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| 1 | 城市污水厂污泥快速好氧堆肥技术研究显示文摘以污泥静态堆肥工艺为基础,针对上海曲阳污水处理厂的脱水污泥进行动态好氧堆肥处理工艺研究,重点研究了控制参数和评价参数(温度、含水率、pH、水溶性有机碳和发芽指数等)变化规律.结果表明:污泥堆肥过程中,含水率、物料温度、水溶性有机碳、发芽指数等指标变化规律性强,效果指示性明显,均可选作堆肥腐熟度的表征参数或评价参数.在优化工艺条件下,通过添加适量的木屑和回流物料,控制物料初始含水率在60%±2%时,堆肥处理可以实现顺利升温并在>55℃维持4d,100%杀灭了病原菌;14d反应周期结束时,物料含水率显著降低,水溶性有机质降解50%左右,出料松散且无臭味,堆肥产品腐熟,卫生学指标达到了我国标准和美国EPA污泥产品A类标准. | 陈玲 赵建夫 李宇庆 C.Paul Lo 方萍 李季 | 2005 | 环境科学2005，26，5： | 48 |
| 2 | Potash-rich volcanic rocks and lamprophyres in western Shandong Province:^(40)Ar-^(39)Ar dating and source tracing显示文摘Highly precise 40Ar-39Ar dating results demon-strate that the ages of potash-rich volcanic rocks in western Shandong Province are 114.7-124.3 Ma, and that of the lamprophyres is 119.6 Ma. The potash-rich volcanic rocks have relatively high (87Sr/86Sr)i ratios ( 0.708715-0.711418) and distinctly negative εNd values ( -11.47--17.54), and are enriched in radiogenic lead (206Pb/204Pb=17.341-17.622, 207Pb/204Pb=15.525-15.538, 208Pb/204Pb=37.563-37.684). Similarly, the lamprophyres also have quite low εNd values (-11.57 - -19.64). Based on the fact that the Sr, Nd and Pb isotopic compositions of potash-rich volcanic rocks are very consistent with that of the clinopyroxene separates, and by integrating comprehensive analyses of their tectonic settings, and extensive comparisons of the Sr, Nd isotopic composi-tions with that of the related simultaneous rocks, it is con-cluded that the potash-rich volcanic rocks and lamprophyres in western Shandong Province were most possibly derived from the partial melting | QIU Jiansheng, XU Xisheng & LO Ching-HuaState Key Laboratory of Mineral Deposit Research of Nanjing University, Nanjing 210093, China Department of Earth Sciences, Nanjing University, Nanjing 210093, China Department of Geology, Taiwan Unive | 2002 | Chinese Science Bulletin2002，47，2： | 39 |
| 3 | Incidental gallbladder cancer during laparoscopic cholecystectomy:Managing an unexpected finding显示文摘AIM:To evaluate the impact of incidental gallbladder cancer on surgical experience.METHODS:Between 1998 and 2008 all cases of cholecystectomy at two divisions of general surgery,one university based and one at a public hospital,were retrospectively reviewed.Gallbladder pathology was diagnosed by history,physical examination,and laboratory and imaging studies [ultrasonography and computed tomography(CT)].Patients with gallbladder cancer(GBC) were further analyzed for demographic data,and type of operation,surgical morbidity and mortality,histopathological classification,and survival.Incidental GBC was compared with suspected or preoperatively diagnosed GBC.The primary endpoint was diseasefree survival(DFS).The secondary endpoint was the difference in DFS between patients previously treated with laparoscopic cholecystectomy and those who had oncological resection as first intervention.RESULTS:Nineteen patients(11 women and eight men) were found to have GBC.The male to female ratio was 1:1.4 and the mean age was 68 years(range:45-82 years).Preoperative diagnosis was made in 10 cases,and eight were diagnosed postoperatively.One was suspected intraoperatively and confirmed by frozen sections.The ratio between incidental and nonincidental cases was 9/19.The tumor node metastasis stage was:pTis(1),pT1a(2),pT1b(4),pT2(6),pT3(4),pT4(2);five cases with stageⅠa(T1 a-b);two with stageⅠb(T2 N0);one with stage Ⅱa(T3 N0);six with stage Ⅱb(T1-T3 N1);two with stage Ⅲ(T4 Nx Nx);and one with stage Ⅳ(Tx Nx Mx).Eighty-eight percent of the incidental cases were discovered at an early stage(≤Ⅱ).Preoperative diagnosis of the 19 patients with GBC was:GBC with liver invasion diagnosed by preoperative CT(nine cases),gallbladder abscess perforated into hepatic parenchyma and involving the transversal mesocolon and hepatic hilum(one case),porcelain gallbladder(one case),gallbladder adenoma(one case),and chronic cholelithiasis(eight cases).Every case,except one,with a T1b or more advanced invasion underwent Ⅳb + Ⅴ wedge liver resection and pericholedochic/hepatoduodenal lymphadenectomy.One patient with stage T1b GBC refused further surgery.Cases with Tis and T1a involvement were treated with cholecystectomy alone.One incidental case was diagnosed by intraoperative frozen section and treated with cholecystectomy alone.Six of the nine patients with incidental diagnosis reached 5-year DFS.One patient reached 38 mo survival despite a port-site recurrence 2 years after original surgery.Cases with non incidental diagnosis were more locally advanced and only two patients experienced 5-year DFS.CONCLUSION:Laparoscopic cholecystectomy does not affect survival if implemented properly.Reoperation should have two objectives:R0 resection and clearance of the lymph nodes. | Andrea Cavallaro Gaetano Piccolo Vincenzo Panebianco Emanuele Lo Menzo Massimiliano Berretta Antonio Zanghì Maria Di Vita Alessandro Cappellani | 2012 | World Journal of Gastroenterology2012，18，30： | 33 |
| 4 | 欧洲儿童急性胃肠炎处理循证指南(2014年版)显示文摘1991年世界卫生组织(WHO)制订了第一版儿童急性腹泻病指南,2005年WHO和联合国儿童基金会(UNICEF)制订了第二版,我国专家在参照WHO指南的基础上,结合我国国情分别于1993年、2009年制订了中国儿童急性腹泻病的专家共识;WH0指南和我国共识对中国儿童急性腹泻病的规范诊治发挥了重要的作用,收到了良好的效果。时至今日,欧洲儿科胃肠病学、肝病学和营养协会及欧洲儿科感染病协会对2008年儿童急性胃肠炎循证指南进行更新,即“2014年版”。指南中腹泻病原、低渗口服补液盐溶液使用、营养管理和常规对症治疗与我国现行共识基本一致。另首次对儿童脱水评估和疾病严重程度评分进行量化并提出通过鼻胃管补液,这是我们可以借鉴的。重度脱水休克的治疗强调了可重复3次20ml/kg0.9%氯化钠溶液,与我国危重专业观点相一致。静脉补充液体成分与我国现行共识存在差异,与指南执笔者之一意大利学者AndreaLoVecehio进行交流,其认同我国现用液体组成。细菌感染所致腹泻使用抗生素的指征与我国现行共识相同,但在抗生素选择上存在差异,建议根据我国药典和药敏结果选择合适抗生素。由于我国社会经济、文化和医学发展等与欧洲存在差异,因此指南中的观点、方法等应结合中国特点进行应用。 | Alfredo Guarino Shai Ashkenazi Dominique Gendrel Andrea Lo Vecchio Raanan Shamir Hania Szajewska 方铁夫 耿岚岚 龚四堂 | 2015 | 中华儿科杂志2015，53，7： | 30 |
| 5 | Conceptualizing and Measuring Economic Resilience of Resource-based Cities: Case Study of Northeast China显示文摘This paper develops a conceptual model and an indicator system for measuring economic resilience of resource-based cities based on the theory of evolutionary resilience and the related concepts of persistence, adaptation, and transformation. Nineteen resource-based cities in Northeast China were analyzed using the indicator system. The results showed that Liaoning and Jilin provinces had higher economic resilience than Heilongjiang Province. Panjin, Benxi, and Anshan in Liaoning Province were the top three cities, while Shuangyashan and other coal-based cities in Heilongjiang Province ranked last. Metals-and petroleum-based cities had significantly higher resilience than coal-based cities. The differences in persistence, adaptability, transformation, and resilience among resource-based cities decreased since the introduction of the Northeast Revitalization Strategy in 2003. Forestry-based cities improved the most in terms of resilience, followed by metals-based and multiple-resource cities; however, resilience dropped for coal-based cities, and petroleum-based cities falling the most. The findings illustrate the importance and the way to develop a differentiated approach to improve resilience among resource-based cities. | TAN Juntao ZHANG Pingyu LO Kevin LI Jing LIU Shiwei | 2017 | Chinese Geographical Science2017，27，3： | 27 |
| 6 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 7 | Estimating liver weight of adults by body weight and gender显示文摘瞄准:为了为估计接枝的足够估计标准肝重量,为癌症在主要肝切除术在实时施主肝移植和残余肝缩放。方法:在这研究,体重和身高的人体测量的数据在 159 个实时的肝施主为与肝重量的关联被测试包括中间的肝的静脉经历了施主权利肝切除术。肝重量从在背表格获得的正确脑叶接枝重量被计算,在计算断层摄影术上由正确脑叶的比例划分了。结果:这些题目,所有汉语,有 35.8+/-10.5 年,和女性的吝啬的年龄到 118:41 的男比率。正确脑叶的吝啬的体积是 710.14+/-131.46 mL 并且在计算断层摄影术上占据了整个肝的 64.55%+/-4.47% 。正确脑叶称了 598.90+/-117.39 g,估计的肝重量是 927.54+/-168.78 g。当体重和身高受到多重逐步的线性回归分析时,身高被发现不足道。一样的体重的女性有稍微更低的肝重量。一个公式基于体重和性被导出:估计的标准肝重量(g)= 218 + BW (kg ) x 12.3 + 性 x 51 (R2 = 0.48 )( 女 = 0,男 = 1 ) 。基于这 159 个题目,的人体测量的数据肝重量用在白种人,日语,朝鲜语,和汉语上从研究导出的以前出版的公式被计算。所有公式与这个公式相比过高估计肝重量。日本公式为成年人过高估计估计的标准肝重量(ESLW ) 不到 60 kg。结论:对中国男性和女性适用的一个公式是可得到的。为单个赛跑的一个公式显得必要。 | See Ching Chan Chi Leung Liu Chung Mau Lo Banny K Lam Evelyn W Lee Yik Wong Sheung Tat Fan | 2006 | World Journal of Gastroenterology2006，12，14： | 22 |
| 8 | A different spectrum of DMD gene mutations in local Chinese patients with Duchenne/Becker muscular dystrophy显示文摘背景 Duchenne 肌肉发达的营养障碍(DMD ) 和贝克尔肌肉发达的营养障碍(BMD ) 是 X 连接后退的、突变而产生之遗传的混乱。这研究被进行与 Duchenne 或贝克尔在香港中国病人调查 DMD 基因变化的光谱,并且学习遗传型显型肌肉发达的营养障碍(DMD/BMD ) 关联。67 个病人的方法 Aretrospective 评论。结果 23 (34.3%) 病人们在删除上有前;而 5 (7.5%) 病人们在复制上有前。23 (34.3%) 病人们有小变化,包括 17 个点变化和 6 小插入或删除。没有关联在变化和肌肉显型或智力迟钝的类型之间被发现。显著地,更少母亲的搬运人在删除上与前在病人被发现,并且积极家庭历史在有小变化的那些是更普通的。DMD 显型是显著地不在有在 5'' 热点的 exondeletions/duplications 的病人普通,而与智力迟钝联系的所有 4 个小变化位于 3'' ,基因结束。结论在本地中国病人的 DMD exondeletions 的百分比比显著地低通常引用了 60% 。Thisindicated 在到删除上的 DMD 前的倾向的种族或地区性的差别。 | Ivan Fai-man Lo Kent Keung-san Lai Tony Ming-for Tong Stephen Tak-sum Lam | 2006 | Chinese Medical Journal2006，，13： | 21 |
| 9 | Ferulic acid inhibits nitric oxide-induced apoptosis by enhancing GABA81 receptor expression in transient focal cerebral ischemia in rats显示文摘 | Chin-yi CHENG Shan-yu SU Nou-ying TANG Tin-yun HO Wan-yu LO Ching-liang HSIEH | 2010 | Acta Pharmacologica Sinica2010，31，8： | 20 |
| 10 | Contributions of biofilm and suspended sludge to nitrogen transformation and nitrous oxide emission in hybrid sequencing batch system显示文摘Hybrid system combines the nature of suspended growth and attached growth has been widely applied to wastewater treatment.In this research, the contributions to N transformation and N2O emission by biofilm and suspended sludge in the hybrid sequencing-batch reactor for a simultaneous nitrification, denitrification and phosphorus removal process were investigated. For the hybrid system,nitrification occurred mostly in the suspended sludge, while the biofilm played the major role in denitrification. The interaction ofthe biofilm and the suspended sludge in the same reactor resulted in a better overall nitrogen removal performance with simultaneousnitrification and denitrification. However, N2O emission was the main end product of nitrogen removal for the hybrid system; whileit was N2 for the biofilm. The relative low N2O emissions from the pure biofilm and the pure suspended sludge corresponded to therelatively high nitrate at the end of the aeration period compared with the hybrid system. | Ingwei Wayne Lo Kwang Victor Lo Don S Mavinic Dean Shiskowski William Ramey | 2010 | Journal of Environmental Sciences2010，22，7： | 17 |
| 11 | Effect of Reclamation Time and Land Use on Soil Properties in Changjiang River Estuary,China显示文摘The objective of this study is to analyze soil physical and chemical properties,soil comprehensive functions and impact factors after different years of reclamation.Based on the survey data taken from 216 soil sampling points in the Fengxian Reclamation Area of the Changjiang (Yangtze) River Estuary,China in April 2009 and remotely sensed TM data in 2006,while by virtue of multivariate analysis of variance (MANOVA),geo-statistical analysis (GA),prin-cipal component analysis (PCA) and canonical correspondence analysis (CCA),it was concluded that:1) With the in-crease in reclamation time,soil moisture,soil salinity,soil electric conductivity and soil particle size tended to decline,yet soil organic matter tended to increase.Soil available phosphorous tended to increase in the early reclamation period,yet it tended to decline after about 49 years of reclamation.Soil nitrate nitrogen,soil ammonia nitrogen and pH changed slightly in different reclamation years.Soil physical and chemical properties reached a steady state after about 30 years of reclamation.2) According to the results of PCA analysis,the weighted value (0.97 in total) that represents soil nutrient factors (soil nitrate nitrogen,soil organic matter,soil available phosphorous,soil ammonia nitrogen,pH and soil particle size) were higher than the weighted value (0.48 in total) of soil limiting factors (soil salinity,soil elec-tric conductivity and soil moisture).The higher the F value is,the better the soil quality is.3) Different land use types play different roles in the soil function maturity process,with farmlands providing the best contribution.4) Soil physi-cal and chemical properties in the reclamation area were mainly influenced by reclamation time,and then by land use types.The correlation (0.1905) of the composite index of soil function (F) with reclamation time was greater than that with land use types (-0.1161). | SUN Yongguang LI Xiuzhen ülo MANDER HE Yanlong JIA Yue MA Zhigang GUO Wenyong XIN Zaijun | 2011 | Chinese Geographical Science2011，21，4： | 17 |
| 12 | Inflammation in irritable bowel syndrome:Myth or newtreatment target?显示文摘Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome(IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS, highlighting the relationship of this inflammation to the pathophysiology of IBS and its connection to clinical practice. We carried out a bibliographic search in Medline and the Cochrane Library for the period of January 1966 to December 2014, focusing on publications describing an interaction between inflammation and IBS. Several evidences demonstrate microscopic and molecular abnormalities in IBS patients. Understanding the mechanisms underlying low-grade inflammation in IBS may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism. | Emanuele Sinagra Giancarlo Pompei Giovanni Tomasello Francesco Cappello Gaetano Cristian Morreale Georgios Amvrosiadis Francesca Rossi Attilio Ignazio Lo Monte Aroldo Gabriele Rizzo Dario Raimondo | 2016 | World Journal of Gastroenterology2016，22，7： | 16 |
| 13 | Psychometrics of the chronic liver disease questionnaire for Southern Chinese patients with chronic hepatitis B virus infection显示文摘AIM:To test the psychometric properties of a Chinese [(Hong Kong) HK] translation of the chronic liver disease questionnaire (CLDQ).METHODS:A Chinese (HK) translation of the CLDQ was developed by iterative translation and cognitive debriefing.It was then administered to 72 uncomplicated and 78 complicated chronic hepatitis B (CHB) patients in Hong Kong together with a structured questionnaire on service utilization,and the Chinese (HK) SF-36 Health Survey Version 2 (SF-36v2).RESULTS:Scaling success was ≥ 80% for all but three items.A new factor assessing sleep was found and items of two (Fatigue and Systemic Symptoms) subscales tended to load on the same factor.Internal consistency and test-retest reliabilities ranged from 0.58-0.90 for different subscales.Construct validity was confirmed by the expected correlations between the SF-36v2 Health Survey and CLDQ scores.Mean scores of CLDQ were significantly lower in complicated compared with uncomplicated CHB,supporting sensitivity in detecting differences between groups.CONCLUSION:The Chinese (HK) CLDQ is valid,reliable and sensitive for patients with CHB.Some modif ications to the scaling structure might further improve its psychometric properties. | Elegance Ting Pui Lam Cindy Lo Kuen Lam Ching Lung Lai Man Fung Yuen Daniel Yee Tak Fong | 2009 | World Journal of Gastroenterology2009，15，26： | 16 |
| 14 | Black tea in chemo-prevention of cancer and other human diseases显示文摘Tea is the most popular functional beverage in the world and has been gaining more and more attention for its health beneficial properties.Among common teas,black tea is consumed more than green tea and oolong tea worldwide.Numerous studies have shown the biological activities of black tea and its polyphenols that include anti-oxidant,anti-tumor,anti-inflammation and metabolic regulation.Tea polyphenols such as theaflavins and catechins are considered to be multifunctional compounds that could be effective in the prevention or treatment of various cancers,cardiovascular disease,chronic inflammation,obesity,metabolic syndrome,and neurodegenerative diseases.In this review,we summarized the up-to-date research and underlying molecular mechanisms of black tea and its polyphenols.©2013 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Min-Hsiung Pan Ching-Shu Lai Hong Wang Chih-Yu Lo Chi-Tang Ho Shiming Li | 2013 | Food Science and Human Wellness2013，2，1： | 16 |
| 15 | Outcome of transarterial chemoembolization in patients with inoperable hepatocellular carcinoma eligible for radiofrequency ablation显示文摘AIM: To evaluate the outcome of transarterial chemoembolization (TACE) in patients with unresectable hepatocellular carcinoma (HCC) <5 cm in diameter eligible for radiofrequency ablation (RFA).METHODS: The treatment-related mortality, morbidity,long-term survival, and prognostic factors of HCC patients who had TACE and fulfilled the present inclusion criteria for RFA were evaluated.RESULTS: Of the 748 patients treated with TACE between January 1990 and December 2002, 114 patients were also eligible for RFA. The treatment-related mortality and morbidity were 1% and 19%, respectively. Survival at 1, 3, and 5 years was 80%, 43%, and 23%, respectively. Older age and a high albumin level were associated with a better survival, whereas a high α-fetoprotein level (AFP) and the size of the largest tumor >3 cm in diameter were adverse prognostic factors in multivariate analysis.CONCLUSION: The morbidity, mortality, and survival data after TACE for small HCCs eligible for RFA are comparable to those reported after RFA in the literature. Our data suggest the need for a randomized comparison of the two treatment modalities for small HCCs. | Mike SL Liem Ronnie TP Poon Chung Mau Lo Wai Kuen Tso Sheung Tat Fan | 2005 | World Journal of Gastroenterology2005，11，29： | 15 |
| 16 | Seminal biomarkers for the evaluation of male infertility显示文摘为努力与他们的搭挡一起怀孕的男人,诊断工具被限制并且经常由仅仅标准精液分析组成。这基线测试用作男富饶的一个粗略的评价,离开需要另外的诊断 biomarkers 的病人和临床医生。精液从因此,这评论在某些男不孕情形在当前、新奇的精液的 biomarkers 上集中包括自然富饶,区分精子缺乏病原学,并且预言的繁殖的腺帮助了的男性包含分子的最高的集中繁殖技术成功。当前可得到的测试包括 antisperm 抗体试金, DNA 破碎索引,在 situ 杂交的精子荧光,和另外的历史的精子功能的测试。当前的试金的差的诊断能力导致了继续的努力发现更预兆的 biomarkers。genomics, epigenetics, proteomics, transcriptomics,和为新奇男不孕 biomarkers 的发展的 metabolomics 抓住诺言的地里的新兴的研究。TEX101, ECM1,和 ACRV1 的精液的基于蛋白质的试金已经是可得到的或在为临床的使用的最后的开发中。当我们试图理解男不孕的 pathophysiologic 过程, DNA, RNA,蛋白质,或代谢物的另外的面板正在被探索。未来冒险将需要继续数据集成和确认让临床上有用的不孕 biomarkers 的开发帮助男不孕诊断,处理,并且建议。 | Jared M Bieniek Andrei P Drabovich Kirk C Lo | 2016 | Asian Journal of Andrology2016，18，3： | 15 |
| 17 | Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma显示文摘Lycium barbarum, a traditional Chinese anti-aging herb, has been shown to protect retinal ganglion cells (RGCs) in a rat chronic ocular hypertension (COH) model. Here, we investigated the expression of endothelin-1 (ET-1), a strong vasoconstrictor, and its receptors, ETA and ETB, in the COH model and assessed the effects of Lycium barbarum on the ET-1 axis. Elevated intraocular pressure (IOP) was induced in the right eye of SD rats using argon laser photocoagulation. (1) The expression of ET-1, ETA and ETB in normal and COH retinas was studied. (2) Some COH rats were fed daily with Lycium barbarum Polysaccharides (LBP) using 1 mg/kg or phosphate-buffered saline (PBS) for 3 weeks (started 1 week before photocoagulation). The effects of LBP on the expression of ET-1 and its receptors, ETA and ETB, in COH retina were evaluated. A semi-quantitative analysis of staining intensity was used to evaluate the expression levels of ET-1, ETA and ETB in retinal vasculature. We found that (1) Under COH condition, the immunoreactivity of ET-1 was increased in retina associated with an increase of ETB receptor immunoreactivity and a decrease of ETA receptor immunoreactivity. (2) After feeding COH rats with LBP, the expression of ET-1 was decreased with an increase of ETA expression and a decrease of ETB expression in the retina, especially in RGCs. (3) By comparing the staining intensity in the vasculature of COH retina in LBP-fed group with PBS-fed group, there was a decrease in the expression of ET-1 and ETA and an increase in ETB. In summary, ET-1 expression was up-regulated in the retina in COH model. LBP could decrease the expression of ET-1 and modulate the expression of its receptors, ETA and ETB, under the condition of COH. The neuroprotective effect of LBP on RGCs might be related to its ability to regulate the ET-1-mediated biological effects on RGCs and retinal vasculature. | Xue-Song Mi Kin Chiu Geoffrey Van Justin Wai Chung Leung Amy Cheuk Yin Lo SookjaKim Chung Raymond Chuen-Chung Chang Kwok-Fai So | 2012 | Neural Regeneration Research2012，7，9： | 14 |
| 18 | 冠状动脉内皮功能障碍患者循环MOTS-c水平下调显示文摘MOTS-c是一种新发现的线粒体衍生肽,其在调节代谢稳态中起作用。该研究旨在研究在没有显著冠状动脉结构性病变的患者中循环MOTS-c水平是否也与内皮功能障碍相关。方法:纳入无冠状动脉结构性病变的复发性心绞痛并接受冠状动脉造影和内皮功能检测的患者40例。 | Qin Q Delrio S Wan J Jay Widmer R Cohen P Lerman LO Lerman A 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，2： | 14 |
| 19 | Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: Prognosis and outcomes显示文摘AIM: To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical outcomes.METHODS: This study was a retrospective case comparison study using prospectively collected data. The study covered the period from April 2001 to December 2006. The data of 200 patients with histologically confirmed hepatocellular carcinoma were reviewed. Nineteen patients (17 men and 2 women) having received resection in combination with RFA were chosen as subjects of the study (the combination group). Fiftyfour patients (43 men and 11 women) having received resection alone were selected for comparison (the resection group). The two groups matched tumor number and tumor size, and all the patients in the two groups displayed no tumor rupture, major vascular involvement and distant metastasis. Their demographics, preoperative assessment, disease recurrence patterns, overall survival and diseasefree survival were compared.RESULTS: In the combination group, the medianage was 65 years (range, 3477 years), the median tumor number was 3 (range, 29), and the median tumor size was 6 cm (range, 1.214 cm). In the resection group, the median age was 51.5 years (range, 2780 years, P = 0.003), the median tumor number was 3 (range, 29, P = 0.574), and the median tumor size was 6 cm (range, 114 cm, P = 0.782). The two groups were similar in characteristics of tumors and comorbidities, and had comparable results in preoperative liver function tests. All patients had ChildPugh class A status. Bilobar involvement occurred in 14 patients (73.6%) in the combination group and 3 patients (5.5%) in the resection group (P = 0.04). Six patients (32%) in the combination group and 35 patients (65%) in the resection group underwent major hepatectomy. Thirteen patients (68%) in the combination group and 19 patients (35%) in the resection group underwent minor hepatectomy (P = 0.012). The combination group had fewer major resections (32% vs 65%, P = 0.012), less blood loss (400 vs 657 mL, P = 0.007), shorter operation time (270 vs 400 min, P = 0.001), and shorter hospital stay (7 vs 8.5 d, P = 0.042). The two groups displayed no major differences in surgical complications (15.8% vs 31.5%, P = 0.24), disease recurrence (63.2% vs 50%, P = 0.673), hospital mortality (5.3% vs 5.6%, P = 1), and overall survival (53 vs 44.5 mo, P = 0.496).CONCLUSION: Safe and effective for selected patients with multifocal hepatocellular carcinoma, the combination of resection and intraoperative RFA widens the applicability of surgical intervention for the disease. | Tan To Cheung Kelvin K Ng Kenneth S Chok See Ching Chan Ronnie T Poon Chung Mau Lo Sheung Tat Fan | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 20 | 漂白废水中的氯化有机物及其处理显示文摘本文概括了化学浆漂白废水中的氯化有机物的研究成就,简要地评述了这些氯化有机物的产生、性质、污染、检测和去除的方法。 | 魏鹏月 Sung-Nien Lo | 1993 | 中国造纸1993，12，3： | 13 |
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