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| 1 | Endoscopic submucosal dissection for gastrointestinal neoplasms显示文摘Endoscopic submucosal dissection (ESD) is an advanced technique of therapeutic endoscopy for superficial gastrointestinal neoplasms. Three steps characterize it:injecting fluid into the submucosa to elevate the lesion, cutting the surrounding mucosa of the lesion, and dissecting the submucosa beneath the lesion. The ESD technique has rapidly permeated in Japan for treatment of early gastric cancer, due to its excellent results of en- bloc resection compared to endoscopic mucosal resection (EMR). Although there is still room for improvement to lessen its technical difficulty, ESD has recently been applied to esophageal and colorectal neoplasms. Favorable short-term results have been reported, but the application of ESD should be well considered by three aspects:(1) the possibility of nodal metastases of the lesion, (2) technical difficulty such as location, ulceration and operator’s skill, and (3) organ characteristics. | Naomi Kakushima Mitsuhiro Fujishiro | 2008 | World Journal of Gastroenterology2008，14，19： | 95 |
| 2 | Perspective on the practical indications of endoscopic submucosal dissection of gastrointestinal neoplasms显示文摘Endoscopic submucosal dissection (ESD) is a new endoluminal therapeutic technique involving the use of cutting devices to permit a larger resection of the tissue over the muscularis propria. The major advantages of the technique in comparison with polypectomy and endoscopic mucosal resection are controllable resection size and shape and en bloc resection of a large lesion or a lesion with ulcerative findings. This technique is applied for the endoscopic treatment of epithelial neoplasms in the gastrointestinal tract from the pharynx to the rectum. Furthermore, some carcinoids and submucosal tumors in the gastrointestinal tract are treated by ESD. To determine the indication, two aspects should be considered. The first is a little likelihood of lymph node metastasis and the second is the technical resectability. In this review, practical guidelines of ESD for the gastrointestinal neoplasms are discussed based on the evidence found in the literature. | Mitsuhiro Fujishiro | 2008 | World Journal of Gastroenterology2008，14，27： | 45 |
| 3 | Novel image-enhanced endoscopy with i-scan technology显示文摘i-scan technology is the newly developed imageenhanced endoscopy technology from PENTAX,Japan.This consists of three types of algorithms:surface enhancement (SE),contrast enhancement (CE),and tone enhancement (TE).SE enhances light-dark contrast by obtaining luminance intensity data for each pixel and applying an algorithm that allows detailed observation of a mucosal surface structure.CE digitally adds blue color in relatively dark areas,by obtaining luminance intensity data for each pixel and applying an algorithm that allows detailed observation of subtle irregularities around the surface.Both enhancement functions work in real time without impairing the original color of the organ,therefore,SE and CE are suitable for screening endoscopy to detect gastrointestinal tumors at an early stage.TE dissects and analyzes the individual RGB components of a normal image.The algorithm then alters the color frequencies of each component and recombines the components to a single,new color image.This is designed to enhance minute mucosal structures and subtle changes in color.TE works in real time and consists of three modes such as TE-g for gastric tumors,TE-c for colonic tumors,and TE-e for esophageal tumors.TE is suitable mainly for detailed examination of the lesions that are detected in a screening endoscopy.i-scan technology leads us to easier detection,diagnosis and treatment of gastroi ntestinal diseases. | Shinya Kodashima Mitsuhiro Fujishiro | 2010 | World Journal of Gastroenterology2010，16，9： | 35 |
| 4 | Endoscopic submucosal dissection for stomach neoplasms显示文摘在为胃瘤的治疗学的内视镜检查法的技术的最近的进展很快被完成。这块地里的主要话题之一是内视镜的粘膜下层解剖(ESD ) 。ESD 是用切设备由下列三步移开肿瘤的一种新内视镜的技术:把液体注入粘膜下层从肌肉层提高肿瘤, pre-cutting 包围肿瘤的粘膜,并且把在肿瘤下面的粘膜下层的结缔组织。肿瘤因此是以一种整块方式能的将切除,不管尺寸,形状,共存的溃疡,和地点。为 ESD 的指示被二个方面严格地限制:节的转移和技术困难的可能性,它取决于操作员。尽管长期的结果数据仍然正在缺乏, ESD 的短期的结果是极其赞成的,有胃切除术的剖腹术为早胃的癌症在治疗学的策略的一些部分被 ESD 代替。 | Mitsuhiro Fujishiro | 2006 | World Journal of Gastroenterology2006，12，32： | 35 |
| 5 | Endoscopic submucosal dissection for superficial esophageal neoplasms显示文摘Endoscopic submucosal dissection(ESD) is currently accepted as the major treatment modality for superficial neoplasms in the gastrointestinal tract including the esophagus.An important advantage of ESD is its effectiveness in resecting lesions regardless of their size and severity of fibrosis.Based on excellent outcomes for esophageal neoplasms with a small likelihood of lymph node metastasis,the number of ESD candidates has increased.On the other hand,ESD still requires highly skilled endoscopists due to technical difficulties.To avoid unnecessary complications including perforation and postoperative stricture,the indications for ESD require careful consideration and a full understanding of this modality.This article,in the highlight topic series,provides detailed information on the indication,procedure,outcome,complications and their prevention in ESD of superficial esophageal neoplasms. | Satoshi Ono Mitsuhiro Fujishiro Kazuhiko Koike | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，5： | 32 |
| 6 | Bleeding after endoscopic submucosal dissection: Risk factors and preventive methods显示文摘Endoscopic submucosal dissection(ESD) has become widely accepted as a standard method of treatment for superficial gastrointestinal neoplasms because it enables en block resection even for large lesions or fibrotic lesions with minimal invasiveness, and decreases the local recurrence rate. Moreover, specimens resected in an en block fashion enable accurate histological assessment. Taking these factors into consideration, ESD seems to be more advantageous than conventional endoscopic mucosal resection(EMR), but the associated risks of perioperative adverse events are higher than in EMR. Bleeding after ESD is the most frequent among these adverse events. Although post-ESD bleeding can be controlled by endoscopic hemostasis in most cases, it may lead to serious conditions including hemorrhagic shock. Even with preventive methods including administration of acid secretion inhibitors and preventive hemostasis, post-ESD bleeding cannot be completely prevented. In addition high-risk cases for post-ESD bleeding, which include cases with the use of antithrombotic agents or which require large resection, are increasing. Although there have been many reports about associated risk factors and methods of preventing post-ESD bleeding, many issues remain unsolved. Therefore, in this review, we have overviewed risk factors and methods of preventing post-ESD bleeding from previous studies. Endoscopists should have sufficient knowledge of these risk factors and preventive methods when performing ESD. | Yosuke Kataoka Yosuke Tsuji Yoshiki Sakaguchi Chihiro Minatsuki Itsuko Asada-Hirayama Keiko Niimi Satoshi Ono Shinya Kodashima Nobutake Yamamichi Mitsuhiro Fujishiro Kazuhiko Koike | 2016 | World Journal of Gastroenterology2016，22，26： | 16 |
| 7 | 流血和与内视镜的 submucosal 解剖联系的人工的胃的溃疡的管理显示文摘 Endoscopic submucosal dissection (ESD), an endoscopic procedure for the treatment of gastric epithelial neoplasia without lymph node metastases, spread rapidly, primarily in Japan, starting in the late 1990s. ESD enables en bloc resection of lesions that are difficult to resect using conventional endoscopic mucosal resection (EMR). However, in comparison to EMR, ESD requires a high level of endoscopic competence and a longer resection time. Thus, ESD is associated with a higher risk of adverse events, including intraoperative and postoperative bleeding and gastrointestinal perforation. In particular, because of a higher incidence of intraoperative bleeding with mucosal incision and submucosal dissection, which are distinctive endoscopic procedures in ESD, a strategy for endoscopic hemostasis, mainly by thermo-coagulation hemostasis using hemostatic forceps, is important. In addition, because of iatrogenic artificial ulcers that always form after ESD, endoscopic hemostasis and appropriate pharma-cotherapy during the healing process are essential. | Yosuke Muraki Shotaro Enomoto Mikitaka Iguchi Mitsuhiro Fujishiro Naohisa Yahagi Masao Ichinose | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，1： | 14 |
| 8 | Non-exposed endoscopic wall-inversion surgery as a novel partial gastrectomy technique显示文摘 | Takashi Mitsui Keiko Niimi Hiroharu Yamashita Osamu Goto Susumu Aikou Fumihiko Hatao Ikuo Wada Nobuyuki Shimizu Mitsuhiro Fujishiro Kazuhiko Koike Yasuyuki Seto | 2014 | Gastric Cancer2014，，3： | 5 |
| 9 | Curative ESD for intraepithelial esophageal carcinoma with leiomyoma mimicking submucosal invasive carcinoma显示文摘This case report presents a 65-year-old man who developed early esophageal cancer with leiomyoma treated by endoscopic submucosal dissection(ESD).There have been several reports of co-existing superficial esophageal cancer and leiomyoma treated by endoscopic mucosal resection.However,there is no previous report describing the co-existing lesion treated by ESD.In order to determine treatment strategies for esophageal cancer,accurate endoscopic evaluation of the cancerous depth is essential.In the present case,the combination of endoscopic ultrasonography and narrow-band imaging system with magnifying endoscopy was extremely useful to evaluate the superficial esophageal cancer with leiomyoma,which lead to the appropriate treatment,ESD. | Keiko Niimi Shinya Kodashima Satoshi Ono Osamu Goto Nobutake Yamamichi Mitsuhiro Fujishiro | 2009 | World Journal of Gastrointestinal Endoscopy2009，1，1： | 3 |
| 10 | Double-balloon endoscopic retrograde cholangiopancreatography for patients who underwent liver operation: A retrospective study显示文摘BACKGROUND Double-balloon endoscopic retrograde cholangiography (DB-ERC) is widely performed for biliary diseases after reconstruction in gastrointestinal surgery,but there are few reports on DB-ERC after hepatectomy or living donor liver transplantation (LDLT).AIM To examine the success rates and safety of DB-ERC after hepatectomy or LDLT METHODS The study was performed retrospectively in 26 patients (45 procedures) who underwent hepatectomy or LDLT (liver operation:LO group) and 40 control patients (59 procedures) who underwent pancreatoduodenectomy (control group).The technical success (endoscope reaching the choledochojejunostomy site),diagnostic success (performance of cholangiography),therapeutic success(completed interventions) and overall success rates,insertion and procedure(completion of DB-ERC) time,and adverse events were compared between these groups.RESULTS There were no significant differences between LO and control groups in the technical [93.3%(42/45) vs 96.6%(57/59),P=0.439],diagnostic [83.3%(35/42) vs83.6%(46/55),P=0.968],therapeutic [97.0%(32/33) vs 97.7%(43/44),P=0.836],and overall [75.6%(34/45) vs 79.7%(47/59),P=0.617] success rates.The median insertion time (22 vs 14 min,P <0.001) and procedure time (43.5 vs 30 min,P=0.033) were significantly longer in the LO group.The incidence of adverse events showed no significant difference [11.1%(5/45) vs 6.8%(4/59),P=0.670].CONCLUSION DB-ERC after liver operation is safe and useful but longer time is required,so should be performed with particular care. | Ryo Nishio Hiroki Kawashima Masanao Nakamura Eizaburo Ohno Takuya Ishikawa Takeshi Yamamura Keiko Maeda Tsunaki Sawada Hiroyuki Tanaka Daisuke Sakai Ryoji Miyahara Masatoshi Ishigami Yoshiki Hirooka Mitsuhiro Fujishiro | 2020 | World Journal of Gastroenterology2020，26，10： | 3 |
| 11 | Endoscopic Submucosal Dissection of Esophageal Squamous Cell Neoplasms显示文摘 | Mitsuhiro Fujishiro Naohisa Yahagi Naomi Kakushima Shinya Kodashima Yosuke Muraki Satoshi Ono Nobutake Yamamichi Ayako Tateishi Yasuhito Shimizu Masashi Oka Keiji Ogura Takao Kawabe Masao Ichinose Masao Omata | 2006 | Clinical Gastroenterology and Hepatology2006，，6： | 2 |
| 12 | Outcomes of Endoscopic Submucosal Dissection for Colorectal Epithelial Neoplasms in 200 Consecutive Cases显示文摘 | Mitsuhiro Fujishiro Naohisa Yahagi Naomi Kakushima Shinya Kodashima Yosuke Muraki Satoshi Ono Nobutake Yamamichi Ayako Tateishi Masashi Oka Keiji Ogura Takao Kawabe Masao Ichinose Masao Omata | 2007 | Clinical Gastroenterology and Hepatology2007，，6： | 2 |
| 13 | Endoscopic tissue shielding method with polyglycolic acid sheets and fibrin glue to cover wounds after colorectal endoscopic submucosal dissection (with video)显示文摘 | Yosuke Tsuji Ken Ohata Toshiaki Gunji Meiko Shozushima Jun Hamanaka Akiko Ohno Takafumi Ito Nobutake Yamamichi Mitsuhiro Fujishiro Nobuyuki Matsuhashi Kazuhiko Koike | 2014 | Gastrointestinal Endoscopy2014，，1： | 2 |
| 14 | A Multicenter Survey of the Management After Gastric Endoscopic Submucosal Dissection Related to Postoperative Bleeding显示文摘 | Osamu Goto Mitsuhiro Fujishiro Ichiro Oda Naomi Kakushima Yorimasa Yamamoto Yosuke Tsuji Ken Ohata Takashi Fujiwara Junko Fujiwara Naoki Ishii Chizu Yokoi Shinichi Miyamoto Toshiyuki Itoh Shinji Morishita Takuji Gotoda Kazuhiko Koike | 2012 | Digestive Diseases and Sciences2012，，2： | 2 |
| 15 | Magnifying endoscopy with narrow-band imaging helps determine the management of gastric adenomas显示文摘 | Yosuke Tsuji Ken Ohata Masau Sekiguchi Akiko Ohno Takafumi Ito Hideyuki Chiba Toshiaki Gunji Jun-ichi Fukushima Nobutake Yamamichi Mitsuhiro Fujishiro Nobuyuki Matsuhashi Kazuhiko Koike | 2012 | Gastric Cancer2012，，4： | 2 |
| 16 | Polyglycolic acid sheets and fibrin glue decrease the risk of bleeding after endoscopic submucosal dissection of gastric neoplasms (with video)显示文摘 | Yosuke Tsuji Mitsuhiro Fujishiro Shinya Kodashima Satoshi Ono Keiko Niimi Satoshi Mochizuki Itsuko Asada-Hirayama Rie Matsuda Chihiro Minatsuki Chiemi Nakayama Yu Takahashi Yoshiki Sakaguchi Nobutake Yamamichi Kazuhiko Koike | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 17 | Guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment显示文摘 | Kazuma Fujimoto Mitsuhiro Fujishiro Mototsugu Kato Kazuhide Higuchi Ryuichi Iwakiri Choitsu Sakamoto Shinichiro Uchiyama Atsunori Kashiwagi Hisao Ogawa Kazunari Murakami Tetsuya Mine Junji Yoshino Yoshikazu Kinoshita Masao Ichinose Toshiyuki Matsui | 2014 | Digestive Endoscopy2014，，： | 2 |
| 18 | Sessile serrated adenoma detection rate is correlated with adenoma detection rate显示文摘AIM To investigated the association between adenoma detection rate(ADR) and sessile serrated ADR(SSADR) and significant predictors for sessile serrated adenomas(SSA) detection.METHODS This study is a retrospective, single-center analysis. Total colonoscopies performed by the gastroenterologists at the University of Tokyo Hospital between January and December 2014 were retrospectively identified. Polyps were classified as low-grade or high-grade adenoma, cancer, SSA, or SSA with cytological dysplasia, and the prevalence of each type of polyp was investigated. Predictors of adenoma and SSA detection were examined using logistic generalized estimating equation models. The association between ADR and SSADR for each gastroenterologist was investigated by calculating a correlation coefficient weighted by the number of each gastroenterologist's examination.RESULTS A total of 3691 colonoscopies performed by 35 gastroenterologists were assessed. Overall, 978 (26.5%) low-and 84 (2.2%) high-grade adenomas, 81 (2.2%) cancers, 66 (1.8%) SSAs, and 2 (0.1%) SSAs with cytological dysplasia were detected. Overall ADR was 29.5%(men 33.2%, women 23.8%) and overall SSADR was 1.8%(men 1.7%, women 2.1%). In addition, 672 low-grade adenomas (68.8% of all the detected lowgrade adenomas), 58 (69.9%) high-grade adenomas, 29 (34.5%) cancers, 52 (78.8%) SSAs, and 2 (100%) SSAs with cytological dysplasia were found in the proximal colon. Adenoma detection was the only significant predictor of SSA detection (adjusted OR: 2.53, 95%CI: 1.53-4.20; P < 0.001). The correlation coefficient between ADR and SSADR weighted by the number of each gastroenterologist's examinations was 0.606(P < 0.001).CONCLUSION Our results demonstrated that ADR is correlated to SSADR. In addition, patients with adenomas had a higher prevalence of SSAs than those without adenomas. | Daisuke Ohki Yosuke Tsuji Tomohiro Shinozaki Yoshiki Sakaguchi Chihiro Minatsuki Hiroto Kinoshita Keiko Niimi Satoshi Ono Yoku Hayakawa Shuntaro Yoshida Atsuo Yamada Shinya Kodashima Nobutake Yamamichi Yoshihiro Hirata Tetsuo Ushiku Mitsuhiro Fujishiro Masashi Fukayama Kazuhiko Koike | 2018 | World Journal of Gastrointestinal Oncology2018，10，3： | 2 |
| 19 | Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori?associatedchronic atrophic gastritis: A follow?up study of patients with endoscopicallyresected colorectal neoplasia显示文摘 | Izumi Inoue Jun Kato Noriko Yoshimura Yoshimasa Maeda Kosaku Moribata Naoki Shingaki Hisanobu Deguchi Shotaro Enomoto Takao Maekita Kazuki Ueda Mikitaka Iguchi Hideyuki Tamai Mitsuhiro Fujishiro Nobutake Yamamichi Tatsuya Takeshita Masao Ichinose | 2013 | Molecular and Clinical Oncology2013，，1： | 1 |
| 20 | Gastric cancer incidence based on endoscopic Kyoto classification of gastritis显示文摘BACKGROUND Gastric cancer(GC)incidence based on the endoscopic Kyoto classification of gastritis has not been systematically investigated using time-to-event analysis.AIM To examine GC incidence in an endoscopic surveillance cohort.METHODS This study was retrospectively conducted at the Toyoshima Endoscopy Clinic.Patients who underwent two or more esophagogastroduodenoscopies were enrolled.GC incidence was based on Kyoto classification scores,such as atrophy,intestinal metaplasia(IM),enlarged folds(EFs),nodularity,diffuse redness(DR),and total Kyoto scores.Hazard ratios(HRs)adjusted for age and sex were calculated using a Cox hazard model.RESULTS A total of 6718 patients were enrolled(median age 54.0 years;men 44.2%).During the follow-up period(max 5.02 years;median 2.56 years),GC developed in 34 patients.The average frequency of GCs per year was 0.19%.Kyoto atrophy scores 1[HR with score 0 as reference:3.66,95%confidence interval(CI):1.06 to 12.61],2(11.60,3.82-35.27),IM score 2(9.92,4.37-22.54),EF score 1(4.03,1.63-9.96),DR scores 1(6.22,2.65-14.56),and 2(10.01,3.73-26.86)were associated with GC incidence,whereas nodularity scores were not.The total Kyoto scores of 4(HR with total Kyoto scores 0-1 as reference:6.23,95%CI:1.93 to 20.13,P=0.002)and 5-8(16.45,6.29-43.03,P<0.001)were more likely to develop GC,whereas the total Kyoto scores 2-3 were not.The HR of the total Kyoto score for developing GC per 1 rank was 1.75(95%CI:1.46 to 2.09,P<0.001).CONCLUSION A high total Kyoto score(≥4)was associated with GC incidence.The endoscopy-based diagnosis of gastritis can stratify GC risk. | Osamu Toyoshima Toshihiro Nishizawa Shuntaro Yoshida Tatsuya Matsuno Gota Fujisawa Akira Toyoshima Hirotoshi Ebinuma Mitsuhiro Fujishiro Yutaka Saito Hidekazu Suzuki | 2023 | World Journal of Gastroenterology2023，29，31： | 1 |
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