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| 1 | Bleeding after endoscopic submucosal dissection: Risk factors and preventive methods显示文摘Endoscopic submucosal dissection(ESD) has become widely accepted as a standard method of treatment for superficial gastrointestinal neoplasms because it enables en block resection even for large lesions or fibrotic lesions with minimal invasiveness, and decreases the local recurrence rate. Moreover, specimens resected in an en block fashion enable accurate histological assessment. Taking these factors into consideration, ESD seems to be more advantageous than conventional endoscopic mucosal resection(EMR), but the associated risks of perioperative adverse events are higher than in EMR. Bleeding after ESD is the most frequent among these adverse events. Although post-ESD bleeding can be controlled by endoscopic hemostasis in most cases, it may lead to serious conditions including hemorrhagic shock. Even with preventive methods including administration of acid secretion inhibitors and preventive hemostasis, post-ESD bleeding cannot be completely prevented. In addition high-risk cases for post-ESD bleeding, which include cases with the use of antithrombotic agents or which require large resection, are increasing. Although there have been many reports about associated risk factors and methods of preventing post-ESD bleeding, many issues remain unsolved. Therefore, in this review, we have overviewed risk factors and methods of preventing post-ESD bleeding from previous studies. Endoscopists should have sufficient knowledge of these risk factors and preventive methods when performing ESD. | Yosuke Kataoka Yosuke Tsuji Yoshiki Sakaguchi Chihiro Minatsuki Itsuko Asada-Hirayama Keiko Niimi Satoshi Ono Shinya Kodashima Nobutake Yamamichi Mitsuhiro Fujishiro Kazuhiko Koike | 2016 | World Journal of Gastroenterology2016，22，26： | 16 |
| 2 | Serum anti-Helicobacter pylori antibody titer and its association with gastric nodularity,atrophy,and age:A cross-sectional study显示文摘AIM To clarify the role of serum anti-Helicobacter pylori(H. pylori) antibody titers in gastric cancer.METHODS In this cross-sectional study, the effect of patients' baseline characteristics and endoscopic findings on their serum antibody titers were assessed. We evaluated consecutive patients who underwent esophagogastroduodenoscopy and their first evaluation for H. pylori infection using a serum antibody test. We excluded patients with a history of eradication therapy. The participants were divided into four groups according to their E-plate serum antibody titer. Patients with serum antibody titers < 3, 3-9.9, 10-49.9, and ≥ 50 U/m L were classified into groups A, B, C, and D, respectively. RESULTS In total, 874 participants were analyzed with 70%, 16%, 8.7%, and 5.1% of them in the groups A, B, C, and D, respectively. Patients in group C were older than patients in groups A and B. Gastric open-type atrophy, intestinal metaplasia, enlarged folds, diffuse redness, and duodenal ulcers were associated with a high titer. Regular arrangements of collecting venules, fundic gland polyps, superficial gastritis, and gastroesophageal reflux disease were related to a low titer. Multivariate analysis revealed that nodularity(P = 0.0094), atrophy(P = 0.0076), and age 40-59 years(vs age ≥ 60 years, P = 0.0090) were correlated with a high serum antibody titer in H. pylori-infected patients. Intestinal metaplasia and atrophy were related to age ≥ 60 years in group C and D.CONCLUSION Serum antibody titer changes with age, reflects gastric mucosal inflammation, and is useful in predicting the risk of gastric cancer. | Osamu Toyoshima Toshihiro Nishizawa Kosuke Sakitani Tadahiro Yamakawa Yoshiyuki Takahashi Nobutake Yamamichi Keisuke Hata Yasuyuki Seto Kazuhiko Koike Hidenobu Watanabe Hidekazu Suzuki | 2018 | World Journal of Gastroenterology2018，24，35： | 9 |
| 3 | Curative ESD for intraepithelial esophageal carcinoma with leiomyoma mimicking submucosal invasive carcinoma显示文摘This case report presents a 65-year-old man who developed early esophageal cancer with leiomyoma treated by endoscopic submucosal dissection(ESD).There have been several reports of co-existing superficial esophageal cancer and leiomyoma treated by endoscopic mucosal resection.However,there is no previous report describing the co-existing lesion treated by ESD.In order to determine treatment strategies for esophageal cancer,accurate endoscopic evaluation of the cancerous depth is essential.In the present case,the combination of endoscopic ultrasonography and narrow-band imaging system with magnifying endoscopy was extremely useful to evaluate the superficial esophageal cancer with leiomyoma,which lead to the appropriate treatment,ESD. | Keiko Niimi Shinya Kodashima Satoshi Ono Osamu Goto Nobutake Yamamichi Mitsuhiro Fujishiro | 2009 | World Journal of Gastrointestinal Endoscopy2009，1，1： | 3 |
| 4 | Ca^(2+)及cAMP调控的神经递质与激素释放显示文摘神经递质和激素的释放受胞内诸多信号通路的调控。这两种内源物质的释放都由依赖于Ca2+浓度的快速引发机制介导,相对于其他介导因素,[Ca2+]占主导地位。神经递质和激素释放的调控大多是通过调节释放小泡数量实现的。尽管在处于静息状态的神经末梢中,释放小泡的数量相对恒定,但当释放小泡被胞吐作用“消耗”后,其再生速度受调控作用介导而发生改变,从而导致小泡数量“稳中有变”的动态调控过程。这一动态调控作用表明了“消耗”与“再生”之间的平衡机制。 | 艾尔温·尼尔 Nobutake Hosoi Takeshi Sakaba 方守狮(组稿) | 2006 | 自然杂志2006，28，5： | 3 |
| 5 | 同时测定无机离子的改良离子色谱法在河水和废水质量监控中的应用(英文)显示文摘In this study,our recent work on advanced ion chromatographic methods for the simultaneous determination of inorganic ionic species such as common anions(SO2-4,Cl-and NO-3) and cations(Na+,NH+4,K+,Mg2+,and Ca2+),nutrients(phosphate and silicate) and hydrogen ion/alkalinity are summarized first.Then,the applications using these methods for monitoring environmental water quality are also presented.For the determination of common anions and cations with nutrients,the separation was successfully performed by a polymethacrylate-based weakly acidic cation-exchange column of TSKgel Super IC-A/C(Tosoh,150 mm×6.0 mm i.d.) and a mixture solution of 100 mmol/L ascorbic acid and 4 mmol/L 18-crown-6 as acidic eluent with dual detection of conductivity and spectrophotometry.For the determination of hydrogen ion/alkalinity,the separation was conducted by TSKgel ODS-100Z column(Tosoh,150 mm×4.5 mm i.d.) modified with lithium dodecylsulfate and an eluent of 40 mmol/L LiCl/0.1 mmol/L lithium dodecylsulfate/0.05 mmol/L H2SO4 with conductivity detector.The differences of ion concentration between untreated and treated wastewater showed the variation of ionic species during biological treatment process in a sewage treatment plant.Occurrence and distribution of water-quality conditions were related to the bioavailability and human activity in watershed.From these results,our advanced ion chromatographic methods have contributed significantly for water quality monitoring of environmental waters. | Nobutake NAKATANI Daisuke KOZAKI Kazuhiko TANAKA | 2012 | 色谱2012，30，4： | 3 |
| 6 | Endoscopic Submucosal Dissection of Esophageal Squamous Cell Neoplasms显示文摘 | Mitsuhiro Fujishiro Naohisa Yahagi Naomi Kakushima Shinya Kodashima Yosuke Muraki Satoshi Ono Nobutake Yamamichi Ayako Tateishi Yasuhito Shimizu Masashi Oka Keiji Ogura Takao Kawabe Masao Ichinose Masao Omata | 2006 | Clinical Gastroenterology and Hepatology2006，，6： | 2 |
| 7 | Outcomes of Endoscopic Submucosal Dissection for Colorectal Epithelial Neoplasms in 200 Consecutive Cases显示文摘 | Mitsuhiro Fujishiro Naohisa Yahagi Naomi Kakushima Shinya Kodashima Yosuke Muraki Satoshi Ono Nobutake Yamamichi Ayako Tateishi Masashi Oka Keiji Ogura Takao Kawabe Masao Ichinose Masao Omata | 2007 | Clinical Gastroenterology and Hepatology2007，，6： | 2 |
| 8 | Endoscopic tissue shielding method with polyglycolic acid sheets and fibrin glue to cover wounds after colorectal endoscopic submucosal dissection (with video)显示文摘 | Yosuke Tsuji Ken Ohata Toshiaki Gunji Meiko Shozushima Jun Hamanaka Akiko Ohno Takafumi Ito Nobutake Yamamichi Mitsuhiro Fujishiro Nobuyuki Matsuhashi Kazuhiko Koike | 2014 | Gastrointestinal Endoscopy2014，，1： | 2 |
| 9 | Magnifying endoscopy with narrow-band imaging helps determine the management of gastric adenomas显示文摘 | Yosuke Tsuji Ken Ohata Masau Sekiguchi Akiko Ohno Takafumi Ito Hideyuki Chiba Toshiaki Gunji Jun-ichi Fukushima Nobutake Yamamichi Mitsuhiro Fujishiro Nobuyuki Matsuhashi Kazuhiko Koike | 2012 | Gastric Cancer2012，，4： | 2 |
| 10 | 离子排斥色谱结合光度检测的水质监测系统用于测定离子型营养物(英文)显示文摘A unified ion-exclusion chromatography(IEC) system for monitoring anionic and cationic nutrients like NH + 4,NO 2,NO 3,phosphate ion,silicate ion and HCO 3 was developed and applied to several environmental waters.The IEC system consisted of four IEC methodologies,including the IEC with ultraviolet(UV) detection at 210 nm for determining NH + 4 on anion-exchange separation column in OH form connected with anion-exchange UV-conversion column in I form in tandem,the IEC with UV-detection at 210 nm for determining simultaneously NO 2 and NO 3 on cation-exchange separation column in H + form,the IEC with UV-detection at 210 nm for determining HCO 3 on cation-exchange separation column in H + form connected with anion-exchange UV-conversion column in I form in tandem,and the IEC with visible-detection based on molybdenum-blue reaction for determining simultaneously silicate and phosphate ions on cation-exchange separation column in H + form.These IEC systems were combined through three manually-driven 6-port column selection valves to select each separation column to determine selectively the ionic nutrients.Using this sequential water quality monitoring system,the analytical performances such as calibration linearity,reproducibility,detection limit and recovery were also tested under the optimized chromatographic conditions.This novel water quality monitoring system has been applied successfully for the determination of the ionic eutrophication components in sub-urban river waters. | Daisuke KOZAKI Nobutake NAKATANI Masanobu MORI Nobukazu NAKAGOSHI Kazuhiko TANAKA | 2012 | 色谱2012，30，7： | 2 |
| 11 | Polyglycolic acid sheets and fibrin glue decrease the risk of bleeding after endoscopic submucosal dissection of gastric neoplasms (with video)显示文摘 | Yosuke Tsuji Mitsuhiro Fujishiro Shinya Kodashima Satoshi Ono Keiko Niimi Satoshi Mochizuki Itsuko Asada-Hirayama Rie Matsuda Chihiro Minatsuki Chiemi Nakayama Yu Takahashi Yoshiki Sakaguchi Nobutake Yamamichi Kazuhiko Koike | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 12 | Sessile serrated adenoma detection rate is correlated with adenoma detection rate显示文摘AIM To investigated the association between adenoma detection rate(ADR) and sessile serrated ADR(SSADR) and significant predictors for sessile serrated adenomas(SSA) detection.METHODS This study is a retrospective, single-center analysis. Total colonoscopies performed by the gastroenterologists at the University of Tokyo Hospital between January and December 2014 were retrospectively identified. Polyps were classified as low-grade or high-grade adenoma, cancer, SSA, or SSA with cytological dysplasia, and the prevalence of each type of polyp was investigated. Predictors of adenoma and SSA detection were examined using logistic generalized estimating equation models. The association between ADR and SSADR for each gastroenterologist was investigated by calculating a correlation coefficient weighted by the number of each gastroenterologist's examination.RESULTS A total of 3691 colonoscopies performed by 35 gastroenterologists were assessed. Overall, 978 (26.5%) low-and 84 (2.2%) high-grade adenomas, 81 (2.2%) cancers, 66 (1.8%) SSAs, and 2 (0.1%) SSAs with cytological dysplasia were detected. Overall ADR was 29.5%(men 33.2%, women 23.8%) and overall SSADR was 1.8%(men 1.7%, women 2.1%). In addition, 672 low-grade adenomas (68.8% of all the detected lowgrade adenomas), 58 (69.9%) high-grade adenomas, 29 (34.5%) cancers, 52 (78.8%) SSAs, and 2 (100%) SSAs with cytological dysplasia were found in the proximal colon. Adenoma detection was the only significant predictor of SSA detection (adjusted OR: 2.53, 95%CI: 1.53-4.20; P < 0.001). The correlation coefficient between ADR and SSADR weighted by the number of each gastroenterologist's examinations was 0.606(P < 0.001).CONCLUSION Our results demonstrated that ADR is correlated to SSADR. In addition, patients with adenomas had a higher prevalence of SSAs than those without adenomas. | Daisuke Ohki Yosuke Tsuji Tomohiro Shinozaki Yoshiki Sakaguchi Chihiro Minatsuki Hiroto Kinoshita Keiko Niimi Satoshi Ono Yoku Hayakawa Shuntaro Yoshida Atsuo Yamada Shinya Kodashima Nobutake Yamamichi Yoshihiro Hirata Tetsuo Ushiku Mitsuhiro Fujishiro Masashi Fukayama Kazuhiko Koike | 2018 | World Journal of Gastrointestinal Oncology2018，10，3： | 2 |
| 13 | Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori?associatedchronic atrophic gastritis: A follow?up study of patients with endoscopicallyresected colorectal neoplasia显示文摘 | Izumi Inoue Jun Kato Noriko Yoshimura Yoshimasa Maeda Kosaku Moribata Naoki Shingaki Hisanobu Deguchi Shotaro Enomoto Takao Maekita Kazuki Ueda Mikitaka Iguchi Hideyuki Tamai Mitsuhiro Fujishiro Nobutake Yamamichi Tatsuya Takeshita Masao Ichinose | 2013 | Molecular and Clinical Oncology2013，，1： | 1 |
| 14 | SimuRaneous spectrophotometric determination of phosphate and silicate ions in river water by using ion-exclusion chromatographic separation and post-column derivatization显示文摘 | Nobutake Nakatania Daisuke Kozaki | 2008 | Analytica Chimica Acta2008，，619： | 1 |
| 15 | Independent predictors for recurrence of chronic subdural hematoma:A review of 343 consecutive surgical class显示文摘 | Kouichi Torihashi MD Nobutake Sadamasa MD Kazumichi Yoshida MD | 2008 | Neurosurgery2008，63，6： | 1 |
| 16 | Turner Syndrome and Xp deletions: clinical and molecular studies in 47 patients显示文摘 | Tsutomu O Koji M Nobutake M | 2001 | J Clin Endocrinol Metab2001，86，11： | 1 |
| 17 | ation rates and scavenging Determination of photoform- rate constants of hydroxyl radicals in natural waters using anautomatic light irradiat- ion and injection system 显示文摘 | NOBUTAKE NAKATANI NORICHIKA HASHIMOTO HIROTAKA SHINDO | 2007 | Analytica Chimica Acta2007，581，2： | 1 |
| 18 | Three-dimensional structures of the flagellar dynein-microtubule complex by cryoelectron microscopy 显示文摘 | Toshiyuki O Nobutake H Masahide K | 2007 | Cell Biol2007，177，2： | 1 |
| 19 | Microtubule-bundling activity of APC is stimulated by interaction with PSD-95显示文摘 | Nobutake Takamori Atsushi Shimomura Takao Senda | 2006 | Neuroscience Letters2006，，1： | 1 |
| 20 | Left Ventricular Strain and Transmural Distribution of Structural Remodeling in Hypertensive Heart Disease显示文摘 | Tomoko Ishizu Yoshihiro Seo Yuri Kameda Ryo Kawamura Taizou Kimura Nobutake Shimojo Dongzhu Xu Nobuyuki Murakoshi Kazutaka Aonuma | 2014 | Hypertension2014，，3： | 1 |
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