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| 1 | Risk factors for bleeding after endoscopic submucosal dissection for gastric lesions显示文摘AIM:To assess risk factors for bleeding after gastric endoscopic submucosal dissection(ESD) and to develop preventive measures.METHODS:This retrospective study was performed in a tertiary referral center.A total of 328 patients underwent ESD for 398 gastric neoplasms between July 2007 and June 2009.The main outcome was association between post-ESD bleeding and the following:age;sex;comorbidities;daily use of medicine potentially related to gastric injury/bleeding;location,size,and histological depth of lesions;ulceration;experience of operator coagulating the ulcer floor,and duration of operation.We also determined the relationship between the location of post-ESD bleeding and risk factors for hemorrhage.RESULTS:Univariate analysis revealed significant risk factors:tumor location [odds ratio(OR),2.86;95% CI:1.21-6.79,P=0.024],coagulator experience(OR,4.29;95% CI:1.43-12.86,P=0.009),and medicine potentially related to gastric injury/bleeding(OR,2.80;95% CI:1.14-6.90,P=0.039).Multivariate logistic regression analysis confirmed significant,independent risk factors:tumor in lower third of stomach(OR,2.47;95% CI:1.02-5.96,P=0.044),beginner coagulator(OR,3.93;95% CI:1.29-11.9,P=0.016),and medicine(OR,2.76;95% CI:1.09-6.98,P=0.032).We classif ied cases of post-ESD bleeding into two groups(bleeding at the ulcer margin vs bleeding at the center) and found that bleeding at the margin occurred more frequently with beginner coagulators compared with experts(OR,16.00;95% CI:1.22-210.59,P=0.040).CONCLUSION:Beginner coagulators,tumor in the antrum,and medicines were significant risk factors for post-ESD bleeding.Bleeding at the ulcer margin frequently occurred with beginner operators. | Yosuke Tsuji Ken Ohata Takafumi Ito Hideyuki Chiba Tomohiko Ohya Toshiaki Gunji Nobuyuki Matsuhashi | 2010 | World Journal of Gastroenterology2010，16，23： | 60 |
| 2 | A prospective randomized trial of lafutidine vs rabeprazole on post-ESD gastric ulcers显示文摘AIM:To compare the effects of rabeprazole and lafutidine on post-endoscopic submucosal dissection(ESD) gastric ulcers.METHODS:Patients with gastric tumors indicated for ESD were prospectively studied.After ESD,all patients were treated with intravenous omeprazole for the first 3 d.Patients were then randomly assigned to oral lafutidine or rabeprazole.Ulcer size,ulcer size reduction rate,and ulcer stage were evaluated 4 wk later.Occurrence of complication was monitored throughout the 4-wk period.RESULTS:Sixty five patients were enrolled in the study,and 60 patients were subjected to the final analysis.In the lafutidine group(30 lesions in 29 patients),initial and 4-wk post-ESD ulcer sizes were 33.3 ± 9.2 and 10.5 ± 4.8 mm,respectively.In the rabeprazole group(34 lesions in 31 patients),the values were 34.7 ± 11.3 and 11.8 ± 6.7 mm,respectively.Ulcer size reduction rates in lafutidine and rabeprazole groups were 32.3% and 33.5%,respectively(P=0.974).Ulcer stage 4 wk post-ESD did not differ significantly between the two groups(P=0.868).Two cases in the rabeprazole group and no cases in the lafutidine group developed ulcer bleeding during the oral dose period,although the difference of bleeding rate between the two groups was not statistically significant(P=0.157).CONCLUSION:Lafutidine and rabeprazole have equivalent therapeutic effects on post-ESD gastric ulcers. | Tomohiko Richard Ohya Hiroki Endo Kei Kawagoe Tatsuro Yanagawa Katsuhiro Hanawa Ken Ohata Masako Asayama Kantaro Hisatomi Takuma Teratani Toshiaki Gunji Hajime Sato Nobuyuki Matsuhashi | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，1： | 7 |
| 3 | Bank profitability and the bank lending channel: Evidence from China显示文摘 | Hiroshi Gunji Yuan Yuan | 2009 | Journal of Asian Economics2009，，2： | 5 |
| 4 | High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer显示文摘 | Hideaki Shimada Nobuhiro Takiguchi Osamu Kainuma Hiroaki Soda Atsushi Ikeda Akihiro Cho Akinari Miyazaki Hisashi Gunji Hiroshi Yamamoto Matsuo Nagata | 2010 | Gastric Cancer2010，，3： | 4 |
| 5 | Prospective randomized study of open versus laparoscopy-assisted distal gastrectomy with extraperigastric lymph node dissection for early gastric cancer显示文摘 | H. Hayashi T. Ochiai H. Shimada Y. Gunji | 2005 | Surgical Endoscopy2005，，9： | 3 |
| 6 | Protocol for laparoscopic cholecystectomy: Is it rocket science?显示文摘Laparoscopic cholecystectomy(LC) does not require advanced techniques, and its performance has therefore rapidly spread worldwide. However, the rate of biliary injuries has not decreased. The concept of the critical view of safety(CVS) was first documented two decades ago. Unexpected injuries are principally due to misidentification of human factors. The surgeon's assumption is a major cause of misidentification, and a high level of experience alone is not sufficient for successful LC. We herein describe tips and pitfalls of LC in detail and discuss various technical considerations.Finally, based on a review of important papers and our own experience, we summarize the following mandatory protocol for safe LC:(1) consideration that a high level of experience alone is not enough;(2) recognition of the plateau involving the common hepatic duct and hepatic hilum;(3) blunt dissection until CVS exposure;(4) Calot's triangle clearance in the overhead view;(5) Calot's triangle clearance in the view from underneath;(6) dissection of the posterior right side of Calot's triangle;(7) removal of the gallbladder body; and(8) positive CVS exposure. We believe that adherence to this protocol will ensure successful and beneficial LC worldwide, even in patients with inflammatory changes and rare anatomies. | Tomohide Hori Fumitaka Oike Hiroaki Furuyama Takafumi Machimoto Yoshio Kadokawa Toshiyuki Hata Shigeru Kato Daiki Yasukawa Yuki Aisu Maho Sasaki Yusuke Kimura Yuichiro Takamatsu Masato Naito Masaya Nakauchi Takahiro Tanaka Daigo Gunji Kiyokuni Nakamura Kiyoko Sato Masahiro Mizuno Taku Iida Shintaro Yagi Shinji Uemoto Tsunehiro Yoshimura | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 7 | Prospective randomized study of open versus laparoscopy-assisted distal gastrectomy with extraperigastric lymph node dissection for early gastric cancer显示文摘 | H. Hayashi T. Ochiai H. Shimada Y. Gunji | 2005 | Surgical Endoscopy2005，，9： | 3 |
| 8 | Laparoscopic-assisted catheter insertion for continuous ambulatory peritoneal dialysis:A case report of simple technique for optimal placement显示文摘A 40-year-old male underwent tube placement surgery for continuous ambulatory peritoneal dialysis(CAPD).A2-cm skin incision was made,and the peritoneum was reflected enough to perform secure fixation.A swannecked,double-felted silicone CAPD catheter was inserted,and the felt cuff was sutured to the peritoneum to avoid postoperative leakage.An adequate gradient for tube fixation to the abdominal wall was confirmed.The CAPD tube was passed through a subcutaneous tunnel.Aeroperitoneum was induced to confirm that there was no air leakage from the sites of CAPD insertion.Two trocars were placed,and we confirmed that the CAPD tube led to the rectovesical pouch.Tip position was reliably observed laparoscopically.Optimal patency of the CAPD tube was confirmed during surgery.Placement of CAPD catheters by laparoscopic-assisted surgery has clear advantages in simplicity,safety,flexibility,and certainty.Laparoscopic technique should be considered the first choice for CAPD tube insertion. | Tomohide Hori Masaya Nakauchi Kazuhiro Nagao Fumitaka Oike Takahiro Tanaka Daigo Gunji Noriyuki Okada | 2013 | World Journal of Gastrointestinal Surgery2013，5，10： | 2 |
| 9 | Hematogenous umbilical metastasis from colon cancer treated by palliative single-incision laparoscopic surgery显示文摘Sister Mary Joseph’s nodule(SMJN)is a rare umbilical nodule that develops secondary to metastatic cancer.Primary malignancies are located in the abdomen or pelvis.Patients with SMJN have a poor prognosis.An 83-year-old woman presented to our hospital with a1-month history of a rapidly enlarging umbilical mass.Endoscopic findings revealed advanced transverse colon cancer.computer tomography and fluorodeoxyglucose-positron emission tomography revealed tumors of the transverse colon,umbilicus,right inguinal lymph nodes,and left lung.The feeding arteries and drainage veins for the SMJN were the inferior epigastric vessels.Imaging findings of the left lung tumor allowed for identification of the primary lung cancer,and a diagnosis of advanced transverse colon cancer with SMJN and primary lung cancer was made.The patient underwent local resection of the SMNJ and subsequent single-site laparoscopic surgery involving right hemicolectomy and paracolic lymph node dissection.Intra-abdominal dissemination to the mesocolon was confirmed during surgery.Histopathologically,the transverse colon cancer was confirmed to be moderately differentiated tubular adenocarcinoma.We suspect that SMJN may occur via a hematogenous pathway.Although chemotherapy for colon cancer and thoracoscopic surgery for the primary lung cancer were scheduled,the patient and her family desired home hospice.Seven months after surgery,she died of rapidly growing lung cancer. | Tomohide Hori Noriyuki Okada Masaya Nakauchi Shuji Hiramoto Ayako Kikuchi-Mizota Masahisa Kyogoku Fumitaka Oike Hidemitsu Sugimoto Junya Tanaka Yoshiki Morikami Kaori Shigemoto Toyotsugu Ota Masanobu Kaneko Masato Nakatsuji Shunji Okae Takahiro Tanaka Daigo Gunji Akira Yoshioka | 2013 | World Journal of Gastrointestinal Surgery2013，5，10： | 2 |
| 10 | Endoscopic tissue shielding method with polyglycolic acid sheets and fibrin glue to cover wounds after colorectal endoscopic submucosal dissection (with video)显示文摘 | Yosuke Tsuji Ken Ohata Toshiaki Gunji Meiko Shozushima Jun Hamanaka Akiko Ohno Takafumi Ito Nobutake Yamamichi Mitsuhiro Fujishiro Nobuyuki Matsuhashi Kazuhiko Koike | 2014 | Gastrointestinal Endoscopy2014，，1： | 2 |
| 11 | 为与窒息肠塞痛联系的肠的局部缺血的察觉的动态 CT 的动脉的阶段的用途显示文摘 AIM:To clarify the usefulness of arterial phase scans in contrast computed tomography (CT) imaging of stran-gulation ileus in order to make an early diagnosis. METHODS:A comparative examination was carried out with respect to the CT value of the intestinal tract wall in each scanning phase, the CT value of the content in the intestinal tract, and the CT value of ascites fluid in the portal vein phase for a group in which ischemia was observed (Group Ⅰ) and a group in which ischemia was not observed (Group N) based on the pathological findings or intra-surgical findings. Moreover, a comparative examination was carried out in Group Ⅰ subjects for each scanning phase with respect to average differences in the CT values of the intestinal tract wall where ischemia was suspected and in the intestinal tract wall in non-ischemic areas. RESULTS:There were 15 subjects in Group Ⅰ and 30 subjects in Group N. The CT value of the intestinal tract wall was 41.8 ± 11.2 Hounsfield Unit (HU) in Group Ⅰ and 69.6 ± 18.4 HU in Group N in the arterial phase, with the CT value of the ischemic bowel wall being significantly lower in Group Ⅰ. In the portal vein phase, the CT value of the ischemic bowel wall was 60.6 ± 14.6 HU in Group Ⅰ and 80.7 ± 17.7 HU in Group N, with the CT value of the ischemic bowel wall being significantly lower in Group Ⅰ; however, no significant differences were observed in the equilibrium phase. The CT value of the solution in the intestine was 18.6 ± 9.5 HU in Group Ⅰ and 10.4 ± 5.1 HU in Group N, being signifi-cantly higher in Group Ⅰ. No significant differences were observed in the CT value of the accumulation of ascites fluid. The average difference in the CT values between the ischemic bowel wall and the non-ischemic bowel wall for each subject in Group Ⅰ was 33.7 ± 20.1 HU in the arterial phase, being significantly larger compared to the other two phases. CONCLUSION:This is a retrospective study using a small number of subjects; however, it suggests that there is a possibility that CT scanning in the arterial phase is useful for the early diagnosis of strangulation ileus. | Gaku Ohira Kiyohiko Shuto Tsuguaki Kono Takayuki Tohma Hisashi Gunji Kazuo Narushima Shunsuke Imanishi Takeshi Fujishiro Tohru Tochigi Toshiharu Hanaoka Hideaki Miyauchi Naoyuki Hanari Hisahiro Matsubara Noriyuki Yanagawa | 2012 | World Journal of Radiology2012，4，11： | 2 |
| 12 | Magnifying endoscopy with narrow-band imaging helps determine the management of gastric adenomas显示文摘 | Yosuke Tsuji Ken Ohata Masau Sekiguchi Akiko Ohno Takafumi Ito Hideyuki Chiba Toshiaki Gunji Jun-ichi Fukushima Nobutake Yamamichi Mitsuhiro Fujishiro Nobuyuki Matsuhashi Kazuhiko Koike | 2012 | Gastric Cancer2012，，4： | 2 |
| 13 | Tests for Serum Levels of Trefoil Factor Family Proteins Can Improve Gastric Cancer Screening显示文摘 | Susumu Aikou Yasukazu Ohmoto Toshiaki Gunji Nobuyuki Matsuhashi Hiroshi Ohtsu Hirona Miura Kensuke Kubota Yukinori Yamagata Yasuyuki Seto Atsushi Nakajima James R. Goldenring Michio Kaminishi Sachiyo Nomura | 2011 | Gastroenterology2011，，3： | 2 |
| 14 | Substrate specificity of 6-deoxy-erythronolide B hydroxylase,a bacterial cytochrome P450 of erythromycinAbiosynthesis显示文摘 | Andersen J F Tatsuta K Gunji H | 1993 | Biochemistry1993，32，： | 1 |
| 15 | Primary non-Hodgkin's lymphoma of the breast: report of a case with special reference to 380 cases in the Japanese literature 显示文摘 | Uesato M Miyazawa Y Gunji Y | 2005 | Breast Cancer2005，12，2： | 1 |
| 16 | Helicobacter pylori infection significantly increases insulin resistance in the asymptomatic Japanese population显示文摘 | Gunji T Matsuhashi N Sato H | 2009 | Helicobacter2009，14，5： | 1 |
| 17 | Helicobacterpylori infection is significantly associated with metabolic syndrome in the Japanese population显示文摘 | Gunji T Matsuhashi N Sato H | 2008 | Am J Gastroenterol2008，103，12： | 1 |
| 18 | Study of irradiation effects on cytokine secretion from retrovirally transduced tumor cells: a model for tumor vaccination显示文摘 | Matsubara H Tagawa M Gunji Y Takenaga K Sugaya M Urashima T Koide Y Suzuki T Asano T Ochiai T IsonoK Kageyama H Nakamura Y Sakiyama S | 1996 | Anticaner Res1996，16，3： | 1 |
| 19 | Prognostic significance of the number of metastatic lymph nodes in early gastric cancer显示文摘 | Gunji Y Suzuki T Hori S | 2003 | Dig Surg2003，20，2： | 1 |
| 20 | Effects of a platelet activating fac- tor antagonist on oedema formation following burns显示文摘 | Ono 1 Gunji H Hasegawa T | 1993 | Bums1993，19，3： | 1 |
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