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| 1 | Mechanical and Antibacterial Properties of Injection Molded Polypropylene/TiO_2 Nano-Composites:Effects of Surface Modification显示文摘Polypropylene (PP)/titanium dioxide (TiO2) nano-composites were prepared by melt compounding with a twin screw extruder. Nanoparticles were modified prior to melt mixing with maleic anhydride grafted styrene-ethylene-butylene-styrene (SEBS-g-MA) and silane. The composites were injection molded and mechanical tests were applied to obtain tensile strength, elastic modulus and impact strength. Antibacterial efficiency test was applied on the injection molded composite plaques by viable cell counting technique. The results showed that the composites including SEBS-g-MA and silane coated TiO2 gave better mechanical properties than the composites without SEBS-g-MA. Antibacterial efficiency of the composites varied according to the dispersion and the concentration of the particles and it was observed that composites at low content of TiO2 showed higher antibacterial property due to the better photocatalytic activity of the particles during UV exposure. | Mirigul Altan Huseyin Yildirim | 2012 | Journal of Materials Science & Technology2012，28，8： | 7 |
| 2 | A novel anti-slip control approach for railway vehicles with traction based on adhesion estimation with swarm intelligence显示文摘Anti-slip control systems are essential for railway vehicle systems with traction.In order to propose an effective anti-slip control system,adhesion information between wheel and rail can be useful.However,direct measurement or observation of adhesion condition for a railway vehicle in operation is quite demanding.Therefore,a proportional–integral controller,which operates simultaneously with a recently proposed swarm intelligencebased adhesion estimation algorithm,is proposed in this study.This approach provides determination of the adhesion optimum on the adhesion-slip curve so that a reference slip value for the controller can be determined according to the adhesion conditions between wheel and rail.To validate the methodology,a tram wheel test stand with an independently rotating wheel,which is a model of some low floor trams produced in Czechia,is considered.Results reveal that this new approach is more effective than a conventional controller without adhesion condition estimation. | Abdulkadir Zirek Altan Onat | 2020 | Railway Engineering Science2020，28，4： | 5 |
| 3 | Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis显示文摘AIM To investigate the significance of heat shock protein 110(HSP110) in gastric cancer(GC) patients with peritoneal metastasis undergoing hyperthermochemotherapy.METHODS Primary GC patients(n = 14) with peritoneal metastasis or positive peritoneal lavage cytology who underwent distal or total gastrectomy between April 2000 and December 2011 were enrolled in this study. The patients underwent postoperative intraperitoneal hyperthermo-chemotherapy using a Thermotron RF-8 heating device two weeks after surgery. We analyzed nuclear HSP110 expression in surgically resected tumors using immunohistochemistry. Additionally, the effect of HSP110 suppression on hyptherthermochemosensitivity was assessed in vitro in the MKN45 GC cell line using the HSP inhibitor KNK437. RESULTS HSP110 immnohistochemical staining in 14 GC patients showed that five(35.7%) samples belonged to the low expression group, and nine(64.3%) samples belonged to the high expression group. Progression-free survival was significantly shorter in the HSP110 high-expression group than in the low-expression group(P = 0.0313). However, no significant relationships were identified between HSP110 expression and the clinicopathological characteristics of patients. Furthermore, high HSP110 expression was not an independent prognostic factor in GC patients with peritoneal metastasis(P = 0.0625). HSP110 expression in MKN45 cells was suppressed by KNK437 at the hyperthermic temperature of 43 ℃ in vitro. Comparison of MKN45 cell proliferation in the presence and absence of KNK437 at 43 ℃, revealed that proliferation was significantly decreased when HSP110 was inhibited by KNK437. Additionally, HSP110 suppression via HSP inhibitor treatment increased cellular sensitivity to hyperthermo-chemotherapy in vitro.CONCLUSION The expression of nuclear HSP110 in GC patients might be a new marker of chemosensitivity and a therapeutic target for patients who are tolerant to existing hyperthermo-chemotherapies. | Akiharu Kimura Kyoichi Ogata Bolag Altan Takehiko Yokobori Erito Mochiki Mitsuhiro Yanai Norimichi Kogure Toru Yanoma Masaki Suzuki Tuya Bai Hiroyuki Kuwano | 2017 | World Journal of Gastroenterology2017，23，42： | 5 |
| 4 | Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats显示文摘AIM: To investigate whether antioxidants vitamin E and C can retard development of hepatic fibrosis in the bili- ary-obstructed rats. METHODS: Fifty Wistar albino rats were randomly as- signed to 5 groups (10 rats in each). Bile duct was liga- ted in 40 rats and they were treated as follows: group vitC, vitamin C 10 mg/kg sc daily; group vitE, vitamin E 15 mg/kg sc daily; group vitEC, both of the vitamins; bile duct-ligated (BDL, control) group, physiological saline sc. The fifth group was assigned to sham operation. At the end of fourth week, the rats were decapitated, and hepatic tissue biochemical collagen content and collagen surface area were measured. Hepatic tissue specimens were histopathologically evaluated according to Scheuer system. Serum hyaluronate levels were measured by ELISA method. RESULTS: Despite being higher than sham group, he- patic collagen level was significantly decreased in each of the vitC, vitE and vitEC groups (32.7 ± 1.2, 33.8 ± 2.9, 36.7 ± 0.5 μg collagen/mg protein, respectively) compared to BDL (48.3 ± 0.6 mg collagen/g protein) (P < 0.001 for each vitamin group). Each isolated vitamin C, isolated vitamin E and combined vitamin E/C supp-lementation prevented the increase in hepatic collagen surface density (7.0% ± 1.1%, 6.2% ± 1.7%, 12.3% ± 2.0%, respectively) compared to BDL (17.4% ± 5.6%) (P < 0.05 for each). The same beneficial effect of vitamin C, vitamin E and combined vitamin E/C treatment was also observed on the decrease of serum hyaluronate levels compared to BDL group (P < 0.001). The relative liver and spleen weights, serum transaminases, cholestatic enzymes, bilirubins and histopathological inflammation scores were not different between the antioxidant treat- ment groups and the control. However, fibrosis staging scores were obviously reduced only in the vitamin E/C combination group (vit EC: 2.4 ± 0.8 vs BDL: 3.1 ± 0.7; P < 0.05). CONCLUSION: Each antioxidant vitamin E, vitamin C and their combination retard hepatic fibrosis in biliary-obs- tructed rats. Oxidative stress may play a role in the patho- genesis of hepatic fibrosis in secondary biliary cirrhosis. | Ali Riza Soylu Nurettin Aydogdu Umit Nusret Basaran Semsi Altaner Orhan Tarcin Nursal Gedik Hasan Umit Ahmet Tezel Gulbin Dokmeci Huseyin Baloglu Mevlut Ture Kemal Kutlu Kadir Kaymak | 2006 | World Journal of Gastroenterology2006，12，42： | 4 |
| 5 | High adiponectin levels fail to protect against the risk of hypertension and,in women,against coronary disease:involvement in autoimmunity?显示文摘AIM:To investigate whether serum adiponectin protects against cardiometabolic risk in a population sample with prevailing metabolic syndrome.METHODS:Middle-aged adults representative of a general population with baseline circulating adiponectin measurements(n=1224)were analyzed prospectively at a mean of 3.8 years’follow-up,using continuous values or sex-specific tertiles.Total adiponectin was assayed by an ELISA kit.Type-2 diabetes was identified by criteria of the American Diabetes Association.Hypertension was defined as a blood pressure≥140 mmHg and/or≥90 mmHg and/or use of antihypertensive medication.Outcomes were predicted using Cox proportional hazards regression analysis in models that were controlled for potential confounders.RESULTS:In models of multiple linear regression,sex hormone-binding globulin,fasting insulin(inverse)and,in men,age were significant independent covariates of serum adiponectin which further tended in women to be positively associated with serum creatinine.Cox regression analyses for incident coronary heart disease(CHD),adjusted for sex,age,non-HDL cholesterol,waist circumference and C-reactive protein,revealed significant inverse association with adiponectin tertiles in men but not women(HR=0.66;95%CI:0.32-1.38 for highest tertile).Cox regression for type-2 diabetes in a similar model(wherein glucose replaced non-HDL cholesterol),adiponectin tertiles appeared to protect in each gender.HR for incident hypertension roughly displayed unity in each of the adiponectin tertiles(P-trend=0.67).CONCLUSION:High adiponectin levels failed to protect against the development of hypertension and,in women,against CHD,presumably paralleling impairment in renal function as well.Involvement of adiponectin in autoimmune complex with loss of antioxidative-antiatherogenic properties may be underlying. | Altan Onat Mesut Aydln Günay Can Bayram Kroglu Ahmet Karagz Servet Altay | 2013 | World Journal of Diabetes2013，4，5： | 3 |
| 6 | Comparison of long-term results of trabeculectomy to treat pseudoexfoliative glaucoma and primary open angle glaucoma显示文摘AIM: To compare the long term outcome of trabeculectomy in patients with pseudoexfoliative glaucoma(PEG) and primary open angle glaucoma(POAG) in terms of surgical success. METHODS: The success of the trabeculectomy was evaluated by three criteria. Criterion A: intraocular pressure(IOP) ≤21 mm Hg and decrease in IOP ≥20%; Criterion B: IOP ≤18 mm Hg and decrease in IOP ≥30%; Criterion C: IOP ≤15 mm Hg and decrease in IOP ≥50%. Patients that met these criteria without medical treatment were considered to be completely successful, while those that met these criteria with medical treatment were considered partially successful. Significance levels of differences between the POAG and PEG groups in the Kaplan-Meier survival curves were calculated with the log-rank test. RESULTS: Sixty-four eyes from 64 patients with PEG and 51 eyes from 51 patients with POAG were evaluated. No significant differences were detected between the PEG and POAG groups according to full or partial success relative to each of the three criteria(A: P=0.73, 0.32; B: P=0.73, 0.31; C:P=0.90, 0.27). CONCLUSION: There is no difference in the long-term success of trabeculectomy between PEG and POAG patients whose clinical characteristics are otherwise the same. | Vuslat Pelitli Gürlü Hande Gürlü Altan Ozal Omer Benian Levent Alimgil | 2018 | International Journal of Ophthalmology(English edition)2018，11，1： | 3 |
| 7 | Determinants and definition of abdominal obesity as related to risk of diabetes, metabolic syndrome and coronary disease in Turkish men: A prospective cohort study显示文摘 | Altan Onat Hüseyin Uyarel Gülay Hergen? Ahmet Karabulut Sinan Albayrak Günay Can | 2006 | Atherosclerosis2006，，1： | 2 |
| 8 | Pentacam Scheimpflug成像测量晶状体密度与torsional超声乳化参数间的关系(英文)显示文摘目的:评价运用Pentacam Scheimpflug成像测量晶状体核密度与torsinal超声乳化动力学参数(如:运用于老年核性白内障患者的超声能量水平、液体留存时间及液体量)间的关系。方法:此研究为前瞻性双盲研究。瞳孔扩大后运用Pentacam Scheimpflug 成像进行测量。白内障的等级由pentacam核密度测定法[ pentacam nucleus densitometry, PND;又名Pentacam核分段( Pentacam nucleus staging, PNS)软件]自主分为1到5个等级。超声乳化术后,自动在Infiniti Ozil IP超声乳化系统监视器上计算并显示总超声( U/S)时间、累计耗散能、Torsional U/S时间以及估算液体的使用情况。组间差异运用单因素方差分析( ANOVA )进行评定,多组分析运用Tamhane测试法,PND测量的晶状体密度与torsinal超声乳化动力学参数间的关系运用Spearman相关分析进行评定。界定P〈0.05时具有统计学意义。结果:此项研究包括125例患者(125眼),平均年龄为69.7±9.4岁(范围:48~88岁),其中61例男性、64例女性。 U/S总时间、torsional U/S时间、CDE及估算液体使用情况的范围分别为0.70~158.9s,0.70~158.5s,0.11~42.65和21~98mL. PND组间数据有统计学差异。评估超声乳化动力学参数与PND数据间关系后得出PND数据与总超声时间( r=0.767; P〈0.01)、torsional超声时间(r=0.767;P〈0.01)、CDE(r=0.758; P〈0.01)及液体使用量(r=0.602;P〈0.01)均有显著相关性。结论:白内障手术前运用PND评分法获得核密度的客观程度可为超声乳化术中的参数提供可靠的预见性。因此,对每一位患者进行每一单项超声乳化参数的评估,有助于降低超声乳化能量的使用量,减少内皮细胞丢失和类固醇的使用,加速视力的恢复。 | Suleyman Demircan Mustafa Atas Murat Koksal Emine Pangal Isa Yuvaci Altan Goktas | 2014 | 国际眼科杂志2014，14，10： | 2 |
| 9 | Finite element simulation of magnesium alloy sheet forming at elevated temperatures显示文摘 | Hariharasudhan Palaniswamy Gracious Ngaile Taylan Altan | 2003 | Journal of Materials Processing Tech2003，，1： | 2 |
| 10 | Risk factors and cardiovascular disease in Turkey显示文摘 | Altan Onat | 2001 | Atherosclerosis2001，，1： | 2 |
| 11 | Reducing shrinkage in injection moldings via the Taguchi, ANOVA and neural network methods显示文摘 | Mirigul Altan | 2009 | Materials and Design2009，，1： | 2 |
| 12 | An adaptive FEM simulation for prediction of variable blank holder force in conical cup drawing 显示文摘 | Sheng Z Q Jirathearanat S Altan T | 2004 | International Journal of Machine Tool & Manufacture2004，44，5： | 1 |
| 13 | Process Simulation in Stamping-recent Applications for Production Process Desigen显示文摘 | Thomas W Oenoki T Altan T | 2000 | Journal of Materials Processing Technology2000，98，2： | 1 |
| 14 | Failure and Wrinkle Criteria and m Athem Atical Modeling of Shrink and Stretch Flanging Operations in Sheet metal Forming显示文摘 | WANG C T KINZEK G ALTAN T | 1995 | J Mater Proc Tech1995，53，： | 1 |
| 15 | An overall review of the tube Hydrofonning ( IHF) technology 显示文摘 | Muammer K Altan T | 2001 | Journal of Materials Processing Technolo?gy2001，108，： | 1 |
| 16 | FEM simulation of orthogonal cutting: serrated chip formation显示文摘 | CERETTI E LUCCHI M ALTAN T | 1999 | Journal of Materials Processing Technology1999，95，1： | 1 |
| 17 | Process simulation using finite element method-prediction of cutting forces, tool stresses and temperatures in high speed flat end milling 显示文摘 | OZEL T ALTAN T | 2000 | International Journal Machining Tools & Manufaetures2000，，40： | 1 |
| 18 | Evaluation of sheet metal formability, viscous pressure forming (VPF)dome test 显示文摘 | Liu J Ahmetoglu M Altan T | 2000 | J Mater Proce Tech2000，，98： | 1 |
| 19 | Association of HER-2/neu overexpression with the number of involved axillary lymph nodes in hormone receptor positive breast cancer patients显示文摘 | Tokatli F Altaner S Uzal C | 2005 | Exp Oncol2005，27，2： | 1 |
| 20 | An experimental study on improvement of a Savonius rotor per- formance with curtaining 显示文摘 | Burcin Deda Altan Mehmet Atilgan Aydogan Ozdamar | 2008 | Experimental Thermal and Fluid Science2008，，32： | 1 |
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