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| 1 | Fluid resuscitation in acute pancreatitis: Normal saline or lactated Ringer's solution?显示文摘AIM: To investigate whether administration of Ringer's solution(RL) could have an impact on the outcome of acute pancreatitis(AP).METHODS: We conducted a retrospective study on 103 patients [68 men and 35 women,mean age 51.2 years(range,19-92 years)] hospitalized between 2011 and 2012. All patients admitted to the Department of Gastroenterology of the Central Clinical Hospital of the Ministry of Interior(Poland) with a diagnosis of AP who had disease onset within 48 h of presentation were included in this study. Based on the presence of persistent organ failure(longer than 48 h) as a criterion for the diagnosis of severe AP(SAP) and the presence of local complications [diagnosis of moderately severe AP(MSAP)],patients were classified into 3 groups: mild AP(MAP),MSAP and SAP. Data were compared between the groups in terms of severity(using the revised Atlanta criteria) and outcome. Patients were stratified into 2 groups based on the type of fluid resuscitation: the 1-RL group who underwent standard fluid resuscitation with a RL 1000 m L solution or the 2-NS group who underwent standard fluid resuscitation with 1000 m L normal saline(NS). All patients from both groups received an additional 5% glucose solution(1000-1500 m L) and a multi-electrolyte solution(500-1000 m L).RESULTS: We observed 64(62.1%) patients with MAP,26(25.24%) patients with MSAP and 13(12.62%) patients with SAP. No significant difference in the distribution of AP severity between the two groups was found. In the 1-RL group,we identified 22(55.5%) MAP,10(25.5%) MSAP and 8(20.0%) SAP patients,compared with 42(66.7%) MAP,16(24.4%) MSAP and 5(7.9%) SAP cases in the 2-NS group(P = 0.187). The volumes of fluid administered during the initial 72-h period of hospitalization were similar among the patients from both the 1-RL and 2-NS groups(mean 3400 m L vs 3000 m L,respectively). No significant differences between the 1-RL and 2-NS groups were found in confirmed pancreatic necrosis [10 patients(25%) vs 12 patients(19%),respectively,P = 0.637]. There were no statistically significant differences between the 1-RL and 2-NS groups in the percentage of patients who required enteral nutrition(23 patients vs 17 patients,respectively,P = 0.534). Logistic regression analysis confirmed these findings(OR = 1.344,95%CI: 0.595-3.035,P = 0.477). There were no significant differences between the 1-RL and 2-NS groups in mortality and the duration of hospital stay(median of 9 d for both groups,P = 0.776).CONCLUSION: Our study failed to find any evidence that the administration of RL in the first days of AP leads to improved clinical outcomes. | Michal Lipinski Alicja Rydzewska-Rosolowska Andrzej Rydzewski Grazyna Rydzewska | 2015 | World Journal of Gastroenterology2015，21，31： | 21 |
| 2 | Safety of epinephrine for anaphylaxis in the emergency setting显示文摘BACKGROUND:While epinephrine is the recommended first-line therapy for the reversal of anaphylaxis symptoms,inappropriate use persists because of misunderstandings about proper dosing and administration or misconceptions about its safety.The objective of this review was to evaluate the safety of epinephrine for patients with anaphylaxis,including other emergent conditions,treated in emergency care settings.METHODS:A MEDLINE search using PubMed was conducted to identify articles that discuss the dosing,administration,and safety of epinephrine in the emergency setting for anaphylaxis and other conditions.RESULTS:Epinephrine is safe for anaphylaxis when given at the correct dose by intramuscular injection.The majority of dosing errors and cardiovascular adverse reactions occur when epinephrine is given intravenously or incorrectly dosed.CONCLUSION:Epinephrine by intramuscular injection is a safe therapy for anaphylaxis but training may still be necessary in emergency care settings to minimize drug dosing and administration errors and to allay concerns about its safety. | Joseph P Wood Stephen J Traub Christopher Lipinski | 2013 | World Journal of Emergency Medicine2013，4，4： | 7 |
| 3 | 如何选择最佳的甜味剂显示文摘在工业化国家,人们的保健意识日益增强,肥胖人群不断增多,开始促使人们改变自己的饮食习惯。人们希望食品含低热量,副作用少,同时又能保留或增强食品的可口性。 除了蔗糖等糖类之外,甜味剂的使用为无糖的甜味食品的生产,提供了广泛的可能性。甜味剂发展到今天,已广泛应用于低热量或糖尿病患者食品。 增体性甜味剂与强甜味剂 具有甜味的碳水化合物如蔗糖或葡萄糖是多功能的食品配料。在这些碳水化合物的功能性质中,增体性功能是最重要的。很明显。 | G.-W.von Rymon Lipinski | 1997 | 中国食品工业1997，，5： | 3 |
| 4 | Biofunctionalized upconverting CaF2:Yb,Tm nanoparticles for Candida albicans detection and imaging显示文摘合成方法的万用的优化和 Yb 3+ 和 Tm 3+ 的作文共同做 CaF 2 nanoparticles 以及一个新奇 biofunctionalization 方法被开发并且评估。通过 multistep 合成, Tm 3+ 使活跃之物的光紧张被超过 10 褶层与标准一步舞合成相比提高。建议方法被用来同质地在 nanoparticles 卷以内散布做的离子并且因此减少光熄灭。掺杂物离子集中的优化导致了最有效的可见、在红外线附近的起来变换的 nanoparticles 的选择,它是与 10% Yb 3+ 做的 CaF 20.05% Tm 3+ 和 20% Yb 3+0.5% Tm 3+, 分别地。作为简历标签说明综合 nanoparticles 的适用性,一个奉献 biofunctionalization 方法被使用,并且 nanoparticles 被申请标记并且 Candida albicans 房间的成像。因为依附的分子的存在,这个方法因为极其低的背景和高特性显示出大诺言。 | Malgorzata Misiak Michal Skowicki Tomasz Lipinski Agnieszka Kowalczyk Katarzyna Prorok Sebastian Arabasz Artur Bednarkiewicz | 2017 | Nano Research2017，10，10： | 2 |
| 5 | Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRI显示文摘 | Amirbekian V Lipinski M J Briley-Saebo KC | 2007 | Proc Natl Acad Sci USA2007，104，3： | 1 |
| 6 | Diversity in the mecha-nisrns of neuronal cell death 显示文摘 | Yuan J Lipinski M Degterev A | 2003 | Neuron2003，40，2： | 1 |
| 7 | Response of growing-finishing pigs to reduced levels of energy and amino acids in diets supplemented with betaine and feed enzymes显示文摘 | Szramko E Lipinski K Purwin C | 2006 | Polish Journal of Natural Sciences Supplement2006，，3： | 1 |
| 8 | Self- assembling InAs and InP quantum dots for optoelectronic devices显示文摘 | Lipinski U M Manz Y M | 2000 | Thin Solid Films2000，，380： | 1 |
| 9 | Optical fibers in time and frequency transfer显示文摘 | L Sliwczynski P Krehlik M Lipinski | 2010 | Measurement Science and Technology2010，21，07： | 1 |
| 10 | Enhanced wood fuels via torrefaction显示文摘 | LIPINSKY E S ARCATE J R Reed T B | 2002 | Fuel Chemistry Division Preprints2002，47，1： | 1 |
| 11 | Meta- analysis of randomized controlled trials of statins versus placebo in patients with heart failure 显示文摘 | Lipinski M J Cauthen C A Biondi-Zoccai G G | 2009 | Am J Cardiol2009，104，12： | 1 |
| 12 | Poor aqueous solubility--an industry wide problem in drug discovery显示文摘 | Lipinski C | 2002 | Am Pharm Rev2002，5，3： | 1 |
| 13 | A systematic re- view and collaborative meta-analysis to determine the incremental value of copeptin for rapid rule-out of acute myocardial infarction 显示文摘 | Lipinski M J Escrrcega R O D'Ascenzo F | 2014 | The American journal of cardiology2014，113，9： | 1 |
| 14 | Experi-mental and computational approaches to estimate solubility andpermeability in drug discovery and development settings显示文摘 | LIPINSKI C A LOMBARDO F DOMINY B W | 2001 | Adv Drug Deliv Rev2001，46，13： | 1 |
| 15 | Sphingosine-l-phos- phate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosis 显示文摘 | Keul P Lucke S von Wnuck Lipinski K | 2011 | Circ Res2011，108，3： | 1 |
| 16 | Possibility of reducing energy and amino acid levels in diets for growing pigs supplemented with betaine and feed enzymes显示文摘 | Szramko E Lipinski K Purwin C | 2006 | Annals of Animal Science Supplement2006，2，1： | 1 |
| 17 | Drug-like properties and the causes of poor solubility and poor permeability显示文摘 | LIPINSKI C A | 2000 | J Pharacol Toxicol Methods2000，44，1： | 1 |
| 18 | Automated neurite labeling and analysis in fluorescence microscopy images显示文摘 | XIONG Guanglei ZHOU Xiaobo Lipinski Marta | 2006 | Cytometry Part A2006，69，： | 1 |
| 19 | Drugqike properties and the causes of poor solubility and poor permeability显示文摘 | Lipinski C A | 2000 | J Pharmaeol Toxi- col Methods2000，44，： | 1 |
| 20 | Ultrasonic prediction of complications following normal vaginal delivery显示文摘 | Lipinski JK Adam AH | 1981 | J Clin Ultrasound1981，9，1： | 1 |
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