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| 1 | 瑞舒伐他汀对存在亚临床动脉粥样硬化的低危人群颈动脉内膜中层厚度进展的影响——METEOR试验显示文摘背景:动脉粥样硬化往往在机体出现症状之前就已有所进展。目前,我们尚不清楚Framingham风险评分(Framinghaln risk score,FRS)较低的轻中度亚临床动脉粥样硬化中年人群是否能从治疗中获益。
目的:评价为期2年的他汀类药物治疗能否减缓颈动脉内膜中层厚度(carotid intimamedia thickness,CIMT)继续增厚或使粥样斑块消退。
设计、地点及参试者:“瑞舒伐他汀对内膜中层厚度影响的测评研究(Measuring Effects on Intima-Media Thickness:an Evaluation of Rosuvastatin,METEOR)”是2002年8月至2006年5月在美国及欧洲61个基层医疗中心开展的一项随机、双盲、安慰剂对照研究,共纳入984名参试者,有的参试者仅以年龄(平均年龄,57岁)为冠心病的危险因素,有的参试者10年内FRS低于10%、CIMT重庞增厚(1.2~3.5mm)、LDL胆固醇水平有所升高(平均值,154mg/dL)。
干预:参试者服用40mg瑞舒伐他汀或安慰剂。
主要观测指标:12个颈动脉位点最大CIMT的变化率(经B超检测);颈总动脉位点、颈动脉窦位点及颈内动脉位点最大CIMT的变化,颈总动脉位点平均CIMT的变化。仅在瑞舒伐他汀组中评估CIMT的消退情况。
结果:瑞舒伐他汀组参试者LDL胆固醇平均(SD)水平由基线时的155(24.1)mg/dL降至78(27.5)mg/dL,平均降低49%(与安慰剂组相比P〈0.001)。瑞舒伐他汀组12个颈动脉位点最大CIMT的变化值为-0.0014(95%CI,-0.0041~0.0014)mm/y,安慰剂组12个颈动脉位点最大CIMT的变化值为Q0131(95%CI,Q0087~Q0174)mm/y(P〈0.001)。瑞舒伐他汀组颈总动脉位点最大CIMT的变化值为-0.0038(95%CI,-0.0064~-0.0013)mm/y(P〈0.001),颈动脉窦位点最大CIMT的变化值为-0.0040(95%CI,-0.0090~0.0010)mm/y(P〈0.001),颈内动脉位点最大CIMT的变化值为0.0039(95%CI,-0.0009~0.0088)mm/y(P=0.02)。瑞舒伐他汀组颈总动脉位点平均CIMT的变化值为0.0004(95%CI,-0.0011~0.0019)mm/y(P〈0.001)。P值均为与安慰剂组相比。总的来说,瑞舒伐他汀具有良好的耐受性,很少引发严重的心血管不良事件(在2年内有6名参试者[0.86%]出现8起不良事件[1.1%])。
结论:对于FRS低于10%的亚临床动脉粥样硬化中年人群而言,瑞舒伐他汀能够在2年内显著降低最大CIMT的进展速率,与安慰剂相比差异具有统计学显著性。但是,瑞舒伐他汀无法诱导病变消退。今后,我们仍需开展大型远期试验来明确上述研究结果的临床意义. | John R. Crouse Ⅲ Joel S. Raichlen Ward A. Riley Gregory W. Evans Mike K. Palmer Daniel H. O' Leary Diederick E. Grobbee Michiel L. Bots 李军(译) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 44 |
| 2 | Bedside ultrasound in the diagnosis of nonalcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease in the United States.While the American Association for the Study of Liver Diseases guidelines define NAFLD as hepatic steatosis detected either on histology or imaging without a secondary cause of abnormal hepatic fat accumulation,no imaging modality is recommended as standard of care for screening or diagnosis.Bedside ultrasound has been evaluated as a non-invasive method of diagnosing NAFLD with the presence of characteristic sonographic findings.Prior studies suggest characteristic sonographic findings for NAFLD include bright hepatic echoes,increased hepatorenal echogenicity,vascular blurring of portal or hepatic vein and subcutaneous tissue thickness.These sonographic characteristics have not been shown to aid bedside clinicians easily identify potential cases of NAFLD.While sonographic findings such as attenuation of image,diffuse echogenicity,uniform heterogeneous liver,thick subcutaneous depth,and enlarged liver filling of the entire field could be identifiedby clinicians from bedside ultrasound.The accessibility,ease of use,and low-side effect profile of ultrasound make bedside ultrasound an appealing imaging modality in the detection of hepatic steatosis.When used with appropriate clinical risk factors and steatosis involves greater than 33%of the liver,ultrasound can reliably diagnose NAFLD.Despite the ability of ultrasound in detecting moderate hepatic steatosis,it cannot replace liver biopsy in staging the degree of fibrosis.The purpose of this review is to examine the diagnostic accuracy,utility,and limitations of ultrasound in the diagnosis of NAFLD and its potential use by clinicians in routine practices. | Nancy Khov Amol Sharma Thomas R Riley | 2014 | World Journal of Gastroenterology2014，20，22： | 11 |
| 3 | 煤中形态硫分析及脱除能力研究显示文摘在实验室自动定硫仪上采用形态硫直接测定法,测定了7种煤样的脂肪硫、黄铁矿硫与噻吩硫的含量及它们脱除难易程度(能力),结果表明采用本实验方法测得的形态硫结果与X-射线吸收精细结构能谱(XAFS)所分析的结果一致。煤中形态硫在加热条件下脱除能力为:脂肪硫>黄铁矿硫>噻吩硫>硫酸盐硫,而在弱碱性氧化脱硫条件下各形态硫脱除能力为:黄铁矿硫>脂肪硫>噻吩硫>硫酸盐硫。 | 张德祥 Riley,JT | 1996 | 燃料化学学报1996，24，2： | 10 |
| 4 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 5 | Nanoscale control of Ag nanostructures for plasmonic fluorescence enhancement of near-infrared dyes显示文摘为各种各样的疾病的早察觉和诊断的蛋白质的潜在的利用在基于蛋白质的察觉技术的发展拉了可观的兴趣。导致的荧光改进为在临床的应用增加蛋白质察觉的敏感的可能性提供的金属。我们为荧光改进报导悦耳的 plasmonic 银 nanostructures 的使用一在红外线附近(NIR ) 染料(Alexa Fluor 790 ) 。2 个数量级的广泛的荧光改进被 Ag nanostructure 尺寸和 interparticle 距离的 nanoscale 控制获得。这些 Ag nanostructures 也与很高的量产量从染料提高了荧光(为 Alexa Fluor 488 的 7.8 褶层,量效率(Qy )= 0.92 ) 。极大地提高的刺激和增加的放射的腐烂率的联合,导致量效率的联系改进导致大改进。这些结果作为金属显示出 Ag nanostructures 的潜力为在 NIR 生物窗户以及可见区域中的染料的导致的荧光改进(MIFE ) 底层。胶体的平版印刷术制作的 Ag nanostructured 数组因此为 NIR 基于染料的 biosensing 应用显示出大潜力。 | Fang Xie Jing S. Pang Anthony Centeno Mary P. Ryan D. Jason Riley Neil M. Alford | 2013 | Nano Research2013，6，7： | 8 |
| 6 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 7 | National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants显示文摘 | Goodarz Danaei Mariel M Finucane Yuan Lu Gitanjali M Singh Melanie J Cowan Christopher J Paciorek John K Lin Farshad Farzadfar Young-Ho Khang Gretchen A Stevens Mayuree Rao Mohammed K Ali Leanne M Riley Carolyn A Robinson Majid Ezzati | 2011 | The Lancet2011，，9785： | 6 |
| 8 | Advances in targeted nanotherapeutics: From bioconjugation to biomimicry显示文摘 | Danielle M. Valcourt Jenna Harris Rachel S. Riley Megan Dang Jianxin Wang Emily S. Day | 2018 | Nano Research2018，11，10： | 5 |
| 9 | 四城市初中生吸烟与不健康行为的关系研究显示文摘目的了解北京、杭州、武汉和乌鲁木齐四城市初中生的吸烟情况,并分析其吸烟行为与多种危害健康的行为和心理问题的关系。方法中国疾病预防控制中心(CDC)健康教育所提供四城市所有中学资料,由美国CDC用特殊的抽样软件从中抽取100所学校,采用WHO的全球学校学生健康调查问卷对9015名初中生进行调查。结果参加调查的初中生尝试吸烟率为29.496,过去30d中6.6%的学生使用过烟草。27.0%的吸烟学生在9岁及以前开始吸第1支烟,31.8%的学生从学校教育中学到过拒烟技巧。吸烟组的饮酒、使用毒品、伤害、旷课行为和心理问题发生率均显著高于不吸烟组。结论初中生的尝试吸烟率和吸烟率有上升趋势。吸烟行为的发生与多种不健康行为和心理问题密切相关。 | 田本淳 孟宪鹏 吕书红 钱玲 张巍 张继彬 田向阳 熊光练 严维红 张新卫 Laura Kann Leanne Riley | 2007 | 中华流行病学杂志2007，28，3： | 5 |
| 10 | 中国头针治疗小儿脑瘫(英文)显示文摘目的:观察头针治疗脑性瘫痪的疗效。方法:笔者在美国对36位脑性瘫痪儿童进行了头针治疗。选穴以足运感区、平衡区为主,根据患者个体情况,配合选择言语Ⅰ区,言语Ⅱ区,视区等,针刺过程中行针捻转后留置头针30分钟。结果:在3到20次治疗后,治愈5例,14例取得了显著疗效,14例有效,3例无效。在治疗过程中无不良反应发生。结论:目前头皮针刺已成为脑瘫治疗的首选方法,通过观察纳入病例,发现头针缓解了脑瘫患儿的肢体痉挛、运动障碍、言语不能、认知障碍等,提高了病人的生活质量,改善了身体残疾症状,部分脑瘫患者可以完全康复。这些脑瘫的病例为美国神经针灸研究院与博瑞西医大学联合研究头针治疗小儿脑瘫的临床应用奠定了良好的基础。 | 吕晓琳 郝吉顺 孙忠人 David Riley 南志忠 Brian McKenna Thomas Hodge | 2017 | World Journal of Acupuncture-Moxibustion2017，27，2： | 5 |
| 11 | Cardiac arrhythmias and cardiac arrest related to mushroom poisoning: A case report显示文摘BACKGROUND Mushroom exposure is a global health issue.The manifestations of mushroom poisoning (MP) may vary.Some species have been reported as rhabdomyolytic,hallucinogenic,or gastrointestinal poisons.Critical or even fatal MPs are mostly attributable to Amanita phalloides,with the development of severe liver or renal failure.Myocardial injury and even cases mimicking ST-segment elevation myocardial infarction (STEMI) have been previously reported,while cardiac arrhythmia or cardiac arrest is not commonly seen.CASE SUMMARY We report a 68-year-old woman with MP who suffered from delirium,seizure,long QT syndrome on electrocardiogram (ECG),severe cardiac arrhythmias of multiple origins,and cardiac arrest.She was intubated and put on blood perfusion.Her kidney and liver functions were intact;creatine kinase-MB was mildly elevated,and then fell within normal range during her hospital stay.We sent the mushrooms she left for translation elongation factor subunit 1α,ribosomal RNA gene sequence,and internal transcribed spacer sequence analyses.There were four kinds of mushrooms identified,two of which were found to be toxic.CONCLUSION This is the first time that we found cardiac toxicity caused by Panaeolus subbalteatus and Conocybe lactea,which were believed to be toxic to the liver,kidney,and brain.We suggest that intensive monitoring and ECG follow-up are essential to diagnose prolonged QT interval and different forms of tachycardia in MP patients,even without the development of severe liver or renal failure.The mechanisms need to be further investigated and clarified based on animal experiments and molecular signal pathways. | Shu Li Qing-Bian Ma Ci Tian Hong-Xia Ge Yang Liang Zhi-Guo Guo Cheng-Duo Zhang Bei Yao Jia-Ning Geng Fran Riley | 2019 | World Journal of Clinical Cases2019，7，16： | 4 |
| 12 | Full-aperture backscatter diagnostics and applications at the Texas Petawatt Laser facility显示文摘 | C. Wang C. Wagner G. Dyer E. Gaul N. Kandadai N. Riley D. Kuk E. McCary A. Meadows I. Pomerantz M. Spinks T. Borger A. Bernstein M. Donovan M. Martinez T. Ditmire Bjorn M. Hegelich | 2014 | Chinese Optics Letters2014，12，A02： | 4 |
| 13 | Process engineering for primary care:Quality improvement and population health显示文摘A fundamental paradox of the health care delivery systems in many industrialized nations is that desired population health metrics are often not achieved despite large expenditures in the health care delivery system.For example,the United States commits nearly 18%of its GDP to the health care delivery system,the largest amount of any nation,yet is 37th in achieving health or health care delivery metrics.This article addresses how general practice can be an important driver of population health in the Chinese health care delivery system through the application of quality improvement methods.The article shows examples of how the cause-and-effect diagram,the process map,and the plan,do,study,act(PDSA)cycle are important techniques to assist primary care practitioners for improving population health. | William Riley | 2016 | Family Medicine and Community Health2016，4，2： | 3 |
| 14 | Epidemiology of prostatitis: new evidence for a world-wide problem显示文摘 | John N. Krieger Donald E. Riley Phaik Yeong Cheah Men Long Liong Kah Hay Yuen | 2003 | World Journal of Urology2003，，2： | 3 |
| 15 | 煤粉炉烟气中汞浓度测试和分布(英文)显示文摘参照美国标准实验方法(ASTM)中关于汞的OHM等速取样和化学分析法,结合汞的SCEM在线测量技术,利用一多功能流动实验室,对一满负荷运行的100MW煤粉锅炉尾部烟气系统进行了单质汞、氧化态汞和颗粒态汞的现场测试和分析.得到了空气预热器、静电除尘器前后烟气中气态、固态和烟气中总汞的浓度及其分布.结果表明烟气中气态总汞的浓度随温度的降低发生着氧化态汞向颗粒汞的转化.在ESP之后的清洁烟气中,OHM和SCEM方法的测试结果吻合较好;在含颗粒浓度较高的烟气中,2种方法存在较大的偏差,原因在于OHM取样过滤器中形成一定厚度的飞灰.该飞灰颗粒对烟气中气态汞有吸附作用并形成颗粒汞. | 段钰锋 Cao Yan Shawn Kellie Kunlei Liu John Riley Weiping Pan | 2005 | Journal of Southeast University(English Edition)2005，21，1： | 3 |
| 16 | Synthesis and degradation of cytochrome c oxidase subunit mRNAs in neurons: differential bigenomic regulation by neuronal activity显示文摘 | Zhang C Wong Riley M T | 2000 | J Neurosci Res2000，60，3： | 2 |
| 17 | Intragastric distribution and gastric emptying of solids and liquids in functional dyspepsia显示文摘 | A. M. Scott FRACP Dr. J. E. Kellow MD FRACP B. Shuter MSc H. Cowan RN A.-M. Corbett NMT J. W. Riley MD FRACP M. R. Lunzer FRCP FRACP R. P. Eckstein FRCPA R. H?schl MD S.-K. Lam MD FRCP FRACP M. P. Jones PhD | 1993 | Digestive Diseases and Sciences1993，，12： | 2 |
| 18 | Oxycodone: a review of its use in the management of pain显示文摘 | Julia Riley Elon Eisenberg Gerhard Müller-Schwefe Asbj?rn M. Drewes Lars Arendt-Nielsen | 2007 | Current Medical Research and Opinion?2007，，1： | 2 |
| 19 | Thermal hypersensitivity in a subset of irritable bowel syndrome patients显示文摘AIM:To characterize thermal hypersensitivity in patients with constipation-and diarrhea-predominant irritable bowel syndrome (IBS).METHODS:Thermal pain sensitivity was tested among patients with diarrhea-predominant IBS (D-IBS) and constipation-predominant IBS (C-IBS) compared to healthy subjects.A total of 42 patients (29 female and 13 male;mean age 27.0±6.4 years) with D-IBS;24 patients (16 female and eight male;mean age 32.5±8.8 years) with C-IBS;and 52 control subjects (34 female and 18 male;mean age 27.3±8.0 years) participated in the study.Thermal stimuli were delivered using a Medoc Thermal Sensory Analyzer with a 3 cm × 3 cm surface area.Heat pain threshold (HPTh) and heat pain tolerance (HPTo) were assessed on the left ventral forearm and left calf using an ascending method of limits.The Functional Bowel Disease Severity Index (FBDSI) was also obtained for all subjects.RESULTS:Controls were less sensitive than C-IBS and D-IBS (both at P < 0.001) with no differences between C-IBS and D-IBS for HPTh and HPTo.Thermal hyperalgesia was present in both groups of IBS patients relative to controls,with IBS patients reporting significantly lower pain threshold and pain tolerance at both test sites.Cluster analysis revealed the presence of subgroups of IBS patients based on thermal hyperalgesia.One cluster (17% of the sample) showed a profile of heat pain sensitivity very similar to that of healthy controls;a second cluster (47% of the sample) showed moderate heat pain sensitivity;and a third cluster (36% of the sample) showed a very high degree of thermal hyperalgesia.CONCLUSION:A subset of IBS patients had thermal hypersensitivity compared to controls,who reported significantly lower HPTh and HPTo.All IBS patients had a higher score on the FBDSI than controls.Interestingly,the subset of IBS patients with high thermal sensitivity (36%) had the highest FBDSI score compared to the other two groups of IBS patients. | QiQi Zhou Roger B Fillingim Joseph L Riley Ⅲ G Nicholas Verne | 2009 | World Journal of Gastroenterology2009，15，26： | 2 |
| 20 | 多重结局的多元Meta分析和多重治疗的网状Meta分析:原理、概念及实例显示文摘英国国家健康与临床优选研究所(NICE)等组织需要对现有研究获得的证据进行整合来指导决策,需要确定关于多重疗效及安全性结局的最佳治疗。但是,相关的研究不一定对所有关注的治疗或结局都进行了直接比较,多元Meta分析及网状Meta分析为如何确定最佳治疗这一问题提供了思路,该方法不仅考虑了直接证据,还利用了关联或间接的证据。本文中,研究者描述了这些方法学的重要概念及假设,并阐述关联及间接证据如何产生,同时通过图表说明这些证据在涉及多重结局和多重治疗的真实临床案例中如何使用。 | Richard D Riley Dan Jackson Georgia Salanti Danielle L Burke Malcolm Price Jamie Kirkham Ian R White 孙至佳(译) 张岩(译) 刘雪晴(译) 杨智荣(校) 孙凤(校) | 2018 | 英国医学杂志中文版2018，21，12： | 2 |
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