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| 1 | Feasibility of cold snare polypectomy in Japan: A pilot study显示文摘AIM: To investigate the feasibility of cold snare polypectomy(CSP) in Japan.METHODS: The outcomes of 234 non-pedunculated polyps smaller than 10 mm in 61 patients who underwent CSP in a Japanese referral center were retrospectively analyzed. The cold snare polypectomies were performed by nine endoscopists with no prior experience in CSP using an electrosurgical snare without electrocautery.RESULTS: CSPs were completed for 232 of the 234 polyps. Two(0.9%) polyps could not be removed without electrocautery. Immediate postpolypectomy bleeding requiring endoscopic hemostasis occurred in eight lesions(3.4%; 95%CI: 1.1%-5.8%), but all were easily managed. The incidence of immediate bleeding after CSP for small polyps(6-9 mm) was significantly higher than that of diminutive polyps(≤ 5 mm; 15% vs 1%, respectively). Three(5%) patients complained of minor bleeding after the procedure but required no intervention. The incidence of delayed bleeding requiringendoscopic intervention was 0.0%(95%CI: 0.0%-1.7%). In total, 12% of the resected lesions could not be retrieved for pathological examination. Tumor involvement in the lateral margin could not be histologically assessed in 70(40%) lesions.CONCLUSION: CSP is feasible in Japan. However, immediate bleeding, retrieval failure and uncertain assessment of the lateral tumor margin should not be underestimated. Careful endoscopic diagnosis before and evaluation of the tumor residue after CSP are recommended when implementing CSP in Japan. | Yoji Takeuchi Takeshi Yamashina Noriko Matsuura Takashi Ito Mototsugu Fujii Kengo Nagai Fumi Matsui Tomofumi Akasaka Noboru Hanaoka Koji Higashino Hiroyasu Iishi Ryu Ishihara Henrik Thorlacius Noriya Uedo | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，17： | 14 |
| 2 | Pink-color sign in esophageal squamous neoplasia, and speculation regarding the underlying mechanism显示文摘AIM:To investigate the reasons for the occurrence of the pink-color sign of iodine-unstained lesions. METHODS:In chromoendoscopy, the pink-color sign of iodine-unstained lesions is recognized as useful for the diagnosis of esophageal squamous cell carcinoma. Patients with superficial esophageal neoplasms treated by endoscopic resection were included in the study. Areas of mucosa with and without the pink-color sign were evaluated histologically. The following histologic features that were possibly associated with the pinkcolor sign were evaluated. The keratinous layer and basal cell layer were classified as present or absent. Cellular atypia was classified as high grade, moderate grade or low grade, based on nuclear irregularity, mitotic figures, loss of polarity, chromatin pattern and nuclear/cytoplasmic ratio. Vascular change was assessed based on dilatation, tortuosity, caliber change and variability in shape. Vessels with these four findings were classified as positive for vascular change. Endoscopic images of the lesions were captured immediately after iodine staining, 2-3 min after iodine staining and after complete fading of iodine staining. Quantitative analysis of color changes after iodine staining was also performed. RESULTS:A total of 61 superficial esophageal neoplasms in 54 patients were included in the study. The lesions were located in the cervical esophagus in one case, the upper thoracic esophagus in 10 cases, the mid-thoracic esophagus in 33 cases, and the lower thoracic esophagus in 17 cases. The median diameter of the lesions was 20 mm (range:2-74 mm). Of the 61 lesions, 28 were classified as pink-color sign positive and 33 as pink-color sign negative. The histologic diagnosis was high-grade intraepithelial neoplasia (HGIN) or cancer invading into the lamina propria in 26 of the 28 pink-color sign positive lesions. There was a significant association between pink-color sign positive epithelium and HGIN or invasive cancer (P = 0.0001). Univariate analyses found that absence of the keratinous layer and cellular atypia were significantly associated with the pink-color sign. After Bonferroni correction, there were no significant associations between the pink-color sign and presence of the basal membrane or vascular change. Multivariate analyses found that only absence of the keratinous layer was independently associated with the pink-color sign (OR = 58.8, 95%CI:5.5-632).Quantitative analysis was performed on 10 superficial esophageal neoplasms with both pink-color sign positive and negative areas in 10 patients. Pink-color sign positive mucosa had a lower mean color value in the late phase (pinkish color) than in the early phase (yellowish color), and had similar mean color values in the late and final phases. These findings suggest that pinkcolor positive mucosa underwent color fading from the color of the iodine (yellow) to the color of the mucosa (pink) within 2-3 min after iodine staining. Pink-color sign negative mucosa had similar mean color values in the late and early phases (yellowish color), and had a lower mean color value in the final phase (pinkish color) than in the late phase. These findings suggest that pink-color sign negative mucosa did not undergo color fading during the 2-3 min after iodine staining, and underwent color fading only after spraying of sodium thiosulfate. CONCLUSION:The pink-color sign was associated with absence of the keratinous layer. This sign may be caused by early fading of iodine staining. | Ryu Ishihara Hiromitsu Kanzaki Hiroyasu Iishi Kengo Nagai Fumi Matsui Takeshi Yamashina Noriko Matsuura Takashi Ito Mototsugu Fujii Sachiko Yamamoto Noboru Hanaoka Yoji Takeuchi Koji Higashino Noriya Uedo Masaharu Tatsuta Yasuhiko Tomita Shingo Ishiguro | 2013 | World Journal of Gastroenterology2013，19，27： | 10 |
| 3 | Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial显示文摘 | Kazutoshi Fukase Mototsugu Kato Shogo Kikuchi Kazuhiko Inoue Naomi Uemura Shiro Okamoto Shuichi Terao Kenji Amagai Shunji Hayashi Masahiro Asaka | 2008 | The Lancet2008，，9636： | 7 |
| 4 | Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial显示文摘 | Kazutoshi Fukase Mototsugu Kato Shogo Kikuchi Kazuhiko Inoue Naomi Uemura Shiro Okamoto Shuichi Terao Kenji Amagai Shunji Hayashi Masahiro Asaka | 2008 | The Lancet . 2008 (9636)2008，，： | 4 |
| 5 | Evaluation of small bowel blood flow in healthy subjects receiving low-dose aspirin显示文摘AIM:To investigate the relationship between low-dose aspirin-induced small bowel mucosal damage and blood flow,and the effect of rebamipide. METHODS:Ten healthy volunteers were enrolled in this study.The subjects were divided into two groups:a placebo group given low-dose aspirin plus placebo and a rebamipide group given low-dose aspirin plus rebamipide for a period of 14 d.Capsule endoscopy and contrast-enhanced ultrasonography were performed before and after administration of drugs.Areas under the curves and peak value of time-intensity curve were calculated. RESULTS:Absolute differences in areas under the curves were-1102.5(95%CI:-1980.3 to-224.7,P=0.0194) in the placebo group and-152.7(95%CI:-1604.2 to 641.6,P=0.8172) in the rebamipide group. Peak values of time intensity curves were-148.0(95% CI:-269.4 to-26.2,P=0.0225) in the placebo group and 28.3(95%CI:-269.0 to 325.6,P=0.8343) in the rebamipide group.Capsule endoscopy showed mucosal breaks only in the placebo group. CONCLUSION:Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow. | Urara Nishida Mototsugu Kato Mutsumi Nishida Go Kamada Takeshi Yoshida Shouko Ono Yuichi Shimizu Masahiro Asaka | 2011 | World Journal of Gastroenterology2011，17，2： | 3 |
| 6 | Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial显示文摘 | Kazutoshi Fukase Mototsugu Kato Shogo Kikuchi Kazuhiko Inoue Naomi Uemura Shiro Okamoto Shuichi Terao Kenji Amagai Shunji Hayashi Masahiro Asaka | 2008 | The Lancet2008，，9636： | 3 |
| 7 | Pathological factors related to lymph node metastasis of submucosally invasive gastric cancer: criteria for additional gastrectomy after endoscopic resection显示文摘 | Mototsugu Fujii Yutaro Egashira Hiroshi Akutagawa Tsukasa Nishida Toshikatsu Nitta Go Edagawa Yoshitaka Kurisu Yuro Shibayama | 2013 | Gastric Cancer2013，，4： | 3 |
| 8 | Comparative study of therapeutic effects of PPI and H2RA on ulcers during continuous aspirin therapy显示文摘AIM:To compare the therapeutic effects of proton pump inhibitors(PPI) and histamine 2 receptor antagonists(H2RA) on gastroduodenal ulcers under continuous use of low-dose aspirin.METHODS:Sixty patients who had a gastroduodenal ulcer on screening endoscopy but required continuous use of low-dose aspirin were randomly assigned to receive PPI(lansoprazole 30 mg,n = 30) or H2RA(famotidine 40 mg or if famotidine had been administered before assignment,ranitidine 300 mg,n = 30).The therapeutic effects were evaluated by endoscopy after 8-wk treatment.The presence or absence of Helicobacter pylori(H.pylori) was determined by urea breath test before treatment.Abdominal symptoms were compared with the gastrointestinal symptom rating scale(GSRS) questionnaire before and after treatment.RESULTS:Twenty-six patients in the PPI group and 26 patients in the H2RA group,excluding dropouts,were analyzed.There were no significant differences in median age,sex,underlying disease,smoking status,H.pylori infection,prevalence of ulcers before treatment,and lesion site between the two groups.The therapeutic effects were endoscopically evaluated as healed in 23 patients(88.5%) and not healed in 3 patients in the PPI group and as healed in 22 patients(84.6%) and not healed in 4 patients in the H2RA group.Abdominal symptoms before treatment were uncommon in both groups;the GSRS scores were not significantly reduced after treatment as compared with before treatment.CONCLUSION:The healing rate of gastroduodenal ulcers during continuous use of low-dose aspirin was greater than 80% in both the PPI group and the H2RA group,with no significant difference between the two groups. | Hiroaki Nema Mototsugu Kato | 2010 | World Journal of Gastroenterology2010，16，42： | 3 |
| 9 | Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial显示文摘 | Kazutoshi Fukase Mototsugu Kato Shogo Kikuchi Kazuhiko Inoue Naomi Uemura Shiro Okamoto Shuichi Terao Kenji Amagai Shunji Hayashi Masahiro Asaka | 2008 | 2008 (9636)2008，，9636： | 2 |
| 10 | Guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment显示文摘 | Kazuma Fujimoto Mitsuhiro Fujishiro Mototsugu Kato Kazuhide Higuchi Ryuichi Iwakiri Choitsu Sakamoto Shinichiro Uchiyama Atsunori Kashiwagi Hisao Ogawa Kazunari Murakami Tetsuya Mine Junji Yoshino Yoshikazu Kinoshita Masao Ichinose Toshiyuki Matsui | 2014 | Digestive Endoscopy2014，，： | 2 |
| 11 | Exchange Rate Pass-through and Inflation:A Nonlinear Time Series Analysis显示文摘 | Shintani Mototsugu Akiko Terada-Hagiwara Tomoyoshi Yabu | 2013 | Journal of International Money and Finance2013，，32： | 1 |
| 12 | Changes in endoscopic findings of gastritis after cure of H. pylori infection: Multicenter prospective trial显示文摘 | Mototsugu Kato Shuichi Terao Kyoichi Adachi Shigemi Nakajima Takashi Ando Norimasa Yoshida Noriya Uedo Kazunari Murakami Shuichi Ohara Masanori Ito Naomi Uemura Takuro Shimbo Hidenobu Watanabe Takahiro Kato Kazunori Ida | 2012 | Digestive Endoscopy2012，，3： | 1 |
| 13 | The Effect of Demo- graphics on the Japanese Housing Market 显示文摘 | Fumio Ohtake Mototsugu Shintani | 1996 | Regional Science and Urban Economics1996，，26： | 1 |
| 14 | Short-term and long-term outcome of endoluminal gastroplication for the treatment of GERD: the first multicenter trial in Japan显示文摘 | Soji Ozawa Koichiro Kumai Kazuhide Higuchi Tetsuo Arakawa Mototsugu Kato Masahiro Asaka Natsuya Katada Hiroyuki Kuwano Masaki Kitajima | 2009 | Journal of Gastroenterology2009，，7： | 1 |
| 15 | Isolation of helicobacter pylori from sheep—implications for transmission to humans显示文摘 | Maria P Dore Antonia R Sepulveda Hala El-Zimaity Yoshio Yamaoka Michael S Osato Kato Mototsugu Antonio M Nieddu Giuseppe Realdi David Y Graham | 2001 | The American Journal of Gastroenterology2001，，5： | 1 |
| 16 | Effects of residual stress and interracial frictional shear stress on interfacial debonding at notchtip in two-dimensional unidirectional composite显示文摘 | Oehiai Shojiro Tanaka Mototsugu Hojo Masaki | 1998 | Composite Interfaces1998，5，5： | 1 |
| 17 | The effect of demographics on the Japanese housing market显示文摘 | Fumio Ohtake Mototsugu Shintani | 1996 | Regional Science and Urban Economics1996，，2： | 1 |
| 18 | The Benefit of Laparoscopic Partial Nephrectomy in High Body Mass Index Patients显示文摘 | Gou Kaneko Akira Miyajima Eiji Kikuchi Ken Nakagawa Mototsugu Oya | 2012 | Japanese Journal of Clinical Oncology2012，，7： | 1 |
| 19 | Superselective Bronchial Artery Embolization for Hemoptysis with a Coaxial Microcatheter System显示文摘 | Naoshi Tanaka Koichiro Yamakado Shuichi Murashima Kan Takeda Kaname Matsumura Tsuyoshi Nakagawa Katsuhiro Takano Mototsugu Ono Takao Hattori | 1997 | Journal of Vascular and Interventional Radiology1997，，1： | 1 |
| 20 | Phase II study of S-1 as first-line treatment for elderly patients over 75 years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study显示文摘 | Wasaburo Koizumi Toshikazu Akiya Atsushi Sato Toshikazu Sakuyama Eisaku Sasaki Takashi Tomidokoro Tsutomu Hamada Mototsugu Fujimori Yoshinori Kikuchi Ken Shimada Tetsuya Mine Kensei Yamaguchi Tsuneo Sasaki Minoru Kurihara | 2010 | Cancer Chemotherapy and Pharmacology2010，，： | 1 |
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