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| 1 | Comparison between combination therapy of percutaneous ethanol injection and radiofrequency ablation and radiofrequency ablation alone for patients with hepatocellular carcinoma显示文摘AIM: In the present study, the characteristics of PEI-RFA treatment were further elucidated by analyzing the relationship between the volume of coagulated necrosis and the energy requirement for ablation or the amount of ethanol injected into HCC.METHODS: The volume of coagulated necrosis, total energy requirement and energy requirement for coagulation of per unit volume were examined in the groups of PEI-RFA and RFA alone using the Cool-tip RF system.RESULTS: The results showed that the volume of coagulated necrosis induced was significantly larger in PEI-RFA group than in routine RFA group, when the total energy administered was comparable in both groups.In PEI-RFA, enlargement of coagulated necrosis was admitted in 3 dimensions and the amount of energy requirement per unit volume of coagulated necrosis was negatively correlated with the amount of ethanol injected into HCC.CONCLUSION: These results suggest that, compared to RFA alone, PEI-RFA enables to induce comparable coagulated necrosis with smaller energy requirement, and that PEI-RFA is likely to be less invasive than RFA alone irrespective of inducing enhanced coagulated necrosis.Thus, simple prior injection of ethanol may make RFA treatment more effective and less invasive for the treatment of patients with HCC. | Kazutaka Kurokohchi Seishiro Watanabe Tsutomu Masaki Naoki Hosomi Yoshiaki Miyauchi Takashi Himoto Yasuhiko Kimura Seiji Nakai Akihiro Deguchi Hirohito Yoneyama Shuhei Yoshida Shigeki Kuriyama | 2005 | World Journal of Gastroenterology2005，11，10： | 29 |
| 2 | A rare case of hyaline-type Castleman disease in the liver显示文摘Castleman disease often develops in the neck, mediastinum and pulmonary hilum. Its onset in the peritoneal cavity is very rare. The patient, a woman in her 70s, was referred to our department for a detailed examination of an abdominal mass. On abdominal ultrasonography, computed tomography scan, magnetic resonance imaging and positron emission tomography, a mass approximately 15 mm in diameter was noted in the hepatic S6. We attempted radical treatment and conducted a laparoscope-assisted right lobectomy. On the basis of histopathological findings, the patient was diagnosed as having hyaline type Castleman disease in the liver, a very rare condition. | Hisaaki Miyoshi Shima Mimura Takako Nomura Joji Tani Asahiro Morishita Hideki Kobara Hirohito Mori Hirohito Yoneyama Akihiro Deguchi Takashi Himoto Naoki Yamamoto Keiichi Okano Yasuyuki Suzuki Tsutomu Masaki | 2013 | World Journal of Hepatology2013，5，7： | 14 |
| 3 | A combination therapy of ethanol injection and radiofrequency ablation under general anesthesia for the treatment of hepatocellular carcinoma显示文摘AIM: To summarize the effects of laparoscopic ethanol injection and radiofrequency ablation (L-EI-RFA), thora- coscopic (T-EI-RFA) and open-surgery assisted EI-RFA (O-EI-RFA) under general anesthesia for the treatment of hepatocellular carcinoma (HCC). METHODS: Time-lag performance of RFA after ethanol injection (Time-lag PEI-RFA) was performed in all cases. The volume of coagulated necrosis and the applied en- ergy for total and per unit volume coagulated necrosis were examined in the groups treated under general (group G) or local anesthesia (group L). RESULTS: The results showed that the total applied energy and the applied energy per unit volume of whole and marginal, coagulated necrosis were significantly larger in group G than those in the group L, resulting in a larger volume of coagulated necrosis in the group G. The rate of local tumor recurrence within one year was extremely low in group G. CONCLUSION: These results suggest that EI-RFA, un- der general anesthesia, may be effective for the treat- ment of HCC because a larger quantity of ethanol and energy could be applied during treatment under pain- free condition for the patients. | Kazutaka Kurokohchi Seishiro Watanabe Hirohito Yoneyama Akihiro Deguchi Tsutomu Masaki Takashi Himoto Hisaaki Miyoshi Hamdy Saad Mohammad Akira Kitanaka Tomohiko Taminato Shigeki Kuriyama | 2008 | World Journal of Gastroenterology2008，14，13： | 10 |
| 4 | Performance Improvements in Temperature Reconstructions of 2-D Tunable Diode Laser Absorption Spectroscopy(TDLAS)显示文摘Performance improvement was attained in data reconstructions of 2-dimensional tunable diode laser absorption spectroscopy(TDLAS). Multiplicative Algebraic Reconstruction Technique(MART) algorithm was adopted for data reconstruction. The data obtained in an experiment for the measurement of temperature and concentration fields of gas flows were used. The measurement theory is based upon the Beer-Lambert law, and the measurement system consists of a tunable laser, collimators, detectors, and an analyzer. Methane was used as a fuel for combustion with air in the Bunsen-type burner. The data used for the reconstruction are from the optical signals of 8-laser beams passed on a cross-section of the methane flame. The performances of MART algorithm in data reconstruction were validated and compared with those obtained by Algebraic Reconstruction Technique(ART) algorithm. | Doo-Won Choi Min-Gyu Jeon Gyeong-Rae Cho Takahiro Kamimoto Yoshihiro Deguchi Deog-Hee Doh | 2016 | Journal of Thermal Science2016，25，1： | 8 |
| 5 | Development of 2D Temperature and Concentration Measurement Method Using Tunable Diode Laser Absorption Spectroscopy显示文摘 | Yoshihiro Deguchi Daisuke Yasui Akira Adachi | 2012 | Journal of Mechanics Engineering and Automation2012，2，9： | 7 |
| 6 | Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori -related gastritis显示文摘 | Takeichi Yoshida Jun Kato Takao Maekita Satoshi Yamashita Shotaro Enomoto Takayuki Ando Tohru Niwa Hisanobu Deguchi Kazuki Ueda Izumi Inoue Mikitaka Iguchi Hideyuki Tamai Toshikazu Ushijima Masao Ichinose | 2013 | Gastric Cancer2013，，4： | 3 |
| 7 | Effect of the anti-diabetic drug metformin in hepatocellular carcinomain vitro and in vivo显示文摘 | Hisaaki Miyoshi Kiyohito Kato Hisakazu Iwama Emiko Maeda Teppei Sakamoto Koji Fujita Yuka Toyota Joji Tani Takako Nomura Shima Mimura Mitsuyoshi Kobayashi Asahiro Morishita Hideki Kobara Hirohito Mori Hirohito Yoneyama Akihiro Deguchi Takashi Himoto Kazut | 2014 | International Journal of Oncology2014，，1： | 3 |
| 8 | EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells显示文摘 | Masahito Shimizu Atsuko Deguchi Yukihiko Hara Hisataka Moriwaki I. Bernard Weinstein | 2005 | Biochemical and Biophysical Research Communications2005，，3： | 2 |
| 9 | Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts显示文摘 | T Komori H Yagi S Nomura A Yamaguchi K Sasaki K Deguchi Y Shimizu R.T Bronson Y.-H Gao M Inada M Sato R Okamoto Y Kitamura S Yoshiki T Kishimoto | 1997 | Cell1997，，5： | 2 |
| 10 | Usefulness of liver infiltrating CD86-positive mononuclear cells for diagnosis of autoimmune hepatitis显示文摘瞄准:尽管位于自体免疫的肝炎(AIH ) 下面的病原的机制仍然保持不清楚,免疫系统被认为为疾病的前进批评。细胞的有免疫力的回答可以在 AIH 被连接到肝细胞损坏。最近,许多注意集中于在有效 T 调停房间的有免疫力的回答的产生在单音的原子房间上表示的 costimulatory 分子的批评功能。与 AIH 从病人在单音的原子房间上表示的 costimulatory 分子的分析可以在 AIH 给我们卓见进肝细胞损坏的病原的机制。方法:单音的原子房间(PBMC ) 与 AIH (34 个盒子) 和健康控制(25 个盒子) 从病人被拿的外部血。渗透的单音的原子房间(LIMC ) 与 AIH (18 个盒子) 从病人被拿的肝,有长期的丙肝(CH-C )(13 个盒子) 的病人和有脂肝(2 个盒子) 的病人。用流动血细胞计数,房间为 costimulatory 分子的表示被分析,例如 CD80, CD86,和 CD152 (CTLA-4 ) 。结果与象到 corticosteroids 的 corticosteroids 管理和反应的 gammaglobulin,组织学的等级,存在或缺席的水平那样的临床的数据相比。结果:CD80+ , CD86+ 和 CD152+ PBMC 的层次显著地作为与健康控制相比与 AIH 在病人被减少。由对比,那些房间比在有 AIH 的病人的 PBMC 在 LIMC 是显著地更高的。特别,不管疾病活动的度, CD86+ LIMC 的水平与 AIH 在病人显示出显著增加,尽管 CD86+ 房间是很少在 PBMC 在场。CD86+ 房间的层次显著地是在场的在里面在有 AIH 的病人的高频率比在有 CH-C 的病人。而且,有有 CD86+ LIMC 的高水平的 AIH 的病人显示出好回答到 corticosteroids,而有 CD86+ LIMC 的底层的 AIH 的 2 个盒子没反应很好。结论:这些结果建议那 LIMC 过去表示的 costimulatory 分子象 CD80 和 CD86 那样看起来在 AIH 的致病起一个作用。特别,在 LIMC 上表示的 CD86 分子可能为 AIH 的诊断并且为 AIH 上的 corticosteroids 的治疗学的效果的预言是有用的。 | Kazutaka Kurokohchi Tsutomu Masaki Takashi Himoto Akihiro Deguchi Seiji Nakai Asahiro Morishita Hirohito Yoneyama Yasuhiko Kimura Seishiro Watanabe Shigeki Kuriyama | 2006 | World Journal of Gastroenterology2006，12，16： | 2 |
| 11 | Identification of Risk Factors for Esophagojejunal Anastomotic Leakage after Gastric Surgery显示文摘 | Yasunori Deguchi Takeo Fukagawa Shinji Morita Masaki Ohashi Makoto Saka Hitoshi Katai | 2012 | World Journal of Surgery2012，，7： | 2 |
| 12 | A case of chronic pancreatitis in which endoscopic ultrasonography was effective in the diagnosis of a pseudoaneurysm显示文摘Endoscopic ultrasonography (EUS) was performed on a patient being treated for chronic pancreatitis because a submucosal tumor was observed in the stomach during gastrointestinal endoscopy. As internal pulsa- tile blood flow on Doppler was present, the diagnosis of an aneurysm was made. The pseudoaneurysm of the left gastric artery was embolized with histoacryl and lipiodol and the splenic artery was embolized with coils at the location of the pseudoaneurysm to prevent hemorrhage. Follow up EUS confirmed the cessation of blood flow from the pseudoaneurysm. Clinicians encountering a gastric submucosal tumor-like protrusion in a patient with chronic pancreatitis should use EUS to investigate the possibility of a pseudoaneurysm, which must be treated as quickly as possible once identified. | Kazuhiro Fukatsu Kazuki Ueda Hiroki Maeda Yasunobu Yamashita Masahiro Itonaga Yoshiyuki Mori Kosaku Moribata Naoki Shingaki Hisanobu Deguchi Shotaro Enomoto Izumi Inoue Takao Maekita Mikitaka Iguchi Hideyuki Tamai Jun Kato Masao Ichinose | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，7： | 2 |
| 13 | Cag PAI and gastric carcinogenesis-association with p53 gene mutation显示文摘 | Deguchi R Mine T Miwa T | 2003 | Nippon Rinsho2003，61，1： | 2 |
| 14 | Laser-induced breakdown spectroscopy in Asia显示文摘Laser-induced breakdown spectroscopy (LIBS) is an analytical detection technique based on atomicemission spectroscopy to measure the elemental composition. LIBS has been extensively studied anddeveloped due to the non-contact, fast response, high sensitivity, real-time and multi-elemental de-tection features. The development and applications of LIBS technique in Asia are summarized anddiscussed in this review paper. The researchers in Asia work on different aspects of the LIBS studyin fundamentals, data processing and modeling, applications and instrumentations. According to thecurrent research status, the challenges, opportunities and further development of LIBS technique inAsia are also evaluated to promote LIBS research and its applications. | Zhen-ZhenWang Yoshihiro Deguchi Zhen-Zhen Zhang Zhe Wang Xiao-Yan Zeng Jun-Jie Yan | 2016 | Frontiers of physics2016，11，6： | 2 |
| 15 | The use of small titanium screws for orthodontic anchorage显示文摘 | Deguchi D Yamamoto TT Kanomi R | 2003 | Dent Res2003，82，5： | 1 |
| 16 | Expression of neurocan after transient middle cerebral artery occlusion in adult rat brain显示文摘 | Deguchi K Takaishi M Hayashi T | 2005 | Brain Res2005，1037，12： | 1 |
| 17 | Aminated gelatin as a nasal absorption enhancer for peptide drugs: evaluation of absorption enhancing effect and nasal mucosa perturbation in rats显示文摘 | Sakai S Deguchi Y | 2002 | J Pharm Pharmacol2002，54，2： | 1 |
| 18 | Novel size effect of LaMnO3+δ nanocrystals embedded in SBA-15 mesoporous silica显示文摘 | Tajiri T Deguchi H Kohiki S Mito M Takagi S Tsuda K Murakami Y | 2006 | J Phys Soc Jpn2006，75，11： | 1 |
| 19 | Selenium and fertility in animals and man -a review显示文摘 | HANSEN J C DEGUCHI Y | 1996 | Acta Vet Scand1996，37，： | 1 |
| 20 | Analysis of cell growth inhibitory effects of catechin through MAPK in human breast cancer cell line T47D显示文摘 | Deguchi H Fujii T Nakagawa S | 2002 | International Journal of Oncol2002，21，6： | 1 |
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