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| 1 | Bleeding after endoscopic submucosal dissection: Risk factors and preventive methods显示文摘Endoscopic submucosal dissection(ESD) has become widely accepted as a standard method of treatment for superficial gastrointestinal neoplasms because it enables en block resection even for large lesions or fibrotic lesions with minimal invasiveness, and decreases the local recurrence rate. Moreover, specimens resected in an en block fashion enable accurate histological assessment. Taking these factors into consideration, ESD seems to be more advantageous than conventional endoscopic mucosal resection(EMR), but the associated risks of perioperative adverse events are higher than in EMR. Bleeding after ESD is the most frequent among these adverse events. Although post-ESD bleeding can be controlled by endoscopic hemostasis in most cases, it may lead to serious conditions including hemorrhagic shock. Even with preventive methods including administration of acid secretion inhibitors and preventive hemostasis, post-ESD bleeding cannot be completely prevented. In addition high-risk cases for post-ESD bleeding, which include cases with the use of antithrombotic agents or which require large resection, are increasing. Although there have been many reports about associated risk factors and methods of preventing post-ESD bleeding, many issues remain unsolved. Therefore, in this review, we have overviewed risk factors and methods of preventing post-ESD bleeding from previous studies. Endoscopists should have sufficient knowledge of these risk factors and preventive methods when performing ESD. | Yosuke Kataoka Yosuke Tsuji Yoshiki Sakaguchi Chihiro Minatsuki Itsuko Asada-Hirayama Keiko Niimi Satoshi Ono Shinya Kodashima Nobutake Yamamichi Mitsuhiro Fujishiro Kazuhiko Koike | 2016 | World Journal of Gastroenterology2016，22，26： | 16 |
| 2 | Long-term outcomes of endoscopic submucosal dissection for colorectal epithelial neoplasms显示文摘 | K. Niimi M. Fujishiro S. Kodashima O. Goto S. Ono K. Hirano C. Minatsuki N. Yamamichi K. Koike | 2010 | Endoscopy2010，，09： | 3 |
| 3 | Polyglycolic acid sheets and fibrin glue decrease the risk of bleeding after endoscopic submucosal dissection of gastric neoplasms (with video)显示文摘 | Yosuke Tsuji Mitsuhiro Fujishiro Shinya Kodashima Satoshi Ono Keiko Niimi Satoshi Mochizuki Itsuko Asada-Hirayama Rie Matsuda Chihiro Minatsuki Chiemi Nakayama Yu Takahashi Yoshiki Sakaguchi Nobutake Yamamichi Kazuhiko Koike | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 4 | Sessile serrated adenoma detection rate is correlated with adenoma detection rate显示文摘AIM To investigated the association between adenoma detection rate(ADR) and sessile serrated ADR(SSADR) and significant predictors for sessile serrated adenomas(SSA) detection.METHODS This study is a retrospective, single-center analysis. Total colonoscopies performed by the gastroenterologists at the University of Tokyo Hospital between January and December 2014 were retrospectively identified. Polyps were classified as low-grade or high-grade adenoma, cancer, SSA, or SSA with cytological dysplasia, and the prevalence of each type of polyp was investigated. Predictors of adenoma and SSA detection were examined using logistic generalized estimating equation models. The association between ADR and SSADR for each gastroenterologist was investigated by calculating a correlation coefficient weighted by the number of each gastroenterologist's examination.RESULTS A total of 3691 colonoscopies performed by 35 gastroenterologists were assessed. Overall, 978 (26.5%) low-and 84 (2.2%) high-grade adenomas, 81 (2.2%) cancers, 66 (1.8%) SSAs, and 2 (0.1%) SSAs with cytological dysplasia were detected. Overall ADR was 29.5%(men 33.2%, women 23.8%) and overall SSADR was 1.8%(men 1.7%, women 2.1%). In addition, 672 low-grade adenomas (68.8% of all the detected lowgrade adenomas), 58 (69.9%) high-grade adenomas, 29 (34.5%) cancers, 52 (78.8%) SSAs, and 2 (100%) SSAs with cytological dysplasia were found in the proximal colon. Adenoma detection was the only significant predictor of SSA detection (adjusted OR: 2.53, 95%CI: 1.53-4.20; P < 0.001). The correlation coefficient between ADR and SSADR weighted by the number of each gastroenterologist's examinations was 0.606(P < 0.001).CONCLUSION Our results demonstrated that ADR is correlated to SSADR. In addition, patients with adenomas had a higher prevalence of SSAs than those without adenomas. | Daisuke Ohki Yosuke Tsuji Tomohiro Shinozaki Yoshiki Sakaguchi Chihiro Minatsuki Hiroto Kinoshita Keiko Niimi Satoshi Ono Yoku Hayakawa Shuntaro Yoshida Atsuo Yamada Shinya Kodashima Nobutake Yamamichi Yoshihiro Hirata Tetsuo Ushiku Mitsuhiro Fujishiro Masashi Fukayama Kazuhiko Koike | 2018 | World Journal of Gastrointestinal Oncology2018，10，3： | 2 |
| 5 | Background factors of reflux esophagitis and non-erosive reflux disease:a cross-sectional study of 10,837subjects in Japan显示文摘 | Minatsuki C Yamamichi N Shimamoto T | 2013 | PLoS One2013，8，69： | 1 |
| 6 | Endoscopic mucosal resection with a ligation device or endoscopic submucosal dissection for rectal carcinoid tumors: An analysis of 24 consecutive cases显示文摘 | Keiko Niimi Osamu Goto Mitsuhiro Fujishiro Shinya Kodashima Satoshi Ono Satoshi Mochizuki Itsuko Asada‐Hirayama Maki Konno‐Shimizu Rie Mikami‐Matsuda Chihiro Minatsuki Nobutake Yamamichi Kazuhiko Koike | 2012 | Digestive Endoscopy2012，，6： | 1 |
| 7 | Background factors of reflux esophagitis and non-erosive reflux disease: a cross-sectional study of 10 837 subjects in Japan显示文摘 | Minatsuki C Yamamichi N Shimamoto T | 2013 | PLOS One2013，8，69： | 1 |
| 8 | Tolvaptan Can Improve Clinical Course in Responders ValidationAnalysis for the Defi nition of Responsiveness by UrineVolume显示文摘 | Teruhiko Imamura Koichiro Kinugawa Shun Minatsuki | 2013 | Int Heart J2013，54，5： | 1 |
| 9 | A de- velopment of ceramics cylinder type sulfuric acid de- composer for thermo-chemical iodine-sulfur process pilot plant显示文摘 | Minatsuki Isao Fukui Hiroshi Ishino Kazuo | 2007 | Power and Energy Systems2007，12，1： | 1 |
| 10 | Background fac- tors of reflux esophagitis and non,erosive reflux disease: a cross- sectional study of 10,837 subjects in Japan显示文摘 | Minatsuki C Yamamichi N Shimamoto T | 2013 | PLoS One2013，8，69： | 1 |
| 11 | Platelet-derived growth factor receptor-tyrosine kinase inhibitor, Imatinib, is effective for treating pulmonary hypertension induced by pulmonary tumor thrombotic microangiopathy显示文摘 | Minatsuki S Miura I Yao A | 2015 | Int Heart J2015，56，2： | 1 |
| 12 | Tolvaptan can improve clinical course in responders 显示文摘 | IMAMURA T KINUGAWA K MINATSUKI S | 2013 | Int Heart J2013，54，6： | 1 |
| 13 | Background factors of reflux esophagitis and nonerosive reflux disease:a cross-sectional study of 10,837subjects in Japan显示文摘 | Minatsuki C Yamamichi N Shimamoto T | 2013 | PLoS One2013，8，69： | 1 |
| 14 | Evaluation of safety of endoscopic biopsy without cessation of antithrombotic agents in Japan显示文摘 | Satoshi Ono Mitsuhiro Fujishiro Shinya Kodashima Yu Takahashi Chihiro Minatsuki Rie Mikami-Matsuda Itsuko Asada-Hirayama Maki Konno-Shimizu Yosuke Tsuji Satoshi Mochizuki Keiko Niimi Nobutake Yamamichi Makoto Kaneko Yutaka Yatomi Kazuhiko Koike | 2012 | Journal of Gastroenterology2012，，7： | 1 |
| 15 | Evaluation of preferable insertion routes for esophagogastroduodenoscopy using ultrathin endoscopes显示文摘AIM:To evaluate the discomfort associated with esophagogastroduodenoscopy(EGD)using an ultrathin endoscope through different insertion routes.METHODS:This study(January 2012-March 2013)included 1971 consecutive patients[male/female(M/F),1158/813,57.5±11.9 years]who visited a single institute for annual health checkups.Transnasal EGD was performed in 1394 patients and transoral EGD in 577.EGD-associated discomfort was assessed using a visual analog scale score(VAS score:0-10).RESULTS:Multivariate analysis revealed gender(M vs F:4.02±2.15 vs 5.06±2.43)as the only independent predictor of the VAS score in 180 patients who underwent EGD for the first time;whereas it revealed gender(M vs F 3.60±2.20 vs 4.84±2.37),operator,age group(A:<39 years;B:40-49 years;C:50-59years;D:60-69 years;E:>70 years;A/B/C/D/E:4.99±2.32/4.34±2.49/4.19±2.31/3.99±2.27/3.63±2.31),and type of insertion as independent predictors in the remaining patients.Subanalysis for gender,age group,and insertion route revealed that the VAS score decreased with age regardless of gender and insertion route,was high in female patients regardless of age and insertion route,and was low in males aged over60 years who underwent transoral insertion.CONCLUSION:Although comprehensive analysis revealed that the insertion route may not be an independent predictor of the VAS score,transoral insertion may reduce EGD-associated discomfort in elderly patients. | Satoshi Ono Keiko Niimi Mitsuhiro Fujishiro Yu Takahashi Yoshiki Sakaguchi Chiemi Nakayama Chihiro Minatsuki Rie Matsuda Itsuko Hirayama-Asada Yosuke Tsuji Satoshi Mochizuki Shinya Kodashima Nobutake Yamamichi Atsuko Ozeki Lumine Matsumoto Yumiko Ohike Tsutomu Yamazaki Kazuhiko Koike | 2014 | World Journal of Gastroenterology2014，20，17： | 0 |
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