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| 1 | Mitochondrial protein sulfenation during aging in the rat brain显示文摘There is accumulating evidence that cysteine sulfenation (cys-SOH) in proteins plays an important rolein cellular response to oxidative stress. The purpose of the present study was to identify mitochondrialproteins that undergo changes in cys-SOH during aging. Studies were conducted in rats when they were5 or 30 months of age. Following blocking of free protein thiols with N-ethylmaleimide, protein sulfenicacids were reduced by arsenite to free thiol groups that were subsequently labeled with biotin-maleimide. Samples were then comparatively analyzed by two-dimensional Western blots, and proteinsshowing changes in sulfenation were selectively identified by mass spectrometry peptide sequencing.As a result, five proteins were identified. Proteins showing an age-related decrease in sulfenationinclude pyruvate carboxylase and pyruvate dehydrogenase; while those showing an age-relatedincrease in sulfenation include aconitase, mitofilin, and tubulin (α-1). Results of the present studyprovide a general picture of mitochondrial protein sulfenation in brain oxidative stress and implicatethe involvement of protein sulfenation in overall decline of mitochondrial function during brain aging. | Xiaorong Yang Jinzi Wu Siqun ling Michael J. Forster Liang-Jun Yan | 2018 | Biophysics Reports2018，4，2： | 3 |
| 2 | Perforated appendicitis masquerading as acute pancreatitis in a morbidly obese patient显示文摘Diagnosis and treatment of common conditions in morbidly obese patients still pose a challenge to physicians and surgeons.Sometimes too much reliance is put on investigations that can lead to a misdiagnosis.This case demonstrates an obese woman admitted under the medical team with a presumed diagnosis of pneumonia, who was later found to have an acute abdomen and raised amylase,which led to an assumed diagnosis of pancreatitis.She died within 24 h of admission and post mortem confirmed the cause of death as systemic sepsis due to perforated appendicitis,with no evidence of pancreatitis.Significantly elevated serum amylase level may occur in non-pancreatitic acute abdomen. | Michael J Forster Jacob A Akoh | 2008 | World Journal of Gastroenterology2008，14，11： | 2 |
| 3 | Angeli盐对二氢硫辛酰胺脱氢酶的可逆性灭活作用(英文)显示文摘二氢硫辛酰胺脱氢酶(dihydrolipoamide dehydrogenase,DLDH)是线粒体3个α-酮酸脱氢酶复合物(丙酮酸脱氢酶复合物、α-酮戊二酸脱氢酶复合物、支链氨基酸脱氢酶复合物)的关键成分,属于吡啶依赖性二硫化物氧化还原酶类,对活性氮自由基(reactive nitrogen species,RNS)和活性氧自由基(reactive oxygenspecies,ROS)造成的氧化修饰非常敏感。本研究探索由Angeli盐所产生的RNS对DLDH的修饰作用及机制。将大鼠脑线粒体分离,与不同浓度的Angeli盐作用,应用分光光度计、蓝色胶、基于二维电泳的蛋白质组学等手段,测定DLDH酶活性。结果显示,Angeli盐呈浓度依赖性方式灭活DLDH,过氧亚硝酸盐在同样条件下对DLDH酶活性无抑制作用,说明Angeli盐对DLDH的作用可能是非随机的。由于Angeli盐在生理pH条件下可分解为硝基阴离子(nitroxyl anion,HNO)和一氧化氮(nitric oxide,NO),故进一步分析了Angeli盐对DLDH的灭活作用是否由HNO引起,结果证实确实如此。最后,二维电泳Western blot结果显示,Angeli盐对DLDH的灭活伴随着DLDH蛋白质的S-亚硝基硫醇形成,提示S-亚硝基硫醇化可能是导致DLDH酶失活的原因。综上,本研究为研究Angeli盐灭活DLDH的机制提供了新证据。 | 晏良军 刘莉 Michael J Forster | 2012 | 生物物理学报2012，28，4： | 1 |
| 4 | A new structural model for graphite oxide显示文摘 | HEYONG HE JACEK KLINOWSKI MICHAEL FORSTER | 1998 | Chemical Physics Letters1998，287，： | 1 |
| 5 | Effects of age and caloric restriction on mitochondrial protein oxidative damage in mice显示文摘 | Xiao-Dong Li Igor Rebrin Michael J. Forster Rajindar S. Sohal | 2011 | Mechanisms of Ageing and Development2011，，1： | 1 |
| 6 | Calretinin expression in human normal and neoplastic tissues: a tissue microarray analysis on 5233 tissue samples显示文摘 | Alessandro Lugli Yvonne Forster Philippe Haas Antoinio Nocito Christoph Bucher Heidi Bissig Martina Mirlacher Martina Storz Michael J Mihatsch Guido Sauter | 2003 | Human Pathology2003，，10： | 1 |
| 7 | A Cathepsin D-Cleaved 16 kDa Form of Prolactin Mediates Postpartum Cardiomyopathy显示文摘 | Denise Hilfiker-Kleiner Karol Kaminski Edith Podewski Tomasz Bonda Arnd Schaefer Karen Sliwa Olaf Forster Anja Quint Ulf Landmesser Carola Doerries Maren Luchtefeld Valeria Poli Michael D. Schneider Jean-Luc Balligand Fanny Desjardins Aftab Ansari Ingrid | 2007 | Cell2007，，3： | 1 |
| 8 | Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of the mouse显示文摘 | Anju D Michael J Forster H L | 1996 | Arch Biochem Biophys1996，333，： | 1 |
| 9 | Isolation of a sequence common to A- and B-chromosomes of rye (Secale cereale) by microcloning显示文摘 | Michael J. Sandery John W. Forster Simon R. Macadam Richard Blunden R. Neil Jones Stephen D. M. Brown | 1991 | Plant Molecular Biology Reporter1991，，1： | 1 |
| 10 | Association Between Variants of PRDM1 and NDP52 and Crohn’s Disease, Based on Exome Sequencing and Functional Studies显示文摘 | David Ellinghaus Hu Zhang Sebastian Zeissig Simone Lipinski Andreas Till Tao Jiang Bj?rn Stade Yana Bromberg Eva Ellinghaus Andreas Keller Manuel A. Rivas Jurgita Skieceviciene Nadezhda T. Doncheva Xiao Liu Qing Liu Fuman Jiang Michael Forster Gabriele Ma | 2013 | Gastroenterology2013，，2： | 1 |
| 11 | Isolation of a sequence common to A- and B-chromosomes of rye (Secale cereale) by microcloning显示文摘 | Michael J. Sandery John W. Forster Simon R. Macadam Richard Blunden R. Neil Jones Stephen D. M. Brown | 1991 | Plant Molecular Biology Reporter1991，，1： | 1 |
| 12 | Analysis of rye B-chromosome structure using fluorescencein situ hybridization (FISH)显示文摘 | Timothy M. Wilkes Michael G. Francki Peter Langridge Angela Karp R. Neil Jones John W. Forster | 1995 | Chromosome Research1995，，8： | 1 |
| 13 | Image Guided Radiation Therapy (IGRT) Technologies for Radiation Therapy Localization and Delivery显示文摘 | Jennifer De Los Santos Richard Popple Nzhde Agazaryan John E. Bayouth Jean-Pierre Bissonnette Mary Kara Bucci Sonja Dieterich Lei Dong Kenneth M. Forster Daniel Indelicato Katja Langen Joerg Lehmann Nina Mayr Ishmael Parsai William Salter Michael Tomblyn | 2013 | International Journal of Radiation Oncology, Biology, Physics2013，，： | 1 |
| 14 | A microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma显示文摘 | Ory Benjamin Ramsey Matthew R Wilson Catherine Vadysirisack Douangsone D Forster Nicole Rocco James W Rothenberg S Michael Ellisen Leif W | 2011 | Journal of Clinical Investigation2011，，2： | 1 |
| 15 | Age - related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain显示文摘 | Michael J Forster Anju Dubey | 1996 | PNAS1996，93，： | 1 |
| 16 | A Cathepsin D-Cleaved 16 kDa Form of Prolactin Mediates Postpartum Cardiomyopathy显示文摘 | Denise Hilfiker-Kleiner Karol Kaminski Edith Podewski Tomasz Bonda Arnd Schaefer Karen Sliwa Olaf Forster Anja Quint Ulf Landmesser Carola Doerries Maren Luchtefeld Valeria Poli Michael D. Schneider Jean-Luc Balligand Fanny Desjardins Aftab Ansari Ingrid | 2007 | Cell2007，，： | 1 |
| 17 | Structure of graphite oxide revisited显示文摘 | Anton Lerf Heyong He Michael Forster | 1998 | J Phys Chem B1998，102，： | 1 |
| 18 | A new structural model :for graphite oxide显示文摘 | He Heyong Jacek Klinowski Michael Forster | 1998 | Chem Phys Lett1998，287，12： | 1 |
| 19 | Isolation of a sequence common to A- and B-chromosomes of rye (Secale cereale) by microcloning显示文摘 | Michael J. Sandery John W. Forster Simon R. Macadam Richard Blunden R. Neil Jones Stephen D. M. Brown | 1991 | Plant Molecular Biology Reporter1991，，1： | 1 |
| 20 | Catalyst-and solvent-free,thermal generation of microporous polymer networks显示文摘Multifunctional iodoaryl monomers were used for the catalyst-and solvent-free generation of microporous polymer networks of high surface areas up to 732 m^2 g^(-1). The thermal conversion of the monomers relies on the homolytic cleavage of weak iodine–carbon bonds followed by a C–C coupling of the radicalic intermediates. By using tri-or tetrafunctional monomers and by tuning reaction temperature and time, the optimum reaction conditions allow the formation of the corresponding microporous networks in good yields of 71%–86%. The resulting networks exhibit notable high CO_2 and H_2 adsorption capacities of up to 8.89wt%(273 K, 1 bar) and up to 1.31 wt%(77 K, 1 bar), respectively. | christian widling michael forster venkata m.suresh ullrich scherf | 2017 | Science China Chemistry2017，60，8： | 0 |
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