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| 1 | Bloating and functional gastro-intestinal disorders: Where are we and where are we going?显示文摘Bloating is one of the most common and bothersome symptoms complained by a large proportion of patients. This symptom has been described with various definitions, such as sensation of a distended abdomen or an abdominal tension or even excessive gas in the abdomen, although bloating should probably be defined as the feeling(e.g. a subjective sensation) of increased pressure within the abdomen. It is usually associated with functional gastrointestinal disorders, like irritable bowel syndrome, but when bloating is not part of another functional bowel or gastrointestinal disorder it is included as an independent entity in Rome Ⅲ criteria named functional bloating. In terms of diagnosis, major difficulties are due to the lack of measurable parameters to assess and grade this symptom. In addition, it is still unclear to what extent the individual patient complaint of subjective bloating correlates with the objective evidence of abdominal distension. In fact, despite its clinical, social and economic relevance, bloating lacks a clear pathophysiology explanation, and an effective management endorsement, turning this common symptom into a true challenge for both patients and clinicians. Different theories on bloating etiology call into questions an increased luminal contents(gas, stools, liquid or fat) and/or an impaired abdominal empting and/or an altered intra-abdominal volume displacement(abdomino-phrenic theory) and/or an increased perception of intestinal stimuli with a subsequent use of empirical treatments(diet modifications, antibiotics and/or probiotics, prokinetic drugs, antispasmodics, gas reducing agents and tricyclic antidepressants). In this review, our aim was to review the latest knowledge on bloating physiopathology and therapeutic options trying to shed lights on those processes where a clinician could intervene to modify disease course. | Paola Iovino Cristina Bucci Fabrizio Tremolaterra Antonella Santonicola Giuseppe Chiarioni | 2014 | World Journal of Gastroenterology2014，20，39： | 9 |
| 2 | 兆伏级锥形束CT:系统说明及IGRT临床应用介绍显示文摘阐述临床用兆伏级锥形束CT(MV CBCT)系统,介绍图像采集和患者摆位的过程,并就摆位精度和图像质量进行讨论,并通过所选病例介绍该系统在影像引导下的放射治疗(IGRT)中的潜在应用价值。兆伏级锥形束CT系统由一台标准直线加速器外加配备以非晶硅平板型EPID,能够适合兆伏级光子射线。一体化的计算机工作平台能够支持投照图像的自动采集,图像重建,CT到锥形束CT图像的注册,以及治疗床的移动计算。系统具有亚毫米级的定位精度和足够的软组织分辨率,能够显示前列腺等软组织结构。在我院,已经使用兆伏级锥形束CT系统检测脊髓的非刚性形变,监控肿瘤的生长和消退,以及肺内固定肿瘤的定位等。对于受到金属伪影干扰的结构,兆伏级锥形束CT还提高了其勾画的准确性。在过去的几年中,兆伏级锥形束CT有了较快的发展。现在的图像质量完全可以满足IGRT应用的需要。此外,我们希望兆伏级锥形束CT在临床上的应用将随着影像技术的发展而不断扩大。 | Olivier Morin Amy Gillis Josephine Chen Michèle Aubin M.Kara Bucci Jean Pouliot 索京涛 陆嘉德 | 2006 | 中国癌症杂志2006，16，6： | 9 |
| 3 | Impaired coagulation,liver dysfunction and COVID-19:Discovering an intriguing relationship显示文摘Coronavirus disease 2019(COVID-19)is,at present,one of the most relevant global health problems.In the literature hepatic alterations have been described in COVID-19 patients,and they are mainly represented by worsening of underlying chronic liver disease leading to hepatic decompensation and liver failure with higher mortality.Several potential mechanisms used by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)to cause liver damage have been hypothesized.COVID-19 primary liver injury is less common than secondary liver injury.Most of the available data demonstrate how liver damage in SARSCo V-2 infection is likely due to systemic inflammation,and it is less likely mediated by a cytopathic effect directed on liver cells.Moreover,liver alterations could be caused by hypoxic injury and drugs(antibiotics and non-steroidal antiinflammatory drugs,remdesivir,tocilizumab,tofacitinib and dexamethasone).SARS-Co V-2 infection can induce multiple vascular district atherothrombosis by affecting simultaneously cerebral,coronary and peripheral vascular beds.Data in the literature highlight how the virus triggers an exaggerated immune response,which added to the cytopathic effect of the virus can induce endothelial damage and a prothrombotic dysregulation of hemostasis.This leads to a higher incidence of symptomatic and confirmed venous thrombosis and of pulmonary embolisms,especially in central,lobar or segmental pulmonary arteries,in COVID-19.There are currently fewer data for arterial thrombosis,while myocardial injury was identified in 7%-17%of patients hospitalized with SARS-Co V-2 infection and 22%-31%in the intensive care unit setting.Available data also revealed a higher occurrence of stroke and more serious forms of peripheral arterial disease in COVID-19 patients.Hemostasis dysregulation is observed during the COVID-19 course.Lower platelet count,mildly increased prothrombin time and increased Ddimer are typical laboratory features of patients with severe SARS-Co V-2 infection,described as“COVID-19 associated coagulopathy.”These alterations are correlated to poor outcomes.Moreover,patients with severe SARS-Co V-2 infection are characterized by high levels of von Willebrand factor with subsequent ADAMTS13 deficiency and impaired fibrinolysis.Platelet hyperreactivity,hypercoagulability and hypofibrinolysis during SARS-Co V-2 infection induce a pathological state named as“immuno-thromboinflammation.”Finally,liver dysfunction and coagulopathy are often observed at the same time in patients with COVID-19.The hypothesis that liver dysfunction could be mediated by microvascular thrombosis has been supported by postmortem findings and extensive vascular portal and sinusoidal thrombosis observation.Other evidence has shown a correlation between coagulation and liver damage in COVID-19,underlined by the transaminase association with coagulopathy,identified through laboratory markers such as prothrombin time,international normalized ratio,fibrinogen,D-dimer,fibrin/fibrinogen degradation products and platelet count.Other possible mechanisms like immunogenesis of COVID-19 damage or massive pericyte activation with consequent vessel wall fibrosis have been suggested. | Damiano D'Ardes Andrea Boccatonda Giulio Cocco Stefano Fabiani Ilaria Rossi Marco Bucci Maria Teresa Guagnano Cosima Schiavone Francesco Cipollone | 2022 | World Journal of Gastroenterology2022，28，11： | 5 |
| 4 | ERCC1 predicts outcome in patients with gastric cancer treated with adjuvant cisplatin-based chemotherapy显示文摘 | Sara Dosso Elena Zanellato Martina Nucifora Renzo Boldorini Angelica Sonzogni Roberto Biffi Nicola Fazio Eraldo Bucci Ottavio Beretta Stefano Crippa Piercarlo Saletti Milo Frattini | 2013 | Cancer Chemotherapy and Pharmacology2013，，1： | 2 |
| 5 | Inguinal recurrence of malignant mesothelioma of the tunica vaginalis: one case report with delayed recurrence and review of the literature显示文摘亲爱的先生,我是 Giovanni Liguori 从泌尿学的部门, Trieste 的大学,意大利。我们 wrtite 到你讨论大桶集成通信适配器的恶意的间皮瘤阴道。恶意的间皮瘤最经常包含肋膜或到石棉的腹洞和暴露是为它的发展的一个著名风险因素[1 ] 。在他们注意在几个月的功课期间的阴囊的胀大以后,大多数病人寻求治疗。在临床的评价以后,这些瘤经常被相信代表阴囊积水或 epididymal 包囊。作为结果,大多数病人开始为一个怀疑的良性的实体保存地被对待,恶意的诊断经常手术后地被做。 | Giovanni Liguori Giulio Garaffa Carlo Trombetta Rossana Bussani Stefano Bucci Emanuele Belgrano | 2007 | Asian Journal of Andrology2007，9，6： | 2 |
| 6 | Need for new materials in aging aircraft structures显示文摘 | BUCCI R J WARRE C J | 2000 | J of Aircraft2000，37，1： | 2 |
| 7 | A Novel Gaussian Extrapolation Approach for 2D Gel Electrophoresis Saturated Protein Spots显示文摘Analysis of images obtained from two-dimensional gel electrophoresis (2D-GE) is a topic of utmost importance in bioinformatics research, since commercial and academic software available currently has proven to be neither completely effective nor fully automatic, often requiring manual revision and refinement of computer generated matches. In this work, we present an effective technique for the detection and the reconstruction of over-saturated protein spots. Firstly, the algorithm reveals overexposed areas, where spots may be truncated, and plateau regions caused by smeared and overlapping spots. Next, it reconstructs the correct distribution of pixel values in these overexposed areas and plateau regions, using a two-dimensional least-squares fitting based on a generalized Gaussian distribution. Pixel correction in saturated and smeared spots allows more accurate quantification, providing more reliable image analysis results. The method is validated for processing highly exposed 2D-GE images, comparing reconstructed spots with the corresponding non-saturated image, demonstrating that the algorithm enables correct spot quantification. | Massimo Natale Alfonso Caiazzo Enrico M. Bucci Elisa Ficarra | 2012 | Genomics, Proteomics & Bioinformatics2012，10，6： | 2 |
| 8 | Mechanism of cell death during warm hepatic ischemia-reperfusion in rats: Apoptosis or necrosis?显示文摘 | Jaspreet S. Gujral Thomas J. Bucci Anwar Farhood Hartmut Jaeschke | 2001 | Hepatology2001，，2： | 2 |
| 9 | Fertility preservation after bilateral severe testicular trauma显示文摘 | Giovanni Liguori Nicola Pavan Gianluca d'Aloia Stefano Bucci Bernardino de Concilio Giorgio Mazzon Giangiacomo Ollandini Carlo Trombetta | 2014 | Asian Journal of Andrology2014，16，4： | 2 |
| 10 | Overexpression of microRNA-145 in atherosclerotic plaques from hypertensive patients显示文摘 | Donato Santovito Claudia Mandolini Pamela Marcantonio Velia De Nardis Marco Bucci Camilla Paganelli Francesco Magnacca Sante Ucchino Daniela Mastroiacovo Giovambattista Desideri Andrea Mezzetti Francesco Cipollone | 2012 | Expert Opinion on Therapeutic Targets2012，，3： | 2 |
| 11 | Effects of dietary genistein exposure during development on male and female CD (sprague-Dawley) rats 显示文摘 | Delclos K B Bucci T J Lomar L G | 2001 | Reprod Toxicol2001，15，6： | 2 |
| 12 | Cardiovascular outcome in treated hypertensive patients with responder,masked,false resistant,and true resistant hypertension显示文摘 | Pierdomenieo SD Lapenna D Bucci A | 2005 | Am J Hypertens2005，18，11： | 1 |
| 13 | Ultrasound demonstration of gallbladder wall thickening as a method to differentiate cirrhotic ascites from other ascites显示文摘 | BROGNA A BUCCI A M CATALANO F | 1996 | Invest Radiol1996，31，： | 1 |
| 14 | Precision determination of lattice parameters and coefficients of thermal expansion of BiFeO3显示文摘 | Bucci J D Robertson B K James W J | 1972 | J Appl Cryst1972，5，： | 1 |
| 15 | Basic science focus on blood substitutes: a summary of the NHLBI Division of Blood Diseases and Resources Working Group Workshop, March 1, 2006显示文摘 | Estep T Bucci E Farmer M | 2008 | Transfusion2008，48，4： | 1 |
| 16 | Final report of a pilottrial of accelerated radiotherapy plus concurrent 96-hour infusional paclitaxel for locally advanced head and neck cancer显示文摘 | Bucci M K Rosenthal D I Hershock D | 2004 | Am J Clin Oncol2004，27，6： | 1 |
| 17 | Total pupillary capture with a foldable silicone intraocular lens 显示文摘 | Bucci FA Jr Lindstrom RL | 1991 | Ophthalmic Surg1991，22，7： | 1 |
| 18 | Circadian blood pressure changes and myocardial isfhemia in hypertensive patients with coronary artery disease 显示文摘 | Pierdomenico SD Bucci A Costantini F | 1998 | J Am Coil Cardiol1998，31，： | 1 |
| 19 | Central nicotinic cho- linergic systems: A role in the cognitive dysfunction in At- tentionDeficit/Hyperactivity Disorder? 显示文摘 | Potter AS Newhouse PA Bucci D J | 2006 | Behav Brain Res2006，，： | 1 |
| 20 | Isolation and structure of bombesin and alytesin, two analogous active peptides from the skin of the European amphibians Bombina and Alytes显示文摘 | Anastasi A Erspamer V Bucci M | 1971 | Experi- entia1971，27，2： | 1 |
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