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| 1 | Sperm chromatin structure assay (SCSA): a tool in diagnosis and treatment of infertility显示文摘男不孕的诊断主要基于世界健康组织() 基于手册的精液参数的集中,活动性和形态学。然而,任何一个这些参数都不是为几的富饶潜力的评估的可靠标记,变得明显。为更好的标记的搜索在在富饶病情的检查测试的精子染色质正直上导致了一个增加的焦点并且帮助了繁殖技术。在最后对十年期间,众多的精子 DNA 正直测试被开发了。这些被宣称被一个更低的 intraindividual 变化,更少的 intralaboratory 和 interlaboratory 变化并且这样描绘不比常规精子分析主观。然而,不是都,精子染色质完整测试还被显示了具有临床的价值。到目前为止,被发现了在与富饶的关系有最稳定的临床的阀值价值的测试是精子染色质结构试金(SCSA ) ,在 situ 测量精子 DNA 的危险性到导致酸的 DNA 变性作用的流动 cytometric 测试。由 SCSA 测量了的精子 DNA 破碎出现了是在第一个怀孕规划者以及在经历子宫内的授精的夫妇的成功的怀孕的一个独立预言者,并且能在调查被用作一个工具,建议并且非自愿的无儿女的处理。冲突数据的更多存在在与授精,胚胎前发展和怀孕结果的关系考虑精子 DNA 破碎的角色在在 vitro 授精和 intracytoplasmic 精子注射(ICSI ) 。 | Mona Bungum Leif Bungum Aleksander Giwercman | 2011 | Asian Journal of Andrology2011,13,1: | 35 |
| 2 | 参考家系鸡黑素皮质素受体3基因多态性与体重关系研究显示文摘鼠遗传学研究显示黑素皮质素受体 3(melanocortin 3receptor,MC3R)和MC4R在能量平衡控制中具有互补作用。敲除MC3R基因鼠表现为独有的代谢综合征和增加脂肪重量。以 8周龄高体重或低体重独立选择的高体重系 (highweight,HW)和低体重系 (lowweight,LW)白洛克鸡 3代参考家系群体作为实验材料 ,发现了 5个新的MC3R基因单核苷酸多态性 (singlenucleotidepolymorphisms,SNPs) ;建立了基于限制性内切酶DdeⅠ的MC3R基因型的PCR RFLP分子检测方法。方差分析结果显示MC3R基因型显著影响公鸡和母鸡的体重 ,以及公鸡腹脂含量。 | 蒋思文 JACOBSSON Lina KERJE Susanne ANDERSSON Leif 熊远著 | 2002 | Acta Genetica Sinica2002,29,4: | 24 |
| 3 | 20世纪气候变暖和瑞典斯堪的纳维亚山系南部树线升高显示文摘19世纪末至20世纪末,由于气候变暖温度上升幅度高达0.8℃。尽管存在波动状况,气候变暖已使斯堪的纳维亚山系瑞典区域的主要树种树线上升了100m以上。树线的这类变化过程主要是指某些老的成林树种的生长高度和沿山坡缓慢向上生长的新树种。1940年之后的几十年之内,因温度偏低而减缓了树线升高速率。20世纪90年代,随着一系列异常暖冬和暖夏出现了一个新的活跃阶段。20世纪树线升高的总体幅度随地形气候而变,而且主要局限在避风处和多雪的地方。树线升高地段浓密的白桦林在很大程度上改变了亚高山/低高山地貌的基本特征,并为其进一步的进化和从短期降温阶段中恢复过来提供了一种正的反馈。20世纪所有的树线沿坡上移现象和相关的地形变化基本上不存在时间滞后情况。这对于新一代真实的植被对未来可能变暖响应模式的研究是很重要的。在过去4000个^(14)C年期间,新的松树树线上升幅度可能是最高的。因此,似乎可以推论,20世纪的气候在全新世晚期是异常温暖的。 | Leif Kullman 赵希友 | 2001 | AMBIO-人类环境杂志2001,30,2: | 16 |
| 4 | 中国安全社区发展需求与展望显示文摘 | 赵仲堂 Leif Svanstrm | 2003 | 中国公共卫生2003,19,1: | 14 |
| 5 | 6个中国猪地方品种和3个瑞典猪DNA分子系统发育相关关系(英文)显示文摘线粒体DNA遗传多样性用于评价 6个中国地方猪种和 3个瑞典家猪系统发育关系。采用PCR和序列分析方法得到了来自 9个品种 1 40头猪的线粒体中控制区 4 4 0bp和细胞色素b基因 798bp核苷酸序列。系统发育分析结果表明 :6个中国地方猪种起源于亚洲野猪。中国地方猪种和欧洲野猪的线粒体DNA核苷酸序列变异发生在 4 1 30 0 0~8750 0 0年以前 ,而亚洲野猪的变异仅发生在 70 0 0~ 1 560 0 0年以前。由于 2 0 0 0年以前或1 8世纪初中国猪种导入欧洲家猪 。 | 蒋思文 Elisabetta Giuffra Leif Andersson 熊远著 | 2001 | Acta Genetica Sinica2001,28,12: | 13 |
| 6 | 糖尿病的未来:精准预测,精准诊断,精准治疗显示文摘精准医学倡导的是在对疾病制定预防和治疗方案时需要考虑每一个体的不同遗传背景、环境因素以及生活方式的理念。虽然糖尿病和肿瘤是最先被提出需要实现精准医学的疾病,然而相比于肿瘤领域,糖尿病在精准医学的发展上,从诊断、分型到治疗,均明显落后。但是随着科学的进步,新的技术及研究手段不断涌现,尤其是'组学(omics)'的发展,我们也看到了精准医学在糖尿病领域的曙光。本文从糖尿病及其并发症发病的预测、诊断与分型到治疗,梳理了糖尿病领域精准医学的进展;并提出要真正实现糖尿病的精准医疗,须着眼于全身的整体性。全面理解疾病发生、进展的本质和规律,应用精准医学理念和手段,朝向整合遗传-环境-生活方式的方向,才能真正推动和促进未来早期干预、早期预防、精准管理糖尿病的方向发展。 | 翁建平 朱大龙 母义明 赵家军 纪立农 Leif Groop 宁光 | 2019 | 中华糖尿病杂志2019,11,6: | 10 |
| 7 | 男性肥胖对精液质量和辅助生殖结局的影响显示文摘已有文献报道男性超重及肥胖造成内分泌紊乱,可能会降低男性的生育能力。然而,男性体重指数(BMI)对精液质量和辅助生殖结局的影响却仍具争议。本研究将肥胖男性与正常体重男性对比,探明男性BMI的升高对精液质量和辅助生殖结局的影响。本研究纳入的612例肥胖不育男性来自丹麦生育中心,记录身高和体重数据并计算BMI值。根据BMI值(kgm^-2)将男性分为4组:〈20为体重不足组,20-24.9为正常体重组,25—29.9为超重组,〉30为超重组。依据WHO指南进行常规精液分析,按照SCSA检测精液DNA完整性。结果发现,男性BMI对常规精液参数(包括精子浓度、精子数目、精子体积及活动力)并无统计学影响。此外,诸如受孕率、GQE等辅助生殖结局,妊娠结局并未因BMI的升高而受显著影响。 | Lise Thomsen Peter Humaidan Leif Bungum Mona Bungum | 2014 | Asian Journal of Andrology2014,16,5: | 9 |
| 8 | 俄罗斯高速列车Velaro RUS的低温技术方案及运营经验显示文摘针对俄罗斯冬季低温、多雪的运用环境,西门子公司对出口俄罗斯的高速列车Velaro RUS在结构、选材和维修等方面进行了系统的考虑,以适应俄罗斯的运营要求。 | Leif Paulukuhn 吴新民(摘译) | 2012 | 国外铁道车辆2012,49,3: | 8 |
| 9 | 导致乳粉贮藏加工劣变的主要化学反应和物化因素的研究进展显示文摘我国乳制品安全日益受到大众的关注,其中乳粉是焦点之一。目前乳粉贮藏加工中引起质量劣变的因素主要为三类化学反应——脂质氧化,美拉德反应和乳糖结晶,它们之间存在相互作用,但机理尚未明确。文中针对乳粉贮藏加工中的重要化学变化和它们的影响因素、测定方法和相互作用的研究进展进行了综述,并对乳粉贮藏中化学反应的研究方向提出了展望,为进一步从机理上研究乳粉劣变并确保乳粉质量安全提供依据。 | 刘玲 Leif H Skibsted 蒋东华 | 2012 | 食品与发酵工业2012,38,11: | 5 |
| 10 | 参与式管理解决冲突:遥感和GIS用作瑞典北部驯鹿业土地利用需求信息交流的工具显示文摘在解决复杂的土地管理问题时,对短缺或者有争执的资源进行地理评估有助于不同利益相关者之间沟通认识和增进理解。本文中,我们说明如何使用遥感和GIS收集和汇总瑞典北部驯鹿放牧者和其他土地使用者(林业、采矿业、旅游业等等)的土地使用活动及使用模式的信息。该项目主要基于最终的土地使用者,即驯鹿放牧者们所做的工作,体现了面向土地使用者的新的努力。发展驯鹿业的土地利用规划的基础有以下几个方面:收集并数字化传统的驯鹿栖息地生态学和景观信息;将这些信息与来自野外调查及基于人造卫星观测的植被分类结果整合;绘制其他土地使用者的活动情况图。最终的土地利用规划提供的信息有利于驯鹿放牧者与其他利益相关者之间的磋商,并有助于驯鹿管理实施。该项目可作为一种大众参与和计划编制的模式,从而使本土信息和先进的遥感技术融入一个交互式的过程中。 | Per Sandstrm Tina Granqvist Pahlén Lars Edenius Hans Tφmmervik Olle Hagner Leif Hemberg Hkan Olsson Karin Baer Thomas Stenlund Lars Gran Brandt Mikael Egberth 周立志 程利群 | 2003 | AMBIO-人类环境杂志2003,32,8: | 4 |
| 11 | Characteristics, development and utilization of geothermal resources- a Nordic perspective显示文摘 | John W. Lund Leif Bjelm Gordon Bloomquist Anette K. Mortensen | 2008 | Episodes2008,31,1: | 4 |
| 12 | Air-core fiber distribution of hybrid vector vortex-polarization entangled states显示文摘Entanglement distribution between distant parties is one of the most important and challenging tasks in quantum communication.Distribution of photonic entangled states using optical fiber links is a fundamental building block toward quantum networks.Among the different degrees of freedom,orbital angular momentum(OAM)is one of the most promising due to its natural capability to encode high dimensional quantum states.We experimentally demonstrate fiber distribution of hybrid polarization-vector vortex entangled photon pairs.To this end,we exploit a recently developed air-core fiber that supports OAM modes.High fidelity distribution of the entangled states is demonstrated by performing quantum state tomography in the polarization-OAM Hilbert space after fiber propagation and by violations of Bell inequalities and multipartite entanglement tests.The results open new scenarios for quantum applications where correlated complex states can be transmitted by exploiting the vectorial nature of light. | Daniele Cozzolino Emanuele Polino Mauro Valeri Gonzalo Carvacho Davide Bacco NicoloSpagnolo Leif K.Oxenløwe Fabio Sciarrino | 2019 | Advanced Photonics2019,1,4: | 4 |
| 13 | Combining population genomics and ecological niche modeling to assess taxon limits between Carex jemtlandica and C. lepidocarpa显示文摘Carex section Ceratocystis(Cyperaceae)is a group of recently evolved plant species,in which hybridization is frequent,introgression is documented,taxonomy is complex,and morphological boundaries are vague.Within this section,a unified taxonomic treatment of the Carex jemtlandica-Carex lepidocarpa species complex does not exist,and Norway may currently be the sole country accepting species rank for both.Carex jemtlandica is mainly confined to Fennoscandia and is thus a Fennoscandian conservation responsibility.This motivated us to test the principal hypothesis that both C jemtlandica and C lepidocarpa represent evolutionary significant units,and that both deserve their current recognition at species level.We investigated their evolutionary distinctiveness in Norway,using restriction site-associated DNA sequencing and ecological niche modeling.Our genomic results reveal two genetic clusters,largely corresponding to C jemtlandica and C lepidocarpa that also remain distinct in sympatry,despite clear indications of ongoing hybridization and introgression.The ecological niche modeling suggests that they occupy different environmental niches.Jointly,our results clearly show that C.jemtlandica and C lepidocarpa represent separately evolving entities that should qualify recognition as evolutionary significant units.Given the high level of introgression compared to other hybridizing species pairs in Carex we recommend treating C jemtlandica as a subspecies of C lepidocarpa. | Malene Nygaard Petri Kemppainen James D.M.Speed Reidar Elven Kjell Ivar Flatberg Leif P.Galten Narjes Yousefi Heidi Solstad Mika Bendiksby | 2021 | Journal of Systematics and Evolution2021,59,4: | 3 |
| 14 | Graphene photodetector employing double slot structure with enhanced responsivity and large bandwidth显示文摘Silicon photonics integrated with graphene provides a promising solution to realize integrated photodetectors operating at the communication window thanks to graphene’s ultrafast response and compatibility with CMOS fabrication process.However, current hybrid graphene/silicon photodetectors suffer from low responsivity due to the weak light-graphene interaction. Plasmonic structures have been explored to enhance the responsivity, but the intrinsic metallic Ohmic absorption of the plasmonic mode limits its performance. In this work, by combining the silicon slot and the plasmonic slot waveguide, we demonstrate a novel double slot structure supporting high-performance photodetection, taking advantages of both silicon photonics and plasmonics. With the optimized structural parameters, the double slot structure significantly promotes graphene absorption while maintaining low metallic absorption within the double slot waveguide. Based on the double slot structure, the demonstrated photodetector holds a high responsivity of 603.92 m A/W and a large bandwidth of 78 GHz. The high-performance photodetector provides a competitive solution for the silicon photodetector. Moreover,the double slot structure could be beneficial to a broader range of hybrid two-dimensional material/silicon devices to achieve stronger light-matter interaction with lower metallic absorption. | Siqi Yan Yan Zuo Sanshui Xiao Leif Katsuo Oxenlowe Yunhong Ding | 2022 | Opto-Electronic Advances2022,5,12: | 3 |
| 15 | Internal fixation versus nonoperative treatment of displaced 3-part proximal humeral fractures in elderly patients: a randomized controlled trial显示文摘 | Per Olerud Leif Ahrengart Sari Ponzer Jenny Saving Jan Tidermark | 2011 | Journal of Shoulder and Elbow Surgery2011,,5: | 3 |
| 16 | Intramedullary Nails Result in More Reoperations Than Sliding Hip Screws in Two-part Intertrochanteric Fractures显示文摘 | Kjell Matre Leif Ivar Havelin Jan-Erik Gjertsen Birgitte Espehaug Jonas Meling Fevang | 2013 | Clinical Orthopaedics and Related Research?2013,,4: | 3 |
| 17 | Biomarkers of Coagulation, Inflammation, and Angiogenesis are Independently Associated with Preeclampsia显示文摘 | Roland Boij Judit Svensson Kristina Nilsson‐Ekdahl Kerstin Sandholm Tomas L. Lindahl Elzbieta Palonek Mats Garle G?ran Berg Jan Ernerudh Maria Jenmalm Leif Matthiesen | 2012 | Am J Reprod Immunol2012,,3: | 2 |
| 18 | 权利显示文摘权利是为(或不为)特定行为或是处于(或不处于)特定状态的资格;或是使他人为(或不为)特定行为或是处于(或不处于)特定状态的资格。权利支配着当代对何种行为是容许的以及哪些制度是公正的理解。正如其现在被理解的那样,权利形塑着政府的形式、法律的内容以及道德的状况。接受一套权利就是赞同一套对自由与权力的分配,也是支持一种可以做什么、必须做什么以及不得做什么的特定观点。 | Leif Wenar 瞿郑龙 张梦婉 | 2013 | 法理学论丛2013,,1: | 2 |
| 19 | Significant Association between Serum Interleukin-6 and Helicobacter pylori Antibody Levels among H. pylori -Positive Japanese Adults显示文摘 | Hiroko Nakagawa Takashi Tamura Yoko Mitsuda Yasuyuki Goto Yoshikazu Kamiya Takaaki Kondo Kenji Wakai Nobuyuki Hamajima Leif P. Andersen | 2013 | Mediators of Inflammation2013,,: | 2 |
| 20 | Management of Newly Diagnosed Symptomatic Multiple Myeloma: Updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines 2013显示文摘 | Joseph R. Mikhael David Dingli Vivek Roy Craig B. Reeder Francis K. Buadi Suzanne R. Hayman Angela Dispenzieri Rafael Fonseca Taimur Sher Robert A. Kyle Yi Lin Stephen J. Russell Shaji Kumar P. Leif Bergsagel Steven R. Zeldenrust Nelson Leung Matthew T. D | 2013 | Mayo Clinic Proceedings2013,,4: | 2 |