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| 1 | 智能网联汽车架构、功能与应用关键技术显示文摘智能化技术与网联化技术的快速进步促进智能化车辆由驾驶辅助到无人驾驶、由单车智能到多车协同的方向发展。智能网联汽车技术能提升交通安全与效率,但也面临着来自真实交通环境的复杂挑战。该文基于智能网联汽车架构、功能与应用3方面关键技术,对用于单车自主式驾驶与网联协同式驾驶的智能网联汽车研究进行分析。首先,针对系统架构设计,分析了有关智能车辆平台架构与车-路-云一体化架构的研究;其次,面向人-车-路多因素耦合的真实交通环境,重点分析了感知、决策、控制3种关键功能技术的发展现状、面临挑战与前沿探索;最后,阐述了不同等级智能网联汽车技术的产业落地情况和特点,并对其未来发展趋势进行展望。 | 崔明阳 黄荷叶 许庆 王建强 Takaaki SEKIGUCHI 耿璐 李克强 | 2022 | 清华大学学报(自然科学版)2022，62，3： | 39 |
| 2 | Management and associated factors of delayed perforation after gastric endoscopic submucosal dissection显示文摘AIM: To identify the actual clinical management and associated factors of delayed perforation after gastric endoscopic submucosal dissection(ESD).METHODS: A total of 4943 early gastric cancer(EGC) patients underwent ESD at our hospital between January 1999 and June 2012. We retrospectively assessed the actual management of delayed perforation. In addition, to determine the factors associated with delayed perforation, after excluding 123 EGC patients with perforations that occurred during the ESD procedure, we analyzed the following clinicopathological factors among the remaining 4820 EGC patients by comparing the ESD cases with delayed perforation and the ESD cases without perforation: age, sex, chronological periods, clinical indications for ESD, status of the stomach, location, gastric circumference, tumor size, invasion depth, presence/absence of ulceration, histological type, type of resection, and procedure time.RESULTS: Delayed perforation occurred in 7(0.1%) cases. The median time until the occurrence of delayed perforation was 11 h(range, 6-172 h). Three(43%) of the 7 cases required emergency surgery, while four were conservatively managed without surgical intervention. Among the 4 cases with conservative management, 2 were successfully managed endoscopically using the endoloop-endoclip technique. The median hospital stay was 18 d(range, 15-45 d). There were no delayed perforation-related deaths. Based on a multivariate analysis, gastric tube cases(OR = 11.0; 95%CI: 1.7-73.3; P = 0.013) were significantly associated with delayed perforation.CONCLUSION: Endoscopists must be aware of not only the identified factors associated with delayed perforation, but also how to treat this complicationeffectively and promptly. | Haruhisa Suzuki Ichiro Oda Masau Sekiguchi Seiichiro Abe Satoru Nonaka Shigetaka Yoshinaga Takeshi Nakajima Yutaka Saito | 2015 | World Journal of Gastroenterology2015，21，44： | 21 |
| 3 | Autoimmune thrombocytopenia in response to splenectomy in cirrhotic patients with accompanying hepatitis C显示文摘瞄准:估计自体免疫的血小板减少的贡献到丙肝病毒相关的肝肝硬化(类型 C 肝硬化) ,我们在联系血小板的免疫球蛋白 G (PAIgG ) 层次和血小板数字之上评估了脾切除术的影响。方法:PAIgG 乳头 ers 和有免疫力的标记与一口未经触动的怒气与一口未经触动的怒气,提交到脾切除术的 17 个类型 C 肝脏硬化症的病人,和 21 non-C 肝硬化在 24 个类型 C 肝脏硬化症的病人被决定。结果:血小板减少(PLT <
15 x 10 (4 )/microL ) 在类型 C,肝硬化与一口未经触动的怒气在所有病人被诊断,提交到脾切除术的 8 个病人,并且在有未经触动的怒气的 19 non-C 肝硬化。在超过 25.0 ng/10 (7 ) 的 PAIgG 的提高的乳头 ers 房间除了一个 splenectomized 病人在所有肝脏硬化症的病人被检测。PAIgG 乳头 ers (ng/10 (7 ) 房间) 与 splenectomized 病人(125.6+/-87.8 ) 或 non-C 肝硬化(152.4+/-127.4 ) 相比在有一口未经触动的怒气(247.9+/-197.0 ) 的类型 C 肝硬化是显著地更高的。PAIgG 乳头 ers 否定地与一口未经触动的怒气在类型 C 肝脏硬化症的病人与血小板计数被相关。与有一口未经触动的怒气的类型 C 肝硬化比较, splenectomized 病人有减少的 CD4/CD8 比率和浆液 neopterin 层次。怒气索引(cm2 ) 否定地在 non-C 肝硬化,然而并非在类型 C 肝硬化与血小板计数被相关。结论:我们的数据显示自体免疫的机制在由 HCV 积极的肝硬化复杂的血小板增多起一个重要作用。另外,脾切除术可以损害 T 房间功能通过,至少部分地, CD4/CD8 比率的减小,因而压制 PAIgG 生产。 | Tetsuro Sekiguchi Takeaki Nagamine Hitoshi Takagi Masatomo Mori | 2006 | World Journal of Gastroenterology2006，12，8： | 16 |
| 4 | Excessive portal flow causes graft failure in extremely small-for-size liver transplantation in pigs显示文摘AIM: To evaluate the effects of a portocaval shunt on the decrease of excessive portal flow for the prevention of sinusoidal microcirculatory injury in extremely smallfor-size liver transplantation in pigs.METHODS: The right lateral lobe of pigs, i.e. the 25%of the liver, was transplanted orthotopically. The pigs were divided into two groups: graft without portocaval shunt (n = 11) and graft with portocaval shunt (n=11).Survival rate, portal flow, hepatic arterial flow, and histological findings were investigated.RESULTS: In the group without portocaval shunt, all pigs except one died of liver dysfunction within 24 h after transplantation. In the group with portocaval shunt,eight pigs survived for more than 4 d. The portal flow volumes before and after transplantation in the group without portocaval shunt were 118.2±26.9 mL/min/100 g liver tissue and 270.5±72.9 mL/min/100 g liver tissue,respectively. On the other hand, in the group with portocaval shunt, those volumes were 124.2±27.8 mL/min/100 g liver tissue and 42.7±32.3 mL/min/100 g liver tissue, respectively (P<0.01). As for histological findings in the group without portocaval shunt, destruction of the sinusoidal lining and bleeding in the peri-portal areas were observed after reperfusion, but these findings were not recognized in the group with portocaval shunt.CONCLUSION: These results suggest that excessive portal flow is attributed to post transplant liver dysfunction after extreme small-for-size liver transplantation caused by sinusoidal microcirculatory injury. | Hong-Sheng Wang Nobuhiro Ohkohchi Yoshitaka Enomoto Masahiro Usuda Shigehito Miyagi Takeshi Asakura Hiroo Masuoka Takashi Aiso Keisuke Fukushima Tomohiro Narita Hideyuki Yamaya Atsushi Nakamura Satoshi Sekiguchi Naoki Kawagishi Akira Sato Susumu Satomi | 2005 | World Journal of Gastroenterology2005，11，44： | 8 |
| 5 | Dehiscence following successful endoscopic closure of gastric perforation during endoscopic submucosal dissection显示文摘Gastric perforation is one of the most serious complications that can occur during endoscopic submucosal dissection(ESD).In terms of the treatment of such perforations,we previously reported that perforations immediately observed and successfully closed with endoclips during endoscopic resection could be managed conservatively.We now report the first case in our medical facility of a gastric perforation during ESD that was ineffectively treated conservatively even after successful endoscopic closure.In December 2006,we performed ESD on a recurrent early gastric cancer in an 81-year-old man with a medical history of laparotomy for cholelithiasis.A perforation occurred during ESD that was immediately observed and successfully closed with endoclips so that ESD could be continued resulting in an en-bloc resection.Intensive conservative management was conducted following ESD,however,an endoscopic examination five days after ESD revealed dehiscence of the perforation requiring an emergency laparotomy. | Masau Sekiguchi Haruhisa Suzuki Ichiro Oda Shigetaka Yoshinaga Satoru Nonaka Makoto Saka Hitoshi Katai Hirokazu Taniguchi Ryoji Kushima Yutaka Saito | 2012 | World Journal of Gastroenterology2012，18，31： | 7 |
| 6 | Reduction of virus burden-induced splenectomy in patients with liver cirrhosis related to hepatitis C virus infection显示文摘瞄准:检验丙肝病毒(HCV ) 在在脾切除术以后的肝脏硬化症的病人的层次和免疫学的标记。方法:HCV RNA 乳头 ers 以及细胞、体液的有免疫力的标记与一口未经触动的怒气在脾切除术以后并且在 32 肝脏硬化症的控制在 20 个肝脏硬化症的病人被决定。结果:浆液 HCV RNA 乳头 ers 比在控制在 splenectomized 病人是更低的(186+/-225 x 10 (3 ) copies/mL 对 541+/-417 x 10 (3 ) copies/mL, P<0.01 ) 。HCV RNA 被判定到自发地控制在 4 个 splenectomized 病人,但是在没有被根除了。自然漂亮房间活动比在控制在 splenectomized 病人是更高的(41.2+/-19.3% 对 24.7+/-15.3% , P<0.01 ) ,并且除了在那些,自然漂亮房间活动否定地与血清型 2-related 感染在 splenectomized 病人被相关到 HCV RNA 乳头 ers。CD4/CD8 比率比在控制在 splenectomized 病人是显著地更低的。结论:调查结果建议那脾切除术可以减少在有 HCV 感染的肝脏硬化症的病人的病毒负担至少部分地,通过自然漂亮房间活动的扩大。 | Tetsuro Sekiguchi Takeaki Nagamine Hitoshi Takagi Masatomo Mori | 2006 | World Journal of Gastroenterology2006，12，13： | 4 |
| 7 | Performance of 18-fluoro-2-deoxyglucose positron emission tomography for esophageal cancer screening显示文摘AIM To evaluate the performance of 18-fluoro-2-deoxyglucose positron emission tomography(FDG-PET) for esophageal cancer(EC) screening.METHODS We retrospectively analyzed the data of consecutive asymptomatic individuals who underwent FDG-PET and esophagogastroduodenoscopy(EGD) simultaneously for cancer screening at our institution from February 2004 to March 2013. In total, 14790 FDG-PET and EGD procedures performed for 8468 individuals were included in this study, and the performance of FDGPET for EC screening was assessed by comparing the results of FDG-PET and EGD, considering the latter as the reference.RESULTS Thirty-two EC lesions were detected in 28 individuals(31 squamous cell carcinomas and 1 adenocarcinoma). The median tumor size was 12.5 mm, and the depths of the lesions were as follows: Tis(n = 12), T1a(n = 15), and T1b(n = 5). Among the 14790 FDG-PET procedures, 51 examinations(0.3%) showed positive findings in the esophagus; only 1 was a true-positive finding. The screen sensitivity, specificity, positive predictive value, and negative predictive value of FDGPET for ECs were 3.6%(95%CI: 0.1-18.3), 99.7%(95%CI: 99.6-99.7), 2.0%(95%CI: 0.0-10.4), and 99.8%(95%CI: 99.7-99.9), respectively. Of the 50 FDG-PET false-positive cases, 31 were observed in the lower esophagus, and gastroesophageal reflux disease was observed in 17 of these 31 cases.CONCLUSION This study is the first to clarify the FDG-PET performance for EC screening. Based on the low screen sensitivity, FDG-PET is considered to be difficult to use as a screening modality for ECs. | Masau Sekiguchi Takashi Terauchi Yasuo Kakugawa Naoki Shimada Yutaka Saito Takahisa Matsuda | 2017 | World Journal of Gastroenterology2017，23，15： | 3 |
| 8 | Effect of Portocaval Shunt on Residual Extreme Small Liver after Extended Hepatectomy in Porcine显示文摘 | HongSheng Wang MD PhD Nobuhiro Ohkohchi MD PhD Yoshitaka Enomoto MD Masahiro Usuda MD Shigehito Miyagi MD Hiroo Masuoka MD Satoshi Sekiguchi MD Naoki Kawagishi MD Keisei Fujimori MD Akira Sato MD Susumu Satomi MD PhD | 2006 | World Journal of Surgery2006，，11： | 2 |
| 9 | Magnifying endoscopy with narrow-band imaging helps determine the management of gastric adenomas显示文摘 | Yosuke Tsuji Ken Ohata Masau Sekiguchi Akiko Ohno Takafumi Ito Hideyuki Chiba Toshiaki Gunji Jun-ichi Fukushima Nobutake Yamamichi Mitsuhiro Fujishiro Nobuyuki Matsuhashi Kazuhiko Koike | 2012 | Gastric Cancer2012，，4： | 2 |
| 10 | Angiotensin Ⅱand mechanical stretch induce production of tumor necrosis factor in cardiac fibroblasts显示文摘 | Yokoyama T Sekiguchi K Tanaka T | 1999 | Am J Physiol1999，276，62： | 2 |
| 11 | Antitumor activity of trastuzumab in combination with chemotherapy in human gastric cancer xenograft models显示文摘 | Kaori Fujimoto-Ouchi Fumiko Sekiguchi Hideyuki Yasuno Yoichiro Moriya Kazushige Mori Yutaka Tanaka | 2007 | Cancer Chemotherapy and Pharmacology2007，，6： | 2 |
| 12 | Early Repolarization Is an Independent Predictor of Occurrences of Ventricular Fibrillation in the Very Early Phase of Acute Myocardial Infarction显示文摘 | Yoshihisa Naruse Hiroshi Tada Yoshie Harimura Mayu Hayashi Yuichi Noguchi Akira Sato Kentaro Yoshida Yukio Sekiguchi Kazutaka Aonuma | 2012 | Circulation: Arrhythmia and Electrophysiology2012，，3： | 2 |
| 13 | Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX显示文摘 | Bassing CH Chua KF Sekiguchi J | 2002 | Proc Natl Acad Sci USA2002，99，12： | 1 |
| 14 | Approximation by positive operators显示文摘 | AUDO T SEKIGUCHI T SUZUKI T | 1973 | Math Z1973，131，3： | 1 |
| 15 | Angiotensin Ⅱ and mechanical stretch induce production of tumor necrosis factorin cardiac fibroblasts 显示文摘 | Yokoyama T Sekiguchi K Tanaka T | 1999 | Am J Physiol1999，276，62： | 1 |
| 16 | Optimization of solar hydrogen system based on hydrogen production cost显示文摘 | Tan T Sekiguchi N Sakai M | 2000 | Solar Energy2000，68，2： | 1 |
| 17 | Partial agonis?tic effect of yokukansan on human recombinant serotonin 1 A receptors expressed in the membranes of Chinese ham?ster ovary cells 显示文摘 | Terawaki K Ikarashi Y Sekiguchi K | 2010 | J Ethnopharmacol2010，127，2： | 1 |
| 18 | Treating ulcera-tive colitis by Adacolumn therapeutic leucocytapheresis:clinical efficacy and safety based on surveillance of656patients in53cen-tres in Japan显示文摘 | Hibi T Sameshima Y Sekiguchi Y | 2009 | Dig Liver Dis2009，41，8： | 1 |
| 19 | Differentia- tion of neural cells in the fetal cerebral cortex of cynomol- gus monkeys ( Macaca fascicularis) 显示文摘 | Toyoshima Y Sekiguchi S Negishi T | 2012 | Comp Med2012，62，1： | 1 |
| 20 | Two-wheeled mobile robot motion control in dynamic environments显示文摘 | M Deng A Inoue K Sekiguchi L Jiang | | 0，，03： | 1 |
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