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| 1 | Effects of tyrosine kinase inhibitor E7080 and eNOS inhibitor L-NIO on colorectal cancer alone and in combination显示文摘Objective:To investigate the effects of E7080 and N5-(1-iminoethyl)-L-ornithine dihydrochloride(L-NIO)on colorectal cancer alone and in combination.Methods:HT29 colorectal cancer cell line from Sap Institute was used.Real-time cell analysis(xCELLigence system)was performed to determine the effects of E7080 and L-NIO on colorectal cell proliferation.While apoptosis was determined with Annexin V staining,and the effect of agents on angiogenesis was determined with chorioallantoic membrane(CAM)model.Results:We found that E7080 has a strong antiproliferative effect with an half maximum inhibition of concentration(IC50)value of 5.60×10–8mol/L.Also it has been observed that E7080 showed antiangiogenic and apoptotic effects on HT29 colorectal cancer cells.Antiangiogenic scores of E7080 were 1.2,1.0 and 0.6for 100,10 and 1 nmol/L E7080 concentrations,respectively.Furthermore,apoptosis has been detected in71%of HT29 colorectal cancer cells after administration of 100 nmol/L E7080 which may indicate strong apoptotic effect.Meanwhile administration of L-NIO alone did not show any effect,but the combination of E7080 with L-NIO increased the antiproliferative,antiangiogenic and apoptotic effects of E7080.Conclusions:Results of this study indicate that E7080 may be a good choice in treatment of colorectal tumors.Furthermore the increased effects of E7080 when combined with L-NIO raise the possibility to use a lower dose of E7080 and therefore avoid/minimize the side effects observed with E7080. | Ahmet Altun Tijen Kaya Temiz Ezgi Balc Zübeyde Ak n Polat Mustafa Turan | 2013 | Chinese Journal of Cancer Research2013，25，5： | 4 |
| 2 | Patients with Inflammatory Bowel Disease Have a Lower Response Rate to HBV Vaccination Compared to Controls显示文摘 | Mustafa Erhan Altun?z Ebubekir ?enate? Atakan Ye?il Turan ?alhan Ay?e Oya Kurda? ?vün? | 2012 | Digestive Diseases and Sciences2012，，4： | 3 |
| 3 | Prediction of wear loss quantities of ferro-alloy coating using different machine learning algorithms显示文摘In this study,experimental wear losses under different loads and sliding distances of AISI 1020 steel surfaces coated with(wt.%)50FeCrC‐20FeW‐30FeB and 70FeCrC‐30FeB powder mixtures by plasma transfer arc welding were determined.The dataset comprised 99 different wear amount measurements obtained experimentally in the laboratory.The linear regression(LR),support vector machine(SVM),and Gaussian process regression(GPR)algorithms are used for predicting wear quantities.A success rate of 0.93 was obtained from the LR algorithm and 0.96 from the SVM and GPR algorithms. | Osman ALTAY Turan GURGENC Mustafa ULAS Cihan OZEL | 2020 | Friction2020，8，1： | 2 |
| 4 | Coronary flow reserve is impaired in patients with slow coronary flow显示文摘 | Dogan Erdogan Mustafa Caliskan Hakan Gullu Alpay Turan Sezgin Aylin Yildirir Haldun Muderrisoglu | 2006 | Atherosclerosis2006，，1： | 2 |
| 5 | A new approach for prediction of the wear loss of PTA surface coatings using artificial neural network and basic,kernel-based,and weighted extreme learning machine显示文摘Wear tests are essential in the design of parts intended to work in environments that subject a part to high wear.Wear tests involve high cost and lengthy experiments,and require special test equipment.The use of machine learning algorithms for wear loss quantity predictions is a potentially effective means to eliminate the disadvantages of experimental methods such as cost,labor,and time.In this study,wear loss data of AISI 1020 steel coated by using a plasma transfer arc welding(PTAW)method with FeCrC,FeW,and FeB powders mixed in different ratios were obtained experimentally by some of the researchers in our group.The mechanical properties of the coating layers were detected by microhardness measurements and dry sliding wear tests.The wear tests were performed at three different loads(19.62,39.24,and 58.86 N)over a sliding distance of 900 m.In this study,models have been developed by using four different machine learning algorithms(an artificial neural network(ANN),extreme learning machine(ELM),kernel-based extreme learning machine(KELM),and weighted extreme learning machine(WELM))on the data set obtained from the wear test experiments.The R2 value was calculated as 0.9729 in the model designed with WELM,which obtained the best performance among the models evaluated. | Mustafa ULAS Osman ALTAY Turan GURGENC Cihan OZEL | 2020 | Friction2020，8，6： | 2 |
| 6 | Gastric Necrosis and Perforation Caused by Acute Gastric Dilatation: Report of a Case显示文摘 | Mustafa Turan Metin ?en Emel Canbay Kursat Karadayi Esin Yildiz | 2003 | Surgery Today2003，，4： | 2 |
| 7 | Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature显示文摘 | Turan Buzgan Mustafa Kasim Karahocagil Hasan Irmak Ali Irfan Baran Hasan Karsen Omer Evirgen Hayrettin Akdeniz | 2009 | International Journal of Infectious Diseases2009，，6： | 2 |
| 8 | Comparative analysis of neural network techniques for predicting water consumption time series显示文摘 | Mahmut Firat Mustafa Erkan Turan Mehmet Ali Yurdusev | 2010 | Journal of Hydrology2010，，1： | 2 |
| 9 | Vulvar syringoma exacerbated during pregnancy显示文摘 | Cem Turan Mustafa Ugur Lale Kutluay Selahattin Kükner Tülin Dabakoglu Tugrul Aydogdu Yusuf Ergün Omer Cobanoglu | 1996 | European Journal of Obstetrics and Gynecology1996，，1： | 1 |
| 10 | Goblet cell carcinoid of the appendix and mixed adenoneuroendocrine carcinoma: Report of three cases显示文摘Neuroendocrine neoplasms are the most common epithelial tumors among appendix tumors. Appendix tumors that are completely or partially composed of neuroendocrine cells are divided into two categories: Classic carcinoid tumors and goblet cell carcinoid tumors(GCCT). They are known to progress more aggressively than classic(neuro) endocrine tumors. In this study, three cases with acute appendicitis symptoms are presented, including their clinical and histopathological findings. Microscopic examination detected GCCT in two cases and mixed adenoneuroendocrine carcinoma in one case, in addition to acute appendicitis. | Hatice Karaman Fatma Senel Mustafa Güreli Turan Ekinci Omer Topuz | 2017 | World Journal of Gastrointestinal Oncology2017，9，7： | 1 |
| 11 | Non-dipping pattern in untreated hypertensive patients is related to increased pulse wave velocity independent of raised nocturnal blood pressure显示文摘 | Yuksel Cicek Murtaza Emre Durakoglugil Sinan Altan Kocaman Mustafa Cetin Turan Erdogan Sitki Dogan Yavuz Ugurlu Aytun Canga | 2013 | Blood Pressure2013，，1： | 1 |
| 12 | Equilibrium studies on the adsorption of reactive azo dyes into zeolite显示文摘 | Bülent Armagan Mustafa Turan | 2004 | Desalination2004，，170： | 1 |
| 13 | Clinical manifestations and complications in 1028 cases of brucellosis:a retrospective evaluation and review of the literature显示文摘 | Turan B Mustafa Kasim K Hasan I | 2010 | International Journal of Infectious Diseases2010，14，6： | 1 |
| 14 | Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature显示文摘 | Turan B Mustafa K K Hasan I | 2010 | Int J Infect Dis2010，，： | 1 |
| 15 | α-Lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine显示文摘 | Ahmet Guven Turan Tunc Turgut Topal Mustafa Kul Ahmet Korkmaz Gokhan Gundogdu Onder Onguru Haluk Ozturk | 2008 | Surgery Today2008，，11： | 1 |
| 16 | Lead remov- al in fixed - bed columns by zeolite and sepiolite 显示文摘 | Mustafa Turan Ugur Mart Baris Yuksel | 2005 | Chemo- sphere2005，，60： | 1 |
| 17 | Comparison of seldinger and trocar techniques in the percutaneous treatment of hydatid cysts显示文摘AIM To comparatively evaluate Seldinger and Trocar techniques in the percutaneous treatment of hydatid disease. METHODS Trocar and Seldinger techniques were used for 49 and 56 cysts, respectively, among 106 hydatid cysts in 88 patients. The number of males and females were 22 and 66, respectively with a mean age of 44.9 years(range, 15-87). Follow-up studies included cyst diameter, cyst contents, and morphological changes inthe cyst wall, local recurrence, and secondary invasion, using ultrasound, computerized tomography and chest X-rays. RESULTS The positive criteria of healing were a decrease in cyst diameter, progressive solidification of the cyst contents, and disappearance of the cyst. Local recurrence was defined as an increase in the cyst diameter and contents, and appearance of daughter cysts in the primary cavity, while secondary dissemination was defined as the appearance of new cysts outside the treated cyst. Mean duration of follow-up was 19.23 mo(range, 18-26 mo). Follow-up results demonstrated that no significant differences were present between the Trocar and Seldinger techniques in the percentage of decrease in the cyst volume, rate of early complications, local recurrence and secondary dissemination(P = 0.384, 0.069, 0.215 and 0.533, respectively). CONCLUSION There are no differences between the Seldinger and Trocar techniques that gain entry to the cyst cavity in terms of the efficacy of the treatment and the rates of early and late complications. | Hilal Gülsüm Turan Mustafa Ozdemir Rusen Acu Fahrettin Kücükay Fatma Ayca Edis Ozdemir Baki Hekimoglu Utku Mahir Yildirim | 2017 | World Journal of Radiology2017，9，11： | 1 |
| 18 | Removal of ammonium ion from aqueous solution using natural Turkish clinoptilolite显示文摘 | Dogan Karadag Yunus Koc Mustafa Turan | 2006 | Hazardous Materials2006，，136： | 1 |
| 19 | Beneficial Effects of Nigella Sativa Oil on Intestinal Damage in Necrotizing Enterocolitis显示文摘 | Cuneyt Tayman Ferhat Cekmez Ilker Mustafa Kafa Fuat Emre Canpolat Merih Cetinkaya Sema Uysal Turan Tunc S.Umit Sar?c? | 2012 | Journal of Investigative Surgery2012，，5： | 1 |
| 20 | 添加NaCl提高黄铜矿的铜提取率显示文摘本文研究了在过硫酸铵-APS作为氧化剂中添加NaC l对黄铜矿浸出行为的影响。APS与传统氧化剂相比有许多优势,其标准氧化还原电位为2.0 V。研究了6个参数,包括Na Cl浓度,APS浓度,温度,时间,液固比,搅拌速率对浸出行为的影响,结果表明金属的提取率随Na Cl浓度,APS浓度,浸出温度和液固比的增加而增加。在硫化物矿物的氧化浸出过程中,在颗粒表面出现的硫元素层会降低金属的提取率。本研究结果表明,由于Cl离子的存在,硫元素层的钝化和低溶解度问题都得到消除。在APS浓度为250 g/L,NaC l浓度为150 g/L,时间为180 min,温度为333 K,搅拌速率为400 r/min及液固比为250 mL/g的条件下,铜和铁的提取率分别为75%和80%。 | M.Deniz Turan Mustafa Boyrazli H.Soner Altundogan | 2018 | Journal of Central South University2018，25，1： | 1 |
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