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| 1 | Prevalence of amblyopia among preschool children in central south China显示文摘AIM: To determine the prevalence and factors associated with amblyopia among children aged 30-83 mo in central south of China.METHODS: A population-based, cross-sectional study was conducted in children aged 30-83 mo in Changsha(an urban city) and Zhangjiajie(a rural area) in central south of China. Clinical examinations including ocular alignment, ocular motility, visual acuity(VA), prism cover test, cycloplegic refraction, slit lamp examination and fundus examination were performed by trained study ophthalmologists and optometrists. Unilateral amblyopia was defined as a 2-line difference between eyes with VA<20/32 in the worse eye and with coexisting anisometropia [≥1.00 D spherical eutivalent(SE) for hyperopia, ≥3.00 D SE for myopia, and ≥1.50 D for astigmatism], strabismus, or past or present visual axis obstruction. Bilateral amblyopia was defined as VA in both eyes <20/40(≥ 48-month-old) and <20/50(< 48-month-old), with coexisting hyperopia ≥4.00 D SE, myopia ≤-6.00 D SE, and astigmatism ≥2.50 D, or past or present visual axis obstruction.RESULTS: There were 8042 children enrolled and 7713 children were screened. The amblyopia prevalence in children aged 30-83 mo was 1.09%(95% confidence interval, 0.86%-1.35%) with no age(P=0.81), gender(P=0.46) or area distribution(P=0.93) differences. Of these, 0.68% were unilateral cases and 0.41% were bilateral cases. Underlying causes included anisometropia(40%), binocular refractive error(36%), strabismus(14%) and deprivation(10%). Hyperopia combined with astigmatism was the frequent refractive error for ametropic and anisometropic amblyopia.CONCLUSION: In this rural and urban Chinese population, 1.09% of children with 30-83 mo of age had amblyopia, a prevalence rate similar to that of many other studies. Anisometropia and refractive error are the most common causes of unilateral and bilateral amblyopia respectively. | Yun-Ping Li Meng-Wen Zhou Susan H Forster Si-Ying Chen Xin Qi Hui-Ming Zhang Jing Luo | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 5 |
| 2 | 探讨通过晨间报告训练内科住院医师的临床思维显示文摘晨间报告是住院医师规范化培训(住培)最重要的教学形式之一,但目前我国大多数住培基地没有开展。晨间报告可根据各住培基地设定的项目目标有不同的方式方法,中日友好医院的实践经验表明,晨间报告这一教学形式可以开展,但如何规范是一个问题。本文介绍了美国麻省医学院内科住培项目自创的一套结构化的规定程序和思维模式,该方法易于掌握和规范,值得推广。 | 李颖 代华平 孙继红 高鹏 李琳 王君 王在永 秦岚 Richard Forster 姚树坤 | 2018 | 中国毕业后医学教育2018，2，6： | 3 |
| 3 | Ultrahigh numerical aperture meta-fibre for flexible optical trapping显示文摘Strong focusing on diffraction-limited spots is essential for many photonic applications and is particularly relevant for optical trapping;however,all currently used approaches fail to simultaneously provide flexible transportation of light,straightforward implementation,compatibility with waveguide circuitry,and strong focusing.Here,we demonstrate the design and 3D nanoprinting of an ultrahigh numerical aperture meta-fibre for highly flexible optical trapping.Taking into account the peculiarities of the fibre environment,we implemented an ultrathin meta-lens on the facet of a modified single-mode optical fibre via direct laser writing,leading to a diffraction-limited focal spot with a recordhigh numerical aperture of up to NA≈0.9.The unique capabilities of this flexible,cost-effective,bio-and fibre-circuitrycompatible meta-fibre device were demonstrated by optically trapping microbeads and bacteria for the first time with only one single-mode fibre in combination with diffractive optics.Our study highlights the relevance of the unexplored but exciting field of meta-fibre optics to a multitude of fields,such as bioanalytics,quantum technology and life sciences. | Malte Plidschun Haoran Ren Jisoo Kim Ronny Forster Stefan A.Maier Markus A.Schmidt | 2021 | Light(Science & Applications)2021，10，4： | 3 |
| 4 | The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy显示文摘The chemokine receptor CCR7 and its ligands CCL19 and CCL21 guide the homing and positioning of dendritic and T cells in lymphoid organs,thereby contributing to several aspects of adaptive immunity and immune tolerance.In the present study,we investigated the role of CCR7 in the pathogenesis of collagen-induced arthritis(CIA).By using a novel anti-human CCR7 antibody and humanized CCR7 mice,we evaluated CCR7 as a target in this autoimmune model of rheumatoid arthritis(RA).Ccr7-deficient mice were completely resistant to CIA and presented severely impaired antibody responses to collagen II(CII).Selective CCR7 expression on dendritic cells restored arthritis severity and anti-CII antibody titers.Prophylactic and therapeutic treatment of humanized CCR7 mice with anti-human CCR7 mAb 8H3-16A12 led to complete resistance to CIA and halted CIA progression,respectively.Our data demonstrate that CCR7 signaling is essential for the induction of CIA and identify CCR7 as a potential therapeutic target in RA. | Georgios L.Moschovakis Anja Bubke Michaela Friedrichsen Jasmin Ristenpart Jaap Willem Back Christine S.Falk Elisabeth Kremmer Reinhold Forster | 2019 | Cellular & Molecular Immunology2019，16，10： | 3 |
| 5 | Mitochondrial protein sulfenation during aging in the rat brain显示文摘There is accumulating evidence that cysteine sulfenation (cys-SOH) in proteins plays an important rolein cellular response to oxidative stress. The purpose of the present study was to identify mitochondrialproteins that undergo changes in cys-SOH during aging. Studies were conducted in rats when they were5 or 30 months of age. Following blocking of free protein thiols with N-ethylmaleimide, protein sulfenicacids were reduced by arsenite to free thiol groups that were subsequently labeled with biotin-maleimide. Samples were then comparatively analyzed by two-dimensional Western blots, and proteinsshowing changes in sulfenation were selectively identified by mass spectrometry peptide sequencing.As a result, five proteins were identified. Proteins showing an age-related decrease in sulfenationinclude pyruvate carboxylase and pyruvate dehydrogenase; while those showing an age-relatedincrease in sulfenation include aconitase, mitofilin, and tubulin (α-1). Results of the present studyprovide a general picture of mitochondrial protein sulfenation in brain oxidative stress and implicatethe involvement of protein sulfenation in overall decline of mitochondrial function during brain aging. | Xiaorong Yang Jinzi Wu Siqun ling Michael J. Forster Liang-Jun Yan | 2018 | Biophysics Reports2018，4，2： | 3 |
| 6 | Two subsets of memory T lymphocytes with distinct homing potentials and effector functions 显示文摘 | Sallusto F Lenig D Forster R | 1999 | Nature1999，401，： | 2 |
| 7 | Gastric Electrical Stimulation Improves Outcomes of Patients With Gastroparesis for up to 10 Years显示文摘 | Richard W. McCallum Zhiyue Lin Jameson Forster Katherine Roeser Qingjiang Hou Irene Sarosiek | 2011 | Clinical Gastroenterology and Hepatology2011，，4： | 2 |
| 8 | Absence of the interstitial cells of Cajal in patients with gastroparesis and correlation with clinical findings显示文摘 | Jameson Forster Ivan Damjanov Zhiyue Lin Irene Sarosiek Paul Wetzel Richard W. McCallum | 2005 | Journal of Gastrointestinal Surgery2005，，1： | 2 |
| 9 | 产后早期同伴(母亲之间)电话咨询积极支持母乳喂养:一项多中心、非盲、随机对照研究显示文摘背景:目前全球的母乳喂养率都不太理想,很多婴儿生后6个月内从未摄入母乳。很少有措施能有效延长母乳喂养持续时间,特别是在母乳喂养启动率较高的地区。有研究发现同伴(母亲)间的积极支持在特定情况下可促进母乳喂养.如果被证明有效,可考虑作为一种可持续模式在多个地区实施。本研究旨在确定产后阶段同伴间的积极电话支持能否提高6月龄婴儿的母乳喂养率。 | 高谦 张馨月(审校) Forster DA McLardie-Hore FE McLachlan HL | 2019 | 中华围产医学杂志2019，22，7： | 2 |
| 10 | Perforated appendicitis masquerading as acute pancreatitis in a morbidly obese patient显示文摘Diagnosis and treatment of common conditions in morbidly obese patients still pose a challenge to physicians and surgeons.Sometimes too much reliance is put on investigations that can lead to a misdiagnosis.This case demonstrates an obese woman admitted under the medical team with a presumed diagnosis of pneumonia, who was later found to have an acute abdomen and raised amylase,which led to an assumed diagnosis of pancreatitis.She died within 24 h of admission and post mortem confirmed the cause of death as systemic sepsis due to perforated appendicitis,with no evidence of pancreatitis.Significantly elevated serum amylase level may occur in non-pancreatitic acute abdomen. | Michael J Forster Jacob A Akoh | 2008 | World Journal of Gastroenterology2008，14，11： | 2 |
| 11 | Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods显示文摘Neutralizing antibodies targeting the receptor-binding domain(RBD)of the SARS-CoV-2 spike(S)block severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)entry into cells via surface-expressed angiotensin-converting enzyme 2(ACE2).We used a surrogate virus neutralization test(sVNT)and SARS-CoV-2 S protein-pseudotyped vesicular stomatitis virus(VSV)vector-based neutralization assay(pVNT)to assess the degree to which serum antibodies from coronavirus disease 2019(COVID-19)convalescent patients interfere with the binding of SARS-CoV-2 S to ACE2.Both tests revealed neutralizing anti-SARS-CoV-2 S antibodies in the sera of ~90% of mildly and 100% of severely affected COVID-19 convalescent patients.Importantly,sVNT and pVNT results correlated strongly with each other and to the levels of anti-SARS-CoV-2 S1 IgG and IgA antibodies.Moreover,levels of neutralizing antibodies correlated with the duration and severity of clinical symptoms but not with patient age.Compared to pVNT,sVNT is less sophisticated and does not require any biosafety labs.Since this assay is also much faster and cheaper,sVNT will not only be important for evaluating the prevalence of neutralizing antibodies in a population but also for identifying promising plasma donors for successful passive antibody therapy. | Berislav Bosnjak Saskia Catherina Stein Stefanie Willenzon Anne Katrin Cordes Wolfram Puppe Gunter Bernhardt Inga Ravens Christiane Ritter Christian R.Schultze-Florey Nina Godecke Jorg Martens Hannah Kleine-Weber Markus Hoffmann Anne Cossmann Mustafa Yilmaz Isabelle Pink Marius M.Hoeper Georg M.N.Behrens Stefan Pohlm ann Rainer Blasczyk Thomas F.Schulz Reinhold Forster | 2021 | Cellular & Molecular Immunology2021，18，4： | 2 |
| 12 | Continuously measured changes in redox potential influenced by oxygen penetrating from burrows of Callianassa subterranean显示文摘 | FORSTER S GRAF G | 1992 | Hydrobiology1992，，3： | 1 |
| 13 | The importance of stimu-lus site and intensity in differences of pain-induced vascular reflexes in human orofacial regions显示文摘 | Kemppainen P Forster C Handwerker HO | 2001 | pain2001，91，3： | 1 |
| 14 | Novei clas ses of responsive and unresponsive C nociceptors in humanskin显示文摘 | Schmidt R Schmelz M Forster C | 1995 | J Neurosci1995，15，1： | 1 |
| 15 | Blood pressure changes in spontaneously hypertensive rats correlate with aortic prostacyclin formation 显示文摘 | Forster W Taube C | 1983 | Br J Pharmacol1983，79，： | 1 |
| 16 | Histopathological changes in cerebral arteriovenous malformations following Gamma Knife radiosurgery显示文摘 | Szeifert G T Timperley W R Forster D M | 2007 | Prog Neurol Surg2007，20，： | 1 |
| 17 | Observations of a 'weekend effect' in diurnal temperature range显示文摘 | Forster P M and Solomon S | 2003 | Proc Natl Acad Sci U S A2003，100，20： | 1 |
| 18 | On the mechanism of a rhodium-complex- catalyzed carbonylation of methanol to acetic acid 显示文摘 | FORSTER D | 1976 | J Am Chem Soc1976，，： | 1 |
| 19 | Protein kinase C and calcium channel activation as determinants of renal vasoconstriction by angiotensin Ⅱ and endothelin显示文摘 | Takenaka T Forster H Epstein M | 1993 | Circ Res1993，73，： | 1 |
| 20 | Dynamic susceptibility contrast perfusion MRI identifies persistent vessel pathology in acute pontine stroke 显示文摘 | Forster A Ottomeyer C Wolf ME | 2010 | Cerebrovasc Dis2010，29，4： | 1 |
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