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| 1 | 肌萎缩性侧索硬化蛋白激活小胶质细胞NLRP3炎性小体显示文摘小胶质细胞NLRP3炎性小体激活正在成为神经退行性变过程中神经炎症的关键因素。诸如β-淀粉样蛋白和α-突触核蛋白之类的致病性蛋白质聚集体触发小胶质NLRP3激活,从而导致半胱天冬酶-1激活和IL-1β的分泌。在小鼠肌萎缩性侧索硬化症(ALS)的SOD1G93A模型中,半胱天冬酶-1和IL-1β均促进疾病进展,提示小胶质NLRP3在该进程中发挥作用。然而先前的研究表明,SOD1G93A小鼠小胶质细胞不表达NLRP3,SOD1G93A蛋白在小胶质细胞中产生独立于NLRP3的IL-1β。本研究论证了使用Nlrp3-GFP基因敲入小鼠,在SOD1G93A小鼠中小胶质细胞表达NLRP3。本研究显示聚集和可溶性SOD1G93A均可激活小鼠原代小胶质细胞中的炎性小体,导致半胱天冬酶-1和IL-1β裂解,ASC斑点形成以及呈剂量和时间依赖性的IL-1β分泌。重要的是,SOD1G93A无法从缺乏Nlrp3的小胶质细胞或者用特异性NLRP3抑制剂MCC950预处理的小胶质细胞中诱导IL-1β分泌,从而证实NLRP3是介导SOD1诱导的小胶质细胞IL-1β分泌的关键炎症小体复合物。在TDP-43Q331K ALS小鼠模型中也观察到小胶质NLRP3上调,TDP-43野生型和突变蛋白亦可以NLRP3依赖性的方式激活小胶质炎性小体。从机制上讲,本研究确定了活性氧簇和ATP的生成是SOD1G93A介导的NLRP3激活所需的关键事件。总之,本研究的数据表明ALS小胶质细胞表达NLRP3,而病理ALS蛋白激活小胶质NLRP3炎性小体。因此,NLRP3抑制可能是阻止小胶质细胞神经炎症和ALS疾病进展的潜在治疗方法。 | Vandana Deora John D Lee Eduardo AAlbornoz Luke McAlary Cyril J Jagaraj Avril A B Robertson Julie D Atkin Matthew A Cooper Kate Schroder Justin J Yerbury Richard Gordon Trent MWoodruff 杜一星(编译) | 2020 | 神经损伤与功能重建2020，15，9： | 13 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Stool DNA-based versus colonoscopy-based colorectal cancer screening: Patient perceptions and preferences显示文摘Objective:Stool DNA(sDNA)tests offer a noninvasive form of colon cancer screening for pa-tients,and although the test is expected to increase uptake of colon cancer screening,it is unknown if patients’perceptions of the sDNA test differ according to race and other patient characteristics.Methods:We conducted a self-administered survey of patients undergoing both a colonoscopy and an sDNA test to evaluate perceptions of sDNA testing.Results:Of the 613 participants who were sent surveys,423 responded(69%response rate).Respondents self-identified as African American(n=127,30%),Caucasian(n=284,67%),and other ethnicity(n=12,3%).In general,participants found the sDNA test more suitable than a colonos-copy(n=309,75%).In univariate analyses,a higher percentage of Caucasians as compared with African Americans found the sDNA test more suitable than a colonoscopy(89%vs.76%,p<0.01),and more Caucasians than African Americans preferred the sDNA test(43%vs.32%,p<0.05).Ad-justment for covariates reduced these racial differences to no significance.A family history of colo-rectal cancer remains a significant factor for patient’s preferences for screening regardless of race.Conclusions:Our study shows no racial differences in the perception of and preference for sDNA testing for colon screening.Intervention to increase the uptake of sDNA testing may help reduce racial disparities in colorectal cancer. | Matthew V.Abola Todd F.Fennimore Marcia M.Chen Zhengyi Chen Ashutosh K.Sheth Gregory Cooper Li Li | 2015 | Family Medicine and Community Health2015，3，3： | 2 |
| 4 | Dopamine D 2 -Receptor-Mediated Increase in Vascular and Endothelial NOS Activity Ameliorates Cerebral Vasospasm After Subarachnoid Hemorrhage In Vitro显示文摘 | Gail J. Pyne-Geithman Danielle N. Caudell Matthew Cooper Joseph F. Clark Lori A. Shutter | 2009 | Neurocritical Care2009，，2： | 1 |
| 5 | Penicillium marneffei Infection and Recent Advances in the Epidemiology and Molecular Biology Aspects显示文摘 | Nongnueh V Chester R Cooper Jr Matthew C Fisher | 2006 | Clin Microbiol Rev2006，19，1： | 1 |
| 6 | Advanced Glycation End Products Induce Tubular Epithelial-Myofibroblast Transition through the RAGE-ERK1/2 MAP Kinase Signaling Pathway显示文摘 | Jin H. Li Wansheng Wang Xiao R. Huang Matthew Oldfield Ann M. Schmidt Mark E. Cooper Hui Y. Lan | 2004 | The American Journal of Pathology2004，，4： | 1 |
| 7 | The V 2 Transition Ratio显示文摘 | Brian P. Betensky Robert E. Park Francis E. Marchlinski Matthew D. Hutchinson Fermin C. Garcia Sanjay Dixit David J. Callans Joshua M. Cooper Rupa Bala David Lin Michael P. Riley Edward P. Gerstenfeld | 2011 | Journal of the American College of Cardiology2011，，22： | 1 |
| 8 | Triiodothyronine in the recovery of stunned myocardium in dogs显示文摘 | Novitzky D Matthews N Shawley D Cooper D K Zuhdi N | | 0，，： | 1 |
| 9 | Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the atherosclerosis risk in communities study 1 1 The authors have no proprietary interest in the equipment and techniques described in this article.显示文摘 | Larry D Hubbard Rosemary J Brothers William N King Limin X Clegg Ronald Klein Lawton S Cooper A.Richey Sharrett Matthew D Davis Jianwen Cai | 1999 | Ophthalmology1999，，12： | 1 |
| 10 | Alterations of the blood–brain barrier in cerebral white matter lesions in the ageing brain显示文摘 | Julie E. Simpson Stephen B. Wharton James Cooper Catherine Gelsthorpe Lynne Baxter Gillian Forster Pamela J. Shaw George Savva Fiona E. Matthews Carol Brayne Paul G. Ince | 2010 | Neuroscience Letters2010，，3： | 1 |
| 11 | Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the atherosclerosis risk in communities study 1 1 The authors have no proprietary interest in the equipment and techniques described in this article.显示文摘 | Larry D Hubbard Rosemary J Brothers William N King Limin X Clegg Ronald Klein Lawton S Cooper A.Richey Sharrett Matthew D Davis Jianwen Cai | 1999 | Ophthalmology1999，，12： | 1 |
| 12 | Evaluation of a predictive model for implant surface topography effects on early osseointegration in the rat tibia model显示文摘 | Armin Abron Matthew Hopfensperger Jeffery Thompson Lyndon F. Cooper | 2001 | The Journal of Prosthetic Dentistry2001，，： | 1 |
| 13 | Water level fluctuation and sediment–water nutrient exchange in Great Lakes coastal wetlands显示文摘 | Alan D. Steinman Mary E. Ogdahl Maggie Weinert Kurt Thompson Matthew J. Cooper Donald G. Uzarski | 2012 | Journal of Great Lakes Research2012，，4： | 1 |
| 14 | Antibacterial serrulatane diterpenes from the Australian native plant Eremophila microtheca显示文摘 | Emma C. Barnes Angela M. Kavanagh Soumya Ramu Mark A. Blaskovich Matthew A. Cooper Rohan A. Davis | 2013 | Phytochemistry2013，，： | 1 |
| 15 | Differential ferritin expression is associated with iron deficiency in coeliac disease显示文摘 | Naveen Sharma Jusnara Begum Bertus Eksteen Amul Elagib Matthew Brookes Brian T. Cooper Chris Tselepis Tariq H. Iqbal | 2009 | European Journal of Gastroenterology & Hepatology2009，，7： | 1 |
| 16 | Long-Term Results of a Phase II Trial of Neoadjuvant Chemotherapy Followed by Esophagectomy for Locally Advanced Esophageal Neoplasm显示文摘 | Arjun Pennathur James D. Luketich Rodney J. Landreneau Julie Ward Neil A. Christie Michael K. Gibson Matthew Schuchert Kristi Cooper Stephanie R. Land Chandra P. Belani | 2008 | The Annals of Thoracic Surgery2008，，： | 1 |
| 17 | The pro-inflammatory and chemotactic cytokine microenvironment of the abdominal aortic aneurysm wall: A protein array study显示文摘 | Rachel K. Middleton Geraint M. Lloyd Matthew J. Bown Nicola J. Cooper Nicholas J. London Robert D. Sayers | 2007 | Journal of Vascular Surgery2007，，3： | 1 |
| 18 | Building Bridges between cooperative and collaborative learning 显示文摘 | Matthews Roberta S James L Cooper Neil Davidson | 1995 | Change1995，，： | 1 |
| 19 | Geneious Basic: An integrated and extendable desktop software platform for the organization and analysis of sequence data显示文摘 | Matthew Kearse Richard Moir Amy Wilson Steven Stones-Havas Matthew Cheung Shane Sturrock Simon Buxton Alex Cooper Sidney Markowitz Chris Duran Tobias Thierer Bruce Ashton Peter Meintjes Alexei Drummond | 2012 | Bioinformatics2012，，： | 1 |
| 20 | The Human Gene Mutation Database: building a comprehensive mutation repository for clinical and molecular genetics, diagnostic testing and personalized genomic medicine显示文摘 | Peter D. Stenson Matthew Mort Edward V. Ball Katy Shaw Andrew D. Phillips David N. Cooper | 2014 | Human Genetics2014，，1： | 1 |
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