multiplication efficiency Japanese encephalitis virus(JEV)genotype Ⅰ(G Ⅰ) and genotype Ⅲ(GⅢ) of different cell lines which originated from human,porcine,mosquitoes in order to prove mechanism of JEV G Ⅰ replacement JEV GⅢ since it emerging in nature recent decades.Methods:The mixture of Gi and GⅢ JEV isolates was inoculated on human rhabdomyosarcoma(RD).pig kidney epithelial(PS) and Aedes albopictus C6/36 clone(C6/36) which originated from human,porcine and mosquitoes,respectively.Plaque assays were performed to calculate virus titer and real-time RT-PCR with GⅠand GⅢspecific primer sets to quantify the number of GⅠ and GUI RNA copies.Results:The highest virus titer reached at the 3rd day of post infection when G Ⅰand GⅢ mixture was inoculated on RD and PS and that of C636 was at the 4^(th)day.JEVs were amplified and maintained by C6/36 cells after 10 passages whereas that by RD and PS only limited within 8 and 6 passages,respectively.GⅠ strain amplified and maintained more efficiently on C6/36 and PS but not RD.whereas GⅢ strain amplified and maintained more efficiently on RD.Conclusions:There is a correlation between the multiplication efficiency of GⅠ and GⅢ JEV strains when these two genotype strains co-infected on different cell lines with the predominance of GⅠstrains in C6/36 and PS and the limited detection of G 1 strains in RD cells proving a possible mechanism of shift JEV genotypes in nature recent decades since GⅠ emerging. | Loan Phuong Do Trang Minh Bui Nga Thi Phan | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，4： | 5 |
| 6 | Natural products and food components with anti-Helicobacter pylori activities显示文摘The bacterial pathogen Helicobacter pylori(H. pylori) colonizes in over half of the world's population. H. pylori that establishes life-long infection in the stomach is definitely associated with gastro-duodenal diseases and a wide variety of non-gastrointestinal tract conditions such as immune thrombocytopenia. Triple therapy which consists of a proton pump inhibitor and combinations of two antibiotics(amoxicillin, clarithromycin or amoxicillin, metronidazol) is commonly used for H. pylori eradication. Recently, the occurrence of drug-resistant H. pylori and the adverse effect of antibiotics have severely weakened eradication therapy. Generally antibiotics induce the disturbance of human gastrointestinal microflora. Furthermore, there are inappropriate cases of triple therapy such as allergy to antibiotics, severe complications(liver and/or kidney dysfunction), the aged and people who reject the triple therapy. These prompt us to seek alterative agents instead of antibiotics and to develop more effective and safe therapy with these agents. The combination of these agents actually may result in lower a dose of antibiotics. There are many reports world-wide that non-antibiotic substances from natural products potentially have an anti-H. pylori agent. We briefly review the constituents derived from nature that fight against H. pylori in the literature with our studies. | Hiroaki Takeuchi Vu Thu Trang Norihito Morimoto Yoshie Nishida Yoshihisa Matsumura Tetsuro Sugiura | 2014 | World Journal of Gastroenterology2014，20，27： | 3 |
| 7 | Activated carbon/Fe 3 O 4 nanoparticle composite: Fabrication, methyl orange removal and regeneration by hydrogen peroxide显示文摘 | Manh Huy Do Ngoc Hoa Phan Thi Dung Nguyen Thi Thu Suong Pham Van Khoa Nguyen Thi Thuy Trang Vu Thi Kim Phuong Nguyen | 2011 | Chemosphere2011，，8： | 2 |
| 8 | Measuring the efficiency of the Farm Credit System显示文摘 | Trang Dang David Leatham Bruce A. McCarl Ximing Wu | 2014 | Agricultural Finance Review2014，，1： | 2 |
| 9 | Na_2HPO_4活化木材液化物碳纤维孔隙结构与表面化学结构显示文摘为了探究Na:HP0。活化处理引起的木材苯酚液化物碳纤维微细结构的变化,以 Na2HPO4溶液为活化剂对杉木苯酚液化物碳纤维原丝进行了浸渍、干燥和不同温度的活化处理,对活性碳纤维的晶体结构、孔隙结构和表面化学结构进行了表征。结果表明:随着活化温度的上升,活性碳纤维的得率逐渐减小。活性碳纤维的晶体结构属于类石墨结构;随着活化温度上升,微晶层间距d0002减小,而石墨片层平面尺寸Lc和Lc/d002增加。活化温度在600oC或700℃时,微孔率小于48vol%;当活化温度为800℃或900℃时,微孔率大于60vol%。活性碳纤维的微孔孔径主要集中在0.5~1.6nm范围内,中孔孔径主要分布在2.0~4.0nm范围内。随着活化温度的上升,纤维的比表面积和孔容积均逐渐增加,900℃时二者均达到最大值,此时的比表面积为1306m2/g。C和O是活性碳纤维的基本元素,纤维表面大部分的含碳基团为石墨碳,含有少量的C-0H、C=O和-COOH。研究为制备新型活性碳纤维和进一步探明活化剂同碳纤维分子之间相互作用提供参考。 | VU Thi Trang 刘文静 赵广杰 | 2015 | 复合材料学报2015，32，5： | 2 |
| 10 | p53 protein overexpression in low grade dysplasia (LGD) in barrett’s esophagus: Immunohistochemical marker predictive of progression显示文摘 | Allan P Weston Sushanta K Banerjee Prateek Sharma Trang M Tran Robert Richards Rachel Cherian | 2001 | The American Journal of Gastroenterology2001，，5： | 2 |
| 11 | Phantom bite syndrome:Revelation from clinically focused review显示文摘Phantom bite syndrome(PBS),also called occlusal dysesthesia,is characterized by persistent non-verifiable occlusal discrepancies.Such erroneous and unshakable belief of a“wrong bite”might impel patients to visit multiple dental clinics to meet their requirements to their satisfaction.Subsequently,it takes a toll on their quality of life causing,career disruption,financial loss and suicidal thoughts.In general,patients with PBS are quite rare but distinguishable if ever encountered.Since Marbach reported the first two cases in 1976,there have been dozens of published cases regarding this phenomenon,but only a few original studies were conducted.Despite the lack of official classification and guidelines,many authors agreed on the existence of a PBS“consistent pattern”that clinicians should be made aware.Nevertheless,the treatment approach has been solely based on incomplete knowledge of etiology,in which none of the proposed theories are fully explained in all the available cases.In this review,we have discussed the critical role of enhancing dental professionals’awareness of this phenomenon and suggested a comprehensive approach for PBS,provided by a multidisciplinary team of dentists,psychiatrists and exclusive psychotherapists. | Trang Thi Huyen Tu Motoko Watanabe Gayatri Krishnakumar Nayanar Yojiro Umezaki Haruhiko Motomura Yusuke Sato Akira Toyofuku | 2021 | World Journal of Psychiatry2021，11，11： | 2 |
| 12 | 不同天气条件下青头潜鸭越冬期行为的响应模式显示文摘2018年11—12月在河南民权国家湿地公园,采用定点观察法、扫描取样法对越冬青头潜鸭在不同天气条件下的行为响应模式进行研究。结果表明:在晴天,静息、飞行、运动是青头潜鸭越冬期的优势行为(65.5%),觅食、修整是次要行为(31.9%);行为节律表现为上午觅食、中午静息、下午觅食修整;飞行通常发生在觅食高峰前,运动行为多与其他行为相伴,其时间分配与觅食呈正响应,与静息呈负响应。相较于晴天,阴雨天青头潜鸭增加了对静息和觅食的时间分配,静息、觅食和运动为阴雨天的主要行为(76.5%),修整、飞行为次要行为(20.3%);觅食和静息的高峰时段后移,傍晚时达到高峰,飞行和修整时间显著减少。与晴天相比,雾霭天青头潜鸭静息、觅食、运动和修整的时间分配增加,飞行行为减少;觅食高峰后移至中午和下午,静息高峰后移至下午;静息、运动和觅食为雾霭天的优势行为(70.6%),修整和飞行为次要行为(27.5%)。研究表明,不同天气条件下,民权湿地公园青头潜鸭的越冬期行为在时间分配、行为节律、优势行为方面存在一定的响应;阴雨天和雾霭天青头潜鸭会分配更多的静息和觅食时间,并通过增加能量摄入和减少耗能行为应对恶劣天气。 | 李浙 张琦 吴庆明 高晓冬 Ngo Thi Kieu Trang 徐卓 | 2022 | 应用生态学报2022，33，9： | 2 |
| 13 | P2X4R+microglia drive neuropathic pain显示文摘 | Beggs S Trang T Salter MW | 2012 | Nat Neurosei2012，15，： | 1 |
| 14 | Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more eficiently than doesvitamin D2显示文摘 | TRANG H COLE D E RUBIN L A | | American Journal of Clinical Nutrition0，998，68： | 1 |
| 15 | The let-7 microRNA reduces tumor growth in mouse models of lung cancer显示文摘 | ESQUELA-KERSCHER A TRANG P WIGGINS J F | 2008 | Cell Cycle2008，7，6： | 1 |
| 16 | Urea transporter expression in aging kidney and brain during dehydration显示文摘 | Trinh Trang Tan MM Geelen G Teillet L | | Am J Physiol Regul lntegr Comp Physiol0，285，： | 1 |
| 17 | Regression of murine lung tumors by the let-7 microRNA 显示文摘 | Trang P Medina PP Wiggins JF | 2010 | Oncogene2010，29，11： | 1 |
| 18 | Morphine hyperalgesia gated through microglia-mediated disruption of neuronal C1- homeostasis显示文摘 | Ferrini F Trang T Mattioli TA | 2013 | Nat Neurosci2013，16，2： | 1 |
| 19 | Prevalence of rotavirus antibodies in breast milk and inhibitory effects to rotavirus vaccines显示文摘 | Trang NV Braeckman T Lernout T | 2014 | Hum Vaccin Immunother2014，10，12： | 1 |
| 20 | Brain-derived neurotrophic factor from microglia:a molecular substrate for neuropathic pain显示文摘 | Trang T Beggs S Salter M W | 2011 | Neuron gliabiology2011，7，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员